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    Pex5 Peroxin 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31141, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Pex5provided by FlyBase
    Official Full Name
    Peroxin 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0023516
    Locus tag
    Dmel_CG14815
    See related
    AllianceGenome:FB:FBgn0023516
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14815; DmelPex5; Dmel\CG14815; EG:63B12.5; PEX5
    Summary
    Predicted to enable peroxisome matrix targeting signal-1 binding activity. Involved in protein import into peroxisome matrix and response to anesthetic. Located in cytosol and peroxisome. Is expressed in embryonic cortex and yolk. Used to study peroxisomal biogenesis disorder and peroxisome biogenesis disorder 2A. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 2A; peroxisome biogenesis disorder 2B; and rhizomelic chondrodysplasia punctata type 5. Orthologous to several human genes including PEX5 (peroxisomal biogenesis factor 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pex5 in Genome Data Viewer
    Location:
    2B13-2B13; 1-0.2 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1866832..1869061, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1760865..1763094, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Coat Protein (coatomer) delta Neighboring gene Germ cell nuclear acidic peptidase Neighboring gene Mediator complex subunit 18 Neighboring gene uncharacterized protein Neighboring gene Phosphoglycerate mutase 5 Neighboring gene Vacuolar protein sorting 26 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct Roles for Peroxisomal Targeting Signal Receptors Pex5 and Pex7 in Drosophila. Di Cara F, et al. Genetics, 2019 Jan. PMID 30389805, Free PMC Article
    2. Peroxisomal cholesterol metabolism regulates yap-signaling, which maintains intestinal epithelial barrier function and is altered in Crohn's disease. Pinelli M, et al. Cell Death Dis, 2024 Jul 28. PMID 39069546, Free PMC Article
    3. Dietary rescue of lipotoxicity-induced mitochondrial damage in Peroxin19 mutants. Sellin J, et al. PLoS Biol, 2018 Jun. PMID 29920513, Free PMC Article
    4. Dysfunctional peroxisomes compromise gut structure and host defense by increased cell death and Tor-dependent autophagy. Di Cara F, et al. Mol Biol Cell, 2018 Nov 1. PMID 30188767, Free PMC Article
    5. The role of Peroxin 7 during Drosophila embryonic development. Pridie C, et al. Genome, 2021 Feb. PMID 32191843

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peroxisome matrix targeting signal-1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in peroxisome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into peroxisome matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into peroxisome matrix, docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to anesthetic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peroxin 5
    Names
    CG14815-PA
    CG14815-PB
    Pex5-PA
    Pex5-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1866832..1869061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166910.2 → NP_726771.1  peroxin 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726771.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46085, Q8MSJ5
      Related
      FBpp0070351
      Conserved Domains (4) summary
      sd00006
      Location:454 → 482
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:460 → 487
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:453 → 519
      TPR_11; TPR repeat
      pfam13432
      Location:493 → 549
      TPR_16; Tetratricopeptide repeat

    2. NM_130593.4 → NP_569949.3  peroxin 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569949.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KW08
      Related
      FBpp0070352
      Conserved Domains (4) summary
      sd00006
      Location:399 → 427
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:405 → 432
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:398 → 464
      TPR_11; TPR repeat
      pfam13432
      Location:438 → 494
      TPR_16; Tetratricopeptide repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46085 O46085
    Q7KW08 Q7KW08

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