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Conserved domains on  [gi|568970401|ref|XP_006514834|]
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ankyrin repeat and SOCS box protein 3 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
23-303 1.15e-46

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 164.36  E-value: 1.15e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  23 VKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSSENYIKAKtfeGFCALHLAVSQGHWKITQILLEAG 102
Cdd:COG0666    1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADAL---GALLLLAAALAGDLLVALLLLAAG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 103 ADPNETTLEETTPLFLAVESGRIDVLKLLLQHGANVNgSHSMSGWNSLHQASFQGNAETIRLLLKQGADRECQDDFGITP 182
Cdd:COG0666   78 ADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN-ARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 183 LFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDNWqlPIHAAAQMGHTET 262
Cdd:COG0666  157 LHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKT--ALDLAAENGNLEI 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 568970401 263 LDLLIPRTNRACDTGPDKVSPVYSAVFGGREECLEMLLQNG 303
Cdd:COG0666  235 VKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
458-508 2.97e-25

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239692  Cd Length: 51  Bit Score: 97.94  E-value: 2.97e-25
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568970401 458 ASVPSLTHLCRLEIRASLKAEHLHSDIFIHQLPLPRSLQNYLLYEEVLRMN 508
Cdd:cd03722    1 ASVPSLTHLCRLEIRSSLKSERLRSDSFICQLPLPRSLQDYLLYSDVLRMY 51
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
23-303 1.15e-46

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 164.36  E-value: 1.15e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  23 VKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSSENYIKAKtfeGFCALHLAVSQGHWKITQILLEAG 102
Cdd:COG0666    1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADAL---GALLLLAAALAGDLLVALLLLAAG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 103 ADPNETTLEETTPLFLAVESGRIDVLKLLLQHGANVNgSHSMSGWNSLHQASFQGNAETIRLLLKQGADRECQDDFGITP 182
Cdd:COG0666   78 ADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN-ARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 183 LFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDNWqlPIHAAAQMGHTET 262
Cdd:COG0666  157 LHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKT--ALDLAAENGNLEI 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 568970401 263 LDLLIPRTNRACDTGPDKVSPVYSAVFGGREECLEMLLQNG 303
Cdd:COG0666  235 VKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
458-508 2.97e-25

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 97.94  E-value: 2.97e-25
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568970401 458 ASVPSLTHLCRLEIRASLKAEHLHSDIFIHQLPLPRSLQNYLLYEEVLRMN 508
Cdd:cd03722    1 ASVPSLTHLCRLEIRSSLKSERLRSDSFICQLPLPRSLQDYLLYSDVLRMY 51
Ank_2 pfam12796
Ankyrin repeats (3 copies);
150-240 1.64e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 89.02  E-value: 1.64e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  150 LHQASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSgANVNCQaLDKATPLFIAAQEGHTKCVE 229
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLK-DNGRTALHYAARSGHLEIVK 78
                          90
                  ....*....|.
gi 568970401  230 LLLSSGADPDL 240
Cdd:pfam12796  79 LLLEKGADINV 89
PHA03100 PHA03100
ankyrin repeat protein; Provisional
22-237 1.28e-20

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 94.35  E-value: 1.28e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  22 NVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSSENyIKAKTFegFCALHLAVSQGH-----WKITQ 96
Cdd:PHA03100  14 KVKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADIN-SSTKNN--STPLHYLSNIKYnltdvKEIVK 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  97 ILLEAGADPNETTLEETTPLFLAV--ESGRIDVLKLLLQHGANVNgSHSMSGWNSLHQASFQG----------------- 157
Cdd:PHA03100  91 LLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEYLLDNGANVN-IKNSDGENLLHLYLESNkidlkilkllidkgvdi 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 158 NAET-IRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGA 236
Cdd:PHA03100 170 NAKNrVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249

                 .
gi 568970401 237 D 237
Cdd:PHA03100 250 S 250
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
42-234 2.72e-14

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 75.43  E-value: 2.72e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  42 RGW-MPIHEAAYHNAVECLQMLIHTDSSENYikAKTFEGFCALHLAVSQGHWKITQILLEAgaDPNETTLEET------- 113
Cdd:cd22192   15 RISeSPLLLAAKENDVQAIKKLLKCPSCDLF--QRGALGETALHVAALYDNLEAAVVLMEA--APELVNEPMTsdlyqge 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 114 TPLFLAVESGRIDVLKLLLQHGANVN-----GSHSMSGWNSL-----HQASF---QGNAETIRLLLKQGADRECQDDFGI 180
Cdd:cd22192   91 TALHIAVVNQNLNLVRELIARGADVVspratGTFFRPGPKNLiyygeHPLSFaacVGNEEIVRLLIEHGADIRAQDSLGN 170
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568970401 181 TPLFV-AAQYGKL---ESMSILISSGANVNCQALDKA------TPLFIAAQEGHTKCVELLLSS 234
Cdd:cd22192  171 TVLHIlVLQPNKTfacQMYDLILSYDKEDDLQPLDLVpnnqglTPFKLAAKEGNIVMFQHLVQK 234
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
459-500 4.81e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 57.56  E-value: 4.81e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568970401  459 SVPSLTHLCRLEIRASLKAEHLHSdifIHQLPLPRSLQNYLL 500
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGA---IDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
461-502 2.10e-09

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 52.80  E-value: 2.10e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568970401   461 PSLTHLCRLEIRASLKaehlhsdiFIHQLPLPRSLQNYLLYE 502
Cdd:smart00969   1 RSLQHLCRLAIRRSLG--------GIDKLPLPPRLKDYLLYY 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
114-139 6.29e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.96  E-value: 6.29e-06
                           10        20
                   ....*....|....*....|....*.
gi 568970401   114 TPLFLAVESGRIDVLKLLLQHGANVN 139
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
114-267 1.43e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 44.69  E-value: 1.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  114 TPLF-LAVESGRIDVLKLLLQHGANVNgshsmSGWNSLHQAS--FQGNAE-TIRLLLKQGADR--------ECQDDF--G 179
Cdd:TIGR00870  54 SALFvAAIENENLELTELLLNLSCRGA-----VGDTLLHAISleYVDAVEaILLHLLAAFRKSgplelandQYTSEFtpG 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  180 ITPLFVAAQYGKLESMSILISSGANVNCQAldkatplfiaaqeghtKCVELLLSSGADpDLYCNEdnwqLPIHAAAQMGH 259
Cdd:TIGR00870 129 ITALHLAAHRQNYEIVKLLLERGASVPARA----------------CGDFFVKSQGVD-SFYHGE----SPLNAAACLGS 187

                  ....*...
gi 568970401  260 TETLDLLI 267
Cdd:TIGR00870 188 PSIVALLS 195
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
23-303 1.15e-46

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 164.36  E-value: 1.15e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  23 VKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSSENYIKAKtfeGFCALHLAVSQGHWKITQILLEAG 102
Cdd:COG0666    1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADAL---GALLLLAAALAGDLLVALLLLAAG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 103 ADPNETTLEETTPLFLAVESGRIDVLKLLLQHGANVNgSHSMSGWNSLHQASFQGNAETIRLLLKQGADRECQDDFGITP 182
Cdd:COG0666   78 ADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN-ARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 183 LFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDNWqlPIHAAAQMGHTET 262
Cdd:COG0666  157 LHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKT--ALDLAAENGNLEI 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 568970401 263 LDLLIPRTNRACDTGPDKVSPVYSAVFGGREECLEMLLQNG 303
Cdd:COG0666  235 VKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
16-249 3.57e-46

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 163.20  E-value: 3.57e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  16 LAAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSSenyIKAKTFEGFCALHLAVSQGHWKIT 95
Cdd:COG0666   60 AAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD---VNARDKDGETPLHLAAYNGNLEIV 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  96 QILLEAGADPNETTLEETTPLFLAVESGRIDVLKLLLQHGANVNGSHSmSGWNSLHQASFQGNAETIRLLLKQGADRECQ 175
Cdd:COG0666  137 KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDN-DGETPLHLAAENGHLEIVKLLLEAGADVNAK 215
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568970401 176 DDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDNWQL 249
Cdd:COG0666  216 DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
16-267 5.86e-46

