|
Name |
Accession |
Description |
Interval |
E-value |
| SM-ATX |
pfam14438 |
Ataxin 2 SM domain; This SM domain is found in Ataxin-2. |
64-146 |
5.04e-19 |
|
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
Pssm-ID: 464173 Cd Length: 78 Bit Score: 82.22 E-value: 5.04e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 64 MLHFLTAVVGSRCDVMVKNGSLYEGIFKTLS--SRCELAVDAVHKVKNEEGDGGGgggtavhPRKEEITDTMIFGPSDLV 141
Cdd:pfam14438 1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASleKDFGVVLKMARRIKKSNGSGLN-------PVRGEIVDTMIFPAKDIV 73
|
....*
gi 688541774 142 TMICR 146
Cdd:pfam14438 74 DIEAK 78
|
|
| LsmAD |
pfam06741 |
LsmAD domain; This domain is found associated with Lsm domain. |
213-275 |
1.24e-17 |
|
LsmAD domain; This domain is found associated with Lsm domain.
Pssm-ID: 461998 [Multi-domain] Cd Length: 65 Bit Score: 78.00 E-value: 1.24e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 688541774 213 YGVKSTYDSSLsmYTVPLERgSSEGFRQREARAARLANEIEASSQYRHRVALEN-----DEGRTDEDK 275
Cdd:pfam06741 1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERgldvdDSGLDEEDK 65
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
385-974 |
3.10e-13 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 74.59 E-value: 3.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 385 PTQSRPSEPGHSSPPSPHtlSHSLSHPQSLSDVARPVNGVSPKSQRTGQTNRNMRTSNSHSSPTVSRSPKPDAPPQDPLL 464
Cdd:PHA03247 2556 PPAAPPAAPDRSVPPPRP--APRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSP 2633
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 465 TGSYLDPSSKPVGPTPLFPVDvneilskermeSPVGPQEGKSNKIPSVQQRSQISEELRKFgntfRLQQNPKTLPTESTQ 544
Cdd:PHA03247 2634 AANEPDPHPPPTVPPPERPRD-----------DPAPGRVSRPRRARRLGRAAQASSPPQRP----RRRAARPTVGSLTSL 2698
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 545 ANPAHNTQTDPAAPTEAKPAPPTTPNTElsaeeRSRETNPEGPVTSTPPPATSISAPSGiGMQNPPAEGQTAGAPQPART 624
Cdd:PHA03247 2699 ADPPPPPPTPEPAPHALVSATPLPPGPA-----AARQASPALPAAPAPPAVPAGPATPG-GPARPARPPTTAGPPAPAPP 2772
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 625 PGSEDGKPEAPERSEGMTDQVKKSTLNPNAKEFNPTKAPLSMVKPSATPTPPRPTPPSPTVVLQTQPGQGAVYNPQYLSy 704
Cdd:PHA03247 2773 AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP- 2851
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 705 vsqvpiqiQGHSVQPQIPYSymtavsqgKYPRTKGSVVTPrpdhssSAPPMIQAASAAGPPLVASPYPPSYLQYNQVIPA 784
Cdd:PHA03247 2852 --------LGGSVAPGGDVR--------RRPPSRSPAAKP------AAPARPPVRRLARPAVSRSTESFALPPDQPERPP 2909
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 785 MPHYPghqvysmlqgGPRMLGSGGHPQALGPPGPQYPGQTEGPSAPQQGmyapqsfshhsgsihPQPSSTPTGSQPPPQH 864
Cdd:PHA03247 2910 QPQAP----------PPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD---------------PAGAGEPSGAVPQPWL 2964
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 865 PAPSPGQSgqsgPQPQSLYHSGPLSAPTP-PNLPPGHSSPQASYSLQGYSLPGHQPLPHPYSSLGQ-------------- 929
Cdd:PHA03247 2965 GALVPGRV----AVPRFRVPQPAPSREAPaSSTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQtlwppddtedsdad 3040
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|...
