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mei-S332 meiotic from via Salaria 332 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37523, updated on 4-Jan-2025

Summary

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Official Symbol
mei-S332provided by FlyBase
Official Full Name
meiotic from via Salaria 332provided by FlyBase
Primary source
FLYBASE:FBgn0002715
Locus tag
Dmel_CG5303
See related
AllianceGenome:FB:FBgn0002715
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:LD13774; CG5303; Dmel\CG5303; mei-S322; MEI-S322; mei-s332; Mei-S332; MEI-S332; Mei-S332/Shugoshin; meiS322; meiS332; MeiS332
Summary
Involved in male meiosis sister chromatid cohesion and meiotic nuclear division. Located in condensed chromosome, centromeric region and pericentric heterochromatin. Is expressed in several structures, including embryonic brain; gonad; larval nervous system; pole plasm; and ventral nerve cord. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See mei-S332 in Genome Data Viewer
Location:
58B9-58B10; 2-98 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22122101..22124566)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18009606..18012071)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Verprolin 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Golgi matrix protein 130 kD Neighboring gene NtR Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The influence of chromosome content on the size and shape of sperm heads in Drosophila melanogaster and the demonstration of chromosome loss during spermiogenesis. Hardy RW. Genetics, 1975 Feb. PMID 805747, Free PMC Article
  2. Meiosis: Rec8 is the reason for cohesion. Stoop-Myer C, et al. Nat Cell Biol, 1999 Sep. PMID 10559953
  3. Maintenance of sister-chromatid cohesion at the centromere by the Drosophila MEI-S332 protein. Tang TT, et al. Genes Dev, 1998 Dec 15. PMID 9869638, Free PMC Article
  4. The cohesion protein MEI-S332 localizes to condensed meiotic and mitotic centromeres until sister chromatids separate. Moore DP, et al. J Cell Biol, 1998 Mar 9. PMID 9490715, Free PMC Article
  5. The mitotic centromeric protein MEI-S332 and its role in sister-chromatid cohesion. LeBlanc HN, et al. Chromosoma, 1999 Dec. PMID 10654079

See all (121) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Wdb and Wrd contribute to MEI-S332's ability to ensure accurate segregation of sister chromatids but in centromere localization, they do not act solely downstream of MEI-S332.
    Title: Drosophila protein phosphatases 2A B' Wdb and Wrd regulate meiotic centromere localization and function of the MEI-S332 Shugoshin.
  2. INCENP binds to the cohesion protector protein MEI-S332, which is also an excellent in vitro substrate for Aurora B kinase.
    Title: INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in female meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male meiosis sister chromatid cohesion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sister chromatid cohesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in pericentric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
meiotic from via salaria 332
Names
CG5303-PA
CG5303-PB
Mei-S332
MeiS332
mei-S332-PA
mei-S332-PB
meiotic from salaria 332
shugoshin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    22122101..22124566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057286.5 → NP_476634.1  meiotic from via salaria 332, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476634.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24141
    UniProtKB/TrEMBL
    A0A0B4LG47
    Related
    FBpp0071675
    Conserved Domains (2) summary
    pfam07558
    Location:5 → 49
    Shugoshin_N; Shugoshin N-terminal coiled-coil region
    pfam13874
    Location:15 → 102
    Nup54; Nucleoporin complex subunit 54

  2. NM_001299776.1 → NP_001286705.1  meiotic from via salaria 332, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286705.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24141
    UniProtKB/TrEMBL
    A0A0B4LG47
    Conserved Domains (2) summary
    pfam07558
    Location:5 → 49
    Shugoshin_N; Shugoshin N-terminal coiled-coil region
    pfam13874
    Location:15 → 102
    Nup54; Nucleoporin complex subunit 54
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LG47 A0A0B4LG47
Q24141.1 Q24141

Gene LinkOut

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