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 162.82  E-value: 5.86e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  16 LAAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHtdsSENYIKAKTFEGFCALHLAVSQGHWKIT 95
Cdd:COG0666   27 AAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLA---AGADINAKDDGGNTLLHAAARNGDLEIV 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  96 QILLEAGADPNETTLEETTPLFLAVESGRIDVLKLLLQHGANVNgSHSMSGWNSLHQASFQGNAETIRLLLKQGADRECQ 175
Cdd:COG0666  104 KLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVN-AQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNAR 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 176 DDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDNwqLPIHAAA 255
Cdd:COG0666  183 DNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGL--TALLLAA 260
                        250
                 ....*....|..
gi 568970401 256 QMGHTETLDLLI 267
Cdd:COG0666  261 AAGAALIVKLLL 272
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
97-345 9.95e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.13  E-value: 9.95e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  97 ILLEAGADPNETTLEETTPLFLAVESGRIDVLKLLLQHGANVNGSHSMSGWNSLHQASFQGNAETIRLLLKQGADRECQD 176
Cdd:COG0666    5 LLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKD 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 177 DFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDNwqLPIHAAAQ 256
Cdd:COG0666   85 DGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGN--TPLHLAAA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 257 MGHTETLDLLIprtNRACD---TGPDKVSPVYSAVFGGREECLEMLLQNGYSPDAQMCLvfgFSSPLCMAFQKDCDfsGI 333
Cdd:COG0666  163 NGNLEIVKLLL---EAGADvnaRDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDND---GKTALDLAAENGNL--EI 234
                        250
                 ....*....|..
gi 568970401 334 VNILLKYGAQLN 345
Cdd:COG0666  235 VKLLLEAGADLN 246
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
458-508 2.97e-25

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 97.94  E-value: 2.97e-25
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568970401 458 ASVPSLTHLCRLEIRASLKAEHLHSDIFIHQLPLPRSLQNYLLYEEVLRMN 508
Cdd:cd03722    1 ASVPSLTHLCRLEIRSSLKSERLRSDSFICQLPLPRSLQDYLLYSDVLRMY 51
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
128-345 4.60e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 96.56  E-value: 4.60e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 128 LKLLLQHGANVNGSHSMSGWNSLHQASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNC 207
Cdd:COG0666    3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 208 QALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDNWqlPIHAAAQMGHTETLDLLIprtNRACD---TGPDKVSPV 284
Cdd:COG0666   83 KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGET--PLHLAAYNGNLEIVKLLL---EAGADvnaQDNDGNTPL 157
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568970401 285 YSAVFGGREECLEMLLQNGYSPDAQmcLVFGFsSPLCMAFQKDCDfsGIVNILLKYGAQLN 345
Cdd:COG0666  158 HLAAANGNLEIVKLLLEAGADVNAR--DNDGE-TPLHLAAENGHL--EIVKLLLEAGADVN 213
Ank_2 pfam12796
Ankyrin repeats (3 copies);
150-240 1.64e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 89.02  E-value: 1.64e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  150 LHQASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSgANVNCQaLDKATPLFIAAQEGHTKCVE 229
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLK-DNGRTALHYAARSGHLEIVK 78
                          90
                  ....*....|.
gi 568970401  230 LLLSSGADPDL 240
Cdd:pfam12796  79 LLLEKGADINV 89
PHA03100 PHA03100
ankyrin repeat protein; Provisional
22-237 1.28e-20

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 94.35  E-value: 1.28e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  22 NVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSSENyIKAKTFegFCALHLAVSQGH-----WKITQ 96
Cdd:PHA03100  14 KVKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADIN-SSTKNN--STPLHYLSNIKYnltdvKEIVK 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  97 ILLEAGADPNETTLEETTPLFLAV--ESGRIDVLKLLLQHGANVNgSHSMSGWNSLHQASFQG----------------- 157
Cdd:PHA03100  91 LLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEYLLDNGANVN-IKNSDGENLLHLYLESNkidlkilkllidkgvdi 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 158 NAET-IRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGA 236
Cdd:PHA03100 170 NAKNrVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249

                 .
gi 568970401 237 D 237
Cdd:PHA03100 250 S 250
PHA02875 PHA02875
ankyrin repeat protein; Provisional
21-240 2.33e-20

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 93.52  E-value: 2.33e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  21 GNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSSENYiKAKTFEGfcALHLAVSQGHWKITQILLE 100
Cdd:PHA02875  13 GELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDV-KYPDIES--ELHDAVEEGDVKAVEELLD 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 101 AGADPNETTLEE-TTPLFLAVESGRIDVLKLLLQHGANVNGShSMSGWNSLHQASFQGNAETIRLLLKQGADRECQDDFG 179
Cdd:PHA02875  90 LGKFADDVFYKDgMTPLHLATILKKLDIMKLLIARGADPDIP-NTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCG 168
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568970401 180 ITPLFVAAQYGKLESMSILISSGANVNCQALDK-ATPLFIAAQEGHTKCVELLLSSGADPDL 240
Cdd:PHA02875 169 CTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGcVAALCYAIENNKIDIVRLFIKRGADCNI 230
PHA02874 PHA02874
ankyrin repeat protein; Provisional
52-345 2.93e-20

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 93.10  E-value: 2.93e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  52 YHNAVECLQMLIHTDSseNYIKAKTFEGFCALHLAVSQGHWKITQILLEAGADPNETTLEETTPLFLAVESGRIDVLKLL 131
Cdd:PHA02874  10 YSGDIEAIEKIIKNKG--NCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 132 LQHGANVngshSMSGWNSLhqasfqgNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALD 211
Cdd:PHA02874  88 IDNGVDT----SILPIPCI-------EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDN 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 212 KATPLFIAAQEGHTKCVELLLSSGADPDLycNEDNWQLPIHAAAQMGHTETLDLLIPRTNRACDTGPDKVSPVYSAVFGG 291
Cdd:PHA02874 157 GCYPIHIAIKHNFFDIIKLLLEKGAYANV--KDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568970401 292 ReECLEMLLQNGYSPDAQMclvfGFSSPLCMAFQKDCDFSgIVNILLKYGAQLN 345
Cdd:PHA02874 235 R-SAIELLINNASINDQDI----DGSTPLHHAINPPCDID-IIDILLYHKADIS 282
PHA03095 PHA03095
ankyrin-like protein; Provisional
23-246 1.19e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 91.62  E-value: 1.19e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  23 VKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVE-CLQMLIHTDSSenyIKAKTFEGFCALH--LAVSQGHWKITQILL 99
Cdd:PHA03095  63 KDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTLdVIKLLIKAGAD---VNAKDKVGRTPLHvyLSGFNINPKVIRLLL 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 100 EAGADPNETTLEETTPLFLAVESGRIDV--LKLLLQHGANVNGShSMSGWNSLHQ--ASFQGNAETIRLLLKQGADRECQ 175
Cdd:PHA03095 140 RKGADVNALDLYGMTPLAVLLKSRNANVelLRLLIDAGADVYAV-DDRFRSLLHHhlQSFKPRARIVRELIRAGCDPAAT 218
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568970401 176 DDFGITPLFVAAQYG--KLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDN 246
Cdd:PHA03095 219 DMLGNTPLHSMATGSscKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGN 291
Ank_2 pfam12796
Ankyrin repeats (3 copies);
83-171 2.14e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 82.86  E-value: 2.14e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401   83 LHLAVSQGHWKITQILLEAGADPNETTLEETTPLFLAVESGRIDVLKLLLQHganVNGSHSMSGWNSLHQASFQGNAETI 162
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAARSGHLEIV 77

                  ....*....
gi 568970401  163 RLLLKQGAD 171
Cdd:pfam12796  78 KLLLEKGAD 86
PHA03100 PHA03100
ankyrin repeat protein; Provisional
113-371 3.85e-18

