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    Slik Sterile20-like kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37893, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slikprovided by FlyBase
    Official Full Name
    Sterile20-like kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035001
    Locus tag
    Dmel_CG4527
    See related
    AllianceGenome:FB:FBgn0035001
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4527; Dmel\CG4527; dPlkk; dPlkk/Slik; DPlkk1; Plkk/Slik; Plkk1; PLKK1; slik; SLIK; Slik1; slk; Slk; SLK
    Summary
    Enables protein serine/threonine kinase activity. Involved in several processes, including cytoskeleton organization; metaphase/anaphase transition of mitotic cell cycle; and rhabdomere membrane biogenesis. Located in several cellular components, including cleavage furrow; mitotic spindle midzone; and rhabdomere. Is expressed in adult head and spermatozoon. Orthologous to several human genes including SLK (STE20 like kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Slik in Genome Data Viewer
    Location:
    60C7-60C8; 2-106 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24392129..24402680, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20279652..20290203, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene muscarinic Acetylcholine Receptor, A-type Neighboring gene long non-coding RNA:CR44813 Neighboring gene Regulatory particle non-ATPase 8 Neighboring gene Serotonin transporter Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class Z

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in cell cortex PubMed 
    located_in cleavage furrow PubMed 
    is_active_in cytoplasm  
    located_in mitotic spindle midzone PubMed 
    located_in rhabdomere PubMed 

    General protein information

    Preferred Names
    Sterile20-like kinase
    Names
    CG4527-PA
    CG4527-PB
    CG4527-PD
    CG4527-PE
    CG4527-PF
    CG4527-PG
    Slik-PA
    Slik-PB
    Slik-PD
    Slik-PE
    Slik-PF
    Slik-PG
    Ste20 kinase
    Sterile-20
    dPlkk/Slik threonine kinase
    polo kinase kinase 1
    sterile 20-like kinase
    NP_001014549.1
    NP_001137752.1
    NP_611908.2
    NP_726441.1
    NP_995935.1
    NP_995936.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24392129..24402680 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166669.4 → NP_726441.1  Sterile20-like kinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726441.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W179
      Related
      FBpp0072271
      Conserved Domains (3) summary
      cd06611
      Location:31 → 310
      STKc_SLK_like; Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases
      smart00220
      Location:37 → 295
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12474
      Location:1126 → 1266
      PKK; Polo kinase kinase
    2. NM_206214.4 → NP_995936.2  Sterile20-like kinase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995936.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4UZU8, Q7YZB2
      Conserved Domains (3) summary
      cd06611
      Location:31 → 310
      STKc_SLK_like; Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases
      smart00220
      Location:37 → 295
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12474
      Location:1140 → 1280
      PKK; Polo kinase kinase
    3. NM_206213.3 → NP_995935.1  Sterile20-like kinase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995935.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W179
      Conserved Domains (3) summary
      cd06611
      Location:31 → 310
      STKc_SLK_like; Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases
      smart00220
      Location:37 → 295
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12474
      Location:1126 → 1266
      PKK; Polo kinase kinase
    4. NM_001014549.3 → NP_001014549.1  Sterile20-like kinase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014549.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59E61, Q7YZB2
      Conserved Domains (3) summary
      cd06611
      Location:31 → 310
      STKc_SLK_like; Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases
      smart00220
      Location:37 → 295
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12474
      Location:1126 → 1266
      PKK; Polo kinase kinase
    5. NM_001144280.2 → NP_001137752.1  Sterile20-like kinase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137752.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZQ1, Q7YZB2
      Conserved Domains (3) summary
      cd06611
      Location:31 → 310
      STKc_SLK_like; Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases
      smart00220
      Location:37 → 295
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12474
      Location:1126 → 1266
      PKK; Polo kinase kinase
    6. NM_138064.4 → NP_611908.2  Sterile20-like kinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611908.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YZB2, Q8MLP1
      Related
      FBpp0072270
      Conserved Domains (3) summary
      cd06611
      Location:31 → 310
      STKc_SLK_like; Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases
      smart00220
      Location:37 → 295
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12474
      Location:1126 → 1266
      PKK; Polo kinase kinase
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