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Conserved domains on  [gi|157818167|ref|NP_001100900|]
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pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial [Rattus norvegicus]

Protein Classification

FAD-dependent oxidoreductase( domain architecture ID 11429831)

FAD-dependent oxidoreductase containing a GcvT (glycine cleavage system T) domain such as sarcosine dehydrogenase and dimethylglycine dehydrogenase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 453-867 3.94e-86

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


:

Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 279.66  E-value: 3.94e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 453 GRQLRTSPLYDRLDAQGARWMEKHGFERPKYFVppnkdllaleqsktfykpdwfDIVESEVKCCKEAVCVIDMSSFTKFE 532
Cdd:COG0404    1 FRPLRRTPLHDRHVALGAKFVDFGGWEMPVQYP---------------------GGVIAEHLAVREAVGLFDVSHMGKIE 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 533 ITstGDQALESLQYLFSNDLDV-PVGHIVHTGMLNEYGGHENDCSIARLTKRSFFMISPTDQQVHCWAWLHKYLPKDSNL 611
Cdd:COG0404   60 VT--GPDAAAFLDRLVTNDVSKlKPGRARYTLMLNEDGGIIDDLTVYRLGEDRFLLVVNAANAAKDLAWLEEHLPPDFDV 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 612 LLEDVTWKYTALNLIGPRAVDVLSELsyAPMTPDHFPTLFCKEMSVGYANgIRVMSMTHTGEPGFMLYIPIEYALHVYNE 691
Cdd:COG0404  138 TITDVTDDWALLAVQGPKAREVLAKL--TDADLSALPFMSFREGTVAGVP-VRVSRTGYTGEDGFEIYVPAEDAEALWDA 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 692 VMSVGQKYGIRNAGYYALRSLRIEKFFAFWGQDLNTLTTPLECGGESRVKLEKGiDFIGRDALLQQKQTGVYKRLVMFIL 771
Cdd:COG0404  215 LLEAGEEFGVKPCGLGARDTLRLEAGYPLYGHELDETTTPLEAGLGWAVKLDKG-DFIGKEALLRQKEEGPRRKLVGLEL 293

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 772 DDHDTdldlwPWWGEPIYRNGKYAGKTTSSAYSYTLERHVCLGYVHNFSEDSGEeqvvtadfinrgEYEIDIAGHRFQAK 851
Cdd:COG0404  294 DGRGV-----PRAGAPVLADGEVVGEVTSGTFSPTLGKSIALAYVPAGLARPGT------------ELEVEIRGKRVPAE 356

                        410
                 ....*....|....*.
gi 157818167 852 AKLYPvtsFFTHKRRK 867
Cdd:COG0404  357 VVKPP---FYDPEGER 369
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
40-384 3.53e-65

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


:

Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 222.86  E-value: 3.53e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  40 AQAQVVICGGGIMGTSVAYHLSKMGWqDIVLLEQGRLAAGSTRFCAGILST---ARHSSIEQKMADYSNKLYHQLEQETG 116
Cdd:COG0665    1 ATADVVVIGGGIAGLSTAYHLARRGL-DVTVLERGRPGSGASGRNAGQLRPglaALADRALVRLAREALDLWRELAAELG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 117 IQTGYLRTGSISLAQTQDRLISLKRINSRLNVVGIPSEIISPKKVAELHPLLNVHDLVGAMHVPEDAVVSSADVALALAS 196
Cdd:COG0665   80 IDCDFRRTGVLYLARTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDPAKLVRALAR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 197 AASQNGVQIYDRTSVLHVLTKKGRVTGVDTDKGQIECQYFVNCAGQWAYELGlsSEEPVSIPLHACEHFYLLTRPCDAPL 276
Cdd:COG0665  160 AARAAGVRIREGTPVTGLEREGGRVTGVRTERGTVRADAVVLAAGAWSARLL--PMLGLRLPLRPVRGYVLVTEPLPDLP 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 277 qssTPTVVDaDGRIYIRNWQGG--VLSGGFEKNPkpiftegknqleiQNLREDWDHFEPLLSSLLRRMPGLESVEILKLV 354
Cdd:COG0665  238 ---LRPVLD-DTGVYLRPTADGrlLVGGTAEPAG-------------FDRAPTPERLEALLRRLRRLFPALADAEIVRAW 300

                        330       340       350
                 ....*....|....*....|....*....|
gi 157818167 355 NCPETFTADMKCIMGESPVVQGYFVLAGMN 384
Cdd:COG0665  301 AGLRPMTPDGLPIIGRLPGAPGLYVATGHG 330
FAO_M pfam16350
FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent ...
 405-459 4.64e-16

FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent oxidoreductases: Sarcosine dehydrogenase, Dimethylglycine dehydrogenase and Dimethylglycine dehydrogenase. It is situated between the DAO domain (pfam01266) and the GCV_T domain (pfam01571).