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 86.64  E-value: 3.85e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 113 TTPLFLAVESGRIDVLKLLLQHGANVNgSHSMSGWNSLHQASFQG-----NAETIRLLLKQGADRECQDDFGITPLFVAA 187
Cdd:PHA03100  36 VLPLYLAKEARNIDVVKILLDNGADIN-SSTKNNSTPLHYLSNIKynltdVKEIVKLLLEYGANVNAPDNNGITPLLYAI 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 188 QyGKLESMSI---LISSGANVNCQALDKATPLFIAAQEGH--TKCVELLLSSGADPDLYCNED---NWQLPIHAAAQMGH 259
Cdd:PHA03100 115 S-KKSNSYSIveyLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDINAKNRVNyllSYGVPINIKDVYGF 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 260 TetldlliprtnracdtgpdkvsPVYSAVFGGREECLEMLLQNGYSPDAqmCLVFGfSSPLCMAFqKDCDfSGIVNILLK 339
Cdd:PHA03100 194 T----------------------PLHYAVYNNNPEFVKYLLDLGANPNL--VNKYG-DTPLHIAI-LNNN-KEIFKLLLN 246
                        250       260       270
                 ....*....|....*....|....*....|..
gi 568970401 340 YGAqlNELHLAYCLKYEKFSMFCSFLKKGSLM 371
Cdd:PHA03100 247 NGP--SIKTIIETLLYFKDKDLNTITKIKMLK 276
PHA02876 PHA02876
ankyrin repeat protein; Provisional
17-346 5.67e-18

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 87.43  E-value: 5.67e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  17 AAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSSENyikaktfEGFCALHLAVSQGHWKITQ 96
Cdd:PHA02876 185 AAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNIN-------KNDLSLLKAIRNEDLETSL 257
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  97 ILLEAGADPNETTLEETTPLFLAVESGRIDVL-KLLLQHGANVNgSHSMSGWNSLHQASFQG-NAETIRLLLKQGADREC 174
Cdd:PHA02876 258 LLYDAGFSVNSIDDCKNTPLHHASQAPSLSRLvPKLLERGADVN-AKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNA 336
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 175 QDDFGITPLFVAAQYGKLESMSI-LISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDNWQLPIHA 253
Cdd:PHA02876 337 ADRLYITPLHQASTLDRNKDIVItLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAL 416
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 254 AAQMGHTeTLDLLIPRTNRACDTGPDKVSPV-YSAVFGGREECLEMLLQNGYSPDAqmcLVFGFSSPLCMAFQkdcdFSG 332
Cdd:PHA02876 417 CGTNPYM-SVKTLIDRGANVNSKNKDLSTPLhYACKKNCKLDVIEMLLDNGADVNA---INIQNQYPLLIALE----YHG 488
                        330
                 ....*....|....
gi 568970401 333 IVNILLKYGAQLNE 346
Cdd:PHA02876 489 IVNILLHYGAELRD 502
PHA03100 PHA03100
ankyrin repeat protein; Provisional
22-206 3.29e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 80.86  E-value: 3.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  22 NVKILRKLLKKGRSVD--VADNRGWMPIHEAAYHNA---VECLQMLIhtdSSENYIKAKTFEGFCALHLAVSQ--GHWKI 94
Cdd:PHA03100  47 NIDVVKILLDNGADINssTKNNSTPLHYLSNIKYNLtdvKEIVKLLL---EYGANVNAPDNNGITPLLYAISKksNSYSI 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  95 TQILLEAGADPNETTLEETTPLFLAVESGRID--VLKLLLQHGANVN-----------GSHSMS----GWNSLHQASFQG 157
Cdd:PHA03100 124 VEYLLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINaknrvnyllsyGVPINIkdvyGFTPLHYAVYNN 203
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 568970401 158 NAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVN 206
Cdd:PHA03100 204 NPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
Ank_2 pfam12796
Ankyrin repeats (3 copies);
116-208 4.41e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.61  E-value: 4.41e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  116 LFLAVESGRIDVLKLLLQHGANVNgSHSMSGWNSLHQASFQGNAETIRLLLKQgADRECQDDfGITPLFVAAQYGKLESM 195
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADAN-LQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIV 77
                          90
                  ....*....|...
gi 568970401  196 SILISSGANVNCQ 208
Cdd:pfam12796  78 KLLLEKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
16-106 6.08e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.23  E-value: 6.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401   16 LAAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIhtdssENYIKAKTFEGFCALHLAVSQGHWKIT 95
Cdd:pfam12796   3 LAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-----EHADVNLKDNGRTALHYAARSGHLEIV 77
                          90
                  ....*....|.
gi 568970401   96 QILLEAGADPN 106
Cdd:pfam12796  78 KLLLEKGADIN 88
Ank_2 pfam12796
Ankyrin repeats (3 copies);
47-139 2.40e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.30  E-value: 2.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401   47 IHEAAYHNAVECLQMLIhtdSSENYIKAKTFEGFCALHLAVSQGHWKITQILLEaGADPNETTlEETTPLFLAVESGRID 126
Cdd:pfam12796   1 LHLAAKNGNLELVKLLL---ENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLE 75
                          90
                  ....*....|...
gi 568970401  127 VLKLLLQHGANVN 139
Cdd:pfam12796  76 IVKLLLEKGADIN 88
Ank_2 pfam12796
Ankyrin repeats (3 copies);
216-309 7.02e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.14  E-value: 7.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  216 LFIAAQEGHTKCVELLLSSGADPDlyCNEDNWQLPIHAAAQMGHTETLDLLIPRTNRACDTgpDKVSPVYSAVFGGREEC 295
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADAN--LQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD--NGRTALHYAARSGHLEI 76
                          90
                  ....*....|....
gi 568970401  296 LEMLLQNGYSPDAQ 309
Cdd:pfam12796  77 VKLLLEKGADINVK 90
PHA02875 PHA02875
ankyrin repeat protein; Provisional
86-370 8.04e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 76.57  E-value: 8.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  86 AVSQGHWKITQILLEAGADPNETTLEETTPLFLAVESGRIDVLKLLLQHGA--NVNGSHSMSgwnSLHQASFQGNAETIR 163
Cdd:PHA02875   9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAipDVKYPDIES---ELHDAVEEGDVKAVE 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 164 LLLKQG--ADRECQDDfGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLy 241
Cdd:PHA02875  86 ELLDLGkfADDVFYKD-GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDI- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 242 cnEDNWqlpihaaaqmGHTetldlliprtnracdtgpdkvsPVYSAVFGGREECLEMLLQNGYSPDaqmclVFGFS---S 318
Cdd:PHA02875 164 --EDCC----------GCT----------------------PLIIAMAKGDIAICKMLLDSGANID-----YFGKNgcvA 204
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568970401 319 PLCMAFQKdcDFSGIVNILLKYGAQLNELHLA---YCLKYEKFSMFCSFLKKGSL 370
Cdd:PHA02875 205 ALCYAIEN--NKIDIVRLFIKRGADCNIMFMIegeECTILDMICNMCTNLESEAI 257
PHA02876 PHA02876
ankyrin repeat protein; Provisional
72-257 1.35e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 76.64  E-value: 1.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  72 IKAKTFEGFCALHLAVSQGHWKITQILLEAGADPNETTLEETTPLFLAVESGRIDVLKLLLQHGANVNGSHSmsgwnSLH 151
Cdd:PHA02876 171 VNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDL-----SLL 245
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 152 QASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESM-SILISSGANVNCQALDKATPLFIAAQEGH-TKCVE 229
Cdd:PHA02876 246 KAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIR 325
                        170       180
                 ....*....|....*....|....*...
gi 568970401 230 LLLSSGADPDlyCNEDNWQLPIHAAAQM 257
Cdd:PHA02876 326 TLIMLGADVN--AADRLYITPLHQASTL 351
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
42-234 2.72e-14

