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Conserved domains on  [gi|24644436|ref|NP_649594|]
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Hpr1 [Drosophila melanogaster]

Protein Classification

efThoc1 and Death domain-containing protein( domain architecture ID 11191474)

efThoc1 and Death domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
efThoc1 pfam11957
THO complex subunit 1 transcription elongation factor; The THO complex plays a role in ...
81-538 2.43e-153

THO complex subunit 1 transcription elongation factor; The THO complex plays a role in coupling transcription elongation to mRNA export. It is composed of subunits THP2, HPR1, THO2 and MFT1. The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm.


:

Pssm-ID: 463412  Cd Length: 464  Bit Score: 452.61  E-value: 2.43e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644436    81 ELVRLSVEATRAEIVSNTIPVVLLIDTFDVVTLDKCQKIFQFVEDMVEVWKEEIF-FSSCKNNILRMCNDLLRRLSRTQN 159
Cdd:pfam11957   1 VLLDFCFHLSDDPLCWPTLPFVLLEDVLDSLTPDGCLKFWPYVESRIEWFKMKGFsYKQPLSVLLRTCNELLRRLSRPED 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644436   160 TVFCGRIQLFLSKFFPFSERSGLNIVSEFNLDNFTEYGLDSkdhdesdnkelEDTAEDIPLKIDYDLYCKFWSLQDFFRN 239
Cdd:pfam11957  81 TVFCGKILLFLSQLFPLSERSNLNLRGEFSTENVTEFEEEE-----------EEKDEDTKKPIDYNLYPTFWSLQKFFSN 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644436   240 PNQCYNKPQWKMFQMHADNILQSFSSFKLEDVRQSSNENASGTDQAMDVDEEAvDTTAVSSVIKANHFFAKFLTNPKLLA 319
Cdd:pfam11957 150 PLSLYFSPKFKSFEKYLESVLDAFLELEEEFYRRSPIKKKTKKKRAIKEKLND-NYQESWKNFLENLFNPKYLTSPKLLD 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644436   320 LQLSDANFRRAVLVQFLILFQYLQ-----VSVKFKSDTQTLTADQADFIKETESRVYKLLEE-TPPYGKRFSRTVYHMLA 393
Cdd:pfam11957 229 LQLSDPNFRKQVLLQFLILFQFLLsltykTKVKKKSETSVLSDEDAKWIKSTCKKVYERLKEfYPPRGPQFYRMVNHLLS 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644436   394 REEMWNNWKNEGCKEFKKPEEPT--LSEEDSKPTPNKRPRRPlgdalrdasrsGKFYLGNDNLTRLWNYSPDNLQACKSE 471
Cdd:pfam11957 309 SEENWLKWKNEGCPEFEKPPVSEdeLSEAPEKDKSFKKKRLF-----------GFIKMGNKALNRLWKICETGLDDLKKE 377
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644436   472 QRNFLPLLETYLETPH-EKVDPA--------------FEWRALRLLARQTPHFFTSL--SQPSSKISDYLEQVRKRLIRD 534
Cdd:pfam11957 378 ERNPLPSLESYLEEIKlDEKDPEaaveeeykiddkivKQWRALRLLRRQYLFFFDKVdeTTGLKGLFDYSEDSESKEEKE 457

                  ....
gi 24644436   535 KEPK 538
Cdd:pfam11957 458 KLDE 461
Death pfam00531
Death domain;
606-687 3.21e-14

Death domain;


:

Pssm-ID: 459845 [Multi-domain]  Cd Length: 86  Bit Score: 68.55  E-value: 3.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644436   606 KEHIEEVA---PLIGEPWMKVGKKIGFTNDELLFFQMEHPTANVACVKMLTNWISDD-DDATLENWAYMLEGLEMNKAAE 681
Cdd:pfam00531   1 RKQLDRLLdppPPLGKDWRELARKLGLSENEIDEIESENPRLRSQTYELLRLWEQREgKNATVGTLLEALRKLGRRDAAE 80

                  ....*.
gi 24644436   682 AVKAII 687
Cdd:pfam00531  81 KIQSIL 86
 
Name Accession Description Interval E-value
efThoc1 pfam11957
THO complex subunit 1 transcription elongation factor; The THO complex plays a role in ...
81-538 2.43e-153

THO complex subunit 1 transcription elongation factor; The THO complex plays a role in coupling transcription elongation to mRNA export. It is composed of subunits THP2, HPR1, THO2 and MFT1. The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm.


