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    Kank3 KN motif and ankyrin repeat domains 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366848, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kank3provided by RGD
    Official Full Name
    KN motif and ankyrin repeat domains 3provided by RGD
    Primary source
    RGD:1308853
    See related
    EnsemblRapid:ENSRNOG00000007230 AllianceGenome:RGD:1308853
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ankrd47; RGD1308853
    Summary
    Predicted to be involved in negative regulation of actin filament polymerization. Predicted to be active in cytoplasm and cytoskeleton. Orthologous to human KANK3 (KN motif and ankyrin repeat domains 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 262.6), Testes (RPKM 130.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kank3 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (15296538..15309838)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (14594358..14607675)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (18668665..18681945)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene angiopoietin-like 4 Neighboring gene uncharacterized LOC134479827 Neighboring gene ribosomal protein S28 Neighboring gene NADH:ubiquinone oxidoreductase subunit A7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    KN motif and ankyrin repeat domain-containing protein 3
    Names
    ankyrin repeat domain 47

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108989.1 → NP_001102459.1  KN motif and ankyrin repeat domain-containing protein 3

      See identical proteins and their annotated locations for NP_001102459.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474088
      UniProtKB/TrEMBL
      A0A8I6AQY0, B2RYN8
      Related
      ENSRNOP00000096794.2, ENSRNOT00000120241.2
      Conserved Domains (5) summary
      cd00204
      Location:610 → 742
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12075
      Location:32 → 73
      KN_motif; KN motif
      pfam12796
      Location:654 → 753
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:604 → 657
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:615 → 647
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      15296538..15309838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079670.2 → XP_038935598.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X2

      Conserved Domains (1) summary
      pfam12075
      Location:32 → 73
      KN_motif; KN motif

    2. XM_039079671.2 → XP_038935599.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X3

      Conserved Domains (1) summary
      pfam12075
      Location:32 → 73
      KN_motif; KN motif

    3. XM_008765202.3 → XP_008763424.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQY0, F7FCJ4
      Related
      ENSRNOP00000009532.6, ENSRNOT00000009532.8
      Conserved Domains (5) summary
      cd00204
      Location:620 → 752
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12075
      Location:32 → 73
      KN_motif; KN motif
      pfam12796
      Location:664 → 763
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:614 → 667
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:625 → 657
      ANK; ANK repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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