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    Asb3 ankyrin repeat and SOCS box-containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 65257, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Asb3provided by MGI
    Official Full Name
    ankyrin repeat and SOCS box-containing 3provided by MGI
    Primary source
    MGI:MGI:1929749
    See related
    Ensembl:ENSMUSG00000020305 AllianceGenome:MGI:1929749
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Asb-3; 2400011J03Rik
    Summary
    Predicted to enable chloroplast targeting sequence binding activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway; positive regulation of JNK cascade; and protein targeting to chloroplast. Predicted to be active in nucleus. Is expressed in cerebral cortex; cerebral cortex ventricular layer; and trunk somite. Orthologous to human GPR75-ASB3 (GPR75-ASB3 readthrough) and ASB3 (ankyrin repeat and SOCS box containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 3.5), CNS E18 (RPKM 3.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Asb3 in Genome Data Viewer
    Location:
    11 A4; 11 18.19 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (30904398..31052704)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (30954392..31102704)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene endoplasmic reticulum lectin 1 Neighboring gene G protein-coupled receptor 75 Neighboring gene PDZ and LIM domain protein 1 pseudogene Neighboring gene ChaC, cation transport regulator 2 Neighboring gene STARR-seq mESC enhancer starr_29073 Neighboring gene GPN-loop GTPase 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29074 Neighboring gene STARR-seq mESC enhancer starr_29075 Neighboring gene STARR-seq mESC enhancer starr_29076 Neighboring gene predicted gene, 40822 Neighboring gene stanniocalcin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiota. Cheng M, et al. mBio, 2024 Sep 11. PMID 39162488, Free PMC Article
    2. Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. Kile BT, et al. Gene, 2000 Nov 27. PMID 11111040
    3. Functional analysis of Asb-1 using genetic modification in mice. Kile BT, et al. Mol Cell Biol, 2001 Sep. PMID 11509662, Free PMC Article
    4. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiota.
      Title: ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiota.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chloroplast targeting sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to chloroplast IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 3
    Names
    ankyrin repeat and SOCS box-containing protein 3
    ankyrin repeat-containing SOCS box protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023906.3 → NP_076395.2  ankyrin repeat and SOCS box protein 3

      See identical proteins and their annotated locations for NP_076395.2

      Status: VALIDATED

      Source sequence(s)
      AK028489, AK143580, BB618690
      Consensus CDS
      CCDS24511.1
      UniProtKB/Swiss-Prot
      Q5SSV5, Q9WV72
      UniProtKB/TrEMBL
      Q8R5B4
      Related
      ENSMUSP00000020551.7, ENSMUST00000020551.13
      Conserved Domains (4) summary
      cd03722
      Location:458 → 508
      SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
      sd00045
      Location:145 → 176
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:216 → 309
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:22 → 237
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      30904398..31052704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156890.1 → XP_036012783.1  ankyrin repeat and SOCS box protein 3 isoform X2

      Conserved Domains (3) summary
      cd03722
      Location:315 → 365
      SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
      sd00045
      Location:2 → 33
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:7 → 97
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_006514771.5 → XP_006514834.1  ankyrin repeat and SOCS box protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006514834.1

      UniProtKB/Swiss-Prot
      Q5SSV5, Q9WV72
      UniProtKB/TrEMBL
      Q8R5B4
      Related
      ENSMUSP00000144900.2, ENSMUST00000203878.3
      Conserved Domains (4) summary
      cd03722
      Location:458 → 508
      SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
      sd00045
      Location:145 → 176
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:216 → 309
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:22 → 237
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WV72.2 GenPept UniProtKB/Swiss-Prot:Q9WV72

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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