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    Pdpr pyruvate dehydrogenase phosphatase regulatory subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307852, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pdprprovided by RGD
    Official Full Name
    pyruvate dehydrogenase phosphatase regulatory subunitprovided by RGD
    Primary source
    RGD:1308307
    See related
    EnsemblRapid:ENSRNOG00000022593 AllianceGenome:RGD:1308307
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308307
    Summary
    Predicted to be active in mitochondrial matrix. Orthologous to human PDPR (pyruvate dehydrogenase phosphatase regulatory subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 261.8), Muscle (RPKM 240.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pdpr in Genome Data Viewer
    Location:
    19q12
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (55974611..56019045)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (39065226..39109695)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (43107852..43149243, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 18, member A Neighboring gene essential MCU regulator, mitochondrial-like Neighboring gene ribosomal protein S20 like 6 Neighboring gene golgi glycoprotein 1 Neighboring gene ring finger and WD repeat domain 3 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation. Huang B, et al. J Biol Chem, 1998 Jul 10. PMID 9651365
    2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial
    NP_001100900.1
    XP_008770736.1
    XP_017456788.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107430.2 → NP_001100900.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

      See identical proteins and their annotated locations for NP_001100900.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IZ83, D3ZXA6
      Conserved Domains (5) summary
      COG0404
      Location:452 → 867
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      pfam01266
      Location:44 → 384
      DAO; FAD dependent oxidoreductase
      pfam01571
      Location:462 → 735
      GCV_T; Aminomethyltransferase folate-binding domain
      pfam08669
      Location:747 → 851
      GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
      pfam16350
      Location:405 → 459
      FAO_M; FAD dependent oxidoreductase central domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      55974611..56019045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772514.4 → XP_008770736.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A6IZ83, D3ZXA6
      Related
      ENSRNOP00000083707.2, ENSRNOT00000107538.2
      Conserved Domains (5) summary
      COG0404
      Location:452 → 867
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      pfam01266
      Location:44 → 384
      DAO; FAD dependent oxidoreductase
      pfam01571
      Location:462 → 735
      GCV_T; Aminomethyltransferase folate-binding domain
      pfam08669
      Location:747 → 851
      GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
      pfam16350
      Location:405 → 459
      FAO_M; FAD dependent oxidoreductase central domain

    2. XM_017601299.3 → XP_017456788.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X2

      Conserved Domains (3) summary
      COG0404
      Location:276 → 691
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      pfam01266
      Location:1 → 208
      DAO; FAD dependent oxidoreductase
      pfam16350
      Location:229 → 283
      FAO_M; FAD dependent oxidoreductase central domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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