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Conserved domains on  [gi|1907082679|ref|XP_036012783|]
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ankyrin repeat and SOCS box protein 3 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-160 2.48e-33

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 125.84  E-value: 2.48e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679   1 MSGWNSLHQASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEG 80
Cdd:COG0666    85 DGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  81 HTKCVELLLSSGADPDLYCNEDNwqLPIHAAAQMGHTETLDLLIPRTNRACDTGPDKVSPVYSAVFGGREECLEMLLQNG 160
Cdd:COG0666   165 NLEIVKLLLEAGADVNARDNDGE--TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAG 242
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 315-365 3.92e-25

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239692  Cd Length: 51  Bit Score: 96.40  E-value: 3.92e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907082679 315 ASVPSLTHLCRLEIRASLKAEHLHSDIFIHQLPLPRSLQNYLLYEEVLRMN 365
Cdd:cd03722     1 ASVPSLTHLCRLEIRSSLKSERLRSDSFICQLPLPRSLQDYLLYSDVLRMY 51
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-160 2.48e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 125.84  E-value: 2.48e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679   1 MSGWNSLHQASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEG 80
Cdd:COG0666    85 DGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  81 HTKCVELLLSSGADPDLYCNEDNwqLPIHAAAQMGHTETLDLLIPRTNRACDTGPDKVSPVYSAVFGGREECLEMLLQNG 160
Cdd:COG0666   165 NLEIVKLLLEAGADVNARDNDGE--TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAG 242
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 315-365 3.92e-25

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 96.40  E-value: 3.92e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907082679 315 ASVPSLTHLCRLEIRASLKAEHLHSDIFIHQLPLPRSLQNYLLYEEVLRMN 365
Cdd:cd03722     1 ASVPSLTHLCRLEIRSSLKSERLRSDSFICQLPLPRSLQDYLLYSDVLRMY 51
Ank_2 pfam12796
Ankyrin repeats (3 copies);
7-97 3.67e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 89.79  E-value: 3.67e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679   7 LHQASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSgANVNCQaLDKATPLFIAAQEGHTKCVE 86
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLK-DNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|.
gi 1907082679  87 LLLSSGADPDL 97
Cdd:pfam12796  79 LLLEKGADINV 89
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 15-202 4.71e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 69.99  E-value: 4.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  15 NAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGAD 94
Cdd:PHA02874  103 EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  95 PDLycNEDNWQLPIHAAAQMGHTETLDLLIPRTNRACDTGPDKVSPVYSAVFGGReECLEMLLQNGYSPDAQMclvfGFS 174
Cdd:PHA02874  183 ANV--KDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR-SAIELLINNASINDQDI----DGS 255

                         170       180
                  ....*....|....*....|....*...
gi 1907082679 175 SPLCMAFQKDCDFSgIVNILLKYGAQLN 202
Cdd:PHA02874  256 TPLHHAINPPCDID-IIDILLYHKADIS 282
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 316-357 1.00e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 56.40  E-value: 1.00e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907082679 316 SVPSLTHLCRLEIRASLKAEHLHSdifIHQLPLPRSLQNYLL 357
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGA---IDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 318-359 4.46e-09

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 51.26  E-value: 4.46e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907082679  318 PSLTHLCRLEIRASLKaehlhsdiFIHQLPLPRSLQNYLLYE 359
Cdd:smart00969   1 RSLQHLCRLAIRRSLG--------GIDKLPLPPRLKDYLLYY 34
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 8-91 5.19e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.39  E-value: 5.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679   8 HQASF---QGNAETIRLLLKQGADRECQDDFGITPLFV-AAQYGKL---ESMSILISSGANVNCQALDKA------TPLF 74
Cdd:cd22192   138 HPLSFaacVGNEEIVRLLIEHGADIRAQDSLGNTVLHIlVLQPNKTfacQMYDLILSYDKEDDLQPLDLVpnnqglTPFK 217

                          90
                  ....*....|....*..
gi 1907082679  75 IAAQEGHTKCVELLLSS 91
Cdd:cd22192   218 LAAKEGNIVMFQHLVQK 234
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 68-97 1.99e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.34  E-value: 1.99e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907082679   68 DKATPLFIAAQEGHTKCVELLLSSGADPDL 97
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 3-124 4.93e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 38.91  E-value: 4.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679   3 GWNSLHQAS--FQGNAE-TIRLLLKQGADR--------ECQDDF--GITPLFVAAQYGKLESMSILISSGANVNCQAldk 69
Cdd:TIGR00870  82 GDTLLHAISleYVDAVEaILLHLLAAFRKSgplelandQYTSEFtpGITALHLAAHRQNYEIVKLLLERGASVPARA--- 158