:

Pssm-ID: 465100  Cd Length: 56  Bit Score: 72.87  E-value: 4.64e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 157818167  405 GYPSENVWELDLQRFGALQGSRTFLRHRVMEVMPLIYDLKVPRWDFQTGRQLRTS 459
Cdd:pfam16350   2 GEPPIDLWECDIRRFGPHQNNREYLRERVAENYGEVYDIHHPNEEREAGRPLRTS 56
 
Name Accession Description Interval E-value
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 453-867 3.94e-86

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 279.66  E-value: 3.94e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 453 GRQLRTSPLYDRLDAQGARWMEKHGFERPKYFVppnkdllaleqsktfykpdwfDIVESEVKCCKEAVCVIDMSSFTKFE 532
Cdd:COG0404    1 FRPLRRTPLHDRHVALGAKFVDFGGWEMPVQYP---------------------GGVIAEHLAVREAVGLFDVSHMGKIE 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 533 ITstGDQALESLQYLFSNDLDV-PVGHIVHTGMLNEYGGHENDCSIARLTKRSFFMISPTDQQVHCWAWLHKYLPKDSNL 611
Cdd:COG0404   60 VT--GPDAAAFLDRLVTNDVSKlKPGRARYTLMLNEDGGIIDDLTVYRLGEDRFLLVVNAANAAKDLAWLEEHLPPDFDV 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 612 LLEDVTWKYTALNLIGPRAVDVLSELsyAPMTPDHFPTLFCKEMSVGYANgIRVMSMTHTGEPGFMLYIPIEYALHVYNE 691
Cdd:COG0404  138 TITDVTDDWALLAVQGPKAREVLAKL--TDADLSALPFMSFREGTVAGVP-VRVSRTGYTGEDGFEIYVPAEDAEALWDA 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 692 VMSVGQKYGIRNAGYYALRSLRIEKFFAFWGQDLNTLTTPLECGGESRVKLEKGiDFIGRDALLQQKQTGVYKRLVMFIL 771
Cdd:COG0404  215 LLEAGEEFGVKPCGLGARDTLRLEAGYPLYGHELDETTTPLEAGLGWAVKLDKG-DFIGKEALLRQKEEGPRRKLVGLEL 293

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 772 DDHDTdldlwPWWGEPIYRNGKYAGKTTSSAYSYTLERHVCLGYVHNFSEDSGEeqvvtadfinrgEYEIDIAGHRFQAK 851
Cdd:COG0404  294 DGRGV-----PRAGAPVLADGEVVGEVTSGTFSPTLGKSIALAYVPAGLARPGT------------ELEVEIRGKRVPAE 356

                        410
                 ....*....|....*.
gi 157818167 852 AKLYPvtsFFTHKRRK 867
Cdd:COG0404  357 VVKPP---FYDPEGER 369
GCV_T pfam01571
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, ...
 462-735 4.88e-81

Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 460255  Cd Length: 254  Bit Score: 261.75  E-value: 4.88e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  462 YDRLDAQGARWMEKHGFERPKYFVPPNKDllaleqsktfykpdwfdiveSEVKCCKEAVCVIDMSSFTKFEITstGDQAL 541
Cdd:pfam01571   1 YDRHVALGAKFVEFAGWEMPVQYGSNGIL--------------------AEHRAVREAAGLFDVSHMGKIEVS--GPDAA 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  542 ESLQYLFSNDLD-VPVGHIVHTGMLNEYGGHENDCSIARLTKRSFFMISPTDQQVHCWAWLHKYLPKDsNLLLEDVTWKY 620
Cdd:pfam01571  59 AFLQRLTTNDVSkLKPGRATYTLMLNERGGVIDDLTVYRLGDDHFLLVVNAANREKDLAWLRKHAEKL-DVVVVDVTDDY 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  621 TALNLIGPRAVDVLSELSYAPMTPDhFPTLFCKEMSVGYANgIRVMSMTHTGEPGFMLYIPIEYALHVYNEVMSVGQKYG 700
Cdd:pfam01571 138 ALLALQGPKAREVLEKLTDGDLLEA-LPFFSFREIEIGGVP-VRVSRTGYTGEDGFEIYVPAEDAVELWEALLEAGAELG 215

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 157818167  701 IRNAGYYALRSLRIEKFFAFWGQDLNTLTTPLECG 735
Cdd:pfam01571 216 LRPAGLGARDSLRLEAGLPLYGHDLDEETTPLEAG 250
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
40-384 3.53e-65

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 222.86  E-value: 3.53e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  40 AQAQVVICGGGIMGTSVAYHLSKMGWqDIVLLEQGRLAAGSTRFCAGILST---ARHSSIEQKMADYSNKLYHQLEQETG 116
Cdd:COG0665    1 ATADVVVIGGGIAGLSTAYHLARRGL-DVTVLERGRPGSGASGRNAGQLRPglaALADRALVRLAREALDLWRELAAELG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 117 IQTGYLRTGSISLAQTQDRLISLKRINSRLNVVGIPSEIISPKKVAELHPLLNVHDLVGAMHVPEDAVVSSADVALALAS 196
Cdd:COG0665   80 IDCDFRRTGVLYLARTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDPAKLVRALAR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 197 AASQNGVQIYDRTSVLHVLTKKGRVTGVDTDKGQIECQYFVNCAGQWAYELGlsSEEPVSIPLHACEHFYLLTRPCDAPL 276
Cdd:COG0665  160 AARAAGVRIREGTPVTGLEREGGRVTGVRTERGTVRADAVVLAAGAWSARLL--PMLGLRLPLRPVRGYVLVTEPLPDLP 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 277 qssTPTVVDaDGRIYIRNWQGG--VLSGGFEKNPkpiftegknqleiQNLREDWDHFEPLLSSLLRRMPGLESVEILKLV 354
Cdd:COG0665  238 ---LRPVLD-DTGVYLRPTADGrlLVGGTAEPAG-------------FDRAPTPERLEALLRRLRRLFPALADAEIVRAW 300

                        330       340       350
                 ....*....|....*....|....*....|
gi 157818167 355 NCPETFTADMKCIMGESPVVQGYFVLAGMN 384
Cdd:COG0665  301 AGLRPMTPDGLPIIGRLPGAPGLYVATGHG 330
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 44-384 1.02e-48