gi 688541774 930 --------LTQAHVPGALSGPHHTGGHGPPPVMLLHAAPQQGSGPQHGPPPQQ 974
Cdd:PHA03247 3041 slfdsdseRSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLS 3093
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
576-974 |
7.69e-06 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 50.15 E-value: 7.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 576 EERSRETNPEGPVTSTPPPATSISAPSGIGMQNPP---AEGQTAGAPQPARTPGSEDGKPEAPERSEGMTDQVKKSTLNP 652
Cdd:pfam03154 138 DQDNRSTSPSIPSPQDNESDSDSSAQQQILQTQPPvlqAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQP 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 653 nAKEFNPTKAPLSMVKPSATPTPPRPTPPSPTVVLQTQPGQGAVYNPQYL-SYVSQVPIQIQGHSVQ----------PQI 721
Cdd:pfam03154 218 -PNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLpQPSLHGQMPPMPHSLQtgpshmqhpvPPQ 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 722 PYSYMTAVSQGKYPRTKGSVVtPRPDHSSSAPPMIQAASAAGPPLVASPYPPSYLQYNQVIPA----MPHYPGHQvysml 797
Cdd:pfam03154 297 PFPLTPQSSQSQVPPGPSPAA-PGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPpttpIPQLPNPQ----- 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 798 qggprmlgSGGHPQALGPPGP-QYPGQTEGPSAPQQGMYAPqsfSHHSGSIHPQP-SSTPTGSQPPPQHPAPSPGQSGQS 875
Cdd:pfam03154 371 --------SHKHPPHLSGPSPfQMNSNLPPPPALKPLSSLS---THHPPSAHPPPlQLMPQSQQLPPPPAQPPVLTQSQS 439
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 876 GPQ------PQSLYHSGPLSAPTPPN-LPPGHSSPQASYSLQGYSLPGHQPLPHPYSSLGQLTQAHVPGALSGPhhtggh 948
Cdd:pfam03154 440 LPPpaashpPTSGLHQVPSQSPFPQHpFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCP------ 513
|
410 420
....*....|....*....|....*.
gi 688541774 949 gPPPVMLLHAAPQQGSGPQHGPPPQQ 974
Cdd:pfam03154 514 -LPPVQIKEEALDEAEEPESPPPPPR 538
|
|
| PABP-1234 |
TIGR01628 |
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ... |
776-899 |
1.29e-04 |
|
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.
Pssm-ID: 130689 [Multi-domain] Cd Length: 562 Bit Score: 45.95 E-value: 1.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 776 LQYNQVIPAMPHYPGHQVYSMLQGGPRMLGSGGH----PQALGPPGPQYPGQTEGPSAPQQGMYAPQSFSHHSGSIHPQP 851
Cdd:TIGR01628 373 DQFMQLQPRMRQLPMGSPMGGAMGQPPYYGQGPQqqfnGQPLGWPRMSMMPTPMGPGGPLRPNGLAPMNAVRAPSRNAQN 452
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 688541774 852 SSTPTGSQPPPQHPAPSPGQSGQSGPQPQSLYHSG---PLSAPTPPNLPPG 899
Cdd:TIGR01628 453 AAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGgqnKKLAQVLASATPQ 503
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| SM-ATX |
pfam14438 |
Ataxin 2 SM domain; This SM domain is found in Ataxin-2. |
64-146 |
5.04e-19 |
|
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
Pssm-ID: 464173 Cd Length: 78 Bit Score: 82.22 E-value: 5.04e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 64 MLHFLTAVVGSRCDVMVKNGSLYEGIFKTLS--SRCELAVDAVHKVKNEEGDGGGgggtavhPRKEEITDTMIFGPSDLV 141
Cdd:pfam14438 1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASleKDFGVVLKMARRIKKSNGSGLN-------PVRGEIVDTMIFPAKDIV 73
|
....*
gi 688541774 142 TMICR 146
Cdd:pfam14438 74 DIEAK 78
|
|
| LsmAD |
pfam06741 |
LsmAD domain; This domain is found associated with Lsm domain. |
213-275 |
1.24e-17 |
|
LsmAD domain; This domain is found associated with Lsm domain.