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907082679  70 atplfiaaqeghtKCVELLLSSGADpDLYCNEdnwqLPIHAAAQMGHTETLDLLI 124
Cdd:TIGR00870 159 -------------CGDFFVKSQGVD-SFYHGE----SPLNAAACLGSPSIVALLS 195
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-160 2.48e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 125.84  E-value: 2.48e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679   1 MSGWNSLHQASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEG 80
Cdd:COG0666    85 DGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  81 HTKCVELLLSSGADPDLYCNEDNwqLPIHAAAQMGHTETLDLLIPRTNRACDTGPDKVSPVYSAVFGGREECLEMLLQNG 160
Cdd:COG0666   165 NLEIVKLLLEAGADVNARDNDGE--TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAG 242
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-160 2.62e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 125.84  E-value: 2.62e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679   2 SGWNSLHQASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGH 81
Cdd:COG0666   119 DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGH 198

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907082679  82 TKCVELLLSSGADPDLYCNEDNWqlPIHAAAQMGHTETLDLLIPRTNRACDTGPDKVSPVYSAVFGGREECLEMLLQNG 160
Cdd:COG0666   199 LEIVKLLLEAGADVNAKDNDGKT--ALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
3-202 3.26e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 114.67  E-value: 3.26e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679   3 GWNSLHQASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHT 82
Cdd:COG0666    54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNL 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  83 KCVELLLSSGADPDLYCNEDNwqLPIHAAAQMGHTETLDLLIprtNRACD---TGPDKVSPVYSAVFGGREECLEMLLQN 159
Cdd:COG0666   134 EIVKLLLEAGADVNAQDNDGN--TPLHLAAANGNLEIVKLLL---EAGADvnaRDNDGETPLHLAAENGHLEIVKLLLEA 208

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1907082679 160 GYSPDAQMCLvfgFSSPLCMAFQKDCDfsGIVNILLKYGAQLN 202
Cdd:COG0666   209 GADVNAKDND---GKTALDLAAENGNL--EIVKLLLEAGADLN 246
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 315-365 3.92e-25

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 96.40  E-value: 3.92e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907082679 315 ASVPSLTHLCRLEIRASLKAEHLHSDIFIHQLPLPRSLQNYLLYEEVLRMN 365
Cdd:cd03722     1 ASVPSLTHLCRLEIRSSLKSERLRSDSFICQLPLPRSLQDYLLYSDVLRMY 51
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
7-202 1.14e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 96.56  E-value: 1.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679   7 LHQASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVE 86
Cdd:COG0666    25 LLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVK 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  87 LLLSSGADPDLYCNEDNWqlPIHAAAQMGHTETLDLLIprtNRACD---TGPDKVSPVYSAVFGGREECLEMLLQNGYSP 163
Cdd:COG0666   105 LLLEAGADVNARDKDGET--PLHLAAYNGNLEIVKLLL---EAGADvnaQDNDGNTPLHLAAANGNLEIVKLLLEAGADV 179

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1907082679 164 DAQmcLVFGFsSPLCMAFQKDCDfsGIVNILLKYGAQLN 202
Cdd:COG0666   180 NAR--DNDGE-TPLHLAAENGHL--EIVKLLLEAGADVN 213
Ank_2 pfam12796
Ankyrin repeats (3 copies);
7-97 3.67e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 89.79  E-value: 3.67e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679   7 LHQASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSgANVNCQaLDKATPLFIAAQEGHTKCVE 86
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLK-DNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|.
gi 1907082679  87 LLLSSGADPDL 97
Cdd:pfam12796  79 LLLEKGADINV 89
Ank_2 pfam12796
Ankyrin repeats (3 copies);
73-166 2.90e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.53  E-value: 2.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  73 LFIAAQEGHTKCVELLLSSGADPDlyCNEDNWQLPIHAAAQMGHTETLDLLIPRTNRACDTgpDKVSPVYSAVFGGREEC 152
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADAN--LQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD--NGRTALHYAARSGHLEI 76

                          90
                  ....*....|....
gi 1907082679 153 LEMLLQNGYSPDAQ 166
Cdd:pfam12796  77 VKLLLEKGADINVK 90
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
3-106 1.32e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 73.45  E-value: 1.32e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679   3 GWNSLHQASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHT 82
Cdd:COG0666   186 GETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAA 265

                          90       100
                  ....*....|....*....|....
gi 1907082679  83 KCVELLLSSGADPDLYCNEDNWQL 106
Cdd:COG0666   266 LIVKLLLLALLLLAAALLDLLTLL 289
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 315-359 1.51e-13

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 64.05  E-value: 1.51e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907082679 315 ASVPSLTHLCRLEIRASLKAEHLHsdiFIHQLPLPRSLQNYLLYE 359
Cdd:cd03716     1 STPRSLQHLCRLAIRRCLGRRRLE---LIKKLPLPPRLKDYLLYE 42
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 15-202 4.71e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 69.99  E-value: 4.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  15 NAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGAD 94
Cdd:PHA02874  103 EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  95 PDLycNEDNWQLPIHAAAQMGHTETLDLLIPRTNRACDTGPDKVSPVYSAVFGGReECLEMLLQNGYSPDAQMclvfGFS 174
Cdd:PHA02874  183 ANV--KDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR-SAIELLINNASINDQDI----DGS 255