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 176.05  E-value: 1.02e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167   44 VVICGGGIMGTSVAYHLSKMGWqDIVLLEQG-RLAAGSTRFCAGILSTARHS---SIEQKMADYSNKLYHQLEQETGIQT 119
Cdd:pfam01266   2 VVVIGGGIVGLSTAYELARRGL-SVTLLERGdDPGSGASGRNAGLIHPGLRYlepSELARLALEALDLWEELEEELGIDC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  120 GYLRTGSISLAQTQDRlISLKRINSRLNVVGIPSEIISPKKVAELHPLLNvhDLVGAMHVPEDAVVSSADVALALASAAS 199
Cdd:pfam01266  81 GFRRCGVLVLARDEEE-EALEKLLAALRRLGVPAELLDAEELRELEPLLP--GLRGGLFYPDGGHVDPARLLRALARAAE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  200 QNGVQIYDRTSVLHvLTKKGRVTGVDTDkGQIECqyFVNCAGQWAYELGLSseePVSIPLHACEHFYLLTRPC-DAPLQS 278
Cdd:pfam01266 158 ALGVRIIEGTEVTG-IEEEGGVWGVVTT-GEADA--VVNAAGAWADLLALP---GLRLPVRPVRGQVLVLEPLpEALLIL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  279 STPTVVDADGRIYIRN-WQGGVLSGGFEKNPKPiftegknqleiQNLREDWDHFEPLLSSLLRRMPGLESVEilklvncp 357
Cdd:pfam01266 231 PVPITVDPGRGVYLRPrADGRLLLGGTDEEDGF-----------DDPTPDPEEIEELLEAARRLFPALADIE-------- 291

                         330       340       350
                  ....*....|....*....|....*....|..
gi 157818167  358 ETF-----TADMKCIMGEsPVVQGYFVLAGMN 384
Cdd:pfam01266 292 RAWaglrpLPDGLPIIGR-PGSPGLYLATGHG 322
gcvT PRK00389
glycine cleavage system aminomethyltransferase GcvT;
456-816 7.20e-38

glycine cleavage system aminomethyltransferase GcvT;


Pssm-ID: 234742 [Multi-domain]  Cd Length: 359  Bit Score: 145.26  E-value: 7.20e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 456 LRTSPLYDRLDAQGARWMEKHGFERP-KYfvppnkdllaleQSktfykpdwfdIVEsEVKCCKEAVCVIDMSSFTKFEIT 534
Cdd:PRK00389   2 LKRTPLYDLHVALGAKMVDFGGWEMPvQY------------GS----------IIE-EHHAVRTDAGLFDVSHMGEVDVT 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 535 stGDQALESLQYLFSNDLD-VPVGHIVHTGMLNEYGGHENDCSIARLTKRSFFMI--SPTDQQVhcWAWLHKYLpKDSNL 611
Cdd:PRK00389  59 --GPDALAFLQYLLANDVSkLKPGKAQYTCMLNEDGGVIDDLIVYKLSEDEYLLVvnAANREKD--LAWIKSHA-AGFGV 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 612 LLEDVTWKYTALNLIGPRAVDVLSELSYAPMtpDHFPTLFCKEMSVGYANGIRVmSMT-HTGEPGFMLYIPIEYALHVYN 690
Cdd:PRK00389 134 EVTDRSDDLAMIAVQGPKAREKLQKLTDADL--SELKPFFGAQGAEVGGGDVLV-ARTgYTGEDGFEIYLPAEDAEALWD 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 691 EVMSVGqkygIRNAGYYALRSLRIEKFFAFWGQDLNTLTTPLECGGESRVKLEKGIDFIGRDALLQQKQTGVYKRLVMF- 769
Cdd:PRK00389 211 ALLEAG----VKPCGLGARDTLRLEAGMPLYGQDMDETITPLEAGLGWTVKLEEKRDFIGREALEAQKEAGVERKLVGLe 286

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 157818167 770 -----IlddhdtdldlwPWWGEPIYRNGKYAGKTTSSAYSYTLERHVCLGYV 816
Cdd:PRK00389 287 leergI-----------PRHGYPVLADGEEIGEVTSGTFSPTLGKSIALAYV 327
FAO_M pfam16350
FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent ...
 405-459 4.64e-16

FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent oxidoreductases: Sarcosine dehydrogenase, Dimethylglycine dehydrogenase and Dimethylglycine dehydrogenase. It is situated between the DAO domain (pfam01266) and the GCV_T domain (pfam01571).


Pssm-ID: 465100  Cd Length: 56  Bit Score: 72.87  E-value: 4.64e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 157818167  405 GYPSENVWELDLQRFGALQGSRTFLRHRVMEVMPLIYDLKVPRWDFQTGRQLRTS 459
Cdd:pfam16350   2 GEPPIDLWECDIRRFGPHQNNREYLRERVAENYGEVYDIHHPNEEREAGRPLRTS 56
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 44-247 6.22e-08

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 55.61  E-value: 6.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167   44 VVICGGGIMGTSVAYHLSKMGwQDIVLLEQGRL--AAGSTRfcaGILSTARHSSIEQ---KMADYSNKLYHQLEQETGIQ 118
Cdd:TIGR01377   3 VIVVGAGIMGCFAAYHLAKHG-KKTLLLEQFDLphSRGSSH---GQSRIIRKAYPEDfytPMMLECYQLWAQLEKEAGTK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  119 TgYLRTGSISLAQTQDRliSLKRINSRLNVVGIPSEIISPKKVAELHPLLNVHDLVGAMHVPEDAVVSSADVALALASAA 198
Cdd:TIGR01377  79 L-HRQTGLLLLGPKENQ--FLKTIQATLSRHGLEHELLSSKQLKQRFPNIRVPRNEVGLLDPNGGVLYAEKALRALQELA 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 157818167  199 SQNGVQIYDRTSVLHVLTKKGRVTgVDTDKGQIECQYFVNCAGQWAYEL 247
Cdd:TIGR01377 156 EAHGATVRDGTKVVEIEPTELLVT-VKTTKGSYQANKLVVTAGAWTSKL 203
glpA PRK11101
anaerobic glycerol-3-phosphate dehydrogenase subunit A;
39-243 1.66e-07

anaerobic glycerol-3-phosphate dehydrogenase subunit A;