Pssm-ID: 461998 [Multi-domain] Cd Length: 65 Bit Score: 78.00 E-value: 1.24e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 688541774 213 YGVKSTYDSSLsmYTVPLERgSSEGFRQREARAARLANEIEASSQYRHRVALEN-----DEGRTDEDK 275
Cdd:pfam06741 1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERgldvdDSGLDEEDK 65
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
385-974 |
3.10e-13 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 74.59 E-value: 3.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 385 PTQSRPSEPGHSSPPSPHtlSHSLSHPQSLSDVARPVNGVSPKSQRTGQTNRNMRTSNSHSSPTVSRSPKPDAPPQDPLL 464
Cdd:PHA03247 2556 PPAAPPAAPDRSVPPPRP--APRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSP 2633
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 465 TGSYLDPSSKPVGPTPLFPVDvneilskermeSPVGPQEGKSNKIPSVQQRSQISEELRKFgntfRLQQNPKTLPTESTQ 544
Cdd:PHA03247 2634 AANEPDPHPPPTVPPPERPRD-----------DPAPGRVSRPRRARRLGRAAQASSPPQRP----RRRAARPTVGSLTSL 2698
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 545 ANPAHNTQTDPAAPTEAKPAPPTTPNTElsaeeRSRETNPEGPVTSTPPPATSISAPSGiGMQNPPAEGQTAGAPQPART 624
Cdd:PHA03247 2699 ADPPPPPPTPEPAPHALVSATPLPPGPA-----AARQASPALPAAPAPPAVPAGPATPG-GPARPARPPTTAGPPAPAPP 2772
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 625 PGSEDGKPEAPERSEGMTDQVKKSTLNPNAKEFNPTKAPLSMVKPSATPTPPRPTPPSPTVVLQTQPGQGAVYNPQYLSy 704
Cdd:PHA03247 2773 AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP- 2851
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 705 vsqvpiqiQGHSVQPQIPYSymtavsqgKYPRTKGSVVTPrpdhssSAPPMIQAASAAGPPLVASPYPPSYLQYNQVIPA 784
Cdd:PHA03247 2852 --------LGGSVAPGGDVR--------RRPPSRSPAAKP------AAPARPPVRRLARPAVSRSTESFALPPDQPERPP 2909
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 785 MPHYPghqvysmlqgGPRMLGSGGHPQALGPPGPQYPGQTEGPSAPQQGmyapqsfshhsgsihPQPSSTPTGSQPPPQH 864
Cdd:PHA03247 2910 QPQAP----------PPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD---------------PAGAGEPSGAVPQPWL 2964
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 865 PAPSPGQSgqsgPQPQSLYHSGPLSAPTP-PNLPPGHSSPQASYSLQGYSLPGHQPLPHPYSSLGQ-------------- 929
Cdd:PHA03247 2965 GALVPGRV----AVPRFRVPQPAPSREAPaSSTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQtlwppddtedsdad 3040
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|...
gi 688541774 930 --------LTQAHVPGALSGPHHTGGHGPPPVMLLHAAPQQGSGPQHGPPPQQ 974
Cdd:PHA03247 3041 slfdsdseRSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLS 3093
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
390-668 |
1.54e-06 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 52.38 E-value: 1.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 390 PSEPGHSSPPSPHtlshslSHPQSLSDvaRPVNGVSPKSQRTGQTNRNMRTSNSHSS---PTVSRSP----KPDAP--PQ 460
Cdd:PTZ00449 521 PKAPGDKEGEEGE------HEDSKESD--EPKEGGKPGETKEGEVGKKPGPAKEHKPskiPTLSKKPefpkDPKHPkdPE 592
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 461 DPLLTGSYLDPSSKPVGPTPLFPVDVNEILSKERMESPVGPQEGKSNKIPSVQQRSQISEELR--------------KFG 526
Cdd:PTZ00449 593 EPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKspkppkspkppfdpKFK 672
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 527 NTFRLQQNPKTLPTESTQANPAHNtQTDPAAPTEAKPAPPTTPNTELSAEERSRETNPEGPvtSTPPPATSISAPSGIGM 606
Cdd:PTZ00449 673 EKFYDDYLDAAAKSKETKTTVVLD-ESFESILKETLPETPGTPFTTPRPLPPKLPRDEEFP--FEPIGDPDAEQPDDIEF 749
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 688541774 607 QNPPAEGQTAGAPQPARTPG----SEDGKPEAPERSEGMTDQVKKSTLNPNAKEFNPTKAPLSMVK 668
Cdd:PTZ00449 750 FTPPEEERTFFHETPADTPLpdilAEEFKEEDIHAETGEPDEAMKRPDSPSEHEDKPPGDHPSLPK 815
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
