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    lap like-AP180 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40863, updated on 9-Dec-2024

    Summary

    Official Symbol
    lapprovided by FlyBase
    Official Full Name
    like-AP180provided by FlyBase
    Primary source
    FLYBASE:FBgn0086372
    Locus tag
    Dmel_CG2520
    See related
    AllianceGenome:FB:FBgn0086372
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AP180; BcDNA:GM10787; CG2520; dAP-3; Dmel\CG2520; EP(3)3060; EP3060; l(3)neo34; Lap; LAP; lap/AP180; sig
    Summary
    Predicted to enable SNARE binding activity; clathrin heavy chain binding activity; and phosphatidylinositol binding activity. Involved in several processes, including clathrin-dependent synaptic vesicle endocytosis; neuron-neuron synaptic transmission; and positive regulation of clathrin-dependent endocytosis. Located in clathrin-coated pit. Is expressed in several structures, including adult head; adult heart; neuromuscular junction; presumptive embryonic/larval system; and spermatozoon. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to several human genes including PICALM (phosphatidylinositol binding clathrin assembly protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See lap in Genome Data Viewer
    Location:
    84D1-84D2; 3-48 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7186994..7200941)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3012716..3026663)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45909 Neighboring gene stranded at second Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding  
    enables 1-phosphatidylinositol binding  
    enables 1-phosphatidylinositol binding  
    enables SNARE binding  
    enables clathrin binding  
    enables clathrin binding  
    enables clathrin heavy chain binding  
    enables phosphatidylinositol-4,5-bisphosphate binding  
    Component Evidence Code Pubs
    is_active_in clathrin-coated pit  
    located_in clathrin-coated pit PubMed 
    is_active_in clathrin-coated vesicle  
    located_in clathrin-coated vesicle  
    is_active_in extrinsic component of presynaptic endocytic zone membrane  
    is_active_in synaptic vesicle  

    General protein information

    Preferred Names
    like-AP180
    Names
    CG2520-PA
    CG2520-PC
    CG2520-PD
    CG2520-PE
    CG2520-PF
    CG2520-PG
    CG2520-PH
    CG2520-PI
    CG2520-PJ
    EP3060
    Like-AP180
    complementation group 12
    lap-PA
    lap-PC
    lap-PD
    lap-PE
    lap-PF
    lap-PG
    lap-PH
    lap-PI
    lap-PJ
    like AP180
    saisoog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7186994..7200941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275410.1 → NP_001262339.1  like-AP180, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262339.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFE2, C1C3H4
      Conserved Domains (2) summary
      smart00818
      Location:682 → 761
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      pfam07651
      Location:21 → 298
      ANTH; ANTH domain
    2. NM_001170067.2 → NP_001163538.1  like-AP180, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163538.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C3H4, E1JJ78
      Conserved Domains (2) summary
      smart00818
      Location:694 → 773
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      pfam07651
      Location:21 → 298
      ANTH; ANTH domain
    3. NM_001144547.3 → NP_001138019.2  like-AP180, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138019.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0U7, C1C3H4
      Conserved Domains (1) summary
      pfam07651
      Location:21 → 298
      ANTH; ANTH domain
    4. NM_001260031.2 → NP_001246960.1  like-AP180, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246960.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6V2, C1C3H4
      Conserved Domains (2) summary
      smart00818
      Location:579 → 658
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      pfam07651
      Location:21 → 298
      ANTH; ANTH domain
    5. NM_079528.3 → NP_524252.2  like-AP180, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524252.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96528, Q8MQM1, Q9VI75
      Related
      FBpp0081091
      Conserved Domains (1) summary
      pfam07651
      Location:21 → 298
      ANTH; ANTH domain
    6. NM_001275409.1 → NP_001262338.1  like-AP180, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262338.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGC6, C1C3H4
      Conserved Domains (2) summary
      smart00818
      Location:610 → 689
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      pfam07651
      Location:21 → 287
      ANTH; ANTH domain
    7. NM_001275411.1 → NP_001262340.1  like-AP180, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262340.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF90, C1C3H4
      Conserved Domains (2) summary
      smart00818
      Location:584 → 663
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      pfam07651
      Location:21 → 287
      ANTH; ANTH domain
    8. NM_001260030.2 → NP_001246959.1  like-AP180, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246959.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K631, C1C3H4
      Conserved Domains (2) summary
      smart00818
      Location:591 → 670
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      pfam07651
      Location:21 → 298
      ANTH; ANTH domain
    9. NM_001260029.2 → NP_001246958.1  like-AP180, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246958.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K603
      Conserved Domains (1) summary
      pfam07651
      Location:21 → 298
      ANTH; ANTH domain
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