Pssm-ID: 236847 [Multi-domain]  Cd Length: 546  Bit Score: 55.02  E-value: 1.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  39 PAQAQVVICGGGIMGTSVAYHLSKMGWqDIVLLEQGRLAAGSTRFCAGIL-STARHSSIEQKMAD---YSNKLY-----H 109
Cdd:PRK11101   4 SQETDVIIIGGGATGAGIARDCALRGL-RCILVERHDIATGATGRNHGLLhSGARYAVTDAESAReciSENQILkriarH 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 110 QLEQETGIqtgylrtgSISLAQtqDRLISLKRINSRLNVVGIPSEIISPKKVAELHPLLNvHDLVGAMHVPEDAV----V 185
Cdd:PRK11101  83 CVEPTDGL--------FITLPE--DDLAFQATFIRACEEAGIEAEAIDPQQALILEPAVN-PALIGAVKVPDGTVdpfrL 151

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157818167 186 SSADVALALasaasQNGVQIYDRTSVLHVLTKKGRVTGV---DTDKGQ---IECQYFVNCAGQW 243
Cdd:PRK11101 152 TAANMLDAK-----EHGAQILTYHEVTGLIREGDTVCGVrvrDHLTGEtqeIHAPVVVNAAGIW 210
 
Name Accession Description Interval E-value
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 453-867 3.94e-86

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 279.66  E-value: 3.94e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 453 GRQLRTSPLYDRLDAQGARWMEKHGFERPKYFVppnkdllaleqsktfykpdwfDIVESEVKCCKEAVCVIDMSSFTKFE 532
Cdd:COG0404    1 FRPLRRTPLHDRHVALGAKFVDFGGWEMPVQYP---------------------GGVIAEHLAVREAVGLFDVSHMGKIE 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 533 ITstGDQALESLQYLFSNDLDV-PVGHIVHTGMLNEYGGHENDCSIARLTKRSFFMISPTDQQVHCWAWLHKYLPKDSNL 611
Cdd:COG0404   60 VT--GPDAAAFLDRLVTNDVSKlKPGRARYTLMLNEDGGIIDDLTVYRLGEDRFLLVVNAANAAKDLAWLEEHLPPDFDV 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 612 LLEDVTWKYTALNLIGPRAVDVLSELsyAPMTPDHFPTLFCKEMSVGYANgIRVMSMTHTGEPGFMLYIPIEYALHVYNE 691
Cdd:COG0404  138 TITDVTDDWALLAVQGPKAREVLAKL--TDADLSALPFMSFREGTVAGVP-VRVSRTGYTGEDGFEIYVPAEDAEALWDA 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 692 VMSVGQKYGIRNAGYYALRSLRIEKFFAFWGQDLNTLTTPLECGGESRVKLEKGiDFIGRDALLQQKQTGVYKRLVMFIL 771
Cdd:COG0404  215 LLEAGEEFGVKPCGLGARDTLRLEAGYPLYGHELDETTTPLEAGLGWAVKLDKG-DFIGKEALLRQKEEGPRRKLVGLEL 293

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 772 DDHDTdldlwPWWGEPIYRNGKYAGKTTSSAYSYTLERHVCLGYVHNFSEDSGEeqvvtadfinrgEYEIDIAGHRFQAK 851
Cdd:COG0404  294 DGRGV-----PRAGAPVLADGEVVGEVTSGTFSPTLGKSIALAYVPAGLARPGT------------ELEVEIRGKRVPAE 356

                        410
                 ....*....|....*.
gi 157818167 852 AKLYPvtsFFTHKRRK 867
Cdd:COG0404  357 VVKPP---FYDPEGER 369
GCV_T pfam01571
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, ...
 462-735 4.88e-81

Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 460255  Cd Length: 254  Bit Score: 261.75  E-value: 4.88e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  462 YDRLDAQGARWMEKHGFERPKYFVPPNKDllaleqsktfykpdwfdiveSEVKCCKEAVCVIDMSSFTKFEITstGDQAL 541
Cdd:pfam01571   1 YDRHVALGAKFVEFAGWEMPVQYGSNGIL--------------------AEHRAVREAAGLFDVSHMGKIEVS--GPDAA 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  542 ESLQYLFSNDLD-VPVGHIVHTGMLNEYGGHENDCSIARLTKRSFFMISPTDQQVHCWAWLHKYLPKDsNLLLEDVTWKY 620
Cdd:pfam01571  59 AFLQRLTTNDVSkLKPGRATYTLMLNERGGVIDDLTVYRLGDDHFLLVVNAANREKDLAWLRKHAEKL-DVVVVDVTDDY 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  621 TALNLIGPRAVDVLSELSYAPMTPDhFPTLFCKEMSVGYANgIRVMSMTHTGEPGFMLYIPIEYALHVYNEVMSVGQKYG 700
Cdd:pfam01571 138 ALLALQGPKAREVLEKLTDGDLLEA-LPFFSFREIEIGGVP-VRVSRTGYTGEDGFEIYVPAEDAVELWEALLEAGAELG 215