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 75.43  E-value: 2.72e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  42 RGW-MPIHEAAYHNAVECLQMLIHTDSSENYikAKTFEGFCALHLAVSQGHWKITQILLEAgaDPNETTLEET------- 113
Cdd:cd22192   15 RISeSPLLLAAKENDVQAIKKLLKCPSCDLF--QRGALGETALHVAALYDNLEAAVVLMEA--APELVNEPMTsdlyqge 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 114 TPLFLAVESGRIDVLKLLLQHGANVN-----GSHSMSGWNSL-----HQASF---QGNAETIRLLLKQGADRECQDDFGI 180
Cdd:cd22192   91 TALHIAVVNQNLNLVRELIARGADVVspratGTFFRPGPKNLiyygeHPLSFaacVGNEEIVRLLIEHGADIRAQDSLGN 170
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568970401 181 TPLFV-AAQYGKL---ESMSILISSGANVNCQALDKA------TPLFIAAQEGHTKCVELLLSS 234
Cdd:cd22192  171 TVLHIlVLQPNKTfacQMYDLILSYDKEDDLQPLDLVpnnqglTPFKLAAKEGNIVMFQHLVQK 234
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
458-502 7.14e-14

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 65.59  E-value: 7.14e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 568970401 458 ASVPSLTHLCRLEIRASLKAEHLHsdiFIHQLPLPRSLQNYLLYE 502
Cdd:cd03716    1 STPRSLQHLCRLAIRRCLGRRRLE---LIKKLPLPPRLKDYLLYE 42
PHA03100 PHA03100
ankyrin repeat protein; Provisional
83-267 1.32e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 72.78  E-value: 1.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  83 LHLAVSQGHWKITQILLEAGADPNETTLEETTPLFL-----AVESGRIDVLKLLLQHGANVNgSHSMSGWNSLHQASFQ- 156
Cdd:PHA03100  39 LYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYlsnikYNLTDVKEIVKLLLEYGANVN-APDNNGITPLLYAISKk 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 157 -GNAETIRLLLKQGADRECQDDFGITPLFVAAQYG--KLESMSILISSGANVNcqALDKA------------------TP 215
Cdd:PHA03100 118 sNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNkiDLKILKLLIDKGVDIN--AKNRVnyllsygvpinikdvygfTP 195
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568970401 216 LFIAAQEGHTKCVELLLSSGADPDLyCNEDNwQLPIHAAAQMGHTETLDLLI 267
Cdd:PHA03100 196 LHYAVYNNNPEFVKYLLDLGANPNL-VNKYG-DTPLHIAILNNNKEIFKLLL 245
PHA02878 PHA02878
ankyrin repeat protein; Provisional
24-229 1.34e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 72.99  E-value: 1.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  24 KILRKLLKKGRSVDVAD-NRGWMPIHEAAYHNAVECLQMLIHTDSSENyIKAKTFEGfcALHLAVSQGHWKITQILLEAG 102
Cdd:PHA02878 148 EITKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVN-IPDKTNNS--PLHHAVKHYNKPIVHILLENG 224
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 103 ADPNETTLEETTPLFLAVESGR-IDVLKLLLQHGANVNGSHSMSGWNSLHQASfqGNAETIRLLLKQGADRECQDDFGIT 181
Cdd:PHA02878 225 ASTDARDKCGNTPLHISVGYCKdYDILKLLLEHGVDVNAKSYILGLTALHSSI--KSERKLKLLLEYGADINSLNSYKLT 302
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 568970401 182 PLFVAA-QYGKLESMSILISsgaNVNCQALDKAtplFIAAQEGHTKCVE 229
Cdd:PHA02878 303 PLSSAVkQYLCINIGRILIS---NICLLKRIKP---DIKNSEGFIDNMD 345
PHA02874 PHA02874
ankyrin repeat protein; Provisional
17-256 1.40e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 72.69  E-value: 1.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  17 AAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSSENYIKAKTFEGfcalhlavsqghwKITQ 96
Cdd:PHA02874  42 AIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSILPIPCIEK-------------DMIK 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  97 ILLEAGADPNETTLEETTPLFLAVESGRIDVLKLLLQHGANVNgSHSMSGWNSLHQASFQGNAETIRLLLKQGADRECQD 176
Cdd:PHA02874 109 TILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVN-IEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKD 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 177 DFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTkCVELLLSSGA--DPDLycnedNWQLPIHAA 254
Cdd:PHA02874 188 NNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRS-AIELLINNASinDQDI-----DGSTPLHHA 261

                 ..
gi 568970401 255 AQ 256
Cdd:PHA02874 262 IN 263
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
459-502 2.63e-13

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 64.03  E-value: 2.63e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 568970401 459 SVPSLTHLCRLEIRASLKAEHLHsdiFIHQLPLPRSLQNYLLYE 502
Cdd:cd03587    1 NPRSLQHLCRLAIRRCLGKRRLD---LIDKLPLPPRLKDYLLYK 41
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
17-183 1.75e-12

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 69.90  E-value: 1.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  17 AAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSSenyIKAKTFEGFCALHLAVSQGHWKITQ 96
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACN---VHIRDANGNTALWNAISAKHHKIFR 608
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  97 ILLEAGADPNETTLEETtpLFLAVESGRIDVLKLLLQHGANVNgSHSMSGWNSLHQASFQGNAETIRLLLKQGADREC-- 174
Cdd:PLN03192 609 ILYHFASISDPHAAGDL--LCTAAKRNDLTAMKELLKQGLNVD-SEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKan 685
                        170
                 ....*....|
gi 568970401 175 -QDDFGITPL 183
Cdd:PLN03192 686 tDDDFSPTEL 695
PHA02878 PHA02878
ankyrin repeat protein; Provisional
1-237 4.97e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 67.98  E-value: 4.97e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401   1 MDFTEAYSDTCSTVGL-----AAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTdssenYIKAK 75
Cdd:PHA02878  23 IDHTENYSTSASLIPFiplhqAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRS-----INKCS 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  76 TFEGFCALHLAVSQGHWKITQILLEAGADPNETTLEETTPLFLAVESGRIDVLKLLLQHGANVNGSHSMSGWNSLHQASF 155
Cdd:PHA02878  98 VFYTLVAIKDAFNNRNVEIFKIILTNRYKNIQTIDLVYIDKKSKDDIIEAEITKLLLSYGADINMKDRHKGNTALHYATE 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 156 QGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAqeGHTKCVE---LLL 232
Cdd:PHA02878 178 NKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV--GYCKDYDilkLLL 255

                 ....*
gi 568970401 233 SSGAD 237
Cdd:PHA02878 256 EHGVD 260
PHA02874 PHA02874
ankyrin repeat protein; Provisional
17-204 3.77e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.98  E-value: 3.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  17 AAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSsenYIKAKTFEGFCALHLAVSQGHWKITQ 96
Cdd:PHA02874 131 AIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGA---YANVKDNNGESPLHNAAEYGDYACIK 207
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  97 ILLEAGADPNETTLEETTPLFLAVESGRiDVLKLLLQHgANVNgSHSMSGWNSLHQA-SFQGNAETIRLLLKQGADRECQ 175
Cdd:PHA02874 208 LLIDHGNHIMNKCKNGFTPLHNAIIHNR-SAIELLINN-ASIN-DQDIDGSTPLHHAiNPPCDIDIIDILLYHKADISIK 284
                        170       180
                 ....*....|....*....|....*....
gi 568970401 176 DDFGITPLFVAAQYgkLESMSILISSGAN 204
Cdd:PHA02874 285 DNKGENPIDTAFKY--INKDPVIKDIIAN 311
PHA02876 PHA02876
ankyrin repeat protein; Provisional
87-352 3.78e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 65.86  E-value: 3.78e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  87 VSQGHWKITQILLEAGADPNETTLEETTPLFLAVESGRIDVLKLLLQHGANVNgSHSMSGWNSLHQASFQGNAETIRLLL 166
Cdd:PHA02876 153 IQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVN-IIALDDLSVLECAVDSKNIDTIKAII 231
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 167 KQGADRECQDdfgiTPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGH-TKCVELLLSSGADpdlyCNED 245
Cdd:PHA02876 232 DNRSNINKND----LSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGAD----VNAK 303
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 246 N--WQLPIHAAAQMGH-TETLDLLIPRTNRACDTGPDKVSPVYSAVFGGR-EECLEMLLQNGYSPDAQMclvFGFSSPLC 321
Cdd:PHA02876 304 NikGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTLDRnKDIVITLLELGANVNARD---YCDKTPIH 380
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 568970401 322 MAFQKDCDFsgIVNILLKYGAQLNE--------LHLAYC 352
Cdd:PHA02876 381 YAAVRNNVV--IINTLLDYGADIEAlsqkigtaLHFALC 417
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
459-500 4.81e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 57.56  E-value: 4.81e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568970401  459 SVPSLTHLCRLEIRASLKAEHLHSdifIHQLPLPRSLQNYLL 500
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGA---IDKLPLPPLLKDYLL 39
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
86-309 1.09e-10