576-974 |
7.69e-06 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 50.15 E-value: 7.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 576 EERSRETNPEGPVTSTPPPATSISAPSGIGMQNPP---AEGQTAGAPQPARTPGSEDGKPEAPERSEGMTDQVKKSTLNP 652
Cdd:pfam03154 138 DQDNRSTSPSIPSPQDNESDSDSSAQQQILQTQPPvlqAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQP 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 653 nAKEFNPTKAPLSMVKPSATPTPPRPTPPSPTVVLQTQPGQGAVYNPQYL-SYVSQVPIQIQGHSVQ----------PQI 721
Cdd:pfam03154 218 -PNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLpQPSLHGQMPPMPHSLQtgpshmqhpvPPQ 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 722 PYSYMTAVSQGKYPRTKGSVVtPRPDHSSSAPPMIQAASAAGPPLVASPYPPSYLQYNQVIPA----MPHYPGHQvysml 797
Cdd:pfam03154 297 PFPLTPQSSQSQVPPGPSPAA-PGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPpttpIPQLPNPQ----- 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 798 qggprmlgSGGHPQALGPPGP-QYPGQTEGPSAPQQGMYAPqsfSHHSGSIHPQP-SSTPTGSQPPPQHPAPSPGQSGQS 875
Cdd:pfam03154 371 --------SHKHPPHLSGPSPfQMNSNLPPPPALKPLSSLS---THHPPSAHPPPlQLMPQSQQLPPPPAQPPVLTQSQS 439
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 876 GPQ------PQSLYHSGPLSAPTPPN-LPPGHSSPQASYSLQGYSLPGHQPLPHPYSSLGQLTQAHVPGALSGPhhtggh 948
Cdd:pfam03154 440 LPPpaashpPTSGLHQVPSQSPFPQHpFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCP------ 513
|
410 420
....*....|....*....|....*.
gi 688541774 949 gPPPVMLLHAAPQQGSGPQHGPPPQQ 974
Cdd:pfam03154 514 -LPPVQIKEEALDEAEEPESPPPPPR 538
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
311-754 |
3.25e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.40 E-value: 3.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 311 PPQRAREREMGVSGRGERGGAVSTLPNRTNRPGPSSSSPRPLPSANSQALPPTDRNSSLSVRGGFST----HQSQSSTPT 386
Cdd:PHA03247 2580 PAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVpppeRPRDDPAPG 2659
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 387 QSRPSE--------PGHSSPPSPHTLSHSLSHPQSLSDVARP-----VNGVSPKSQRTGQTNRNMRTSNSHSSPTVSRSP 453
Cdd:PHA03247 2660 RVSRPRrarrlgraAQASSPPQRPRRRAARPTVGSLTSLADPpppppTPEPAPHALVSATPLPPGPAAARQASPALPAAP 2739
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 454 KPDAPPQDPLLTGSYLDPSSKPVGPTPLFPVdvneilskermeSPVGPQEGKSNKIPSVQQRSqiseeLRKFGNTFRLQQ 533
Cdd:PHA03247 2740 APPAVPAGPATPGGPARPARPPTTAGPPAPA------------PPAAPAAGPPRRLTRPAVAS-----LSESRESLPSPW 2802
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 534 NPKTLPTESTQANPAHNTQTDPAAPTeakpAPPTTPNTELSAEersretnPEGPVTSTPPPATSIsAPSGIGMQNPPAEG 613
Cdd:PHA03247 2803 DPADPPAAVLAPAAALPPAASPAGPL----PPPTSAQPTAPPP-------PPGPPPPSLPLGGSV-APGGDVRRRPPSRS 2870
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 614 QTAGAPQPARTPGSEDGKPEAPERSEGMtdqvkksTLNPNAKEFNPTKAPlsmvKPSATPTPPRPTPPSPTVVLQTQPGQ 693
Cdd:PHA03247 2871 PAAKPAAPARPPVRRLARPAVSRSTESF-------ALPPDQPERPPQPQA----PPPPQPQPQPPPPPQPQPPPPPPPRP 2939
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 688541774 694 GAVYNPQYLSYVSQVPiqiqghsvQPQIPYSYMTAVSQGKYPRTKGSVVTPRPDHSSSAPP 754
Cdd:PHA03247 2940 QPPLAPTTDPAGAGEP--------SGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASS 2992
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
530-906 |
3.38e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 48.06 E-value: 3.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 530 RLQQNPKTLPTESTQANPAHNTQTDPAAPTEAKPAPPTTPNTELSAEERSRETNPEGPVTSTPPPATSISAPSGIGMQNP 609
Cdd:PRK07764 377 RLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSP 456
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 610 PAEGQTAGAPQPARTPGSEDGKPEAPERSEGMTDQVKKSTLNPNAKEFNPTKAP---------LSMVKPSAT-------P 673
