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thoc6 thoc6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39394, updated on 9-Dec-2024

Summary

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Official Symbol
thoc6provided by FlyBase
Official Full Name
thoc6provided by FlyBase
Primary source
FLYBASE:FBgn0036263
Locus tag
Dmel_CG5632
See related
AllianceGenome:FB:FBgn0036263
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5632; Dmel\CG5632; Thoc6; THOC6
Summary
Predicted to be involved in mRNA export from nucleus. Part of THO complex. Orthologous to human THOC6 (THO complex subunit 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See thoc6 in Genome Data Viewer
Location:
69A1-69A1; 3-38 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12190696..12193688, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12185132..12186788, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Carbonic anhydrase 2 Neighboring gene Myo-inositol oxygenase Neighboring gene Esterase 6 Neighboring gene Esterase P Neighboring gene long non-coding RNA:CR45746 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. p53 and PI3K/AKT signalings are up-regulated in flies with defects in the THO complex. Moon S, et al. Mol Cells, 2013 Mar. PMID 23475424, Free PMC Article
  2. Co-dependent Assembly of Drosophila piRNA Precursor Complexes and piRNA Cluster Heterochromatin. Zhang G, et al. Cell Rep, 2018 Sep 25. PMID 30257203, Free PMC Article
  3. ENY2 protein forms a part of the THO complex of Drosophila melanogaster. Gurskiy DY, et al. Dokl Biochem Biophys, 2010 Jul-Aug. PMID 20714859
  4. Birth and death of genes and functions in the beta-esterase cluster of Drosophila. Robin C, et al. J Mol Evol, 2009 Jul. PMID 19536450, Free PMC Article
  5. Multifunctional factor ENY2 is associated with the THO complex and promotes its recruitment onto nascent mRNA. Kopytova DV, et al. Genes Dev, 2010 Jan 1. PMID 20048002, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA export from nucleus in response to heat stress IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
part_of THO complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of THO complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription export complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
thoc6
Names
CG5632-PA
CG5632-PB
CG5632-PC
thoc6-PA
thoc6-PB
thoc6-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12190696..12193688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316441.1 → NP_001303370.1  thoc6, isoform C [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q705B9, Q9VTV1
    UniProtKB/TrEMBL
    M9PEZ4
    Conserved Domains (3) summary
    COG2319
    Location:45 → 325
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:159 → 194
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:115 → 265
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_140300.4 → NP_648557.1  thoc6, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648557.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q705B9, Q9VTV1
    UniProtKB/TrEMBL
    M9PEZ4
    Related
    FBpp0075751
    Conserved Domains (3) summary
    COG2319
    Location:45 → 325
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:159 → 194
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:115 → 265
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_001274821.1 → NP_001261750.1  thoc6, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261750.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q705B9, Q9VTV1
    UniProtKB/TrEMBL
    M9PEZ4
    Conserved Domains (3) summary
    COG2319
    Location:45 → 325
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:159 → 194
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:115 → 265
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PEZ4 M9PEZ4
Q9VTV1.1 Q9VTV1

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