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 64.50  E-value: 1.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  86 AVSQGHWKITQILLEAGADPNETTLEETTPLFLAVESGRIDVLKLLLQHGANV-----NGSHSMsgWNSL---HQASFQg 157
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVhirdaNGNTAL--WNAIsakHHKIFR- 608
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 158 naetIRLLLKQGADRECQDDFgitpLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGAD 237
Cdd:PLN03192 609 ----ILYHFASISDPHAAGDL----LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGAD 680
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568970401 238 PDlYCNEDNwqlpihaaaQMGHTETLDLLIPRTNRACDTGPDkvSPVYSAVFGGREECLEMLLQNGYSPDAQ 309
Cdd:PLN03192 681 VD-KANTDD---------DFSPTELRELLQKRELGHSITIVD--SVPADEPDLGRDGGSRPGRLQGTSSDNQ 740
PHA02875 PHA02875
ankyrin repeat protein; Provisional
7-139 5.19e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 61.55  E-value: 5.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401   7 YSDTCSTVGLAAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIH----TDSSENYikaktfeGFCA 82
Cdd:PHA02875  99 YKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDhkacLDIEDCC-------GCTP 171
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568970401  83 LHLAVSQGHWKITQILLEAGADPNETTLE-ETTPLFLAVESGRIDVLKLLLQHGANVN 139
Cdd:PHA02875 172 LIIAMAKGDIAICKMLLDSGANIDYFGKNgCVAALCYAIENNKIDIVRLFIKRGADCN 229
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
462-502 1.91e-09

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 53.07  E-value: 1.91e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568970401 462 SLTHLCRLEIRASLKAEHLHSdifIHQLPLPRSLQNYLLYE 502
Cdd:cd03718    5 PLMDLCRRRVRVALGRDRLEE---IEQLPLPPSLKNYLLYQ 42
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
461-502 2.10e-09

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 52.80  E-value: 2.10e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568970401   461 PSLTHLCRLEIRASLKaehlhsdiFIHQLPLPRSLQNYLLYE 502
Cdd:smart00969   1 RSLQHLCRLAIRRSLG--------GIDKLPLPPRLKDYLLYY 34
PHA03095 PHA03095
ankyrin-like protein; Provisional
22-183 2.45e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 59.65  E-value: 2.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  22 NVKILRKLLKKGRSVDVADNRGWMPIHeaAY---HNA-VECLQMLIHTDSsenYIKAKTFEGFCALH-LAVS-QGHWKIT 95
Cdd:PHA03095 131 NPKVIRLLLRKGADVNALDLYGMTPLA--VLlksRNAnVELLRLLIDAGA---DVYAVDDRFRSLLHhHLQSfKPRARIV 205
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  96 QILLEAGADPNETTLEETTPLFLAVESG---RIDVLKLLLqHGANVNGSHSmSGWNSLHQASFQGNAETIRLLLKQGADR 172
Cdd:PHA03095 206 RELIRAGCDPAATDMLGNTPLHSMATGSsckRSLVLPLLI-AGISINARNR-YGQTPLHYAAVFNNPRACRRLIALGADI 283
                        170
                 ....*....|.
gi 568970401 173 ECQDDFGITPL 183
Cdd:PHA03095 284 NAVSSDGNTPL 294
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
459-501 7.31e-09

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 51.44  E-value: 7.31e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 568970401 459 SVPSLTHLCRLEIRASLKAEHlhsdifIHQLPLPRSLQNYLLY 501
Cdd:cd03717    2 SVRSLQHLCRFVIRQCTRRDL------IDQLPLPRRLKDYLKE 38
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
462-503 2.18e-08

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 50.62  E-value: 2.18e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 568970401 462 SLTHLCRLEIRASLKAEHLHSDIFIHQLPLPRSLQNYLLYEE 503
Cdd:cd03730    5 SLKHLCRLKIRACMGRLRLRCPVFMSFLPLPNRLKAYILYKE 46
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
77-134 3.25e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 56.45  E-value: 3.25e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568970401  77 FEGFCALHLAVSQGHWKITQILLEAGADPNETTLEETTPLFLAVESGRIDVLKLLLQH 134
Cdd:PTZ00322 113 YDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
PHA02884 PHA02884
ankyrin repeat protein; Provisional
52-219 3.97e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 54.99  E-value: 3.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  52 YHNAVECLQMLIHTDSSENYIKAKTFEGFC---ALHLAVSQGHWKITQILLEAGADPN----ETTLEETTPLFLAVESGR 124
Cdd:PHA02884   3 IINLIDIITLLCRIFYIIFYIAIKKKNKICianILYSSIKFHYTDIIDAILKLGADPEapfpLSENSKTNPLIYAIDCDN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 125 IDVLKLLLQHGANVNgshsmsgwnslhqasfqgnaetirlllkqgadrECQDDFGITPLFVAAQYGKLESMSILISSGAN 204
Cdd:PHA02884  83 DDAAKLLIRYGADVN---------------------------------RYAEEAKITPLYISVLHGCLKCLEILLSYGAD 129
                        170
                 ....*....|....*
gi 568970401 205 VNCQALDKATPLFIA 219
Cdd:PHA02884 130 INIQTNDMVTPIELA 144
Ank_4 pfam13637
Ankyrin repeats (many copies);
214-267 4.87e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.58  E-value: 4.87e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568970401  214 TPLFIAAQEGHTKCVELLLSSGADPDlYCNEDNWQlPIHAAAQMGHTETLDLLI 267
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADIN-AVDGNGET-ALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
150-233 4.88e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 55.67  E-value: 4.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 150 LHQASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVE 229
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165

