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Conserved domains on  [gi|528473443|ref|XP_005163857|]
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ataxin-2-like protein isoform X2 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 30-112 4.99e-19

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


:

Pssm-ID: 464173  Cd Length: 78  Bit Score: 82.22  E-value: 4.99e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443   30 MLHFLTAVVGSRCDVMVKNGSLYEGIFKTLS--SRCELAVDAVHKVKNEEGDGGGgggtavhPRKEEITDTMIFGPSDLV 107
Cdd:pfam14438   1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASleKDFGVVLKMARRIKKSNGSGLN-------PVRGEIVDTMIFPAKDIV 73


                  ....*
gi 528473443  108 TMICR 112
Cdd:pfam14438  74 DIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 179-241 1.20e-17

LsmAD domain; This domain is found associated with Lsm domain.


:

Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 78.00  E-value: 1.20e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528473443  179 YGVKSTYDSSLsmYTVPLERgSSEGFRQREARAARLANEIEASSQYRHRVALEN-----DEGRTDEDK 241
Cdd:pfam06741   1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERgldvdDSGLDEEDK 65
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 351-940 2.60e-13

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 74.59  E-value: 2.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  351 PTQSRPSEPGHSSPPSPHtlSHSLSHPQSLSDVARPVNGVSPKSQRTGQTNRNMRTSNSHSSPTVSRSPKPDAPPQDPLL 430
Cdd:PHA03247 2556 PPAAPPAAPDRSVPPPRP--APRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSP 2633

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  431 TGSYLDPSSKPVGPTPLFPVDvneilskermeSPVGPQEGKSNKIPSVQQRSQISEELRKFgntfRLQQNPKTLPTESTQ 510
Cdd:PHA03247 2634 AANEPDPHPPPTVPPPERPRD-----------DPAPGRVSRPRRARRLGRAAQASSPPQRP----RRRAARPTVGSLTSL 2698

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  511 ANPAHNTQTDPAAPTEAKPAPPTTPNTElsaeeRSRETNPEGPVTSTPPPATSISAPSGiGMQNPPAEGQTAGAPQPART 590
Cdd:PHA03247 2699 ADPPPPPPTPEPAPHALVSATPLPPGPA-----AARQASPALPAAPAPPAVPAGPATPG-GPARPARPPTTAGPPAPAPP 2772

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  591 PGSEDGKPEAPERSEGMTDQVKKSTLNPNAKEFNPTKAPLSMVKPSATPTPPRPTPPSPTVVLQTQPGQGAVYNPQYLSy 670
Cdd:PHA03247 2773 AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP- 2851

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  671 vsqvpiqiQGHSVQPQIPYSymtavsqgKYPRTKGSVVTPrpdhssSAPPMIQAASAAGPPLVASPYPPSYLQYNQVIPA 750
Cdd:PHA03247 2852 --------LGGSVAPGGDVR--------RRPPSRSPAAKP------AAPARPPVRRLARPAVSRSTESFALPPDQPERPP 2909

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  751 MPHYPghqvysmlqgGPRMLGSGGHPQALGPPGPQYPGQTEGPSAPQQGmyapqsfshhsgsihPQPSSTPTGSQPPPQH 830
Cdd:PHA03247 2910 QPQAP----------PPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD---------------PAGAGEPSGAVPQPWL 2964

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  831 PAPSPGQSgqsgPQPQSLYHSGPLSAPTP-PNLPPGHSSPQASYSLQGYSLPGHQPLPHPYSSLGQ-------------- 895
Cdd:PHA03247 2965 GALVPGRV----AVPRFRVPQPAPSREAPaSSTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQtlwppddtedsdad 3040

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|...
gi 528473443  896 --------LTQAHVPGALSGPHHTGGHGPPPVMLLHAAPQQGSGPQHGPPPQQ 940
Cdd:PHA03247 3041 slfdsdseRSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLS 3093
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 30-112 4.99e-19

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 82.22  E-value: 4.99e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443   30 MLHFLTAVVGSRCDVMVKNGSLYEGIFKTLS--SRCELAVDAVHKVKNEEGDGGGgggtavhPRKEEITDTMIFGPSDLV 107
Cdd:pfam14438   1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASleKDFGVVLKMARRIKKSNGSGLN-------PVRGEIVDTMIFPAKDIV 73


                  ....*
gi 528473443  108 TMICR 112
Cdd:pfam14438  74 DIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 179-241 1.20e-17

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 78.00  E-value: 1.20e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528473443  179 YGVKSTYDSSLsmYTVPLERgSSEGFRQREARAARLANEIEASSQYRHRVALEN-----DEGRTDEDK 241
Cdd:pfam06741   1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERgldvdDSGLDEEDK 65
PHA03247 PHA03247
large tegument protein UL36; Provisional
 351-940 2.60e-13