Cdd:PRK07764 457 PPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAAtlrerwpeiLAAVPKRSRktwaillP 536
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 674 TPPRPTPPSPTVVL--QTQPGQGAVYNPQYLSYVSQVPIQIQGHSVQPQIPYSYMTAVSQGKYPRTKGSVVTP----RPD 747
Cdd:PRK07764 537 EATVLGVRGDTLVLgfSTGGLARRFASPGNAEVLVTALAEELGGDWQVEAVVGPAPGAAGGEGPPAPASSGPPeeaaRPA 616
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 748 HSSSAPPMIQAASAAGPplvASPYPPSYLQYNQVIPAMPHYPGHQVYSMLQGGPRMLGSGGHPQALGPPGPQYPGQTEGP 827
Cdd:PRK07764 617 APAAPAAPAAPAPAGAA---AAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAP 693
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 688541774 828 SAPQQGMYAPQSFSHHSGSIHPQPSSTPTGSQPPPQHPAPSPGQSGQSGPQPQSLYHSGPLSAPTPPNLPPGHSSPQAS 906
Cdd:PRK07764 694 AGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAA 772
|
|
| PABP-1234 |
TIGR01628 |
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ... |
776-899 |
1.29e-04 |
|
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.
Pssm-ID: 130689 [Multi-domain] Cd Length: 562 Bit Score: 45.95 E-value: 1.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 776 LQYNQVIPAMPHYPGHQVYSMLQGGPRMLGSGGH----PQALGPPGPQYPGQTEGPSAPQQGMYAPQSFSHHSGSIHPQP 851
Cdd:TIGR01628 373 DQFMQLQPRMRQLPMGSPMGGAMGQPPYYGQGPQqqfnGQPLGWPRMSMMPTPMGPGGPLRPNGLAPMNAVRAPSRNAQN 452
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 688541774 852 SSTPTGSQPPPQHPAPSPGQSGQSGPQPQSLYHSG---PLSAPTPPNLPPG 899
Cdd:TIGR01628 453 AAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGgqnKKLAQVLASATPQ 503
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
297-881 |
2.40e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 45.31 E-value: 2.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 297 PGFSSAGSREGK-YIPPQRARERE-MGVSGRGERGGAVSTLPNRTNR----PGPSSSSPRPLPSANSQALPPTDRNSSLS 370
Cdd:PHA03247 2577 PSEPAVTSRARRpDAPPQSARPRApVDDRGDPRGPAPPSPLPPDTHApdppPPSPSPAANEPDPHPPPTVPPPERPRDDP 2656
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 371 VRGGFSTHQSQSStptQSRPsePGHSSPPSPHTLSHSLSHPQSLSDVARP-----VNGVSPKSQRTGQTNRNMRTSNSHS 445
Cdd:PHA03247 2657 APGRVSRPRRARR---LGRA--AQASSPPQRPRRRAARPTVGSLTSLADPpppppTPEPAPHALVSATPLPPGPAAARQA 2731
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 446 SPTVSRSPKPDAPPQDPLLTGSYLDPSSKPVGPTPLFPVdvneilskermeSPVGPQEGKSNKIPSVQQRSqiseeLRKF 525
Cdd:PHA03247 2732 SPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPA------------PPAAPAAGPPRRLTRPAVAS-----LSES 2794
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 526 GNTFRLQQNPKTLPTESTQANPAHNTQTDPAAPTeakpAPPTTPNTELSAEersretnPEGPVTSTPPPATSIsAPSGIG 605
Cdd:PHA03247 2795 RESLPSPWDPADPPAAVLAPAAALPPAASPAGPL----PPPTSAQPTAPPP-------PPGPPPPSLPLGGSV-APGGDV 2862
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 606 MQNPPAEGQTAGAPQPARTPGSEDGKPEAPERSEGMTdqvkkstLNPNAKEFNPTKAPlsmvKPSATPTPPRPTPPSPTV 685
Cdd:PHA03247 2863 RRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFA-------LPPDQPERPPQPQA----PPPPQPQPQPPPPPQPQP 2931
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 686 VLQTQPGQGAVYNPQYLSYVSQVPiqiqghsvQPQIPYSYMTAVSQGKYPRTKGSVVTPRPDHSSSAPPMiqaasaagPP 765
Cdd:PHA03247 2932 PPPPPPRPQPPLAPTTDPAGAGEP--------SGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASST--------PP 2995
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 766 LVASPYPPSYLQYNQVipAMPHYPGHQVYSMLQggprmlgsgghpqALGPPGpqypgQTEGPSAPQQGMYAPQSFSHHSG 845
Cdd:PHA03247 2996 LTGHSLSRVSSWASSL--ALHEETDPPPVSLKQ-------------TLWPPD-----DTEDSDADSLFDSDSERSDLEAL 3055
|
570 580 590
....*....|....*....|....*....|....*...