                 ....
gi 568970401 230 LLLS 233
Cdd:PTZ00322 166 LLSR 169
Ank_4 pfam13637
Ankyrin repeats (many copies);
112-166 5.21e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.20  E-value: 5.21e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568970401  112 ETTPLFLAVESGRIDVLKLLLQHGANVNGSHSmSGWNSLHQASFQGNAETIRLLL 166
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDG-NGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
181-232 5.42e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.20  E-value: 5.42e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568970401  181 TPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLL 232
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02989 PHA02989
ankyrin repeat protein; Provisional
93-206 6.82e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 55.13  E-value: 6.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  93 KITQILLEAGADPNETTLEETTPLFLAVESGRI---DVLKLLLQHGANVNGSHSMSGWNSLHQ--ASFQGNAETIRLLLK 167
Cdd:PHA02989  89 KIVKLLLKFGADINLKTFNGVSPIVCFIYNSNInncDMLRFLLSKGINVNDVKNSRGYNLLHMylESFSVKKDVIKILLS 168
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568970401 168 QGADR-ECQDDFGITPLFV----AAQYGKLESMSILISSGANVN 206
Cdd:PHA02989 169 FGVNLfEKTSLYGLTPMNIylrnDIDVISIKVIKYLIKKGVNIE 212
PHA02874 PHA02874
ankyrin repeat protein; Provisional
11-139 1.43e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 53.81  E-value: 1.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  11 CSTVGLAAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIhtdSSENYIKAKTFEGFCALHLAVSQG 90
Cdd:PHA02874 158 CYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLI---DHGNHIMNKCKNGFTPLHNAIIHN 234
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 568970401  91 HWKITqiLLEAGADPNETTLEETTPLFLAVE-SGRIDVLKLLLQHGANVN 139
Cdd:PHA02874 235 RSAIE--LLINNASINDQDIDGSTPLHHAINpPCDIDIIDILLYHKADIS 282
PHA03100 PHA03100
ankyrin repeat protein; Provisional
162-391 1.54e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.52  E-value: 1.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 162 IRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHT-----KCVELLLSSGA 236
Cdd:PHA03100  18 IKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGA 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 237 DPDLYCNEDNWQLPIHAAAQMGHTETLDLLIprtNRACDTGPDK-----VSPVYSAVFGGREECLEMLLQNGYSPDAqmc 311
Cdd:PHA03100  98 NVNAPDNNGITPLLYAISKKSNSYSIVEYLL---DNGANVNIKNsdgenLLHLYLESNKIDLKILKLLIDKGVDINA--- 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 312 lvfgfssplcmafqKDcdfsgIVNILLKYGAQLNE--------LHLAycLKYEKFSMFCSFLKKGSLMvpwNHTSEF--- 380
Cdd:PHA03100 172 --------------KN-----RVNYLLSYGVPINIkdvygftpLHYA--VYNNNPEFVKYLLDLGANP---NLVNKYgdt 227
                        250
                 ....*....|..
gi 568970401 381 -ISYAVKAQTKY 391
Cdd:PHA03100 228 pLHIAILNNNKE 239
Ank_4 pfam13637
Ankyrin repeats (many copies);
17-63 1.76e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.04  E-value: 1.76e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 568970401   17 AAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLI 63
Cdd:pfam13637   8 AAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
197-307 2.28e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 53.75  E-value: 2.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 197 ILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDNwqLPIHAAAQMGHTETLDLLIprTNRACDT 276
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGK--TPLELAEENGFREVVQLLS--RHSQCHF 175
                         90       100       110
                 ....*....|....*....|....*....|.
gi 568970401 277 GPDKVSPVYSavFGGREECLEMLLQNGYSPD 307
Cdd:PTZ00322 176 ELGANAKPDS--FTGKPPSLEDSPISSHHPD 204
PHA02884 PHA02884
ankyrin repeat protein; Provisional
160-244 2.33e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 52.68  E-value: 2.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 160 ETIRLLLKQGADRECQDDFG----ITPLFVAAQYGKLESMSILISSGANVNCQALD-KATPLFIAAQEGHTKCVELLLSS 234
Cdd:PHA02884  47 DIIDAILKLGADPEAPFPLSenskTNPLIYAIDCDNDDAAKLLIRYGADVNRYAEEaKITPLYISVLHGCLKCLEILLSY 126
                         90
                 ....*....|
gi 568970401 235 GADPDLYCNE 244
Cdd:PHA02884 127 GADINIQTND 136
Ank_4 pfam13637
Ankyrin repeats (many copies);
82-132 6.54e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.11  E-value: 6.54e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568970401   82 ALHLAVSQGHWKITQILLEAGADPNETTLEETTPLFLAVESGRIDVLKLLL 132
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
462-502 1.48e-06

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 44.97  E-value: 1.48e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568970401 462 SLTHLCRLEIRASLKAEHLHSdifIHQLPLPRSLQNYLLYE 502
Cdd:cd03744    5 PLMDLCRRSVRLALGRERLSE---IHTLPLPASLKNYLLYQ 42
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
462-503 3.48e-06

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 44.44  E-value: 3.48e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 568970401 462 SLTHLCRLEIRASLKAEHLHSDIFIHQLPLPRSLQNYLLYEE 503
Cdd:cd03731    5 PLKHLCRLKIRKLMGLQKLQQPSSMKKLPLPPALKRYILYKE 46
PHA03095 PHA03095
ankyrin-like protein; Provisional
159-369 3.67e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 49.25  E-value: 3.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 159 AETIRLLLKQGADRECQDDFGITPLFVAAQYGK---LESMSILISSGANVNCQALDKATPLFIAAQEGHT-KCVELLLSS 234
Cdd:PHA03095  27 VEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTlDVIKLLIKA 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 235 GADPDLYCNEDNWQLPIHAAAQMGHTETLDLLIPRTNRACDTGPDKVSPVYSAV-------------------------- 288
Cdd:PHA03095 107 GADVNAKDKVGRTPLHVYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLksrnanvellrllidagadvyavddr 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 289 -----------FGGREECLEMLLQNGYSPDAQMclVFGFSSPLCMAFQKDCDFSGIVNILLKyGAQLNE--------LHL 349
Cdd:PHA03095 187 frsllhhhlqsFKPRARIVRELIRAGCDPAATD--MLGNTPLHSMATGSSCKRSLVLPLLIA-GISINArnrygqtpLHY 263
                        250       260
                 ....*....|....*....|
gi 568970401 350 AYClkYEKFSMFCSFLKKGS 369
Cdd:PHA03095 264 AAV--FNNPRACRRLIALGA 281
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
114-306 4.03e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 49.63  E-value: 4.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 114 TPLFLAVESGRIDVLK-LLLQHGANV--NGSHsmsGWNSLHQASFQGNAETIRLLLKqgADRE-----CQDDF--GITPL 183
Cdd:cd22192   19 SPLLLAAKENDVQAIKkLLKCPSCDLfqRGAL---GETALHVAALYDNLEAAVVLME--AAPElvnepMTSDLyqGETAL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 184 FVAAQYGKLESMSILISSGANVncqALDKAT-----------------PLFIAAQEGHTKCVELLLSSGADpdlycnedn 246
Cdd:cd22192   94 HIAVVNQNLNLVRELIARGADV---VSPRATgtffrpgpknliyygehPLSFAACVGNEEIVRLLIEHGAD--------- 161
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568970401 247 wqlpIHAAAQMGHTETLDL-LIPRTNRACDtgpdkvspVY----SAVFGGREECLEMLLQN-GYSP 306
Cdd:cd22192  162 ----IRAQDSLGNTVLHILvLQPNKTFACQ--------MYdlilSYDKEDDLQPLDLVPNNqGLTP 215
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
462-502 5.11e-06

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 43.58  E-value: 5.11e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568970401 462 SLTHLCRLEIRASLKAEhlhSDIFIHQLPLPRSLQNYLLYE 502
Cdd:cd03723    5 SLQHLCRCAIRKLLGSR---CHKLVPQLSLPTSLKNYLLLE 42
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
114-139 6.29e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.96  E-value: 6.29e-06
                           10        20
                   ....*....|....*....|....*.
gi 568970401   114 TPLFLAVESGRIDVLKLLLQHGANVN 139
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
SOCS_SOCS7 cd03741
SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the ...
460-501 7.35e-06

SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239710  Cd Length: 49  Bit Score: 43.16  E-value: 7.35e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 568970401 460 VPSLTHLCRLEIRASLKAEHlhsdifIHQLPLPRSLQNYLLY 501
Cdd:cd03741    3 VQSLQHLCRFVIRKLVRRDH------IPALPLPRRLIDYLRE 38
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
58-193 1.25e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 47.83  E-value: 1.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  58 CLQMLIHTDSSEnyikaKTFEGFCALHLAVSQGHWKITQILLEAGADPN--------------ETTLEETTPLFLAVESG 123
Cdd:cd22194  125 ILDRFINAEYTE-----EAYEGQTALNIAIERRQGDIVKLLIAKGADVNahakgvffnpkykhEGFYFGETPLALAACTN 199
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 124 RIDVLKLLLQHGANVNGSHSMSGWNSLH------QASFQGNAETIRL---LLKQGADRECQ---DDFGITPLFVAAQYGK 191
Cdd:cd22194  200 QPEIVQLLMEKESTDITSQDSRGNTVLHalvtvaEDSKTQNDFVKRMydmILLKSENKNLEtirNNEGLTPLQLAAKMGK 279

                 ..
gi 568970401 192 LE 193
Cdd:cd22194  280 AE 281
Ank_4 pfam13637
Ankyrin repeats (many copies);
146-199 1.77e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.26  E-value: 1.77e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568970401  146 GWNSLHQASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILI 199
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
84-178 2.03e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.20  E-value: 2.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  84 HLAVSqGHWKITQILLEAGADPNETTLEETTPLFLAVESGRIDVLKLLLQHGANVNGSHSmSGWNSLHQASFQGNAETIR 163
Cdd:PTZ00322  88 QLAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDK-DGKTPLELAEENGFREVVQ 165
                         90
                 ....*....|....*
gi 568970401 164 LLLkqgadRECQDDF 178
Cdd:PTZ00322 166 LLS-----RHSQCHF 175
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
463-502 2.11e-05