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 74.59  E-value: 2.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  351 PTQSRPSEPGHSSPPSPHtlSHSLSHPQSLSDVARPVNGVSPKSQRTGQTNRNMRTSNSHSSPTVSRSPKPDAPPQDPLL 430
Cdd:PHA03247 2556 PPAAPPAAPDRSVPPPRP--APRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSP 2633

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  431 TGSYLDPSSKPVGPTPLFPVDvneilskermeSPVGPQEGKSNKIPSVQQRSQISEELRKFgntfRLQQNPKTLPTESTQ 510
Cdd:PHA03247 2634 AANEPDPHPPPTVPPPERPRD-----------DPAPGRVSRPRRARRLGRAAQASSPPQRP----RRRAARPTVGSLTSL 2698

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  511 ANPAHNTQTDPAAPTEAKPAPPTTPNTElsaeeRSRETNPEGPVTSTPPPATSISAPSGiGMQNPPAEGQTAGAPQPART 590
Cdd:PHA03247 2699 ADPPPPPPTPEPAPHALVSATPLPPGPA-----AARQASPALPAAPAPPAVPAGPATPG-GPARPARPPTTAGPPAPAPP 2772

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  591 PGSEDGKPEAPERSEGMTDQVKKSTLNPNAKEFNPTKAPLSMVKPSATPTPPRPTPPSPTVVLQTQPGQGAVYNPQYLSy 670
Cdd:PHA03247 2773 AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP- 2851

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  671 vsqvpiqiQGHSVQPQIPYSymtavsqgKYPRTKGSVVTPrpdhssSAPPMIQAASAAGPPLVASPYPPSYLQYNQVIPA 750
Cdd:PHA03247 2852 --------LGGSVAPGGDVR--------RRPPSRSPAAKP------AAPARPPVRRLARPAVSRSTESFALPPDQPERPP 2909

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  751 MPHYPghqvysmlqgGPRMLGSGGHPQALGPPGPQYPGQTEGPSAPQQGmyapqsfshhsgsihPQPSSTPTGSQPPPQH 830
Cdd:PHA03247 2910 QPQAP----------PPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD---------------PAGAGEPSGAVPQPWL 2964

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  831 PAPSPGQSgqsgPQPQSLYHSGPLSAPTP-PNLPPGHSSPQASYSLQGYSLPGHQPLPHPYSSLGQ-------------- 895
Cdd:PHA03247 2965 GALVPGRV----AVPRFRVPQPAPSREAPaSSTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQtlwppddtedsdad 3040

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|...
gi 528473443  896 --------LTQAHVPGALSGPHHTGGHGPPPVMLLHAAPQQGSGPQHGPPPQQ 940
Cdd:PHA03247 3041 slfdsdseRSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLS 3093
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 837-963 1.22e-06

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 52.73  E-value: 1.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  837 QSGQSGPQPQSLYHSGPLSAPTPPNLPPGHSSPQASYSLQGYSLPGHQPLP----HPYSSL----GQLTQAHVPGALSGP 908
Cdd:pfam09770 206 QAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHpgqgHPVTILqrpqSPQPDPAQPSIQPQA 285

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528473443  909 HHTGGHGPP-----------PVMLLHAAPQQGSGPQHG--PPPQQGAHQHFTYLGPQVPVQAHnPQQI 963
Cdd:pfam09770 286 QQFHQQPPPvpvqptqilqnPNRLSAARVGYPQNPQPGvqPAPAHQAHRQQGSFGRQAPIITH-PQQL 352
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 742-865 1.21e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 45.95  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  742 LQYNQVIPAMPHYPGHQVYSMLQGGPRMLGSGGH----PQALGPPGPQYPGQTEGPSAPQQGMYAPQSFSHHSGSIHPQP 817
Cdd:TIGR01628 373 DQFMQLQPRMRQLPMGSPMGGAMGQPPYYGQGPQqqfnGQPLGWPRMSMMPTPMGPGGPLRPNGLAPMNAVRAPSRNAQN 452

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 528473443  818 SSTPTGSQPPPQHPAPSPGQSGQSGPQPQSLYHSG---PLSAPTPPNLPPG 865
Cdd:TIGR01628 453 AAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGgqnKKLAQVLASATPQ 503
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 30-112 4.99e-19

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 82.22  E-value: 4.99e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443   30 MLHFLTAVVGSRCDVMVKNGSLYEGIFKTLS--SRCELAVDAVHKVKNEEGDGGGgggtavhPRKEEITDTMIFGPSDLV 107
Cdd:pfam14438   1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASleKDFGVVLKMARRIKKSNGSGLN-------PVRGEIVDTMIFPAKDIV 73


                  ....*
gi 528473443  108 TMICR 112
Cdd:pfam14438  74 DIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 179-241 1.20e-17

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 78.00  E-value: 1.20e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528473443  179 YGVKSTYDSSLsmYTVPLERgSSEGFRQREARAARLANEIEASSQYRHRVALEN-----DEGRTDEDK 241
Cdd:pfam06741   1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERgldvdDSGLDEEDK 65
PHA03247 PHA03247
large tegument protein UL36; Provisional
 351-940 2.60e-13