gi 688541774 846 SIHPQPSSTPTGSQPPPQHPAPSPGQSGQS--GPQPQS 881
Cdd:PHA03247 3056 DPLPPEPHDPFAHEPDPATPEAGARESPSSqfGPPPLS 3093
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
531-971 |
2.94e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 45.16 E-value: 2.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 531 LQQNPKTLPTESTQ-ANPAHNTQTDPAAPTEAKPAPPTTPNT-ELSAEERSRETNPEGPVTSTPPPAT-SISAPSGIGMQ 607
Cdd:PHA03307 36 LSGSQGQLVSDSAElAAVTVVAGAAACDRFEPPTGPPPGPGTeAPANESRSTPTWSLSTLAPASPAREgSPTPPGPSSPD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 608 NPPAEGQTAGAPQPARTPGSEDGKPEAPERSEGMTDQVKKSTLNPNAKEFNPTKAPLSMVKPSATPTPPRPTPPSPTVVL 687
Cdd:PHA03307 116 PPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPP 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 688 QTQPGQGAvynpqylsyvsqvpiqiqghsvqpqipysymtavsqgKYPRTKGSVVTPRPDHSSSAPPMIQAASAAGPPLV 767
Cdd:PHA03307 196 STPPAAAS-------------------------------------PRPPRRSSPISASASSPAPAPGRSAADDAGASSSD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 768 ASPYPPSYLQYNQ--VIPAMPHYPGHQVYSMLQGGPRMLGSGGHPQALGPPGPQYPGQTEGPSAPQQGMYAPQSF-SHHS 844
Cdd:PHA03307 239 SSSSESSGCGWGPenECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRaSSSS 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 845 GSIHPQPSSTPTGSQPPPQHPAPSPGQSGQSGPQPQSlyHSGPLSAPTPPNLPPGHSSPQAsyslqgyslpghqPLPHPY 924
Cdd:PHA03307 319 SSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSR--PPPPADPSSPRKRPRPSRAPSS-------------PAASAG 383
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 688541774 925 SSLGQLTQAHVPGALSGPHHTG--GHGPPPVMLLHAAPQQGSGPQHGPP 971
Cdd:PHA03307 384 RPTRRRARAAVAGRARRRDATGrfPAGRPRPSPLDAGAASGAFYARYPL 432
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
871-979 |
7.38e-04 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 43.49 E-value: 7.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 871 QSGQSGPQPQSLYHSGPLSAPTPPNLPPGHSSPQASYSLQGYSLPGHQPLP----HPYSSL----GQLTQAHVPGALSGP 942
Cdd:pfam09770 206 QAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHpgqgHPVTILqrpqSPQPDPAQPSIQPQA 285
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 688541774 943 HHTGGHGPPPVM--------------LLHAAPQQGSGPQHGPPPQQGAHQH 979
Cdd:pfam09770 286 QQFHQQPPPVPVqptqilqnpnrlsaARVGYPQNPQPGVQPAPAHQAHRQQ 336
|
|
| PRK13914 |
PRK13914 |
invasion associated endopeptidase; |
418-602 |
8.48e-04 |
|
invasion associated endopeptidase;
Pssm-ID: 237555 [Multi-domain] Cd Length: 481 Bit Score: 43.25 E-value: 8.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 418 ARPVNGVSPKSQRTGQT---NRNMRTSNSHSSPTV-SRSPKPDAPPQDpLLTGSYLDPSSKPVGptplfpvdvnEILSKE 493
Cdd:PRK13914 176 TTQATTPAPKVAETKETpvvDQNATTHAVKSGDTIwALSVKYGVSVQD-IMSWNNLSSSSIYVG----------QKLAIK 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 494 RMESPVGPQEGKSNKIPSVQQRSqiseelrkfgnTFRLQQNPKTLPTESTQANPAHNTQTDPAAPTEA-KPAPPTTPNTE 572
Cdd:PRK13914 245 QTANTATPKAEVKTEAPAAEKQA-----------APVVKENTNTNTATTEKKETTTQQQTAPKAPTEAaKPAPAPSTNTN 313
