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    Act57B Actin 57B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37368, updated on 17-Dec-2024

    Summary

    Official Symbol
    Act57Bprovided by FlyBase
    Official Full Name
    Actin 57Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000044
    Locus tag
    Dmel_CG10067
    See related
    AllianceGenome:FB:FBgn0000044
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    act 57A; ACT3; Act57; act57A; Act57A; act57b; act57B; Act57b; actin; Actin; actin-57B; Actin-57B; anon-EST:CL2c12; ArpE; BEST:RE38067; C; CG10067; CG30294; chr2R:16452771..16452966; Dmel\CG10067; M; T10
    Summary
    Involved in ovarian fusome organization and regulation of synapse organization. Located in plasma membrane. Is expressed in several structures, including adult head; adult heart; border follicle cell; dorsal vessel; and larval muscle cell. Used to study hypertrophic cardiomyopathy and hypertrophic cardiomyopathy 11. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome 1 and thrombocytopenia. Orthologous to human ACTB (actin beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Act57B in Genome Data Viewer
    Location:
    57B5-57B5; 2-92 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20944021..20946431)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16831526..16833936)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Carbonic anhydrase 15 Neighboring gene Retinal Homeobox Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene homeobrain

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    is_active_in actin cytoskeleton  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    actin 57B
    Names
    Act57B-PA
    Actin-57B
    CG10067-PA
    F-actin
    actin
    actin57B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20944021..20946431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079076.4 → NP_523800.1  actin 57B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523800.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P53501, Q9W2Q0
      UniProtKB/TrEMBL
      C6TP14, C8VV69
      Related
      FBpp0071448
      Conserved Domains (1) summary
      PTZ00281
      Location:1 → 376
      PTZ00281; actin; Provisional
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