                         170       180
                  ....*....|....*....|....*...
gi 1907082679 175 SPLCMAFQKDCDFSgIVNILLKYGAQLN 202
Cdd:PHA02874  256 TPLHHAINPPCDID-IIDILLYHKADIS 282
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 316-359 5.16e-13

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 62.87  E-value: 5.16e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1907082679 316 SVPSLTHLCRLEIRASLKAEHLHsdiFIHQLPLPRSLQNYLLYE 359
Cdd:cd03587     1 NPRSLQHLCRLAIRRCLGKRRLD---LIDKLPLPPRLKDYLLYK 41
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 7-145 7.54e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 63.44  E-value: 7.54e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679   7 LHQASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVE 86
Cdd:PHA02874  128 LHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIK 207

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  87 LLLSSGADPDLYCNedNWQLPIHAAAqMGHTETLDLLIprTNRAC-DTGPDKVSPVYSAV 145
Cdd:PHA02874  208 LLIDHGNHIMNKCK--NGFTPLHNAI-IHNRSAIELLI--NNASInDQDIDGSTPLHHAI 262
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-207 7.73e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 62.28  E-value: 7.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  19 IRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLy 98
Cdd:COG0666     4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  99 cNEDNWQLPIHAAAQMGHTETLDLLIPRTNRACDTGPDKVSPVYSAVFGGREECLEMLLQNGYSPDAQmclVFGFSSPLC 178
Cdd:COG0666    83 -KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQ---DNDGNTPLH 158

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1907082679 179 MAFQKDCDfsGIVNILLKYGAQLNE--------LHLA 207
Cdd:COG0666   159 LAAANGNL--EIVKLLLEAGADVNArdndgetpLHLA 193
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 316-357 1.00e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 56.40  E-value: 1.00e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907082679 316 SVPSLTHLCRLEIRASLKAEHLHSdifIHQLPLPRSLQNYLL 357
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGA---IDKLPLPPLLKDYLL 39
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 15-203 1.93e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 62.39  E-value: 1.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  15 NAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSI-LISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGA 93
Cdd:PHA02876  320 DTENIRTLIMLGADVNAADRLYITPLHQASTLDRNKDIVItLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGA 399

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  94 DPDLYCNEDNWQLPIHAAAQMGHTeTLDLLIPRTNRACDTGPDKVSPV-YSAVFGGREECLEMLLQNGYSPDAqmcLVFG 172
Cdd:PHA02876  400 DIEALSQKIGTALHFALCGTNPYM-SVKTLIDRGANVNSKNKDLSTPLhYACKKNCKLDVIEMLLDNGADVNA---INIQ 475

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1907082679 173 FSSPLCMAFQkdcdFSGIVNILLKYGAQLNE 203
Cdd:PHA02876  476 NQYPLLIALE----YHGIVNILLHYGAELRD 502
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 14-226 3.96e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 60.78  E-value: 3.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  14 GNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSG- 92
Cdd:PHA02875   13 GELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGk 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  93 -ADPDLYcneDNWQLPIHAAAQMGHTETLDLLIPRTNRACDTGPDKVSPVYSAVFGGREECLEMLLQNGYSPDAQMClvF 171
Cdd:PHA02875   93 fADDVFY---KDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDC--C 167

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907082679 172 GFsSPLCMAFQKDCdfSGIVNILLKYGAQLNELH-------LAYCLKYEKFSMFCSFLKKGS 226
Cdd:PHA02875  168 GC-TPLIIAMAKGD--IAICKMLLDSGANIDYFGkngcvaaLCYAIENNKIDIVRLFIKRGA 226
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 15-228 1.50e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 59.29  E-value: 1.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  15 NAETIRLLLKQGADRECQDDFGITPLFVAAQyGKLESMSI---LISSGANVNCQALDKATPLFIAAQEGH--TKCVELLL 89
Cdd:PHA03100   85 VKEIVKLLLEYGANVNAPDNNGITPLLYAIS-KKSNSYSIveyLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLI 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  90 SSGADPDLYCNED---NWQLPIHAAAQMGHTetldlliprtnracdtgpdkvsPVYSAVFGGREECLEMLLQNGYSPDAq 166
Cdd:PHA03100  164 DKGVDINAKNRVNyllSYGVPINIKDVYGFT----------------------PLHYAVYNNNPEFVKYLLDLGANPNL- 220

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907082679 167 mCLVFGfSSPLCMAFqKDCDfSGIVNILLKYGAqlNELHLAYCLKYEKFSMFCSFLKKGSLM 228
Cdd:PHA03100  221 -VNKYG-DTPLHIAI-LNNN-KEIFKLLLNNGP--SIKTIIETLLYFKDKDLNTITKIKMLK 276
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 319-359 1.61e-09

