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    mud mushroom body defect [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44839, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mudprovided by FlyBase
    Official Full Name
    mushroom body defectprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002873
    Locus tag
    Dmel_CG12047
    See related
    AllianceGenome:FB:FBgn0002873
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12047; Dmel\CG12047; KS63; Mud; NuMa; NuMA
    Summary
    Enables DNA binding activity. Involved in microtubule cytoskeleton organization; nervous system development; and thermosensory behavior. Located in several cellular components, including basal cortex; microtubule cytoskeleton; and tricellular tight junction. Is expressed in adult head and spermatozoon. Orthologous to human EEA1 (early endosome antigen 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mud in Genome Data Viewer
    Location:
    12E5-12E6; 1-48 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14247732..14258595)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14141765..14152628)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene mRNA-capping-enzyme Neighboring gene antisense RNA:CR46473 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Tyrosine aminotransferase Neighboring gene uncharacterized protein Neighboring gene narrow abdomen

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oriented Cell Divisions Are Not Required for Drosophila Wing Shape. Zhou Z, et al. Curr Biol, 2019 Mar 4. PMID 30799243, Free PMC Article
    2. Presynaptic developmental plasticity allows robust sparse wiring of the Drosophila mushroom body. Elkahlah NA, et al. Elife, 2020 Jan 8. PMID 31913123, Free PMC Article
    3. Normal function of the mushroom body defect gene of Drosophila is required for the regulation of the number and proliferation of neuroblasts. Prokop A, et al. Dev Biol, 1994 Feb. PMID 8313986
    4. Mud binds the kinesin-14 Ncd in Drosophila. Cutillas V, et al. Biochem Biophys Rep, 2021 Jul. PMID 34027137, Free PMC Article
    5. Neural reorganization during metamorphosis of the corpora pedunculata in Drosophila melanogaster. Technau G, et al. Nature, 1982 Feb 4. PMID 6799834

    See all (154) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynein, Mud and Asp operate sequentially during the cell cycle to ensure efficient centrosome-spindle coupling in mitosis, thereby preventing centrosome mis-segregation to maintain centrosome number.
      Title: Sequential activities of Dynein, Mud and Asp in centrosome-spindle coupling maintain centrosome number upon mitosis.
    2. mutation of mushroom body defect (mud) dramatically enhances the phenotype of Netrin or frazzled mutants, resulting in many more axons failing to cross the midline, although mutations in mud alone have little effect.
      Title: Mushroom body defect is required in parallel to Netrin for midline axon guidance in Drosophila.
    3. Data indicate that mushroom body defect protein (Mud) co-localized with centromeres, Klarsicht protein and Klaroid protein.
      Title: Microtubule-driven nuclear rotations promote meiotic chromosome dynamics.
    4. Mud, a microtubule binding protein regulating spindle orientation, is involved in binucleation of Drosophila male accessory gland cells.
      Title: Isoform-specific functions of Mud/NuMA mediate binucleation of Drosophila male accessory gland cells.
    5. Insc-Pins complex requires Galphai for partial activity and that the complex specifically recruits Dlg but not Mud.
      Title: Inscuteable regulates the Pins-Mud spindle orientation pathway.
    6. Inscuteable and NuMA [Mud] proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions.
      Title: Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions.
    7. Canoe binds RanGTP to promote Pins(TPR)/Mud-mediated spindle orientation.
      Title: Canoe binds RanGTP to promote Pins(TPR)/Mud-mediated spindle orientation.
    8. Mud depletion caused chromosome misalignment defects that resembled the defects of Rab5 RNAi cells, and double-knockdown experiments indicated that the two proteins function in a linear pathway.
      Title: Rab5 GTPase controls chromosome alignment through Lamin disassembly and relocation of the NuMA-like protein Mud to the poles during mitosis.
    9. these findings reveal that the centrosomal proteins Ana2 and Ctp regulate Mud function to orient the mitotic spindle during neuroblasts asymmetric division.
      Title: An ana2/ctp/mud complex regulates spindle orientation in Drosophila neuroblasts.
    10. Results describe a Frizzled-Dishevelled-NuMA/Mud pathway that orients division from Drosophila to vertebrates.
      Title: The Fz-Dsh planar cell polarity pathway induces oriented cell division via Mud/NuMA in Drosophila and zebrafish.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in asymmetric neuroblast division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle orientation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule anchoring at centrosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mushroom body development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mushroom body development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in spindle assembly involved in female meiosis II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in thermosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basal cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in tricellular tight junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mushroom body defect
    Names
    CG12047-PF
    CG12047-PG
    CG12047-PH
    CG12047-PI
    CG12047-PJ
    CG12047-PK
    CG12047-PL
    mud-PF
    mud-PG
    mud-PH
    mud-PI
    mud-PJ
    mud-PK
    mud-PL
    mushroom bodies deranged
    mushroom body defective

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      14247732..14258595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258736.2 → NP_001245665.1  mushroom body defect, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245665.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NGE4, Q9NCL3
      Conserved Domains (3) summary
      pfam05483
      Location:853 → 1571
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      TIGR02168
      Location:1232 → 1958
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl01972
      Location:1392 → 1517
      DUF948; Bacterial protein of unknown function (DUF948)

    2. NM_167399.6 → NP_727769.3  mushroom body defect, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727769.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IR55, Q9NCW7
      Conserved Domains (4) summary
      pfam05483
      Location:853 → 1571
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      COG1196
      Location:1234 → 1944
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:319 → 1178
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl01972
      Location:1392 → 1517
      DUF948; Bacterial protein of unknown function (DUF948)

    3. NM_001258737.2 → NP_001245666.1  mushroom body defect, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245666.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NEG4, Q9NCW7
      Conserved Domains (3) summary
      pfam05483
      Location:853 → 1571
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      TIGR02168
      Location:1232 → 1958
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl01972
      Location:1392 → 1517
      DUF948; Bacterial protein of unknown function (DUF948)

    4. NM_167400.5 → NP_727770.2  mushroom body defect, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727770.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NCW7, Q9VY43
      Conserved Domains (3) summary
      pfam05483
      Location:853 → 1571
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      TIGR02168
      Location:319 → 1178
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl01972
      Location:1392 → 1517
      DUF948; Bacterial protein of unknown function (DUF948)

    5. NM_001272616.1 → NP_001259545.1  mushroom body defect, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259545.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEK6, Q9NCW7
      Conserved Domains (2) summary
      pfam05483
      Location:853 → 1622
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      COG1196
      Location:223 → 1196
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    6. NM_080495.6 → NP_536743.3  mushroom body defect, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_536743.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IR54, Q9NCL3
      Conserved Domains (2) summary
      pfam05483
      Location:853 → 1571
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      cl01972
      Location:1392 → 1517
      DUF948; Bacterial protein of unknown function (DUF948)

    7. NM_001272615.2 → NP_001259544.1  mushroom body defect, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259544.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PJN0, Q9NCL3
      Conserved Domains (1) summary
      pfam05483
      Location:853 → 1551
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NEG4 M9NEG4
    M9NGE4 M9NGE4
    M9PEK6 M9PEK6
    M9PJN0 M9PJN0
    Q1KN24 Q1KN24
    Q8IR54 Q8IR54
    Q8IR55 Q8IR55
    Q95TR6 Q95TR6
    Q9NCL3 Q9NCL3
    Q9NCW7 Q9NCW7
    Q9VY43 Q9VY43

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