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    ple pale [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38746, updated on 17-Dec-2024

    Summary

    Official Symbol
    pleprovided by FlyBase
    Official Full Name
    paleprovided by FlyBase
    Primary source
    FLYBASE:FBgn0005626
    Locus tag
    Dmel_CG10118
    See related
    AllianceGenome:FB:FBgn0005626
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10118; DH65B; Dmel\CG10118; DTH; dTH1; dTH65B; Pale; pale/ple; Ple; th; Th; TH; TyrH; VII
    Summary
    Predicted to enable tyrosine 3-monooxygenase activity. Involved in several processes, including adult chitin-containing cuticle pigmentation; regulation of epithelial cell migration, open tracheal system; and thermosensory behavior. Predicted to be active in axon; cytoplasm; and perikaryon. Is expressed in several structures, including aminergic neurons; gut section; neuroblast lineage clone; synaptic neuropil domain; and synaptic neuropil subdomain. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; heroin dependence; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See ple in Genome Data Viewer
    Location:
    65C3-65C3; 3-17 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6713356..6719525, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6706456..6712625, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene SP1173 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44523 Neighboring gene long non-coding RNA:CR45417

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables iron ion binding  
    enables tyrosine 3-monooxygenase activity  
    enables tyrosine 3-monooxygenase activity  
    enables tyrosine 3-monooxygenase activity PubMed 
    enables tyrosine 3-monooxygenase activity PubMed 
    Process Evidence Code Pubs
    involved_in adult chitin-containing cuticle pigmentation PubMed 
    involved_in adult locomotory behavior PubMed 
    involved_in aromatic amino acid metabolic process  
    involved_in catecholamine biosynthetic process  
    involved_in catecholamine metabolic process PubMed 
    involved_in courtship behavior PubMed 
    involved_in cuticle pigmentation PubMed 
    involved_in developmental pigmentation PubMed 
    involved_in dopamine biosynthetic process PubMed 
    involved_in dopamine biosynthetic process PubMed 
    involved_in dopamine biosynthetic process from tyrosine  
    involved_in dopamine metabolic process PubMed 
    involved_in male courtship behavior PubMed 
    involved_in regulation of adult chitin-containing cuticle pigmentation PubMed 
    involved_in regulation of adult chitin-containing cuticle pigmentation PubMed 
    involved_in regulation of epithelial cell migration, open tracheal system PubMed 
    involved_in response to hydrogen peroxide PubMed 
    involved_in response to wounding PubMed 
    involved_in thermosensory behavior PubMed 
    involved_in thermotaxis PubMed 
    involved_in wing disc development PubMed 
    Component Evidence Code Pubs
    is_active_in axon  
    is_active_in cytoplasm  
    is_active_in perikaryon  

    General protein information

    Preferred Names
    pale
    Names
    CG10118-PA
    CG10118-PB
    CG10118-PC
    Tyrosine-3-hydroxylase
    XBB70 group VII
    drosophila tyrosine hydroxylase
    ple-PA
    ple-PB
    ple-PC
    tyrosine 3-monooxygenase
    tyrosine hydrodroxylase
    tyrosine hydroxylase
    tyrosine-hydroxylase
    tyrosone hydroxylase
    NP_001286955.1
    NP_476897.1
    NP_476898.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6713356..6719525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300026.1 → NP_001286955.1  pale, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286955.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18459, Q24000, Q8SY95
      UniProtKB/TrEMBL
      B5X0J4
      Conserved Domains (1) summary
      TIGR01269
      Location:130 → 576
      Tyr_3_monoox; tyrosine 3-monooxygenase, tetrameric
    2. NM_057549.3 → NP_476897.1  pale, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476897.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18459
      Related
      FBpp0076665
      Conserved Domains (3) summary
      TIGR01269
      Location:48 → 505
      Tyr_3_monoox; tyrosine 3-monooxygenase, tetrameric
      cd04930
      Location:48 → 163
      ACT_TH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tyrosine hydroxylases (TH)
      pfam00351
      Location:172 → 502
      Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
    3. NM_057550.4 → NP_476898.1  pale, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476898.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18459, Q24000, Q8SY95
      UniProtKB/TrEMBL
      B5X0J4
      Related
      FBpp0076666
      Conserved Domains (1) summary
      TIGR01269
      Location:130 → 576
      Tyr_3_monoox; tyrosine 3-monooxygenase, tetrameric
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