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 53.07  E-value: 1.61e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907082679 319 SLTHLCRLEIRASLKAEHLHSdifIHQLPLPRSLQNYLLYE 359
Cdd:cd03718     5 PLMDLCRRRVRVALGRDRLEE---IEQLPLPPSLKNYLLYQ 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
3-65 4.22e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.20  E-value: 4.22e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907082679   3 GWNSLHQASFQGNAETIRLLLKQgADRECQDDfGITPLFVAAQYGKLESMSILISSGANVNCQ 65
Cdd:pfam12796  30 GRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVKLLLEKGADINVK 90
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 318-359 4.46e-09

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 51.26  E-value: 4.46e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907082679  318 PSLTHLCRLEIRASLKaehlhsdiFIHQLPLPRSLQNYLLYE 359
Cdd:smart00969   1 RSLQHLCRLAIRRSLG--------GIDKLPLPPRLKDYLLYY 34
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 316-358 9.49e-09

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 50.67  E-value: 9.49e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1907082679 316 SVPSLTHLCRLEIRASLKAEHlhsdifIHQLPLPRSLQNYLLY 358
Cdd:cd03717     2 SVRSLQHLCRFVIRQCTRRDL------IDQLPLPRRLKDYLKE 38
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 3-96 1.75e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 55.77  E-value: 1.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679   3 GWNSLHQASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHT 82
Cdd:PHA02875  102 GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDI 181

                          90
                  ....*....|....
gi 1907082679  83 KCVELLLSSGADPD 96
Cdd:PHA02875  182 AICKMLLDSGANID 195
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 319-360 2.06e-08

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 50.23  E-value: 2.06e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907082679 319 SLTHLCRLEIRASLKAEHLHSDIFIHQLPLPRSLQNYLLYEE 360
Cdd:cd03730     5 SLKHLCRLKIRACMGRLRLRCPVFMSFLPLPNRLKAYILYKE 46
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 7-90 2.62e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 55.67  E-value: 2.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679   7 LHQASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVE 86
Cdd:PTZ00322   86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165


                  ....
gi 1907082679  87 LLLS 90
Cdd:PTZ00322  166 LLSR 169
Ank_4 pfam13637
Ankyrin repeats (many copies);
71-124 3.22e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.58  E-value: 3.22e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907082679  71 TPLFIAAQEGHTKCVELLLSSGADPDlYCNEDNWQlPIHAAAQMGHTETLDLLI 124
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADIN-AVDGNGET-ALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
38-89 3.66e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.58  E-value: 3.66e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907082679  38 TPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLL 89
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 19-248 8.40e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.90  E-value: 8.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  19 IRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHT-----KCVELLLSSGA 93
Cdd:PHA03100   18 IKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  94 DPDLYCNEDNWQLPIHAAAQMGHTETLDLLIprtNRACDTGPDK-----VSPVYSAVFGGREECLEMLLQNGYSPDAqmc 168
Cdd:PHA03100   98 NVNAPDNNGITPLLYAISKKSNSYSIVEYLL---DNGANVNIKNsdgenLLHLYLESNKIDLKILKLLIDKGVDINA--- 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679 169 lvfgfssplcmafqKDcdfsgIVNILLKYGAQLNE--------LHLAycLKYEKFSMFCSFLKKGSLMvpwNHTSEF--- 237
Cdd:PHA03100  172 --------------KN-----RVNYLLSYGVPINIkdvygftpLHYA--VYNNNPEFVKYLLDLGANP---NLVNKYgdt 227

                         250
                  ....*....|..
gi 1907082679 238 -ISYAVKAQTKY 248
Cdd:PHA03100  228 pLHIAILNNNKE 239
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 7-227 1.02e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.46  E-value: 1.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679   7 LHQASFQGNAETIRLLLKQG--ADRECQDDfGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKC 84
Cdd:PHA02875   72 LHDAVEEGDVKAVEELLDLGkfADDVFYKD-GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKG 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  85 VELLLSSGADPDLycnEDNWqlpihaaaqmGHTetldlliprtnracdtgpdkvsPVYSAVFGGREECLEMLLQNGYSPD 164
Cdd:PHA02875  151 IELLIDHKACLDI---EDCC----------GCT----------------------PLIIAMAKGDIAICKMLLDSGANID 195

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907082679 165 aqmclVFGFS---SPLCMAFQKdcDFSGIVNILLKYGAQLNELHLA---YCLKYEKFSMFCSFLKKGSL 227
Cdd:PHA02875  196 -----YFGKNgcvAALCYAIEN--NKIDIVRLFIKRGADCNIMFMIegeECTILDMICNMCTNLESEAI 257
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 54-164 1.25e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 53.75  E-value: 1.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  54 ILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDNwqLPIHAAAQMGHTETLDLLIprTNRACDT 133
Cdd:PTZ00322  100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGK--TPLELAEENGFREVVQLLS--RHSQCHF 175