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 41.87  E-value: 2.11e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568970401 463 LTHLCRLEIRASLKAEHLHSdifIHQLPLPRSLQNYLLYE 502
Cdd:cd03743    6 LMDLCRRSARQALGRHRLHH---IQSLPLPQTLKNYLQYQ 42
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
195-350 2.39e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 46.10  E-value: 2.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 195 MSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDNWQLPIHAAAQMGHTETLDLLIPRTNRAC 274
Cdd:COG0666    2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 275 DTGPDKVSPVYSAVFGGREECLEMLLQNGYSPDAQMclvFGFSSPLCMAFQKDCDfsGIVNILLKYGAQLNE-------- 346
Cdd:COG0666   82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARD---KDGETPLHLAAYNGNL--EIVKLLLEAGADVNAqdndgntp 156

                 ....
gi 568970401 347 LHLA 350
Cdd:COG0666  157 LHLA 160
Ank_2 pfam12796
Ankyrin repeats (3 copies);
251-345 2.96e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.80  E-value: 2.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  251 IHAAAQMGHTETLDLLIPRTNRACDTGPDKVSPVYSAVFGGREECLEMLLQNGyspdAQMCLVFGFsSPLCMAFQKDCdf 330
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHA----DVNLKDNGR-TALHYAARSGH-- 73
                          90
                  ....*....|....*
gi 568970401  331 SGIVNILLKYGAQLN 345
Cdd:pfam12796  74 LEIVKLLLEKGADIN 88
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
459-501 3.35e-05

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 40.87  E-value: 3.35e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 568970401 459 SVPSLTHLCRLEIRASLKAEHlhsdifIHQLPLPRSLQNYLLY 501
Cdd:cd03733    2 VVSSLQHLCRMALRRVMTTQQ------VLALPIPKKMKEFLTY 38
PHA02989 PHA02989
ankyrin repeat protein; Provisional
24-232 4.34e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 45.89  E-value: 4.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  24 KILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSSENYIKA-KTFEGFCALHLAVSQGHWK--ITQILLE 100
Cdd:PHA02989  89 KIVKLLLKFGADINLKTFNGVSPIVCFIYNSNINNCDMLRFLLSKGINVNDvKNSRGYNLLHMYLESFSVKkdVIKILLS 168
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 101 AGADPNETT-LEETTPL------FLAVESgrIDVLKLLLQHGANV--NGSHSMSGWNSL---HQASFQGNAETIRLLLKQ 168
Cdd:PHA02989 169 FGVNLFEKTsLYGLTPMniylrnDIDVIS--IKVIKYLIKKGVNIetNNNGSESVLESFldnNKILSKKEFKVLNFILKY 246
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568970401 169 gADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLL 232
Cdd:PHA02989 247 -IKINKKDKKGFNPLLISAKVDNYEAFNYLLKLGDDIYNVSKDGDTVLTYAIKHGNIDMLNRIL 309
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
459-501 5.75e-05

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 40.36  E-value: 5.75e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 568970401   459 SVPSLTHLCRLEIRASLKAEHlhsdifIHQLPLPRSLQNYLLY 501
Cdd:smart00253   6 NVPSLQHLCRFTIRRCTRTDQ------IKTLPLPPKLKDYLSY 42
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
114-139 1.17e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 39.16  E-value: 1.17e-04
                          10        20
                  ....*....|....*....|....*.
gi 568970401  114 TPLFLAVESGRIDVLKLLLQHGANVN 139
Cdd:pfam13606   4 TPLHLAARNGRLEIVKLLLENGADIN 29
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
114-267 1.43e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 44.69  E-value: 1.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  114 TPLF-LAVESGRIDVLKLLLQHGANVNgshsmSGWNSLHQAS--FQGNAE-TIRLLLKQGADR--------ECQDDF--G 179
Cdd:TIGR00870  54 SALFvAAIENENLELTELLLNLSCRGA-----VGDTLLHAISleYVDAVEaILLHLLAAFRKSgplelandQYTSEFtpG 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  180 ITPLFVAAQYGKLESMSILISSGANVNCQAldkatplfiaaqeghtKCVELLLSSGADpDLYCNEdnwqLPIHAAAQMGH 259
Cdd:TIGR00870 129 ITALHLAAHRQNYEIVKLLLERGASVPARA----------------CGDFFVKSQGVD-SFYHGE----SPLNAAACLGS 187

                  ....*...
gi 568970401  260 TETLDLLI 267
Cdd:TIGR00870 188 PSIVALLS 195
Ank_4 pfam13637
Ankyrin repeats (many copies);
250-300 1.75e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 1.75e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568970401  250 PIHAAAQMGHTETLDLLIPRTNRACDTGPDKVSPVYSAVFGGREECLEMLL 300
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
459-502 2.38e-04

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 38.64  E-value: 2.38e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 568970401 459 SVPSLTHLCRLEIRASLKAEHlhsdifIHQLPLPRSLQNYLLYE 502
Cdd:cd03746    2 QVASLQHLCRMAIRRVMPTQQ------VKELPIPSKLLEFLTYR 39
PHA02946 PHA02946
ankyin-like protein; Provisional
78-234 3.52e-04

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 43.12  E-value: 3.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  78 EGFCALHLAVSQGHWKITQILLEAGADPNETTLEETTPLFL--AVESGRIDVLKLLLQHGANVNGSHSMSGWNSLhQASF 155
Cdd:PHA02946  71 DGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYlsGTDDEVIERINLLVQYGAKINNSVDEEGCGPL-LACT 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 156 QGNAETIRLLLKQGADRECQDDFGITPL--FVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQE--GHTKCVELL 231
Cdd:PHA02946 150 DPSERVFKKIMSIGFEARIVDKFGKNHIhrHLMSDNPKASTISWMMKLGISPSKPDHDGNTPLHIVCSKtvKNVDIINLL 229

                 ...
gi 568970401 232 LSS 234
Cdd:PHA02946 230 LPS 232
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
211-240 3.76e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 3.76e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 568970401   211 DKATPLFIAAQEGHTKCVELLLSSGADPDL 240
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
462-502 4.72e-04

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 37.78  E-value: 4.72e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568970401 462 SLTHLCRLEIRASLKAEHLHSdifIHQLPLPRSLQNYLLYE 502
Cdd:cd03720    5 SLLSLCRIAVRRALGKQRLSL---ICSLPLPDPIKKFLLHE 42
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
114-139 4.96e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.65  E-value: 4.96e-04
                          10        20
                  ....*....|....*....|....*..
gi 568970401  114 TPLFLAVES-GRIDVLKLLLQHGANVN 139
Cdd:pfam00023   4 TPLHLAAGRrGNLEIVKLLLSKGADVN 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
214-240 5.16e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.65  E-value: 5.16e-04
                          10        20
                  ....*....|....*....|....*...
gi 568970401  214 TPLFIAA-QEGHTKCVELLLSSGADPDL 240
Cdd:pfam00023   4 TPLHLAAgRRGNLEIVKLLLSKGADVNA 31
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
78-109 5.47e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 5.47e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568970401   78 EGFCALHLAVSQ-GHWKITQILLEAGADPNETT 109
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
461-501 5.61e-04

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 37.85  E-value: 5.61e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568970401 461 PSLTHLCRLEIRASLKAEHLHSdifIHQLPLPRSLQNYLLY 501
Cdd:cd03728    4 PSLMQLCRLCIRKCFGRKQHHK---IHKLHLPEPLKHFLLY 41
PHA02798 PHA02798
ankyrin-like protein; Provisional
94-171 7.87e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 42.13  E-value: 7.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  94 ITQILLEAGADPNETTLEETTPLFLAVESGRIDVLKLLL---QHGANVNgSHSMSGWNSLH---QASFQGNAETIRLLLK 167
Cdd:PHA02798  91 IVKILIENGADINKKNSDGETPLYCLLSNGYINNLEILLfmiENGADTT-LLDKDGFTMLQvylQSNHHIDIEIIKLLLE 169

