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    Glo1 Glyoxalase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35656, updated on 9-Dec-2024

    Summary

    Official Symbol
    Glo1provided by FlyBase
    Official Full Name
    Glyoxalase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0283450
    Locus tag
    Dmel_CG1707
    See related
    AllianceGenome:FB:FBgn0283450
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1707; Dmel\CG1707; glo1
    Summary
    Enables lactoylglutathione lyase activity. Involved in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione and regulation of insulin receptor signaling pathway. Predicted to be located in cytosol. Is expressed in adult head and organism. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal disease; type 2 diabetes mellitus; and vascular disease. Orthologous to human GLO1 (glyoxalase I). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Glo1 in Genome Data Viewer
    Location:
    43B2-43B2; 2-56 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7393546..7395932, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3281051..3283437, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene costa Neighboring gene DEAH-box helicase 15 Neighboring gene Gustatory receptor 43a Neighboring gene antisense RNA:CR44201 Neighboring gene ELL-associated factor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lactoylglutathione lyase activity PubMed 
    enables lactoylglutathione lyase activity  
    enables lactoylglutathione lyase activity  
    enables metal ion binding  
    Component Evidence Code Pubs
    located_in cytosol  

    General protein information

    Preferred Names
    glyoxalase 1
    Names
    CG1707-PA
    Glo1-PA
    NP_610270.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7393546..7395932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136426.3 → NP_610270.1  glyoxalase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610270.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6X6
      Related
      FBpp0088085
      Conserved Domains (1) summary
      cl14632
      Location:15 → 173
      Glo_EDI_BRP_like; This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins
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