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    Dus1 Dihydrouridine synthase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33190, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dus1provided by FlyBase
    Official Full Name
    Dihydrouridine synthase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0031238
    Locus tag
    Dmel_CG3645
    See related
    AllianceGenome:FB:FBgn0031238
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3645; Dmel\CG3645
    Summary
    Predicted to enable tRNA-dihydrouridine16 synthase activity and tRNA-dihydrouridine17 synthase activity. Predicted to be involved in tRNA processing. Is expressed in organism. Orthologous to human DUS1L (dihydrouridine synthase 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Dus1 in Genome Data Viewer
    Location:
    21B5-21B7; 2-0.5 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (252589..271744, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (252589..271744, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene kismet Neighboring gene long non-coding RNA:CR44218 Neighboring gene RNaseP protein p30 Neighboring gene long non-coding RNA:CR44219 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mushroom body miniature

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding  
    enables tRNA dihydrouridine synthase activity  
    enables tRNA dihydrouridine synthase activity  
    enables tRNA-dihydrouridine16 synthase activity  
    enables tRNA-dihydrouridine17 synthase activity  
    Process Evidence Code Pubs
    involved_in tRNA processing  

    General protein information

    Preferred Names
    dihydrouridine synthase 1
    Names
    CG3645-PA
    CG3645-PB
    CG3645-PC
    Dus1-PA
    Dus1-PB
    Dus1-PC
    NP_001259809.1
    NP_608507.1
    NP_722619.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      252589..271744 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134663.4 → NP_608507.1  dihydrouridine synthase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608507.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960P2, Q9VPM1
      Related
      FBpp0077799
      Conserved Domains (3) summary
      TIGR01623
      Location:426 → 460
      put_zinc_LRP1; putative zinc finger domain, LRP1 type
      cd02801
      Location:29 → 259
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      pfam01207
      Location:31 → 303
      Dus; Dihydrouridine synthase (Dus)
    2. NM_164377.3 → NP_722619.1  dihydrouridine synthase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722619.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960P2, Q9VPM1
      Related
      FBpp0077800
      Conserved Domains (3) summary
      TIGR01623
      Location:426 → 460
      put_zinc_LRP1; putative zinc finger domain, LRP1 type
      cd02801
      Location:29 → 259
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      pfam01207
      Location:31 → 303
      Dus; Dihydrouridine synthase (Dus)
    3. NM_001272880.1 → NP_001259809.1  dihydrouridine synthase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259809.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960P2, Q9VPM1
      Conserved Domains (3) summary
      TIGR01623
      Location:426 → 460
      put_zinc_LRP1; putative zinc finger domain, LRP1 type
      cd02801
      Location:29 → 259
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      pfam01207
      Location:31 → 303
      Dus; Dihydrouridine synthase (Dus)
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