Pssm-ID: 463412  Cd Length: 464  Bit Score: 452.61  E-value: 2.43e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644436    81 ELVRLSVEATRAEIVSNTIPVVLLIDTFDVVTLDKCQKIFQFVEDMVEVWKEEIF-FSSCKNNILRMCNDLLRRLSRTQN 159
Cdd:pfam11957   1 VLLDFCFHLSDDPLCWPTLPFVLLEDVLDSLTPDGCLKFWPYVESRIEWFKMKGFsYKQPLSVLLRTCNELLRRLSRPED 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644436   160 TVFCGRIQLFLSKFFPFSERSGLNIVSEFNLDNFTEYGLDSkdhdesdnkelEDTAEDIPLKIDYDLYCKFWSLQDFFRN 239
Cdd:pfam11957  81 TVFCGKILLFLSQLFPLSERSNLNLRGEFSTENVTEFEEEE-----------EEKDEDTKKPIDYNLYPTFWSLQKFFSN 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644436   240 PNQCYNKPQWKMFQMHADNILQSFSSFKLEDVRQSSNENASGTDQAMDVDEEAvDTTAVSSVIKANHFFAKFLTNPKLLA 319
Cdd:pfam11957 150 PLSLYFSPKFKSFEKYLESVLDAFLELEEEFYRRSPIKKKTKKKRAIKEKLND-NYQESWKNFLENLFNPKYLTSPKLLD 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644436   320 LQLSDANFRRAVLVQFLILFQYLQ-----VSVKFKSDTQTLTADQADFIKETESRVYKLLEE-TPPYGKRFSRTVYHMLA 393
Cdd:pfam11957 229 LQLSDPNFRKQVLLQFLILFQFLLsltykTKVKKKSETSVLSDEDAKWIKSTCKKVYERLKEfYPPRGPQFYRMVNHLLS 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644436   394 REEMWNNWKNEGCKEFKKPEEPT--LSEEDSKPTPNKRPRRPlgdalrdasrsGKFYLGNDNLTRLWNYSPDNLQACKSE 471
Cdd:pfam11957 309 SEENWLKWKNEGCPEFEKPPVSEdeLSEAPEKDKSFKKKRLF-----------GFIKMGNKALNRLWKICETGLDDLKKE 377
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644436   472 QRNFLPLLETYLETPH-EKVDPA--------------FEWRALRLLARQTPHFFTSL--SQPSSKISDYLEQVRKRLIRD 534
Cdd:pfam11957 378 ERNPLPSLESYLEEIKlDEKDPEaaveeeykiddkivKQWRALRLLRRQYLFFFDKVdeTTGLKGLFDYSEDSESKEEKE 457

                  ....
gi 24644436   535 KEPK 538
Cdd:pfam11957 458 KLDE 461
Death pfam00531
Death domain;
606-687 3.21e-14

Death domain;


Pssm-ID: 459845 [Multi-domain]  Cd Length: 86  Bit Score: 68.55  E-value: 3.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644436   606 KEHIEEVA---PLIGEPWMKVGKKIGFTNDELLFFQMEHPTANVACVKMLTNWISDD-DDATLENWAYMLEGLEMNKAAE 681
Cdd:pfam00531   1 RKQLDRLLdppPPLGKDWRELARKLGLSENEIDEIESENPRLRSQTYELLRLWEQREgKNATVGTLLEALRKLGRRDAAE 80

                  ....*.
gi 24644436   682 AVKAII 687
Cdd:pfam00531  81 KIQSIL 86
Death cd01670
Death Domain: a protein-protein interaction domain; Death Domains (DDs) are protein-protein ...
608-684 2.63e-07

Death Domain: a protein-protein interaction domain; Death Domains (DDs) are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN. Structural analysis of DD-DD complexes show that the domains interact with each other in many different ways. DD-containing proteins serve as adaptors in signaling pathways and they can recruit other proteins into signaling complexes. In mammals, they are prominent components of the programmed cell death (apoptosis) pathway and are found in a number of other signaling pathways. In invertebrates, they are involved in transcriptional regulation of zygotic patterning genes in insect embryogenesis, and are components of the ToII/NF-kappaB pathway, a conserved innate immune pathway in animal cells.


Pssm-ID: 260017 [Multi-domain]  Cd Length: 79  Bit Score: 48.43  E-value: 2.63e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24644436 608 HIEEVAPLIGEPWMKVGKKIGFTNDELLFFQMEHPTANV-ACVKMLTNWIS-DDDDATLENWAYMLEGLEMNKAAEAVK 684
Cdd:cd01670   1 YFDLVAEELGRDWKKLARKLGLSEGDIDQIEEDNRDDLKeQAYQMLERWRErEGDEATLGRLIQALREIGRRDLAEKLE 79
 
Name Accession Description Interval E-value
efThoc1 pfam11957
THO complex subunit 1 transcription elongation factor; The THO complex plays a role in ...
81-538 2.43e-153

THO complex subunit 1 transcription elongation factor; The THO complex plays a role in coupling transcription elongation to mRNA export. It is composed of subunits THP2, HPR1, THO2 and MFT1. The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm.