|
170 180 190
....*....|....*....|....*....|
gi 688541774 573 LSAEERSRETNPEGPVTSTPPPATSISAPS 602
Cdd:PRK13914 314 ANKTNTNTNTNTNNTNTSTPSKNTNTNTNS 343
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
379-643 |
1.29e-03 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 42.75 E-value: 1.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 379 QSQSSTPTQSRPSEPGHSSPPSPHTLSHSLSHPQSLSDVARPVNGVSPKSQRTGQTNRNMRTSNSHSSPTVSRSPKPDAP 458
Cdd:PTZ00449 595 KKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKPPFDPKFKEK 674
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 459 PQDplltgSYLDPSSKPV-GPTPLFPVDVNEILSKERMESPVGPQEGKSNKIPSVQQRSQiSEELRKFGNTFRLQQNPKT 537
Cdd:PTZ00449 675 FYD-----DYLDAAAKSKeTKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRDE-EFPFEPIGDPDAEQPDDIE 748
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 538 LPT----ESTQANPAHNTQTDPAAPTEAKPAPPTTPNTELSAEERSRetnPEGPVTSTP-PPATSISAPSGIGMQNPPAE 612
Cdd:PTZ00449 749 FFTppeeERTFFHETPADTPLPDILAEEFKEEDIHAETGEPDEAMKR---PDSPSEHEDkPPGDHPSLPKKRHRLDGLAL 825
|
250 260 270
....*....|....*....|....*....|.
gi 688541774 613 GQTAGAPQPARTPGSEDGKPEAPERSEGMTD 643
Cdd:PTZ00449 826 STTDLESDAGRIAKDASGKIVKLKRSKSFDD 856
|
|
| Med15 |
pfam09606 |
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ... |
686-974 |
1.43e-03 |
|
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.
Pssm-ID: 312941 [Multi-domain] Cd Length: 732 Bit Score: 42.69 E-value: 1.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 686 VLQTQPGQGA--VYNPQYLSYVSQVPIQI--QGHSVQPQIPYSYMTAVS--QGKYPRTKGSVVTPRP-DHSSSAPPMIQA 758
Cdd:pfam09606 146 VGRMQPGGQAggMMQPSSGQPGSGTPNQMgpNGGPGQGQAGGMNGGQQGpmGGQMPPQMGVPGMPGPaDAGAQMGQQAQA 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 759 ASAAGPPLVASPYPPSYLQYNQVIPAMPHYP----GHQVYSMLQGGPRMLGSGGHPQALGPPGPQYPGQTEGPSAPQQGM 834
Cdd:pfam09606 226 NGGMNPQQMGGAPNQVAMQQQQPQQQGQQSQlgmgINQMQQMPQGVGGGAGQGGPGQPMGPPGQQPGAMPNVMSIGDQNN 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 835 YAPQSFSHHSGSIH-PQPSSTPTGSQPPPQHPAPSPGQSGQSGPQPQSLYHSGPLSAPTPPNLPPGH-SSPQASYSLQGY 912
Cdd:pfam09606 306 YQQQQTRQQQQQQGgNHPAAHQQQMNQSVGQGGQVVALGGLNHLETWNPGNFGGLGANPMQRGQPGMmSSPSPVPGQQVR 385
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 688541774 913 SLPGHQPLPHPYSSLGQLTQAhvPGALSGPHHTGGHGPPPVMLLHAAPQQGSGPQHGPPPQQ 974
Cdd:pfam09606 386 QVTPNQFMRQSPQPSVPSPQG--PGSQPPQSHPGGMIPSPALIPSPSPQMSQQPAQQRTIGQ 445
|
|
| PRK11907 |
PRK11907 |
bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase; |
533-615 |
1.53e-03 |
|
bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;
Pssm-ID: 237019 [Multi-domain] Cd Length: 814 Bit Score: 42.53 E-value: 1.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 533 QNPKTLPTESTQANPAHNTQTDPAAPTEAkpAPPTTPNTELSAEERSRETNPEGPVTSTPPPATSISAPSGIGMQNPPAE 612
Cdd:PRK11907 33 TTTPATSTEAEQTTPVESDATEEADNTET--PVAATTAAEAPSSSETAETSDPTSEATDTTTSEARTVTPAATETSKPVE 110
|
...