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 74.59  E-value: 2.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  351 PTQSRPSEPGHSSPPSPHtlSHSLSHPQSLSDVARPVNGVSPKSQRTGQTNRNMRTSNSHSSPTVSRSPKPDAPPQDPLL 430
Cdd:PHA03247 2556 PPAAPPAAPDRSVPPPRP--APRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSP 2633

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  431 TGSYLDPSSKPVGPTPLFPVDvneilskermeSPVGPQEGKSNKIPSVQQRSQISEELRKFgntfRLQQNPKTLPTESTQ 510
Cdd:PHA03247 2634 AANEPDPHPPPTVPPPERPRD-----------DPAPGRVSRPRRARRLGRAAQASSPPQRP----RRRAARPTVGSLTSL 2698

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  511 ANPAHNTQTDPAAPTEAKPAPPTTPNTElsaeeRSRETNPEGPVTSTPPPATSISAPSGiGMQNPPAEGQTAGAPQPART 590
Cdd:PHA03247 2699 ADPPPPPPTPEPAPHALVSATPLPPGPA-----AARQASPALPAAPAPPAVPAGPATPG-GPARPARPPTTAGPPAPAPP 2772

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  591 PGSEDGKPEAPERSEGMTDQVKKSTLNPNAKEFNPTKAPLSMVKPSATPTPPRPTPPSPTVVLQTQPGQGAVYNPQYLSy 670
Cdd:PHA03247 2773 AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP- 2851

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  671 vsqvpiqiQGHSVQPQIPYSymtavsqgKYPRTKGSVVTPrpdhssSAPPMIQAASAAGPPLVASPYPPSYLQYNQVIPA 750
Cdd:PHA03247 2852 --------LGGSVAPGGDVR--------RRPPSRSPAAKP------AAPARPPVRRLARPAVSRSTESFALPPDQPERPP 2909

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  751 MPHYPghqvysmlqgGPRMLGSGGHPQALGPPGPQYPGQTEGPSAPQQGmyapqsfshhsgsihPQPSSTPTGSQPPPQH 830
Cdd:PHA03247 2910 QPQAP----------PPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD---------------PAGAGEPSGAVPQPWL 2964

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  831 PAPSPGQSgqsgPQPQSLYHSGPLSAPTP-PNLPPGHSSPQASYSLQGYSLPGHQPLPHPYSSLGQ-------------- 895
Cdd:PHA03247 2965 GALVPGRV----AVPRFRVPQPAPSREAPaSSTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQtlwppddtedsdad 3040

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|...
gi 528473443  896 --------LTQAHVPGALSGPHHTGGHGPPPVMLLHAAPQQGSGPQHGPPPQQ 940
Cdd:PHA03247 3041 slfdsdseRSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLS 3093
PHA03247 PHA03247
large tegument protein UL36; Provisional
 500-968 4.68e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.64  E-value: 4.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  500 NPKTLPTESTQANPAHNTQTdPAAPTEAKPAPPTTPNT--------ELSAEERSRETNPEGPvtSTPPPATSISAPSGIG 571
Cdd:PHA03247 2497 DPGGGGPPDPDAPPAPSRLA-PAILPDEPVGEPVHPRMltwirgleELASDDAGDPPPPLPP--AAPPAAPDRSVPPPRP 2573

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  572 MQNPPAEGQTAGA------PQPA--RTPGSEDGKPEAPERSegmtdqvkkSTLNPNAKEFNPtkAPLSMVKPSATPTPPR 643
Cdd:PHA03247 2574 APRPSEPAVTSRArrpdapPQSArpRAPVDDRGDPRGPAPP---------SPLPPDTHAPDP--PPPSPSPAANEPDPHP 2642

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  644 PTPPSPTVVLQTQPGQGAVYNPQYLSYVSQVPiqiqGHSVQPQIPY-----SYMTAVSQGKYPRTKGSVVTPRPDHSSSA 718
Cdd:PHA03247 2643 PPTVPPPERPRDDPAPGRVSRPRRARRLGRAA----QASSPPQRPRrraarPTVGSLTSLADPPPPPPTPEPAPHALVSA 2718

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  719 ---PPMIQAASAAGPPLVASPYPPSylqynqvIPAMPHYPGhqvysmlqgGPRMLGSggHPQALGPPGPQYPGQTEGPSA 795
Cdd:PHA03247 2719 tplPPGPAAARQASPALPAAPAPPA-------VPAGPATPG---------GPARPAR--PPTTAGPPAPAPPAAPAAGPP 2780

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  796 PQQGMYAPQSFSHHSGSIhPQPSSTPTGSQPPPQHPAPSPGQSGQSGPQPQSlyhsgPLSAPTPPNLPPGhsSPQASYSL 875
Cdd:PHA03247 2781 RRLTRPAVASLSESRESL-PSPWDPADPPAAVLAPAAALPPAASPAGPLPPP-----TSAQPTAPPPPPG--PPPPSLPL 2852