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 157818167  701 IRNAGYYALRSLRIEKFFAFWGQDLNTLTTPLECG 735
Cdd:pfam01571 216 LRPAGLGARDSLRLEAGLPLYGHDLDEETTPLEAG 250
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
40-384 3.53e-65

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 222.86  E-value: 3.53e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  40 AQAQVVICGGGIMGTSVAYHLSKMGWqDIVLLEQGRLAAGSTRFCAGILST---ARHSSIEQKMADYSNKLYHQLEQETG 116
Cdd:COG0665    1 ATADVVVIGGGIAGLSTAYHLARRGL-DVTVLERGRPGSGASGRNAGQLRPglaALADRALVRLAREALDLWRELAAELG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 117 IQTGYLRTGSISLAQTQDRLISLKRINSRLNVVGIPSEIISPKKVAELHPLLNVHDLVGAMHVPEDAVVSSADVALALAS 196
Cdd:COG0665   80 IDCDFRRTGVLYLARTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDPAKLVRALAR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 197 AASQNGVQIYDRTSVLHVLTKKGRVTGVDTDKGQIECQYFVNCAGQWAYELGlsSEEPVSIPLHACEHFYLLTRPCDAPL 276
Cdd:COG0665  160 AARAAGVRIREGTPVTGLEREGGRVTGVRTERGTVRADAVVLAAGAWSARLL--PMLGLRLPLRPVRGYVLVTEPLPDLP 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 277 qssTPTVVDaDGRIYIRNWQGG--VLSGGFEKNPkpiftegknqleiQNLREDWDHFEPLLSSLLRRMPGLESVEILKLV 354
Cdd:COG0665  238 ---LRPVLD-DTGVYLRPTADGrlLVGGTAEPAG-------------FDRAPTPERLEALLRRLRRLFPALADAEIVRAW 300

                        330       340       350
                 ....*....|....*....|....*....|
gi 157818167 355 NCPETFTADMKCIMGESPVVQGYFVLAGMN 384
Cdd:COG0665  301 AGLRPMTPDGLPIIGRLPGAPGLYVATGHG 330
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 44-384 1.02e-48

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 176.05  E-value: 1.02e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167   44 VVICGGGIMGTSVAYHLSKMGWqDIVLLEQG-RLAAGSTRFCAGILSTARHS---SIEQKMADYSNKLYHQLEQETGIQT 119
Cdd:pfam01266   2 VVVIGGGIVGLSTAYELARRGL-SVTLLERGdDPGSGASGRNAGLIHPGLRYlepSELARLALEALDLWEELEEELGIDC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  120 GYLRTGSISLAQTQDRlISLKRINSRLNVVGIPSEIISPKKVAELHPLLNvhDLVGAMHVPEDAVVSSADVALALASAAS 199
Cdd:pfam01266  81 GFRRCGVLVLARDEEE-EALEKLLAALRRLGVPAELLDAEELRELEPLLP--GLRGGLFYPDGGHVDPARLLRALARAAE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  200 QNGVQIYDRTSVLHvLTKKGRVTGVDTDkGQIECqyFVNCAGQWAYELGLSseePVSIPLHACEHFYLLTRPC-DAPLQS 278
Cdd:pfam01266 158 ALGVRIIEGTEVTG-IEEEGGVWGVVTT-GEADA--VVNAAGAWADLLALP---GLRLPVRPVRGQVLVLEPLpEALLIL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  279 STPTVVDADGRIYIRN-WQGGVLSGGFEKNPKPiftegknqleiQNLREDWDHFEPLLSSLLRRMPGLESVEilklvncp 357
Cdd:pfam01266 231 PVPITVDPGRGVYLRPrADGRLLLGGTDEEDGF-----------DDPTPDPEEIEELLEAARRLFPALADIE-------- 291

                         330       340       350
                  ....*....|....*....|....*....|..
gi 157818167  358 ETF-----TADMKCIMGEsPVVQGYFVLAGMN 384
Cdd:pfam01266 292 RAWaglrpLPDGLPIIGR-PGSPGLYLATGHG 322
gcvT PRK00389
glycine cleavage system aminomethyltransferase GcvT;
456-816 7.20e-38

glycine cleavage system aminomethyltransferase GcvT;


Pssm-ID: 234742 [Multi-domain]  Cd Length: 359  Bit Score: 145.26  E-value: 7.20e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 456 LRTSPLYDRLDAQGARWMEKHGFERP-KYfvppnkdllaleQSktfykpdwfdIVEsEVKCCKEAVCVIDMSSFTKFEIT 534
Cdd:PRK00389   2 LKRTPLYDLHVALGAKMVDFGGWEMPvQY------------GS----------IIE-EHHAVRTDAGLFDVSHMGEVDVT 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 535 stGDQALESLQYLFSNDLD-VPVGHIVHTGMLNEYGGHENDCSIARLTKRSFFMI--SPTDQQVhcWAWLHKYLpKDSNL 611
Cdd:PRK00389  59 --GPDALAFLQYLLANDVSkLKPGKAQYTCMLNEDGGVIDDLIVYKLSEDEYLLVvnAANREKD--LAWIKSHA-AGFGV 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 612 LLEDVTWKYTALNLIGPRAVDVLSELSYAPMtpDHFPTLFCKEMSVGYANGIRVmSMT-HTGEPGFMLYIPIEYALHVYN 690
Cdd:PRK00389 134 EVTDRSDDLAMIAVQGPKAREKLQKLTDADL--SELKPFFGAQGAEVGGGDVLV-ARTgYTGEDGFEIYLPAEDAEALWD 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 691 EVMSVGqkygIRNAGYYALRSLRIEKFFAFWGQDLNTLTTPLECGGESRVKLEKGIDFIGRDALLQQKQTGVYKRLVMF- 769
Cdd:PRK00389 211 ALLEAG----VKPCGLGARDTLRLEAGMPLYGQDMDETITPLEAGLGWTVKLEEKRDFIGREALEAQKEAGVERKLVGLe 286

