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    atxn2l ataxin 2-like [ Danio rerio (zebrafish) ]

    Gene ID: 324525, updated on 9-Dec-2024

    Summary

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    Official Symbol
    atxn2lprovided by ZNC
    Official Full Name
    ataxin 2-likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3246
    See related
    Ensembl:ENSDARG00000011597 AllianceGenome:ZFIN:ZDB-GENE-030131-3246
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:66471; wu:fc31f08; wu:fi19h05
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in stress granule assembly. Predicted to be active in cytoplasmic stress granule. Orthologous to human ATXN2L (ataxin 2 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See atxn2l in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (15394407..15425689)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (15244595..15275840)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol transfer protein, beta, like Neighboring gene SH2B adaptor protein 1 Neighboring gene si:dkey-56d12.4 Neighboring gene linker for activation of T cells Neighboring gene SPNS lysolipid transporter 1, lysophospholipid

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Application of an F0-based genetic assay in adult zebrafish to identify modifier genes of an inherited cardiomyopathy. Ding Y, et al. Dis Model Mech, 2023 May 1. PMID 35481478, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in stress granule assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ataxin-2-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212684.2 → NP_997849.2  ataxin-2-like protein

      Status: VALIDATED

      Source sequence(s)
      BX784026
      UniProtKB/TrEMBL
      A0A8M2BAY3, F1QA42, Q6PFI6
      Related
      ENSDARP00000115477.1, ENSDART00000133168.3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      15394407..15425689
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009299272.4 → XP_009297547.1  ataxin-2-like protein isoform X1

      UniProtKB/TrEMBL
      A0A8M3AQQ2, Q6PFI6
      Conserved Domains (2) summary
      pfam06741
      Location:213 → 275
      LsmAD; LsmAD domain
      pfam14438
      Location:63 → 142
      SM-ATX; Ataxin 2 SM domain

    2. XM_005163800.5 → XP_005163857.1  ataxin-2-like protein isoform X2

      UniProtKB/TrEMBL
      A0A8M2BBA5, Q6PFI6
      Conserved Domains (2) summary
      pfam06741
      Location:179 → 241
      LsmAD; LsmAD domain
      pfam14438
      Location:29 → 108
      SM-ATX; Ataxin 2 SM domain

    3. XM_068215868.1 → XP_068071969.1  ataxin-2-like protein isoform X3

      UniProtKB/TrEMBL
      Q6PFI6

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394524.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      48394..79583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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