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Nup107 Nucleoporin 107kD [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34481, updated on 9-Dec-2024

Summary

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Official Symbol
Nup107provided by FlyBase
Official Full Name
Nucleoporin 107kDprovided by FlyBase
Primary source
FLYBASE:FBgn0027868
Locus tag
Dmel_CG6743
See related
AllianceGenome:FB:FBgn0027868
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD18761; CG6743; Dmel\CG6743; dmNup107; Nup; Nup 107; nup107; Nup170
Summary
Enables chromatin binding activity. Involved in several processes, including meiotic cytokinesis; protein import into nucleus; and spermatocyte division. Located in nuclear envelope and nuclear periphery. Part of nuclear pore. Is expressed in several structures, including Malpighian tubule primordium; adult head; central brain primordium; embryonic/larval midgut primordium; and gut section. Used to study 46 XX gonadal dysgenesis and ovarian dysgenesis 6. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome; nephrotic syndrome type 11; and ovarian dysgenesis 6. Orthologous to human NUP107 (nucleoporin 107). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Nup107 in Genome Data Viewer
Location:
32A5-32A5; 2-43 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10733293..10736071, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10733293..10736071, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ER membrane protein complex subunit 3 Neighboring gene Dpy-30-like 1 Neighboring gene Vacuolar H[+] ATPase 16kD subunit 5 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Postmitotic annulate lamellae assembly contributes to nuclear envelope reconstitution in daughter cells. Ren H, et al. J Biol Chem, 2019 Jul 5. PMID 31152066, Free PMC Article
  2. Efficient In Vivo Introduction of Point Mutations Using ssODN and a Co-CRISPR Approach. Levi T, et al. Biol Proced Online, 2020. PMID 32684853, Free PMC Article
  3. Nup153 is not required for anchoring heterochromatic DSBs to the nuclear periphery. Ryu T, et al. MicroPubl Biol, 2024. PMID 38737725, Free PMC Article
  4. Live imaging of bicoid-dependent transcription in Drosophila embryos. Lucas T, et al. Curr Biol, 2013 Nov 4. PMID 24139736
  5. A mutation in the nucleoporin-107 gene causes XX gonadal dysgenesis. Weinberg-Shukron A, et al. J Clin Invest, 2015 Nov 2. PMID 26485283, Free PMC Article

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of nuclear pore ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in eggshell formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in male meiosis cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiosis I cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of nucleocytoplasmic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatocyte division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore outer ring IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore outer ring ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
nucleoporin 107kD
Names
CG6743-PA
Nup107-PA
Nup170
nucleoporin 107

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10733293..10736071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135602.4 → NP_609446.1  nucleoporin 107kD [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609446.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V466
    UniProtKB/TrEMBL
    A1YK61
    Related
    FBpp0079710
    Conserved Domains (1) summary
    pfam04121
    Location:121 → 828
    Nup84_Nup100; Nuclear pore protein 84 / 107
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1YK54 A1YK54
A1YK55 A1YK55
A1YK56 A1YK56
A1YK57 A1YK57
A1YK58 A1YK58
A1YK59 A1YK59
A1YK60 A1YK60
A1YK61 A1YK61
A1YK62 A1YK62
A1YK63 A1YK63
A1YK65 A1YK65
Q9V466.1 Q9V466

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