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 157818167 770 -----IlddhdtdldlwPWWGEPIYRNGKYAGKTTSSAYSYTLERHVCLGYV 816
Cdd:PRK00389 287 leergI-----------PRHGYPVLADGEEIGEVTSGTFSPTLGKSIALAYV 327
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
44-244 2.15e-25

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 109.85  E-value: 2.15e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  44 VVICGGGIMGTSVAYHLSK-MGWqDIVLLEQG-RLAAGSTRFCAGILstarHS-------SIEQKMADYSNKLYHQLEQE 114
Cdd:COG0579    7 VVIIGAGIVGLALARELSRyEDL-KVLVLEKEdDVAQESSGNNSGVI----HAglyytpgSLKARLCVEGNELFYELCRE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 115 TGIQtgYLRTGSISLAQTQDRLISLKRINSRLNVVGIPS-EIISPKKVAELHPLLNvHDLVGAMHVPEDAVVSSADVALA 193
Cdd:COG0579   82 LGIP--FKRCGKLVVATGEEEVAFLEKLYERGKANGVPGlEILDREELRELEPLLS-DEGVAALYSPSTGIVDPGALTRA 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 157818167 194 LASAASQNGVQIYDRTSVLHVLTKKGRVTgVDTDKGQIECQYFVNCAGQWA 244
Cdd:COG0579  159 LAENAEANGVELLLNTEVTGIEREGDGWE-VTTNGGTIRARFVINAAGLYA 208
FAO_M pfam16350
FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent ...
 405-459 4.64e-16

FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent oxidoreductases: Sarcosine dehydrogenase, Dimethylglycine dehydrogenase and Dimethylglycine dehydrogenase. It is situated between the DAO domain (pfam01266) and the GCV_T domain (pfam01571).


Pssm-ID: 465100  Cd Length: 56  Bit Score: 72.87  E-value: 4.64e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 157818167  405 GYPSENVWELDLQRFGALQGSRTFLRHRVMEVMPLIYDLKVPRWDFQTGRQLRTS 459
Cdd:pfam16350   2 GEPPIDLWECDIRRFGPHQNNREYLRERVAENYGEVYDIHHPNEEREAGRPLRTS 56
PLN02319 PLN02319
aminomethyltransferase
 562-816 6.21e-14

aminomethyltransferase


Pssm-ID: 177953 [Multi-domain]  Cd Length: 404  Bit Score: 74.76  E-value: 6.21e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 562 TGML----NEYGGHENDCSIARLTKRSFFMI-----SPTDQQvHCWAWLHKYLPKDsnlllEDVTW----KYTALNLIGP 628
Cdd:PLN02319 112 TGTLsvftNEKGGIIDDTVITKVTDDHIYLVvnagcRDKDLA-HIEEHMKAFKAKG-----GDVSWhvhdERSLLALQGP 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 629 RAVDVLSELSYAPMTPDHFPTLfcKEMSVgyaNGI--RVMSMTHTGEPGFMLYIPIEYALHVYNEVMSVGQKyGIRNAGY 706
Cdd:PLN02319 186 LAAPVLQHLTKEDLSKMYFGDF--RITDI---NGAdcFLTRTGYTGEDGFEISVPSEHAVDLAKALLEKSEG-KVRLTGL 259

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 707 YALRSLRIEKFFAFWGQDLNTLTTPLECG-----GESRvkLEKGiDFIGRDALLQQKQTGVYKRLVMFILDdhdtdldlw 781
Cdd:PLN02319 260 GARDSLRLEAGLCLYGNDLEEHITPVEAGlawtiGKRR--RAEG-GFLGADVILKQLKEGVSRRRVGFISS--------- 327

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 157818167 782 pwwGEP------IY-RNGKYAGKTTSSAYSYTLERHVCLGYV 816
Cdd:PLN02319 328 ---GAParshseILdESGEKIGEVTSGGFSPCLKKNIAMGYV 366
dmdA PRK12486
dimethylsulfoniopropionate demethylase;
454-838 2.38e-13

dimethylsulfoniopropionate demethylase;


Pssm-ID: 237113 [Multi-domain]  Cd Length: 368  Bit Score: 72.48  E-value: 2.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 454 RQLRTSPLYDRLDAQGArwmekhgferpKYFVPPNKDLLaleqsktfykPDWFDIVESEVKCCKEAVCVIDMSSFTKFEI 533
Cdd:PRK12486   9 RRLRRTPFSDGVEAAGV-----------KAYTVYNHMLL----------PTVFESVEDDYAHLKEHVQVWDVAVERQVEI 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 534 TstGDQALESLQYLFSNDLD-VPVGHIVHTGMLNEYGGHENDCSIARLTKRSFFmISPTDQQVHCWAwlhKYLPKDSNLL 612
Cdd:PRK12486  68 R--GPDAARLVQMLTPRDLRgMKPGQCYYVPIVDETGGMLNDPVALKLAEDRWW-ISIADSDLLLWV---KGLANGRKLD 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 613 LEDVTWKYTALNLIGPRAVDVLSELSYAPMTPDHFptlfckeMSVGYAN--GIRvMSMTHTG---EPGFMLYIP-IEYAL 686
Cdd:PRK12486 142 VLVVEPDVSPLAVQGPKADALMARVFGEAIRDLRF-------FRFGYFDfeGTD-LVIARSGyskQGGFEIYVEgSDLGM 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 687 HVYNEVMSVGQKYGIRnAGYYALRSlRIEKFFAFWGQDLNTLTTPLECGGESRVKLEKGIDFIGRDALLQQKQTGVYKRL 766
Cdd:PRK12486 214 PLWDALFEAGKDLNVR-AGCPNLIE-RIEGGLLSYGNDMTRDNTPHECGLGRFCNTQTDIGCIGKDALLRVAKEGPQKQI 291