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  876 QGYSLPGHQPLPHPYSSlgqlTQAHVPGALSGPHHTGGHGPPPVMLLHAAPQQGSGPQHGPPPQQGAHQHFTYLGPQVPV 955
Cdd:PHA03247 2853 GGSVAPGGDVRRRPPSR----SPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQ 2928

                         490
                  ....*....|...
gi 528473443  956 QAHNPQQIPYHPS 968
Cdd:PHA03247 2929 PQPPPPPPPRPQP 2941
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 837-963 1.22e-06

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 52.73  E-value: 1.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  837 QSGQSGPQPQSLYHSGPLSAPTPPNLPPGHSSPQASYSLQGYSLPGHQPLP----HPYSSL----GQLTQAHVPGALSGP 908
Cdd:pfam09770 206 QAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHpgqgHPVTILqrpqSPQPDPAQPSIQPQA 285

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528473443  909 HHTGGHGPP-----------PVMLLHAAPQQGSGPQHG--PPPQQGAHQHFTYLGPQVPVQAHnPQQI 963
Cdd:pfam09770 286 QQFHQQPPPvpvqptqilqnPNRLSAARVGYPQNPQPGvqPAPAHQAHRQQGSFGRQAPIITH-PQQL 352
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 356-634 1.79e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 52.00  E-value: 1.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443 356 PSEPGHSSPPSPHtlshslSHPQSLSDvaRPVNGVSPKSQRTGQTNRNMRTSNSHSS---PTVSRSP----KPDAP--PQ 426
Cdd:PTZ00449 521 PKAPGDKEGEEGE------HEDSKESD--EPKEGGKPGETKEGEVGKKPGPAKEHKPskiPTLSKKPefpkDPKHPkdPE 592

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443 427 DPLLTGSYLDPSSKPVGPTPLFPVDVNEILSKERMESPVGPQEGKSNKIPSVQQRSQISEELR--------------KFG 492
Cdd:PTZ00449 593 EPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKspkppkspkppfdpKFK 672

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443 493 NTFRLQQNPKTLPTESTQANPAHNtQTDPAAPTEAKPAPPTTPNTELSAEERSRETNPEGPvtSTPPPATSISAPSGIGM 572
Cdd:PTZ00449 673 EKFYDDYLDAAAKSKETKTTVVLD-ESFESILKETLPETPGTPFTTPRPLPPKLPRDEEFP--FEPIGDPDAEQPDDIEF 749

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528473443 573 QNPPAEGQTAGAPQPARTPG----SEDGKPEAPERSEGMTDQVKKSTLNPNAKEFNPTKAPLSMVK 634
Cdd:PTZ00449 750 FTPPEEERTFFHETPADTPLpdilAEEFKEEDIHAETGEPDEAMKRPDSPSEHEDKPPGDHPSLPK 815
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 542-940 8.43e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 49.77  E-value: 8.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  542 EERSRETNPEGPVTSTPPPATSISAPSGIGMQNPP---AEGQTAGAPQPARTPGSEDGKPEAPERSEGMTDQVKKSTLNP 618
Cdd:pfam03154 138 DQDNRSTSPSIPSPQDNESDSDSSAQQQILQTQPPvlqAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQP 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  619 nAKEFNPTKAPLSMVKPSATPTPPRPTPPSPTVVLQTQPGQGAVYNPQYL-SYVSQVPIQIQGHSVQ----------PQI 687
Cdd:pfam03154 218 -PNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLpQPSLHGQMPPMPHSLQtgpshmqhpvPPQ 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  688 PYSYMTAVSQGKYPRTKGSVVtPRPDHSSSAPPMIQAASAAGPPLVASPYPPSYLQYNQVIPA----MPHYPGHQvysml 763
Cdd:pfam03154 297 PFPLTPQSSQSQVPPGPSPAA-PGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPpttpIPQLPNPQ----- 370

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  764 qggprmlgSGGHPQALGPPGP-QYPGQTEGPSAPQQGMYAPqsfSHHSGSIHPQP-SSTPTGSQPPPQHPAPSPGQSGQS 841
Cdd:pfam03154 371 --------SHKHPPHLSGPSPfQMNSNLPPPPALKPLSSLS---THHPPSAHPPPlQLMPQSQQLPPPPAQPPVLTQSQS 439

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  842 GPQ------PQSLYHSGPLSAPTPPN-LPPGHSSPQASYSLQGYSLPGHQPLPHPYSSLGQLTQAHVPGALSGPhhtggh 914
Cdd:pfam03154 440 LPPpaashpPTSGLHQVPSQSPFPQHpFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCP------ 513