                 ....
gi 568970401 168 QGAD 171
Cdd:PHA02798 170 KGVD 173
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
463-503 7.97e-04

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 37.15  E-value: 7.97e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568970401 463 LTHLCRLEIRASLKAEHLHsdiFIHQLPLPRSLQNYLLYEE 503
Cdd:cd03721    6 LAHLCRLKVRTLIGINRIK---LIDTLPLPPRLIRYLNHQE 43
SOCS_WSB2_SWIP2 cd03745
SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists ...
460-501 1.46e-03

SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists of WSB-2 (SOCS-box-containing WD-40 protein) and SWiP-2 (SOCS box and WD-repeats in Protein). No functional information is available for WSB2 or SWiP-2, but limited information is available for the isoforms WSB-1 and SWiP-1. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239714  Cd Length: 39  Bit Score: 36.41  E-value: 1.46e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 568970401 460 VPSLTHLCRLEIRASLKAEHlhsdifIHQLPLPRSLQNYLLY 501
Cdd:cd03745    3 LPSLRHLCRKALRHFLTTYQ------VLALPIPKKMKEFLTY 38
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
461-502 1.63e-03

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239695  Cd Length: 44  Bit Score: 36.27  E-value: 1.63e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 568970401 461 PSLTHLCRLEIRASLKAEHLhsDIFIHQLPLPRSLQNYLLYE 502
Cdd:cd03725    4 PPLKHLCRVFIRLCLRPWPV--DVKVKALPLPDRLKWYLLPE 43
SOCS_CIS1 cd03734
SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like ...
459-499 1.63e-03

SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. CIS1, like SOCS1 and SOCS3, is involved in the down-regulation of the JAK/STAT pathway. CIS1 binds to cytokine receptors at STAT5-docking sites, which prohibits recruitment of STAT5 to the receptor signaling complex and results in the down-regulation of activation by STAT5.


Pssm-ID: 239703  Cd Length: 41  Bit Score: 36.48  E-value: 1.63e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568970401 459 SVPSLTHLCRLEIRaSLKAEhlhsdifIHQLPLPRSLQNYL 499
Cdd:cd03734    2 SARSLQHLCRLVIN-RLVTD-------VDCLPLPRRMADYL 34
SOCS_SOCS6 cd03740
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the ...
460-500 2.00e-03

SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239709  Cd Length: 41  Bit Score: 36.24  E-value: 2.00e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568970401 460 VPSLTHLCRLEIRASLKAEHlhsdifIHQLPLPRSLQNYLL 500
Cdd:cd03740    3 VRSLQYLCRFVIRQYTRIDL------IQKLPLPNKMKGYLL 37
PHA02736 PHA02736
Viral ankyrin protein; Provisional
128-203 2.03e-03

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 39.09  E-value: 2.03e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568970401 128 LKLLLQHGANVNGSHSMSGWNSLHQASFQGNAETIRLLLKQ-GADRECQDDFGITPLFVAAQYGKLESMSILISSGA 203
Cdd:PHA02736  74 LKLLMEWGADINGKERVFGNTPLHIAVYTQNYELATWLCNQpGVNMEILNYAFKTPYYVACERHDAKMMNILRAKGA 150
SOCS_ASB8 cd03727
SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a ...
461-500 2.06e-03

SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239697  Cd Length: 43  Bit Score: 35.97  E-value: 2.06e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568970401 461 PSLTHLCRLEIRASLKAEHLHSDIfiHQLPLPRSLQNYLL 500
Cdd:cd03727    4 GTLKALARYAVRRSLGVQYLPEAV--KQLPLPRSVKEYLL 41
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
220-300 2.74e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.27  E-value: 2.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 220 AQEGHTKCVELLLSSGADPDlyCNEDNWQLPIHAAAQMGHTETLDLLIPRTNRACDTGPDKVSPVYSAVFGGREECLEML 299
Cdd:PTZ00322  90 AASGDAVGARILLTGGADPN--CRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167

                 .
gi 568970401 300 L 300
Cdd:PTZ00322 168 S 168
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
179-207 2.76e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 2.76e-03
                           10        20
                   ....*....|....*....|....*....
gi 568970401   179 GITPLFVAAQYGKLESMSILISSGANVNC 207
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_5 pfam13857
Ankyrin repeats (many copies);
78-119 3.39e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.79  E-value: 3.39e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568970401   78 EGFCALHLAVSQGHWKITQILLEAGADPNETTLEETTPLFLA 119
Cdd:pfam13857  15 EGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02798 PHA02798
ankyrin-like protein; Provisional
23-219 3.55e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 39.82  E-value: 3.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  23 VKILRKLLKKGRSVDVADNRGWMPI-----HEAAYHNAVECLQMLIHTDSSenyIKAKTFEGFCALHLAVSQGHWKITQI 97
Cdd:PHA02798  51 TDIVKLFINLGANVNGLDNEYSTPLctilsNIKDYKHMLDIVKILIENGAD---INKKNSDGETPLYCLLSNGYINNLEI 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401  98 LL---EAGADPNETTLEETTPLFLAVESG---RIDVLKLLLQHGANVNGSHSMSGWNSLHqASFQGN-----AETIRLLL 166
Cdd:PHA02798 128 LLfmiENGADTTLLDKDGFTMLQVYLQSNhhiDIEIIKLLLEKGVDINTHNNKEKYDTLH-CYFKYNidridADILKLFV 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401 167 KQG---------------------------------------ADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNC 207
Cdd:PHA02798 207 DNGfiinkenkshkkkfmeylnsllydnkrfkknildfifsyIDINQVDELGFNPLYYSVSHNNRKIFEYLLQLGGDINI 286
                        250
                 ....*....|..
gi 568970401 208 QALDKATPLFIA 219
Cdd:PHA02798 287 ITELGNTCLFTA 298
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
458-501 3.94e-03

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 35.24  E-value: 3.94e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 568970401 458 ASVPSLTHLCRLEIRASLKAEHLHsdiFIHQLPLPRSLQNYLLY 501
Cdd:cd03724    1 ATPSSLCQLCRLCIRNYIGRSRLH---LIPQLQLPTLLKNFLQY 41
SOCS_SOCS2 cd03736
SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the ...
459-499 5.18e-03

SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate neuronal differentiation by controlling expression of a neurogenic transcription factor, Neurogenin-1. SOCS2 binds to GH receptors and inhibits the activation of STAT5b induced by GH. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239705  Cd Length: 41  Bit Score: 34.82  E-value: 5.18e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568970401 459 SVPSLTHLCRLEIRASLKAehlhsdifIHQLPLPRSLQNYL 499
Cdd:cd03736    2 STPSLQHLCRITINKCTRQ--------IQELPLPTRLKDYL 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
82-107 5.45e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 5.45e-03
                           10        20
                   ....*....|....*....|....*.
gi 568970401    82 ALHLAVSQGHWKITQILLEAGADPNE 107
Cdd:smart00248   5 PLHLAAENGNLEVVKLLLDKGADINA 30
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
16-151 6.91e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 39.29  E-value: 6.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401   16 LAAREGNVKILRKLLK-KGRSVDVADNRgwmpIHEAA--YHNAVE-CLQ-MLIHTDSSENYIKAKT------FEGFCALH 84
Cdd:TIGR00870  58 VAAIENENLELTELLLnLSCRGAVGDTL----LHAISleYVDAVEaILLhLLAAFRKSGPLELANDqytsefTPGITALH 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568970401   85 LAVSQGHWKITQILLEAGADPNET-------TLEETT-------PLFLAVESGRIDVLKLLLQHGANVNGSHSMsGWNSL 150
Cdd:TIGR00870 134 LAAHRQNYEIVKLLLERGASVPARacgdffvKSQGVDsfyhgesPLNAAACLGSPSIVALLSEDPADILTADSL-GNTLL 212

                  .
gi 568970401  151 H 151
Cdd:TIGR00870 213 H 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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