gi 688541774 613 GQT 615
Cdd:PRK11907 111 GQT 113
|
|
| PRK14950 |
PRK14950 |
DNA polymerase III subunits gamma and tau; Provisional |
534-621 |
2.20e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237864 [Multi-domain] Cd Length: 585 Bit Score: 41.72 E-value: 2.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 534 NPKTLPTESTQANPAHNTQTDPAAPTEAKPAPPT--TPNTELSAEERSRETNPEGPVTsTPPPATSISAPSGIGMQNPPA 611
Cdd:PRK14950 361 VPVPAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAanIPPKEPVRETATPPPVPPRPVA-PPVPHTPESAPKLTRAAIPVD 439
|
90
....*....|
gi 688541774 612 EGQTAGAPQP 621
Cdd:PRK14950 440 EKPKYTPPAP 449
|
|
| PRK11901 |
PRK11901 |
hypothetical protein; Reviewed |
420-611 |
3.80e-03 |
|
hypothetical protein; Reviewed
Pssm-ID: 237015 [Multi-domain] Cd Length: 327 Bit Score: 40.44 E-value: 3.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 420 PVNGVSPKSQRTGQTNRNMRTSNSHSSPTVSRSPKPDAPPQDPLLTGSYLDPSSK-------PVGPTPLFPVDVNEILSK 492
Cdd:PRK11901 61 PTEHESQQSSNNAGAEKNIDLSGSSSLSSGNQSSPSAANNTSDGHDASGVKNTAPpqdisapPISPTPTQAAPPQTPNGQ 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 493 ERMESPvgpqegksNKIPSV--QQRSQISEELRKfgntfrLQQNPKTLPTesTQANPAHNTQTDPAAPTEAKPAPPTTPN 570
Cdd:PRK11901 141 QRIELP--------GNISDAlsQQQGQVNAASQN------AQGNTSTLPT--APATVAPSKGAKVPATAETHPTPPQKPA 204
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 688541774 571 TELSAEerSRETNPEGPVTSTPPPATSISAPSGIGMQNPPA 611
Cdd:PRK11901 205 TKKPAV--NHHKTATVAVPPATSGKPKSGAASARALSSAPA 243
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
742-932 |
4.83e-03 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 40.79 E-value: 4.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 742 VTPRPDHSSSAPPMIQAASAAGPPLV---------------ASPYPPSylQYNQVIPAMPHYPGHQVYSMLQGGPRMLGS 806
Cdd:pfam09770 165 VAPKKAAAPAPAPQPAAQPASLPAPSrkmmsleeveaamraQAKKPAQ--QPAPAPAQPPAAPPAQQAQQQQQFPPQIQQ 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 807 GGHPQALGPPGPQYPGQTEGPSAPQQgmyaPQSFSHHSGSIHPQPSSTPTGSQPPPQHPapspgQSGQSGPQPQSLyhsG 886
Cdd:pfam09770 243 QQQPQQQPQQPQQHPGQGHPVTILQR----PQSPQPDPAQPSIQPQAQQFHQQPPPVPV-----QPTQILQNPNRL---S 310
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 688541774 887 PLSAPTPPNLPPGHSSPQASYSLQGYSLPGHQP--LPHPySSLGQLTQ 932
Cdd:pfam09770 311 AARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQApiITHP-QQLAQLSE 357
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
808-978 |
5.47e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.91 E-value: 5.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 808 GHPQALGPPGPQYPGQTEGPSAPQQGMYAPQSFSHHSGSIHPQPSSTPTGSQPPPQHPAPSPGQSGQSgPQPQSLYHSGP 887
Cdd:pfam03154 169 TQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPT-LHPQRLPSPHP 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688541774 888 LSAPTPPNLPPGHSSPQasySLQGYSLPGH-QPLPHPYSSLGQLTQAHVPGALSGPHHTGGHGPPPVMLLHAAPQQGSGP 966
Cdd:pfam03154 248 PLQPMTQPPPPSQVSPQ---PLPQPSLHGQmPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQR 324
|
170
....*....|..
gi 688541774 967 QHGPPPQQGAHQ 978
Cdd:pfam03154 325 IHTPPSQSQLQS 336
|
|
| |
