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Hn Henna [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38871, updated on 4-Jan-2025

Summary

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Official Symbol
Hnprovided by FlyBase
Official Full Name
Hennaprovided by FlyBase
Primary source
FLYBASE:FBgn0001208
Locus tag
Dmel_CG7399
See related
AllianceGenome:FB:FBgn0001208
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
bu; CG7399; Dmel\CG7399; DTPH; DTPHu; pah; Pah; PAH; Tph; TpH; TPH; Trh; TRH
Summary
Enables phenylalanine 4-monooxygenase activity and tryptophan 5-monooxygenase activity. Involved in several processes, including aromatic amino acid metabolic process; dopamine biosynthetic process; and long-term memory. Is expressed in several structures, including aminergic neurons; brain; ellipsoid body; embryonic/larval fat body; and head. Used to study phenylketonuria. Human ortholog(s) of this gene implicated in intellectual disability and phenylketonuria. Orthologous to human PAH (phenylalanine hydroxylase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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Location:
66A12-66A12; 3-21 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7760453..7763166)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7753553..7756266)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Clock Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A comparative study of Drosophila phenylalanine hydroxylase with a natural and a synthetic tetrahydropterin as cofactor. Bel Y, et al. Comp Biochem Physiol B, 1992 Nov. PMID 1458831
  2. Structure of the phenylalanine hydroxylase gene in Drosophila melanogaster and evidence of alternative promoter usage. Ruiz-Vázquez P, et al. Biochem Biophys Res Commun, 1996 Aug 5. PMID 8769124
  3. Aberrant splicing of the Drosophila melanogaster phenylalanine hydroxylase pre-mRNA caused by the insertion of a B104/roo transposable element in the Henna locus. Ruiz-Vázquez P, et al. Insect Biochem Mol Biol, 1999 Apr. PMID 10333570
  4. Commensal bacteria and essential amino acids control food choice behavior and reproduction. Leitão-Gonçalves R, et al. PLoS Biol, 2017 Apr. PMID 28441450, Free PMC Article
  5. The quantitative relations between variation in red eye pigment and related pteridine compounds in Drosophila melanogaster. Barthelmess IB, et al. Genet Res, 1970 Feb. PMID 5415228

See all (104) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen IEA
Inferred from Electronic Annotation
more info
  
enables phenylalanine 4-monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phenylalanine 4-monooxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phenylalanine 4-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables phenylalanine 4-monooxygenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables tryptophan 5-monooxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tryptophan 5-monooxygenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-phenylalanine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-phenylalanine catabolic process IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in L-phenylalanine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in aromatic amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in dopamine biosynthetic process IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in eye pigment biosynthetic process IDA
Inferred from Direct Assay
more info
  
acts_upstream_of germ-band extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in long-term memory IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in serotonin biosynthetic process from tryptophan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tyrosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
henna
Names
CG7399-PA
CG7399-PB
CG7399-PC
CG7399-PD
Hn-PA
Hn-PB
Hn-PC
Hn-PD
Phenylalanine-hydroxylase
brunette
phenylalanine hydroxylase
phenylalanine-tryptophan hydroxylase
tryptophan hydrolase
tryptophan hydroxylase
NP_001014573.1
NP_001261542.1
NP_001261543.1
NP_523963.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    7760453..7763166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079239.4 → NP_523963.2  henna, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523963.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46110, P17276, Q27599, Q27600
    UniProtKB/TrEMBL
    B0LQU2, M9PBV1
    Related
    FBpp0076523
    Conserved Domains (3) summary
    TIGR01268
    Location:15 → 451
    Phe4hydrox_tetr; phenylalanine-4-hydroxylase, tetrameric form
    cd04904
    Location:32 → 107
    ACT_AAAH; ACT domain of the nonheme iron-dependent, aromatic amino acid hydroxylases (AAAH)
    pfam00351
    Location:118 → 447
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase

  2. NM_001274614.1 → NP_001261543.1  henna, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261543.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E8NH57
    Conserved Domains (1) summary
    cl01244
    Location:1 → 173
    arom_aa_hydroxylase; Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan ...

  3. NM_001274613.1 → NP_001261542.1  henna, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261542.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46110, P17276, Q27599, Q27600
    UniProtKB/TrEMBL
    B0LQU2, M9PBV1
    Conserved Domains (3) summary
    TIGR01268
    Location:15 → 451
    Phe4hydrox_tetr; phenylalanine-4-hydroxylase, tetrameric form
    cd04904
    Location:32 → 107
    ACT_AAAH; ACT domain of the nonheme iron-dependent, aromatic amino acid hydroxylases (AAAH)
    pfam00351
    Location:118 → 447
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase

  4. NM_001014573.2 → NP_001014573.1  henna, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014573.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0IN41, Q59E23
    Conserved Domains (3) summary
    TIGR01268
    Location:10 → 446
    Phe4hydrox_tetr; phenylalanine-4-hydroxylase, tetrameric form
    cd04904
    Location:27 → 102
    ACT_AAAH; ACT domain of the nonheme iron-dependent, aromatic amino acid hydroxylases (AAAH)
    pfam00351
    Location:113 → 442
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E8NH57 E8NH57
M9PBV1 M9PBV1
P17276.3 P17276
Q59E23 Q59E23

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