                         410       420
                  ....*....|....*....|....*.
gi 528473443  915 gPPPVMLLHAAPQQGSGPQHGPPPQQ 940
Cdd:pfam03154 514 -LPPVQIKEEALDEAEEPESPPPPPR 538
PHA03247 PHA03247
large tegument protein UL36; Provisional
 277-720 2.74e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 2.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  277 PPQRAREREMGVSGRGERGGAVSTLPNRTNRPGPSSSSPRPLPSANSQALPPTDRNSSLSVRGGFST----HQSQSSTPT 352
Cdd:PHA03247 2580 PAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVpppeRPRDDPAPG 2659

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  353 QSRPSE--------PGHSSPPSPHTLSHSLSHPQSLSDVARP-----VNGVSPKSQRTGQTNRNMRTSNSHSSPTVSRSP 419
Cdd:PHA03247 2660 RVSRPRrarrlgraAQASSPPQRPRRRAARPTVGSLTSLADPpppppTPEPAPHALVSATPLPPGPAAARQASPALPAAP 2739

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  420 KPDAPPQDPLLTGSYLDPSSKPVGPTPLFPVdvneilskermeSPVGPQEGKSNKIPSVQQRSqiseeLRKFGNTFRLQQ 499
Cdd:PHA03247 2740 APPAVPAGPATPGGPARPARPPTTAGPPAPA------------PPAAPAAGPPRRLTRPAVAS-----LSESRESLPSPW 2802

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  500 NPKTLPTESTQANPAHNTQTDPAAPTeakpAPPTTPNTELSAEersretnPEGPVTSTPPPATSIsAPSGIGMQNPPAEG 579
Cdd:PHA03247 2803 DPADPPAAVLAPAAALPPAASPAGPL----PPPTSAQPTAPPP-------PPGPPPPSLPLGGSV-APGGDVRRRPPSRS 2870

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  580 QTAGAPQPARTPGSEDGKPEAPERSEGMtdqvkksTLNPNAKEFNPTKAPlsmvKPSATPTPPRPTPPSPTVVLQTQPGQ 659
Cdd:PHA03247 2871 PAAKPAAPARPPVRRLARPAVSRSTESF-------ALPPDQPERPPQPQA----PPPPQPQPQPPPPPQPQPPPPPPPRP 2939

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528473443  660 GAVYNPQYLSYVSQVPiqiqghsvQPQIPYSYMTAVSQGKYPRTKGSVVTPRPDHSSSAPP 720
Cdd:PHA03247 2940 QPPLAPTTDPAGAGEP--------SGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASS 2992
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 496-872 3.10e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.06  E-value: 3.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443 496 RLQQNPKTLPTESTQANPAHNTQTDPAAPTEAKPAPPTTPNTELSAEERSRETNPEGPVTSTPPPATSISAPSGIGMQNP 575
Cdd:PRK07764 377 RLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSP 456

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443 576 PAEGQTAGAPQPARTPGSEDGKPEAPERSEGMTDQVKKSTLNPNAKEFNPTKAP---------LSMVKPSAT-------P 639
Cdd:PRK07764 457 PPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAAtlrerwpeiLAAVPKRSRktwaillP 536

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443 640 TPPRPTPPSPTVVL--QTQPGQGAVYNPQYLSYVSQVPIQIQGHSVQPQIPYSYMTAVSQGKYPRTKGSVVTP----RPD 713
Cdd:PRK07764 537 EATVLGVRGDTLVLgfSTGGLARRFASPGNAEVLVTALAEELGGDWQVEAVVGPAPGAAGGEGPPAPASSGPPeeaaRPA 616

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443 714 HSSSAPPMIQAASAAGPplvASPYPPSYLQYNQVIPAMPHYPGHQVYSMLQGGPRMLGSGGHPQALGPPGPQYPGQTEGP 793
Cdd:PRK07764 617 APAAPAAPAAPAPAGAA---AAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAP 693

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528473443 794 SAPQQGMYAPQSFSHHSGSIHPQPSSTPTGSQPPPQHPAPSPGQSGQSGPQPQSLYHSGPLSAPTPPNLPPGHSSPQAS 872
Cdd:PRK07764 694 AGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAA 772
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 742-865 1.21e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 45.95  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  742 LQYNQVIPAMPHYPGHQVYSMLQGGPRMLGSGGH----PQALGPPGPQYPGQTEGPSAPQQGMYAPQSFSHHSGSIHPQP 817
Cdd:TIGR01628 373 DQFMQLQPRMRQLPMGSPMGGAMGQPPYYGQGPQqqfnGQPLGWPRMSMMPTPMGPGGPLRPNGLAPMNAVRAPSRNAQN 452