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1907082679 134 GPDKVSPVYSavFGGREECLEMLLQNGYSPD 164
Cdd:PTZ00322  176 ELGANAKPDS--FTGKPPSLEDSPISSHHPD 204
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 17-101 1.40e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 52.68  E-value: 1.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  17 ETIRLLLKQGADRECQDDFG----ITPLFVAAQYGKLESMSILISSGANVNCQALD-KATPLFIAAQEGHTKCVELLLSS 91
Cdd:PHA02884   47 DIIDAILKLGADPEAPFPLSenskTNPLIYAIDCDNDDAAKLLIRYGADVNRYAEEaKITPLYISVLHGCLKCLEILLSY 126

                          90
                  ....*....|
gi 1907082679  92 GADPDLYCNE 101
Cdd:PHA02884  127 GADINIQTND 136
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 21-202 4.48e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 51.99  E-value: 4.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  21 LLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVEL------------- 87
Cdd:PHA02876  163 MLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAiidnrsninkndl 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  88 -LLSSGADPDLYCN-------------EDNWQLPIHAAAQmghTETLDLLIPR-TNRACDTGPDKV---SPVYSAVFGGR 149
Cdd:PHA02876  243 sLLKAIRNEDLETSlllydagfsvnsiDDCKNTPLHHASQ---APSLSRLVPKlLERGADVNAKNIkgeTPLYLMAKNGY 319

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907082679 150 E-ECLEMLLQNGYSPDAQMCLvfgFSSPLCMAFQKDcDFSGIVNILLKYGAQLN 202
Cdd:PHA02876  320 DtENIRTLIMLGADVNAADRL---YITPLHQASTLD-RNKDIVITLLELGANVN 369
PHA03095 PHA03095
ankyrin-like protein; Provisional
 16-226 1.41e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.02  E-value: 1.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  16 AETIRLLLKQGADRECQDDFGITPLFVAAQYGK---LESMSILISSGANVNCQALDKATPLFIAAQEGHT-KCVELLLSS 91
Cdd:PHA03095   27 VEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTlDVIKLLIKA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  92 GADPDLYCNEDNWQLPIHAAAQMGHTETLDLLIPRTNRACDTGPDKVSPVysAVF----------------GG------- 148
Cdd:PHA03095  107 GADVNAKDKVGRTPLHVYLSGFNINPKVIRLLLRKGADVNALDLYGMTPL--AVLlksrnanvellrllidAGadvyavd 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679 149 ----------------REECLEMLLQNGYSPDAQMclVFGFSSPLCMAFQKDCDFSGIVNILLKyGAQLNE--------L 204
Cdd:PHA03095  185 drfrsllhhhlqsfkpRARIVRELIRAGCDPAATD--MLGNTPLHSMATGSSCKRSLVLPLLIA-GISINArnrygqtpL 261

                         250       260
                  ....*....|....*....|..
gi 1907082679 205 HLAYClkYEKFSMFCSFLKKGS 226
Cdd:PHA03095  262 HYAAV--FNNPRACRRLIALGA 281
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 319-359 2.27e-06

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 44.20  E-value: 2.27e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907082679 319 SLTHLCRLEIRASLKAEHLHSdifIHQLPLPRSLQNYLLYE 359
Cdd:cd03744     5 PLMDLCRRSVRLALGRERLSE---IHTLPLPASLKNYLLYQ 42
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 319-360 4.89e-06

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 43.67  E-value: 4.89e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907082679 319 SLTHLCRLEIRASLKAEHLHSDIFIHQLPLPRSLQNYLLYEE 360
Cdd:cd03731     5 PLKHLCRLKIRKLMGLQKLQQPSSMKKLPLPPALKRYILYKE 46
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 16-195 6.04e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 47.95  E-value: 6.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  16 AETIRLLLKQGADRECQD-DFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGAD 94
Cdd:PHA02878  147 AEITKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAS 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  95 PDLYCNEDNwqLPIH-AAAQMGHTETLDLLIPR-TNRACDTGPDKVSPVYSAVFGgrEECLEMLLQNGYSPDAqmcLVFG 172
Cdd:PHA02878  227 TDARDKCGN--TPLHiSVGYCKDYDILKLLLEHgVDVNAKSYILGLTALHSSIKS--ERKLKLLLEYGADINS---LNSY 299

                         170       180
                  ....*....|....*....|...
gi 1907082679 173 FSSPLCMAFQKDCDFSgIVNILL 195
Cdd:PHA02878  300 KLTPLSSAVKQYLCIN-IGRILI 321
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 319-359 6.11e-06

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 42.81  E-value: 6.11e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907082679 319 SLTHLCRLEIRASLKAEhlhSDIFIHQLPLPRSLQNYLLYE 359
Cdd:cd03723     5 SLQHLCRCAIRKLLGSR---CHKLVPQLSLPTSLKNYLLLE 42
SOCS_SOCS7 cd03741
SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the ...
 317-358 8.20e-06

SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239710  Cd Length: 49  Bit Score: 42.78  E-value: 8.20e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907082679 317 VPSLTHLCRLEIRASLKAEHlhsdifIHQLPLPRSLQNYLLY 358
Cdd:cd03741     3 VQSLQHLCRFVIRKLVRRDH------IPALPLPRRLIDYLRE 38
Ank_4 pfam13637
Ankyrin repeats (many copies);
3-56 1.17e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.26  E-value: 1.17e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907082679   3 GWNSLHQASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILI 56
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
108-202 1.53e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.18  E-value: 1.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679 108 IHAAAQMGHTETLDLLIPRTNRACDTGPDKVSPVYSAVFGGREECLEMLLQNGyspdAQMCLVFGFsSPLCMAFQKDCdf 187
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHA----DVNLKDNGR-TALHYAARSGH-- 73

                          90
                  ....*....|....*
gi 1907082679 188 SGIVNILLKYGAQLN 202
Cdd:pfam12796  74 LEIVKLLLEKGADIN 88
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 320-359 2.71e-05

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 41.09  E-value: 2.71e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1907082679 320 LTHLCRLEIRASLKAEHLHSdifIHQLPLPRSLQNYLLYE 359
Cdd:cd03743     6 LMDLCRRSARQALGRHRLHH---IQSLPLPQTLKNYLQYQ 42
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 316-358 3.38e-05

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 40.48  E-value: 3.38e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1907082679 316 SVPSLTHLCRLEIRASLKAEHlhsdifIHQLPLPRSLQNYLLY 358
Cdd:cd03733     2 VVSSLQHLCRMALRRVMTTQQ------VLALPIPKKMKEFLTY 38
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 8-91 5.19e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.39  E-value: 5.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679   8 HQASF---QGNAETIRLLLKQGADRECQDDFGITPLFV-AAQYGKL---ESMSILISSGANVNCQALDKA------TPLF 74
Cdd:cd22192   138 HPLSFaacVGNEEIVRLLIEHGADIRAQDSLGNTVLHIlVLQPNKTfacQMYDLILSYDKEDDLQPLDLVpnnqglTPFK 217

                          90
                  ....*....|....*..
gi 1907082679  75 IAAQEGHTKCVELLLSS 91
Cdd:cd22192   218 LAAKEGNIVMFQHLVQK 234
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 6-114 6.78e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 45.05  E-value: 6.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679   6 SLHQASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESM-SILISSGANVNCQALDKATPLFIAAQEGH-TK 83
Cdd:PHA02876  243 SLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGYdTE 322

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1907082679  84 CVELLLSSGADPDlyCNEDNWQLPIHAAAQM 114
Cdd:PHA02876  323 NIRTLIMLGADVN--AADRLYITPLHQASTL 351
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 43-202 7.29e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 44.60  E-value: 7.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  43 AAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLycNEDNWQLPIHAAAQMGHTETLDL 122
Cdd:PHA02875    9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDV--KYPDIESELHDAVEEGDVKAVEE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679 123 LIPRTNRACDT-GPDKVSPVYSAVFGGREECLEMLLQNGYSPDAQMCLVFgfsSPLCMAFQKDcDFSGIvNILLKYGAQL 201
Cdd:PHA02875   87 LLDLGKFADDVfYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKF---SPLHLAVMMG-DIKGI-ELLIDHKACL 161


                  .
gi 1907082679 202 N 202
Cdd:PHA02875  162 D 162
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 316-358 8.83e-05

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 39.59  E-value: 8.83e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907082679  316 SVPSLTHLCRLEIRASLKAEHlhsdifIHQLPLPRSLQNYLLY 358
Cdd:smart00253   6 NVPSLQHLCRFTIRRCTRTDQ------IKTLPLPPKLKDYLSY 42
Ank_4 pfam13637
Ankyrin repeats (many copies);
107-157 1.20e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 1.20e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907082679 107 PIHAAAQMGHTETLDLLIPRTNRACDTGPDKVSPVYSAVFGGREECLEMLL 157
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 14-99 1.24e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.09  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  14 GNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELL--LSS 91
Cdd:PLN03192  536 GNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILyhFAS 615

                          90
                  ....*....|..
gi 1907082679  92 GADP----DLYC 99
Cdd:PLN03192  616 ISDPhaagDLLC 627
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 15-76 1.26e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 43.43  E-value: 1.26e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907082679  15 NAETIRLLLKQGAD-RECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIA 76
Cdd:PHA02884   82 NDDAAKLLIRYGADvNRYAEEAKITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELA 144
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 3-63 1.85e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 43.12  E-value: 1.85e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907082679   3 GWNSLHQASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVN 63
Cdd:PHA03100  192 GFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 3-166 1.88e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 43.70  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679   3 GWNSLHQASFQGNAETIRLLLKQGADRECQDDFGITPLF-------------------------------VAAQYGKLES 51
Cdd:PLN03192  558 GRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWnaisakhhkifrilyhfasisdphaagdllcTAAKRNDLTA 637