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157818167 767 VMFILDDHDTDLDLWPWwgePIYRNGKYAGKTTSSAYSYTLERHVCLGYVHNFSEDSGEE-QVVTADFINRGE 838
Cdd:PRK12486 292 RGIKIGGERIPPCDRAW---PLLAGDNRVGQVTSAAYSPDFQTNVAIGMVRMTHWDPGTGlEVETPDGMRPAT 361
GCV_T_C pfam08669
Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage ...
 764-851 8.88e-12

Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 462554 [Multi-domain]  Cd Length: 80  Bit Score: 61.34  E-value: 8.88e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  764 KRLVMFILDDHDTdldlWPWWGEPIYRNGKYAGKTTSSAYSYTLERHVCLGYVHnfsedsgeeqvvtADFINRG-EYEID 842
Cdd:pfam08669   1 RRLVGLELDDGDP----LLRGGEPVLRDGEVVGYVTSGAYSPTLGKSIALAYVD-------------AELAKPGtEVEVE 63


                  ....*....
gi 157818167  843 IAGHRFQAK 851
Cdd:pfam08669  64 IRGKRVPAT 72
gcvT PRK13579
glycine cleavage system aminomethyltransferase GcvT;
533-816 5.67e-09

glycine cleavage system aminomethyltransferase GcvT;


Pssm-ID: 237435 [Multi-domain]  Cd Length: 370  Bit Score: 58.81  E-value: 5.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 533 ITSTGDQALESLQYLFSND-LDVPVGHIVHTGMLNEYGGHENDCSIARLTKRsFFMISPTDQQVHCWAWLHKYLPKDSNL 611
Cdd:PRK13579  63 IEVSGKDAAAALERLVPVDiLALKEGRQRYTFFTNEQGGILDDLMVTNLGDH-LFLVVNAACKDADIAHLREHLSDECEV 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 612 -LLEDvtwkYTALNLIGPRAVDVLSELSyapmtPDHFPTLFckeMSVGyanGIRVMSMT-------HTGEPGFMLYIPIE 683
Cdd:PRK13579 142 nPLDD----RALLALQGPEAEAVLADLG-----PPVAALRF---MDGF---EPRLHGVDcfvsrsgYTGEDGFEISVPAD 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 684 YA------LHVYNEVMSVGqkYGIRNagyyalrSLRIEKFFAFWGQDLNTLTTPLECGGE---SRVKLEKGiDFIGRDAL 754
Cdd:PRK13579 207 AAealaeaLLADPRVEPIG--LGARD-------SLRLEAGLCLYGHDIDTTTTPVEAALEwaiQKARREAG-GFPGAKAI 276

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157818167 755 LQQKQTGVYKRLVMFILDDHDTDLDlwpwwGEPIYRN-GKYAGKTTSSAYSYTLERHVCLGYV 816
Cdd:PRK13579 277 LAALAKGASRRRVGLKPEGRAPVRE-----GAPLFDDaGTEIGTVTSGGFGPSVGGPVAMGYV 334
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 44-247 6.22e-08

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 55.61  E-value: 6.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167   44 VVICGGGIMGTSVAYHLSKMGwQDIVLLEQGRL--AAGSTRfcaGILSTARHSSIEQ---KMADYSNKLYHQLEQETGIQ 118
Cdd:TIGR01377   3 VIVVGAGIMGCFAAYHLAKHG-KKTLLLEQFDLphSRGSSH---GQSRIIRKAYPEDfytPMMLECYQLWAQLEKEAGTK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  119 TgYLRTGSISLAQTQDRliSLKRINSRLNVVGIPSEIISPKKVAELHPLLNVHDLVGAMHVPEDAVVSSADVALALASAA 198
Cdd:TIGR01377  79 L-HRQTGLLLLGPKENQ--FLKTIQATLSRHGLEHELLSSKQLKQRFPNIRVPRNEVGLLDPNGGVLYAEKALRALQELA 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 157818167  199 SQNGVQIYDRTSVLHVLTKKGRVTgVDTDKGQIECQYFVNCAGQWAYEL 247
Cdd:TIGR01377 156 EAHGATVRDGTKVVEIEPTELLVT-VKTTKGSYQANKLVVTAGAWTSKL 203
glpA PRK11101
anaerobic glycerol-3-phosphate dehydrogenase subunit A;
39-243 1.66e-07

anaerobic glycerol-3-phosphate dehydrogenase subunit A;


Pssm-ID: 236847 [Multi-domain]  Cd Length: 546  Bit Score: 55.02  E-value: 1.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  39 PAQAQVVICGGGIMGTSVAYHLSKMGWqDIVLLEQGRLAAGSTRFCAGIL-STARHSSIEQKMAD---YSNKLY-----H 109
Cdd:PRK11101   4 SQETDVIIIGGGATGAGIARDCALRGL-RCILVERHDIATGATGRNHGLLhSGARYAVTDAESAReciSENQILkriarH 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 110 QLEQETGIqtgylrtgSISLAQtqDRLISLKRINSRLNVVGIPSEIISPKKVAELHPLLNvHDLVGAMHVPEDAV----V 185
Cdd:PRK11101  83 CVEPTDGL--------FITLPE--DDLAFQATFIRACEEAGIEAEAIDPQQALILEPAVN-PALIGAVKVPDGTVdpfrL 151