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 528473443  818 SSTPTGSQPPPQHPAPSPGQSGQSGPQPQSLYHSG---PLSAPTPPNLPPG 865
Cdd:TIGR01628 453 AAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGgqnKKLAQVLASATPQ 503
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 497-937 1.75e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.55  E-value: 1.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  497 LQQNPKTLPTESTQ-ANPAHNTQTDPAAPTEAKPAPPTTPNT-ELSAEERSRETNPEGPVTSTPPPAT-SISAPSGIGMQ 573
Cdd:PHA03307   36 LSGSQGQLVSDSAElAAVTVVAGAAACDRFEPPTGPPPGPGTeAPANESRSTPTWSLSTLAPASPAREgSPTPPGPSSPD 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  574 NPPAEGQTAGAPQPARTPGSEDGKPEAPERSEGMTDQVKKSTLNPNAKEFNPTKAPLSMVKPSATPTPPRPTPPSPTVVL 653
Cdd:PHA03307  116 PPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPP 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  654 QTQPGQGAvynpqylsyvsqvpiqiqghsvqpqipysymtavsqgKYPRTKGSVVTPRPDHSSSAPPMIQAASAAGPPLV 733
Cdd:PHA03307  196 STPPAAAS-------------------------------------PRPPRRSSPISASASSPAPAPGRSAADDAGASSSD 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  734 ASPYPPSYLQYNQ--VIPAMPHYPGHQVYSMLQGGPRMLGSGGHPQALGPPGPQYPGQTEGPSAPQQGMYAPQSF-SHHS 810
Cdd:PHA03307  239 SSSSESSGCGWGPenECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRaSSSS 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  811 GSIHPQPSSTPTGSQPPPQHPAPSPGQSGQSGPQPQSlyHSGPLSAPTPPNLPPGHSSPQAsyslqgyslpghqPLPHPY 890
Cdd:PHA03307  319 SSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSR--PPPPADPSSPRKRPRPSRAPSS-------------PAASAG 383

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 528473443  891 SSLGQLTQAHVPGALSGPHHTG--GHGPPPVMLLHAAPQQGSGPQHGPP 937
Cdd:PHA03307  384 RPTRRRARAAVAGRARRRDATGrfPAGRPRPSPLDAGAASGAFYARYPL 432
PHA03247 PHA03247
large tegument protein UL36; Provisional
 263-847 2.09e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 2.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  263 PGFSSAGSREGK-YIPPQRARERE-MGVSGRGERGGAVSTLPNRTNR----PGPSSSSPRPLPSANSQALPPTDRNSSLS 336
Cdd:PHA03247 2577 PSEPAVTSRARRpDAPPQSARPRApVDDRGDPRGPAPPSPLPPDTHApdppPPSPSPAANEPDPHPPPTVPPPERPRDDP 2656

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  337 VRGGFSTHQSQSStptQSRPsePGHSSPPSPHTLSHSLSHPQSLSDVARP-----VNGVSPKSQRTGQTNRNMRTSNSHS 411
Cdd:PHA03247 2657 APGRVSRPRRARR---LGRA--AQASSPPQRPRRRAARPTVGSLTSLADPpppppTPEPAPHALVSATPLPPGPAAARQA 2731

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  412 SPTVSRSPKPDAPPQDPLLTGSYLDPSSKPVGPTPLFPVdvneilskermeSPVGPQEGKSNKIPSVQQRSqiseeLRKF 491
Cdd:PHA03247 2732 SPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPA------------PPAAPAAGPPRRLTRPAVAS-----LSES 2794

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  492 GNTFRLQQNPKTLPTESTQANPAHNTQTDPAAPTeakpAPPTTPNTELSAEersretnPEGPVTSTPPPATSIsAPSGIG 571
Cdd:PHA03247 2795 RESLPSPWDPADPPAAVLAPAAALPPAASPAGPL----PPPTSAQPTAPPP-------PPGPPPPSLPLGGSV-APGGDV 2862

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  572 MQNPPAEGQTAGAPQPARTPGSEDGKPEAPERSEGMTdqvkkstLNPNAKEFNPTKAPlsmvKPSATPTPPRPTPPSPTV 651
Cdd:PHA03247 2863 RRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFA-------LPPDQPERPPQPQA----PPPPQPQPQPPPPPQPQP 2931

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  652 VLQTQPGQGAVYNPQYLSYVSQVPiqiqghsvQPQIPYSYMTAVSQGKYPRTKGSVVTPRPDHSSSAPPMiqaasaagPP 731
Cdd:PHA03247 2932 PPPPPPRPQPPLAPTTDPAGAGEP--------SGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASST--------PP 2995

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  732 LVASPYPPSYLQYNQVipAMPHYPGHQVYSMLQggprmlgsgghpqALGPPGpqypgQTEGPSAPQQGMYAPQSFSHHSG 811
Cdd:PHA03247 2996 LTGHSLSRVSSWASSL--ALHEETDPPPVSLKQ-------------TLWPPD-----DTEDSDADSLFDSDSERSDLEAL 3055

                         570       580       590
                  ....*....|....*....|....*....|....*...
gi 528473443  812 SIHPQPSSTPTGSQPPPQHPAPSPGQSGQS--GPQPQS 847
Cdd:PHA03247 3056 DPLPPEPHDPFAHEPDPATPEAGARESPSSqfGPPPLS 3093
PRK13914 PRK13914
invasion associated endopeptidase;
384-568 6.07e-04