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  52 MSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDlYCNEDNwqlpihaaaQMGHTETLDLLIPRTNRAC 131
Cdd:PLN03192  638 MKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVD-KANTDD---------DFSPTELRELLQKRELGHS 707

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1907082679 132 DTGPDkvSPVYSAVFGGREECLEMLLQNGYSPDAQ 166
Cdd:PLN03192  708 ITIVD--SVPADEPDLGRDGGSRPGRLQGTSSDNQ 740
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 68-97 1.99e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.34  E-value: 1.99e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907082679   68 DKATPLFIAAQEGHTKCVELLLSSGADPDL 97
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 71-97 2.45e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.04  E-value: 2.45e-04
                          10        20
                  ....*....|....*....|....*...
gi 1907082679  71 TPLFIAA-QEGHTKCVELLLSSGADPDL 97
Cdd:pfam00023   4 TPLHLAAgRRGNLEIVKLLLSKGADVNA 31
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 316-359 2.60e-04

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 38.25  E-value: 2.60e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1907082679 316 SVPSLTHLCRLEIRASLKAEHlhsdifIHQLPLPRSLQNYLLYE 359
Cdd:cd03746     2 QVASLQHLCRMAIRRVMPTQQ------VKELPIPSKLLEFLTYR 39
PHA03095 PHA03095
ankyrin-like protein; Provisional
 7-103 5.24e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 41.93  E-value: 5.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679   7 LHQ--ASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYG--KLESMSILISSGANVNCQALDKATPLFIAAQEGHT 82
Cdd:PHA03095  191 LHHhlQSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNP 270

                          90       100
                  ....*....|....*....|.
gi 1907082679  83 KCVELLLSSGADPDLYCNEDN 103
Cdd:PHA03095  271 RACRRLIALGADINAVSSDGN 291
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 14-124 5.62e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.57  E-value: 5.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  14 GNAETIRLLLKQGADRECQDDFGITPLFVAAQYG--KLESMSILISSGANVNcqALDKA------------------TPL 73
Cdd:PHA03100  119 NSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNkiDLKILKLLIDKGVDIN--AKNRVnyllsygvpinikdvygfTPL 196

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907082679  74 FIAAQEGHTKCVELLLSSGADPDLyCNEDNwQLPIHAAAQMGHTETLDLLI 124
Cdd:PHA03100  197 HYAVYNNNPEFVKYLLDLGANPNL-VNKYG-DTPLHIAILNNNKEIFKLLL 245
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 320-360 5.79e-04

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 37.15  E-value: 5.79e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907082679 320 LTHLCRLEIRASLKAEHLHsdiFIHQLPLPRSLQNYLLYEE 360
Cdd:cd03721     6 LAHLCRLKVRTLIGINRIK---LIDTLPLPPRLIRYLNHQE 43
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 319-359 5.95e-04

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 37.01  E-value: 5.95e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907082679 319 SLTHLCRLEIRASLKAEHLHSdifIHQLPLPRSLQNYLLYE 359
Cdd:cd03720     5 SLLSLCRIAVRRALGKQRLSL---ICSLPLPDPIKKFLLHE 42
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 318-358 6.80e-04

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 37.08  E-value: 6.80e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907082679 318 PSLTHLCRLEIRASLKAEHLHSdifIHQLPLPRSLQNYLLY 358
Cdd:cd03728     4 PSLMQLCRLCIRKCFGRKQHHK---IHKLHLPEPLKHFLLY 41
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 45-97 1.31e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.82  E-value: 1.31e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907082679  45 QYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 97
Cdd:PHA02876  154 QQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNI 206
SOCS_WSB2_SWIP2 cd03745
SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists ...
 317-358 1.51e-03

SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists of WSB-2 (SOCS-box-containing WD-40 protein) and SWiP-2 (SOCS box and WD-repeats in Protein). No functional information is available for WSB2 or SWiP-2, but limited information is available for the isoforms WSB-1 and SWiP-1. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239714  Cd Length: 39  Bit Score: 36.03  E-value: 1.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907082679 317 VPSLTHLCRLEIRASLKAEHlhsdifIHQLPLPRSLQNYLLY 358
Cdd:cd03745     3 LPSLRHLCRKALRHFLTTYQ------VLALPIPKKMKEFLTY 38
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 36-64 1.52e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.64  E-value: 1.52e-03
                           10        20
                   ....*....|....*....|....*....
gi 1907082679   36 GITPLFVAAQYGKLESMSILISSGANVNC 64
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1-100 1.58e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.39  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679   1 MSGWNSLHQASFQGNAETIRL--LLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQ 78
Cdd:PHA03095  220 MLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVR 299

                          90       100
                  ....*....|....*....|..
gi 1907082679  79 EGHTKCVELLLSSGADPDLYCN 100
Cdd:PHA03095  300 NNNGRAVRAALAKNPSAETVAA 321
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 77-157 1.70e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.27  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  77 AQEGHTKCVELLLSSGADPDlyCNEDNWQLPIHAAAQMGHTETLDLLIPRTNRACDTGPDKVSPVYSAVFGGREECLEML 156
Cdd:PTZ00322   90 AASGDAVGARILLTGGADPN--CRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167


                  .
gi 1907082679 157 L 157
Cdd:PTZ00322  168 S 168
SOCS_CIS1 cd03734
SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like ...
 316-356 1.78e-03

SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. CIS1, like SOCS1 and SOCS3, is involved in the down-regulation of the JAK/STAT pathway. CIS1 binds to cytokine receptors at STAT5-docking sites, which prohibits recruitment of STAT5 to the receptor signaling complex and results in the down-regulation of activation by STAT5.