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157818167 186 SSADVALALasaasQNGVQIYDRTSVLHVLTKKGRVTGV---DTDKGQ---IECQYFVNCAGQW 243
Cdd:PRK11101 152 TAANMLDAK-----EHGAQILTYHEVTGLIREGDTVCGVrvrDHLTGEtqeIHAPVVVNAAGIW 210
PRK11728 PRK11728
L-2-hydroxyglutarate oxidase;
44-241 2.50e-07

L-2-hydroxyglutarate oxidase;


Pssm-ID: 183292 [Multi-domain]  Cd Length: 393  Bit Score: 54.06  E-value: 2.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  44 VVICGGGIMGTSVAYHLSK-MGWQDIVLLE-QGRLAAGSTRFCAGILstarHS-------SIEQKMADYSNKLYHQLEQE 114
Cdd:PRK11728   5 FVIIGGGIVGLSTAMQLQErYPGARIAVLEkESGPARHQTGHNSGVI----HAgvyytpgSLKARFCRRGNEATKAFCDQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 115 TGIqtGYLRTGSISLAQTQDRLISLKRINSRLNVVGIPSEIISPKKVAELHPllNVHDLvGAMHVPEDAVVSSADVALAL 194
Cdd:PRK11728  81 HGI--PYEECGKLLVATSELELERMEALYERARANGIEVERLDAEELREREP--NIRGL-GAIFVPSTGIVDYRAVAEAM 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 157818167 195 ASAASQNGVQIYDRTSVLHVLTKKGRVTgVDTDKGQIECQYFVNCAG 241
Cdd:PRK11728 156 AELIQARGGEIRLGAEVTALDEHANGVV-VRTTQGEYEARTLINCAG 201
PRK00711 PRK00711
D-amino acid dehydrogenase;
43-292 4.95e-07

D-amino acid dehydrogenase;


Pssm-ID: 234819 [Multi-domain]  Cd Length: 416  Bit Score: 52.88  E-value: 4.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  43 QVVICGGGIMGTSVAYHLSKMGWQDIVLLEQGRLA-------AG--STRFCA-----GILSTA------RHS-------- 94
Cdd:PRK00711   2 RVVVLGSGVIGVTSAWYLAQAGHEVTVIDRQPGPAletsfanAGqiSPGYAApwaapGVPLKAikwlfqRHAplairpdg 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  95 SIEQ-----KM-------------------ADYSNKLYHQLEQETGIQTGYLRTGSISLAQTQDRLISLKRINSRLNVVG 150
Cdd:PRK00711  82 DPFQlrwmwQMlrnctasryavnksrmvrlAEYSRDCLKALRAETGIQYEGRQGGTLQLFRTQQQLDAAAKDIAVLEEAG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 151 IPSEIISPKKVAELHP-LLNV-HDLVGAMHVPEDAV-------VSSADvalalasAASQNGVQIYDRTSVLHVLTKKGRV 221
Cdd:PRK00711 162 VPYELLDRDELAAVEPaLAGVrHKLVGGLRLPNDETgdcqlftQRLAA-------MAEQLGVKFRFNTPVDGLLVEGGRI 234

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157818167 222 TGVDTDKGQIECQYFVNCAGQWAYEL--GLSSEEPVsIPLHAcehfYLLTRPCDAPLQSSTPTVVDADGRIYI 292
Cdd:PRK00711 235 TGVQTGGGVITADAYVVALGSYSTALlkPLGVDIPV-YPLKG----YSLTVPITDEDRAPVSTVLDETYKIAI 302
solA PRK11259
N-methyl-L-tryptophan oxidase;
44-247 2.33e-06

N-methyl-L-tryptophan oxidase;


Pssm-ID: 236887 [Multi-domain]  Cd Length: 376  Bit Score: 50.60  E-value: 2.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167  44 VVICGGGIMGTSVAYHLSKMGwQDIVLLEQGRL--AAGS----TRfcagILstaRHSSIEQkmADY------SNKLYHQL 111
Cdd:PRK11259   6 VIVIGLGSMGSAAGYYLARRG-LRVLGLDRFMPphQQGSshgdTR----II---RHAYGEG--PAYvplvlrAQELWREL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818167 112 EQETGiQTGYLRTGSISLAQTQDRLISLKRINSRLNvvGIPSEIISPKKVAELHPLLNVHDlvGAMHV---------PED 182
Cdd:PRK11259  76 ERESG-EPLFVRTGVLNLGPADSDFLANSIRSARQH--GLPHEVLDAAEIRRRFPQFRLPD--GYIALfepdggflrPEL 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157818167 183 AVVSSADValalasaASQNGVQIYDRTSVLHVLTKKGRVTgVDTDKGQIECQYFVNCAGQWAYEL 247
Cdd:PRK11259 151 AIKAHLRL-------AREAGAELLFNEPVTAIEADGDGVT-VTTADGTYEAKKLVVSAGAWVKDL 207
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 44-74 2.32e-03

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 41.36  E-value: 2.32e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 157818167  44 VVICGGGIMGTSVAYHLSKMGwQDIVLLEQG 74
Cdd:COG1232    4 VAVIGGGIAGLTAAYRLAKAG-HEVTVLEAS 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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