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    osk oskar [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41066, updated on 4-Jan-2025

    Summary

    Official Symbol
    oskprovided by FlyBase
    Official Full Name
    oskarprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003015
    Locus tag
    Dmel_CG10901
    See related
    AllianceGenome:FB:FBgn0003015
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10901; Dm-osk; Dmel\CG10901; norka; Osk; OSK; Oskar
    Summary
    Enables mRNA binding activity. Involved in several processes, including axis specification; pole cell formation; and thermosensory behavior. Located in P granule; germ cell nucleus; and posterior cell cortex. Is expressed in several structures, including egg chamber; germarium region 2b; germline cell; ovary; and pole granule. [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See osk in Genome Data Viewer
    Location:
    85B7-85B7; 3-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8935126..8938395)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4760848..4764117)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene polychaetoid Neighboring gene transfer RNA:Arginine-TCG 2-3 Neighboring gene transfer RNA:Arginine-TCG 2-4 Neighboring gene antisense RNA:CR44020 Neighboring gene long non-coding RNA:osk Neighboring gene Succinyl-coenzyme A synthetase beta subunit, ADP-forming Neighboring gene uncharacterized protein Neighboring gene ichor

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in P granule assembly PubMed 
    involved_in P granule organization PubMed 
    involved_in cortical actin cytoskeleton organization PubMed 
    involved_in germ cell development PubMed 
    involved_in long-term memory PubMed 
    involved_in oocyte microtubule cytoskeleton polarization PubMed 
    involved_in oogenesis PubMed 
    involved_in pole cell formation PubMed 
    involved_in pole cell formation PubMed 
    involved_in pole plasm assembly PubMed 
    involved_in pole plasm mRNA localization PubMed 
    involved_in pole plasm protein localization PubMed 
    involved_in posterior abdomen determination PubMed 
    involved_in protein localization to nucleus PubMed 
    involved_in regulation of mRNA stability PubMed 
    involved_in regulation of oskar mRNA translation PubMed 
    involved_in segmentation PubMed 
    involved_in thermosensory behavior PubMed 
    involved_in visual behavior PubMed 
    involved_in visual learning PubMed 
    Component Evidence Code Pubs
    located_in P granule PubMed 
    located_in cell cortex PubMed 
    located_in cytoplasm PubMed 
    located_in germ cell nucleus PubMed 
    located_in pole plasm PubMed 
    located_in posterior cell cortex PubMed 

    General protein information

    Preferred Names
    oskar
    Names
    CG10901-PA
    CG10901-PC
    dmoskar
    osk-PA
    osk-PC

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8935126..8938395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206464.3 → NP_996186.1  oskar, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996186.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25158
      Conserved Domains (1) summary
      cd09972
      Location:16 → 98
      LOTUS_TDRD_OSKAR; The first LOTUS domain in Oskar and Tudor-containing proteins 5 and 7
    2. NM_169248.4 → NP_731295.1  oskar, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731295.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25158, Q59DY0, Q95TT0, Q9V3P1
      UniProtKB/TrEMBL
      E8NH25
      Related
      FBpp0081435
      Conserved Domains (1) summary
      cd09972
      Location:154 → 236
      LOTUS_TDRD_OSKAR; The first LOTUS domain in Oskar and Tudor-containing proteins 5 and 7
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