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    Hpr1 Hpr1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40723, updated on 27-Dec-2024

    Summary

    Official Symbol
    Hpr1provided by FlyBase
    Official Full Name
    Hpr1provided by FlyBase
    Primary source
    FLYBASE:FBgn0037382
    Locus tag
    Dmel_CG2031
    See related
    AllianceGenome:FB:FBgn0037382
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2031; Dmel\CG2031; HPR1; Thoc1; THOC1
    Summary
    Involved in mRNA export from nucleus in response to heat stress. Located in nucleus. Part of THO complex. Is expressed in organism. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 86. Orthologous to human THOC1 (THO complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Hpr1 in Genome Data Viewer
    Location:
    83C4-83C4; 3-47.5 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5818794..5821440, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1644516..1647162, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Secretory 20 Neighboring gene degringolade

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    part_of THO complex PubMed 
    part_of THO complex part of transcription export complex  
    located_in nucleus PubMed 
    part_of protein-containing complex PubMed 
    part_of transcription export complex  

    General protein information

    Preferred Names
    Hpr1
    Names
    CG2031-PA
    Hpr1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5818794..5821440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141337.2 → NP_649594.1  Hpr1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649594.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNI8
      Related
      FBpp0078316
      Conserved Domains (2) summary
      pfam00531
      Location:606 → 687
      Death; Death domain
      pfam11957
      Location:79 → 538
      efThoc1; THO complex subunit 1 transcription elongation factor
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