Pssm-ID: 239703  Cd Length: 41  Bit Score: 35.71  E-value: 1.78e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907082679 316 SVPSLTHLCRLEIRaSLKAEhlhsdifIHQLPLPRSLQNYL 356
Cdd:cd03734     2 SARSLQHLCRLVIN-RLVTD-------VDCLPLPRRMADYL 34
SOCS_SOCS6 cd03740
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the ...
 317-357 1.90e-03

SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239709  Cd Length: 41  Bit Score: 35.86  E-value: 1.90e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907082679 317 VPSLTHLCRLEIRASLKAEHlhsdifIHQLPLPRSLQNYLL 357
Cdd:cd03740     3 VRSLQYLCRFVIRQYTRIDL------IQKLPLPNKMKGYLL 37
SOCS_ASB8 cd03727
SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a ...
 318-357 2.59e-03

SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239697  Cd Length: 43  Bit Score: 35.58  E-value: 2.59e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1907082679 318 PSLTHLCRLEIRASLKAEHLHSDIfiHQLPLPRSLQNYLL 357
Cdd:cd03727     4 GTLKALARYAVRRSLGVQYLPEAV--KQLPLPRSVKEYLL 41
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
 318-359 2.71e-03

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239695  Cd Length: 44  Bit Score: 35.50  E-value: 2.71e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907082679 318 PSLTHLCRLEIRASLKAEHLhsDIFIHQLPLPRSLQNYLLYE 359
Cdd:cd03725     4 PPLKHLCRVFIRLCLRPWPV--DVKVKALPLPDRLKWYLLPE 43
SOCS_SOCS2 cd03736
SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the ...
 316-356 4.24e-03

SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate neuronal differentiation by controlling expression of a neurogenic transcription factor, Neurogenin-1. SOCS2 binds to GH receptors and inhibits the activation of STAT5b induced by GH. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239705  Cd Length: 41  Bit Score: 34.82  E-value: 4.24e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907082679 316 SVPSLTHLCRLEIRASLKAehlhsdifIHQLPLPRSLQNYL 356
Cdd:cd03736     2 STPSLQHLCRITINKCTRQ--------IQELPLPTRLKDYL 34
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 3-124 4.93e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 38.91  E-value: 4.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679   3 GWNSLHQAS--FQGNAE-TIRLLLKQGADR--------ECQDDF--GITPLFVAAQYGKLESMSILISSGANVNCQAldk 69
Cdd:TIGR00870  82 GDTLLHAISleYVDAVEaILLHLLAAFRKSgplelandQYTSEFtpGITALHLAAHRQNYEIVKLLLERGASVPARA--- 158

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907082679  70 atplfiaaqeghtKCVELLLSSGADpDLYCNEdnwqLPIHAAAQMGHTETLDLLI 124
Cdd:TIGR00870 159 -------------CGDFFVKSQGVD-SFYHGE----SPLNAAACLGSPSIVALLS 195
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 3-163 5.14e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 38.84  E-value: 5.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679   3 GWNSLHQASFQGNAETIRLLLKqgADRE-----CQDDF--GITPLFVAAQYGKLESMSILISSGANVncqALDKAT---- 71
Cdd:cd22192    51 GETALHVAALYDNLEAAVVLME--AAPElvnepMTSDLyqGETALHIAVVNQNLNLVRELIARGADV---VSPRATgtff 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082679  72 -------------PLFIAAQEGHTKCVELLLSSGADpdlycnednwqlpIHAAAQMGHTETLDL-LIPRTNRACDtgpdk 137
Cdd:cd22192   126 rpgpknliyygehPLSFAACVGNEEIVRLLIEHGAD-------------IRAQDSLGNTVLHILvLQPNKTFACQ----- 187

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1907082679 138 vspVY----SAVFGGREECLEMLLQN-GYSP 163
Cdd:cd22192   188 ---MYdlilSYDKEDDLQPLDLVPNNqGLTP 215
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 315-358 6.18e-03

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 34.47  E-value: 6.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1907082679 315 ASVPSLTHLCRLEIRASLKAEHLHsdiFIHQLPLPRSLQNYLLY 358
Cdd:cd03724     1 ATPSSLCQLCRLCIRNYIGRSRLH---LIPQLQLPTLLKNFLQY 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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