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 43.64  E-value: 6.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443 384 ARPVNGVSPKSQRTGQT---NRNMRTSNSHSSPTV-SRSPKPDAPPQDpLLTGSYLDPSSKPVGptplfpvdvnEILSKE 459
Cdd:PRK13914 176 TTQATTPAPKVAETKETpvvDQNATTHAVKSGDTIwALSVKYGVSVQD-IMSWNNLSSSSIYVG----------QKLAIK 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443 460 RMESPVGPQEGKSNKIPSVQQRSqiseelrkfgnTFRLQQNPKTLPTESTQANPAHNTQTDPAAPTEA-KPAPPTTPNTE 538
Cdd:PRK13914 245 QTANTATPKAEVKTEAPAAEKQA-----------APVVKENTNTNTATTEKKETTTQQQTAPKAPTEAaKPAPAPSTNTN 313

                        170       180       190
                 ....*....|....*....|....*....|
gi 528473443 539 LSAEERSRETNPEGPVTSTPPPATSISAPS 568
Cdd:PRK13914 314 ANKTNTNTNTNTNNTNTSTPSKNTNTNTNS 343
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 652-940 1.18e-03

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 42.69  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  652 VLQTQPGQGA--VYNPQYLSYVSQVPIQI--QGHSVQPQIPYSYMTAVS--QGKYPRTKGSVVTPRP-DHSSSAPPMIQA 724
Cdd:pfam09606 146 VGRMQPGGQAggMMQPSSGQPGSGTPNQMgpNGGPGQGQAGGMNGGQQGpmGGQMPPQMGVPGMPGPaDAGAQMGQQAQA 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  725 ASAAGPPLVASPYPPSYLQYNQVIPAMPH----YPGHQVYSMLQGGPRMLGSGGHPQALGPPGPQYPGQTEGPSAPQQGM 800
Cdd:pfam09606 226 NGGMNPQQMGGAPNQVAMQQQQPQQQGQQsqlgMGINQMQQMPQGVGGGAGQGGPGQPMGPPGQQPGAMPNVMSIGDQNN 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  801 YAPQSFSHHSGSIH-PQPSSTPTGSQPPPQHPAPSPGQSGQSGPQPQSLYHSGPLSAPTPPNLPPGH-SSPQASYSLQGY 878
Cdd:pfam09606 306 YQQQQTRQQQQQQGgNHPAAHQQQMNQSVGQGGQVVALGGLNHLETWNPGNFGGLGANPMQRGQPGMmSSPSPVPGQQVR 385

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528473443  879 SLPGHQPLPHPYSSLGQLTQAhvPGALSGPHHTGGHGPPPVMLLHAAPQQGSGPQHGPPPQQ 940
Cdd:pfam09606 386 QVTPNQFMRQSPQPSVPSPQG--PGSQPPQSHPGGMIPSPALIPSPSPQMSQQPAQQRTIGQ 445
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 345-609 1.47e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 42.37  E-value: 1.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443 345 QSQSSTPTQSRPSEPGHSSPPSPHTLSHSLSHPQSLSDVARPVNGVSPKSQRTGQTNRNMRTSNSHSSPTVSRSPKPDAP 424
Cdd:PTZ00449 595 KKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKPPFDPKFKEK 674

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443 425 PQDplltgSYLDPSSKPV-GPTPLFPVDVNEILSKERMESPVGPQEGKSNKIPSVQQRSQiSEELRKFGNTFRLQQNPKT 503
Cdd:PTZ00449 675 FYD-----DYLDAAAKSKeTKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRDE-EFPFEPIGDPDAEQPDDIE 748

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443 504 LPT----ESTQANPAHNTQTDPAAPTEAKPAPPTTPNTELSAEERSRetnPEGPVTSTP-PPATSISAPSGIGMQNPPAE 578
Cdd:PTZ00449 749 FFTppeeERTFFHETPADTPLPDILAEEFKEEDIHAETGEPDEAMKR---PDSPSEHEDkPPGDHPSLPKKRHRLDGLAL 825

                        250       260       270
                 ....*....|....*....|....*....|.
gi 528473443 579 GQTAGAPQPARTPGSEDGKPEAPERSEGMTD 609
Cdd:PTZ00449 826 STTDLESDAGRIAKDASGKIVKLKRSKSFDD 856
PRK11907 PRK11907
bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;
499-581 1.54e-03

bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;


Pssm-ID: 237019 [Multi-domain]  Cd Length: 814  Bit Score: 42.53  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443 499 QNPKTLPTESTQANPAHNTQTDPAAPTEAkpAPPTTPNTELSAEERSRETNPEGPVTSTPPPATSISAPSGIGMQNPPAE 578
Cdd:PRK11907  33 TTTPATSTEAEQTTPVESDATEEADNTET--PVAATTAAEAPSSSETAETSDPTSEATDTTTSEARTVTPAATETSKPVE 110