Pssm-ID: 463412  Cd Length: 464  Bit Score: 452.61  E-value: 2.43e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644436    81 ELVRLSVEATRAEIVSNTIPVVLLIDTFDVVTLDKCQKIFQFVEDMVEVWKEEIF-FSSCKNNILRMCNDLLRRLSRTQN 159
Cdd:pfam11957   1 VLLDFCFHLSDDPLCWPTLPFVLLEDVLDSLTPDGCLKFWPYVESRIEWFKMKGFsYKQPLSVLLRTCNELLRRLSRPED 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644436   160 TVFCGRIQLFLSKFFPFSERSGLNIVSEFNLDNFTEYGLDSkdhdesdnkelEDTAEDIPLKIDYDLYCKFWSLQDFFRN 239
Cdd:pfam11957  81 TVFCGKILLFLSQLFPLSERSNLNLRGEFSTENVTEFEEEE-----------EEKDEDTKKPIDYNLYPTFWSLQKFFSN 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644436   240 PNQCYNKPQWKMFQMHADNILQSFSSFKLEDVRQSSNENASGTDQAMDVDEEAvDTTAVSSVIKANHFFAKFLTNPKLLA 319
Cdd:pfam11957 150 PLSLYFSPKFKSFEKYLESVLDAFLELEEEFYRRSPIKKKTKKKRAIKEKLND-NYQESWKNFLENLFNPKYLTSPKLLD 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644436   320 LQLSDANFRRAVLVQFLILFQYLQ-----VSVKFKSDTQTLTADQADFIKETESRVYKLLEE-TPPYGKRFSRTVYHMLA 393
Cdd:pfam11957 229 LQLSDPNFRKQVLLQFLILFQFLLsltykTKVKKKSETSVLSDEDAKWIKSTCKKVYERLKEfYPPRGPQFYRMVNHLLS 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644436   394 REEMWNNWKNEGCKEFKKPEEPT--LSEEDSKPTPNKRPRRPlgdalrdasrsGKFYLGNDNLTRLWNYSPDNLQACKSE 471
Cdd:pfam11957 309 SEENWLKWKNEGCPEFEKPPVSEdeLSEAPEKDKSFKKKRLF-----------GFIKMGNKALNRLWKICETGLDDLKKE 377
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644436   472 QRNFLPLLETYLETPH-EKVDPA--------------FEWRALRLLARQTPHFFTSL--SQPSSKISDYLEQVRKRLIRD 534
Cdd:pfam11957 378 ERNPLPSLESYLEEIKlDEKDPEaaveeeykiddkivKQWRALRLLRRQYLFFFDKVdeTTGLKGLFDYSEDSESKEEKE 457

                  ....
gi 24644436   535 KEPK 538
Cdd:pfam11957 458 KLDE 461
Death pfam00531
Death domain;
606-687 3.21e-14

Death domain;


Pssm-ID: 459845 [Multi-domain]  Cd Length: 86  Bit Score: 68.55  E-value: 3.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644436   606 KEHIEEVA---PLIGEPWMKVGKKIGFTNDELLFFQMEHPTANVACVKMLTNWISDD-DDATLENWAYMLEGLEMNKAAE 681
Cdd:pfam00531   1 RKQLDRLLdppPPLGKDWRELARKLGLSENEIDEIESENPRLRSQTYELLRLWEQREgKNATVGTLLEALRKLGRRDAAE 80

                  ....*.
gi 24644436   682 AVKAII 687
Cdd:pfam00531  81 KIQSIL 86
Death cd01670
Death Domain: a protein-protein interaction domain; Death Domains (DDs) are protein-protein ...
608-684 2.63e-07

Death Domain: a protein-protein interaction domain; Death Domains (DDs) are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN. Structural analysis of DD-DD complexes show that the domains interact with each other in many different ways. DD-containing proteins serve as adaptors in signaling pathways and they can recruit other proteins into signaling complexes. In mammals, they are prominent components of the programmed cell death (apoptosis) pathway and are found in a number of other signaling pathways. In invertebrates, they are involved in transcriptional regulation of zygotic patterning genes in insect embryogenesis, and are components of the ToII/NF-kappaB pathway, a conserved innate immune pathway in animal cells.


Pssm-ID: 260017 [Multi-domain]  Cd Length: 79  Bit Score: 48.43  E-value: 2.63e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24644436 608 HIEEVAPLIGEPWMKVGKKIGFTNDELLFFQMEHPTANV-ACVKMLTNWIS-DDDDATLENWAYMLEGLEMNKAAEAVK 684
Cdd:cd01670   1 YFDLVAEELGRDWKKLARKLGLSEGDIDQIEEDNRDDLKeQAYQMLERWRErEGDEATLGRLIQALREIGRRDLAEKLE 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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