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nSyb neuronal Synaptobrevin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38196, updated on 9-Dec-2024

Summary

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Official Symbol
nSybprovided by FlyBase
Official Full Name
neuronal Synaptobrevinprovided by FlyBase
Primary source
FLYBASE:FBgn0013342
Locus tag
Dmel_CG17248
See related
AllianceGenome:FB:FBgn0013342
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17248; Dmel\CG17248; Dn-syb; n-syb; n-Syb; n-SYB; N-syb; N-Syb; N-SYB; nsyb; nSYB; Nsyb; NSYB; syb; Syb; SYB; Syb62A; VAMP
Summary
Enables SNAP receptor activity and SNARE binding activity. Involved in positive regulation of vesicle fusion; synaptic vesicle exocytosis; and vesicle fusion. Located in plasma membrane; synaptic vesicle; and terminal bouton. Part of SNARE complex. Is active in early endosome membrane and synaptic vesicle membrane. Colocalizes with presynaptic active zone. Is expressed in several structures, including abdominal 1 ventral longitudinal muscle cell; adult brain cell body rind; ganglia; neuron projection bundle; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome and spastic ataxia 1. Orthologous to several human genes including VAMP1 (vesicle associated membrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See nSyb in Genome Data Viewer
Location:
62A9-62A9; 3-0.5 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1630348..1637752, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1630348..1637752, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ATP binding cassette subfamily B member 7 Neighboring gene gamma-glutamyl carboxylase Neighboring gene uncharacterized protein Neighboring gene Methyltransferase like 2 Neighboring gene Big brother

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Somatotopic organization among parallel sensory pathways that promote a grooming sequence in Drosophila. Eichler K, et al. Elife, 2024 Apr 18. PMID 38634460, Free PMC Article
  2. Apolipoprotein E-mimetics inhibit neurodegeneration and restore cognitive functions in a transgenic Drosophila model of Alzheimer's disease. Sarantseva S, et al. PLoS One, 2009 Dec 7. PMID 19997607, Free PMC Article
  3. A genetic model of methionine restriction extends Drosophila health- and lifespan. Parkhitko AA, et al. Proc Natl Acad Sci U S A, 2021 Oct 5. PMID 34588310, Free PMC Article
  4. Effect of juxtamembrane tryptophans on the immersion depth of Synaptobrevin, an integral vesicle membrane protein. Al-Abdul-Wahid MS, et al. Biochim Biophys Acta, 2012 Dec. PMID 22846509
  5. A functionally ordered visual feature map in the Drosophila brain. Klapoetke NC, et al. Neuron, 2022 May 18. PMID 35290791

See all (349) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data indicate that juxtamembrane tryptophan residues are important determinants of the position of Synaptobrevin in the membrane
    Title: Effect of juxtamembrane tryptophans on the immersion depth of Synaptobrevin, an integral vesicle membrane protein.
  2. a role for n-Syb in a neuron-specific sort-and-degrade mechanism that protects neurons from degeneration.
    Title: The synaptic vesicle SNARE neuronal Synaptobrevin promotes endolysosomal degradation and prevents neurodegeneration.
  3. Expression of syb can restore synaptic transmission to n-syb mutants as assayed both by electroretinogram and recordings of excitatory junctional currents at the neuromuscular junction.
    Title: Members of the synaptobrevin/vesicle-associated membrane protein (VAMP) family in Drosophila are functionally interchangeable in vivo for neurotransmitter release and cell viability.
  4. Our study suggests a novel, cell type-specific function of n-Syb in synaptogenesis and it distinguishes between two synapse types: TNT resistant and TNT sensitive ones.
    Title: Distinct functions of neuronal synaptobrevin in developing and mature fly photoreceptors.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNAP receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables SNAP receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables SNAP receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables SNARE binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables SNARE binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in neurotransmitter secretion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of vesicle fusion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle docking ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in early endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
colocalizes_with presynaptic active zone IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in synaptic vesicle NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
neuronal synaptobrevin
Names
CG17248-PA
CG17248-PE
CG17248-PF
CG17248-PG
CG17248-PH
CG17248-PI
CG17248-PJ
CG17248-PK
N-synaptobrevin
Neuronal-synaptobrevin
Synaptobrevin-62A
VAMP3
nSyb-PA
nSyb-PE
nSyb-PF
nSyb-PG
nSyb-PH
nSyb-PI
nSyb-PJ
nSyb-PK
neural-synaptobrevin
neuronal synaptogrevin
synaptobrevin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1630348..1637752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259618.2 → NP_001246547.1  neuronal synaptobrevin, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246547.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IQJ1
    Conserved Domains (2) summary
    cd15870
    Location:49 → 111
    R-SNARE_VAMP2; SNARE motif of VAMP2
    pfam00957
    Location:48 → 129
    Synaptobrevin; Synaptobrevin

  2. NM_167905.4 → NP_728645.1  neuronal synaptobrevin, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728645.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W0C2
    Related
    FBpp0290116
    Conserved Domains (2) summary
    cd15870
    Location:49 → 111
    R-SNARE_VAMP2; SNARE motif of VAMP2
    pfam00957
    Location:48 → 129
    Synaptobrevin; Synaptobrevin

  3. NM_001274340.1 → NP_001261269.1  neuronal synaptobrevin, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261269.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PE71
    Conserved Domains (2) summary
    cd15870
    Location:40 → 102
    R-SNARE_VAMP2; SNARE motif of VAMP2
    pfam00957
    Location:39 → 120
    Synaptobrevin; Synaptobrevin

  4. NM_001274341.1 → NP_001261270.1  neuronal synaptobrevin, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261270.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IQJ1
    Conserved Domains (2) summary
    cd15870
    Location:40 → 102
    R-SNARE_VAMP2; SNARE motif of VAMP2
    pfam00957
    Location:39 → 120
    Synaptobrevin; Synaptobrevin

  5. NM_057710.6 → NP_477058.1  neuronal synaptobrevin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477058.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C6TP85, M9PDW0, M9PE71, Q86BQ0, Q9W0C1, Q9W0C2
    Related
    FBpp0072697
    Conserved Domains (2) summary
    cd15870
    Location:40 → 102
    R-SNARE_VAMP2; SNARE motif of VAMP2
    pfam00957
    Location:39 → 120
    Synaptobrevin; Synaptobrevin

  6. NM_206234.4 → NP_995956.1  neuronal synaptobrevin, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995956.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W0C2
    Conserved Domains (2) summary
    cd15870
    Location:49 → 111
    R-SNARE_VAMP2; SNARE motif of VAMP2
    pfam00957
    Location:48 → 129
    Synaptobrevin; Synaptobrevin

  7. NM_167906.3 → NP_728646.2  neuronal synaptobrevin, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728646.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IQJ1
    Conserved Domains (2) summary
    cd15870
    Location:49 → 111
    R-SNARE_VAMP2; SNARE motif of VAMP2
    pfam00957
    Location:48 → 129
    Synaptobrevin; Synaptobrevin

  8. NM_167904.3 → NP_728644.1  neuronal synaptobrevin, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728644.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C6TP85, M9PDW0, M9PE71, Q86BQ0, Q9W0C1, Q9W0C2
    Related
    FBpp0290115
    Conserved Domains (2) summary
    cd15870
    Location:40 → 102
    R-SNARE_VAMP2; SNARE motif of VAMP2
    pfam00957
    Location:39 → 120
    Synaptobrevin; Synaptobrevin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W0C1.1 Q9W0C1

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