                 ...
gi 528473443 579 GQT 581
Cdd:PRK11907 111 GQT 113
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 500-587 2.24e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 41.72  E-value: 2.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443 500 NPKTLPTESTQANPAHNTQTDPAAPTEAKPAPPT--TPNTELSAEERSRETNPEGPVTsTPPPATSISAPSGIGMQNPPA 577
Cdd:PRK14950 361 VPVPAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAanIPPKEPVRETATPPPVPPRPVA-PPVPHTPESAPKLTRAAIPVD 439

                         90
                 ....*....|
gi 528473443 578 EGQTAGAPQP 587
Cdd:PRK14950 440 EKPKYTPPAP 449
PRK11901 PRK11901
hypothetical protein; Reviewed
 386-577 3.25e-03

hypothetical protein; Reviewed


Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 40.82  E-value: 3.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443 386 PVNGVSPKSQRTGQTNRNMRTSNSHSSPTVSRSPKPDAPPQDPLLTGSYLDPSSK-------PVGPTPLFPVDVNEILSK 458
Cdd:PRK11901  61 PTEHESQQSSNNAGAEKNIDLSGSSSLSSGNQSSPSAANNTSDGHDASGVKNTAPpqdisapPISPTPTQAAPPQTPNGQ 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443 459 ERMESPvgpqegksNKIPSV--QQRSQISEELRKfgntfrLQQNPKTLPTesTQANPAHNTQTDPAAPTEAKPAPPTTPN 536
Cdd:PRK11901 141 QRIELP--------GNISDAlsQQQGQVNAASQN------AQGNTSTLPT--APATVAPSKGAKVPATAETHPTPPQKPA 204

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 528473443 537 TELSAEerSRETNPEGPVTSTPPPATSISAPSGIGMQNPPA 577
Cdd:PRK11901 205 TKKPAV--NHHKTATVAVPPATSGKPKSGAASARALSSAPA 243
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 840-967 4.95e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.84  E-value: 4.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  840 QSGPQPQSlyhSGPLSAPTPPNLPPghsSPQASYSLQGYSLPGHQPLPHPYSSLGQLTQAHVPGALSGPHHTGGHGPPPV 919
Cdd:PRK10263  361 QPVPGPQT---GEPVIAPAPEGYPQ---QSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYY 434

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 528473443  920 MLLHAAPQQGSGPQHgpPPQQGAHQHFTYLGPQVPVQAHNPQQIPYHP 967
Cdd:PRK10263  435 APAPEQPVAGNAWQA--EEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQ 480
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 708-898 5.26e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 40.79  E-value: 5.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  708 VTPRPDHSSSAPPMIQAASAAGPPLV---------------ASPYPPSylQYNQVIPAMPHYPGHQVYSMLQGGPRMLGS 772
Cdd:pfam09770 165 VAPKKAAAPAPAPQPAAQPASLPAPSrkmmsleeveaamraQAKKPAQ--QPAPAPAQPPAAPPAQQAQQQQQFPPQIQQ 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  773 GGHPQALGPPGPQYPGQTEGPSAPQQgmyaPQSFSHHSGSIHPQPSSTPTGSQPPPQHPapspgQSGQSGPQPQSLyhsG 852
Cdd:pfam09770 243 QQQPQQQPQQPQQHPGQGHPVTILQR----PQSPQPDPAQPSIQPQAQQFHQQPPPVPV-----QPTQILQNPNRL---S 310

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 528473443  853 PLSAPTPPNLPPGHSSPQASYSLQGYSLPGHQP--LPHPySSLGQLTQ 898
Cdd:pfam09770 311 AARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQApiITHP-QQLAQLSE 357
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 703-968 5.43e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 5.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  703 TKGSVVTPRPDHSSSAPPMIQAASAAGPPLVASPYPPsylqynqVIPAMPHYPGhqvysmlqggPRMLGSGGHPQALGPP 782
Cdd:pfam03154 144 TSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGA-------ASPPSPPPPG----------TTQAATAGPTPSAPSV 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  783 GPQYPGQTEGPSAPQQGMYAPQSFSHHSGSIHPQPSSTPTGSQPPPQHPAPSPGQSGQSGPQPQslyHSGPlsaptppnL 862
Cdd:pfam03154 207 PPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPS---LHGQ--------M 275

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528473443  863 PPGHSSPQASYSLQGYSLPghqplPHPYSSLGQLTQAHVP----GALSGPHHTGGHGPPPvmllHAAPQQGSGPQHGPPP 938
Cdd:pfam03154 276 PPMPHSLQTGPSHMQHPVP-----PQPFPLTPQSSQSQVPpgpsPAAPGQSQQRIHTPPS----QSQLQSQQPPREQPLP 346

                         250       260       270
                  ....*....|....*....|....*....|
gi 528473443  939 QQGAHQHFTYLGPQVPVQAHNPQQIPYHPS 968
Cdd:pfam03154 347 PAPLSMPHIKPPPTTPIPQLPNPQSHKHPP 376
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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