NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958790792|ref|XP_038935598|]
View 

KN motif and ankyrin repeat domain-containing protein 3 isoform X2 [Rattus norvegicus]

Protein Classification

KN_motif domain-containing protein( domain architecture ID 10572546)

KN_motif domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
 32-73 7.65e-17

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


:

Pssm-ID: 432311  Cd Length: 39  Bit Score: 74.31  E-value: 7.65e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1958790792  32 PYSVETPYGFHLDLDFLKYVEEIERGPASRRApgpPHARRPR 73
Cdd:pfam12075   1 PYSVETPYGFHLDLDFLKYVEDIESGQTIRRA---RVQRRPR 39
COG4913 super family cl25907
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
129-322 9.30e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


The actual alignment was detected with superfamily member COG4913:

Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.21  E-value: 9.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790792  129 VEH--TLLETSRRLEQAQAQERALSPARAATRSpRGSGRSSPAPNPALASPSPVLAspGPAQLQLVREQMAVALRRLREL 206
Cdd:COG4913    231 VEHfdDLERAHEALEDAREQIELLEPIRELAER-YAAARERLAELEYLRAALRLWF--AQRRLELLEAELEELRAELARL 307

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790792  207 EDQARALP----ELQEQVRALRAEKARLLAGRVQP-EQDVEievrpDKLSQLRRLTERLATSDRGVRSRASPRAEDPDGL 281
Cdd:COG4913    308 EAELERLEarldALREELDELEAQIRGNGGDRLEQlEREIE-----RLERELEERERRRARLEALLAALGLPLPASAEEF 382

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1958790792  282 AARRSEGALQVLDPASRTPDGEPQTREAGTEVVPETREVDA 322
Cdd:COG4913    383 AALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRE 423
 
Name Accession Description Interval E-value
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
 32-73 7.65e-17

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


Pssm-ID: 432311  Cd Length: 39  Bit Score: 74.31  E-value: 7.65e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1958790792  32 PYSVETPYGFHLDLDFLKYVEEIERGPASRRApgpPHARRPR 73
Cdd:pfam12075   1 PYSVETPYGFHLDLDFLKYVEDIESGQTIRRA---RVQRRPR 39
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
129-322 9.30e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.21  E-value: 9.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790792  129 VEH--TLLETSRRLEQAQAQERALSPARAATRSpRGSGRSSPAPNPALASPSPVLAspGPAQLQLVREQMAVALRRLREL 206
Cdd:COG4913    231 VEHfdDLERAHEALEDAREQIELLEPIRELAER-YAAARERLAELEYLRAALRLWF--AQRRLELLEAELEELRAELARL 307

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790792  207 EDQARALP----ELQEQVRALRAEKARLLAGRVQP-EQDVEievrpDKLSQLRRLTERLATSDRGVRSRASPRAEDPDGL 281
Cdd:COG4913    308 EAELERLEarldALREELDELEAQIRGNGGDRLEQlEREIE-----RLERELEERERRRARLEALLAALGLPLPASAEEF 382

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1958790792  282 AARRSEGALQVLDPASRTPDGEPQTREAGTEVVPETREVDA 322
Cdd:COG4913    383 AALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRE 423
 
Name Accession Description Interval E-value
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
 32-73 7.65e-17

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


Pssm-ID: 432311  Cd Length: 39  Bit Score: 74.31  E-value: 7.65e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1958790792  32 PYSVETPYGFHLDLDFLKYVEEIERGPASRRApgpPHARRPR 73
Cdd:pfam12075   1 PYSVETPYGFHLDLDFLKYVEDIESGQTIRRA---RVQRRPR 39
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
129-322 9.30e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.21  E-value: 9.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790792  129 VEH--TLLETSRRLEQAQAQERALSPARAATRSpRGSGRSSPAPNPALASPSPVLAspGPAQLQLVREQMAVALRRLREL 206
Cdd:COG4913    231 VEHfdDLERAHEALEDAREQIELLEPIRELAER-YAAARERLAELEYLRAALRLWF--AQRRLELLEAELEELRAELARL 307

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790792  207 EDQARALP----ELQEQVRALRAEKARLLAGRVQP-EQDVEievrpDKLSQLRRLTERLATSDRGVRSRASPRAEDPDGL 281
Cdd:COG4913    308 EAELERLEarldALREELDELEAQIRGNGGDRLEQlEREIE-----RLERELEERERRRARLEALLAALGLPLPASAEEF 382

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1958790792  282 AARRSEGALQVLDPASRTPDGEPQTREAGTEVVPETREVDA 322
Cdd:COG4913    383 AALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRE 423
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 196-329 5.16e-03

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 39.75  E-value: 5.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790792 196 MAVALRRLRELEDQARALPELQEQVRALRAEKARLLAGRVQPEQ---DVEIEVRPDKLSQLRRLTERLATSDrGVRSRAS 272
Cdd:COG2409   374 LALPALGLRLGLPDADSLPADSPSRQGYDALAEHFPPGSNGPLTvvvESDDDLDPADLAALDALAAALAAVP-GVASVQP 452

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958790792 273 P-RAEDPDGLAARrsegaLQVldpasrTPDGEPQTREAgTEVVPETREVDAQAVPETR 329
Cdd:COG2409   453 PtRPEGTDGDAAR-----LQV------VPDGDPDSPEA-IDLVDRLRDAAAPALEGAE 498
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
137-366 8.36e-03

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 38.84  E-value: 8.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790792 137 SRRLEQAQAQERALSPARAATRSPRGSGRSSPAPNPALASPSPVLASPGPAqlqlvREQMAVALRRLRELEDQARALPEL 216
Cdd:COG0515   252 EERYQSAAELAAALRAVLRSLAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-----AAAAAAAAAAAAAAAAAAAAPAAA 326

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790792 217 QEQVRALRAEKARLLAGRVQPEQDVEIEVRPDKLSQLRRLTERLATSDRGVRSRASPRAEDPDGLAARRSEGALQVLDPA 296
Cdd:COG0515   327 AAAAAAAAALAAAAAAAAAAAAAALLAAAAALAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAAAAAAAAAAALAAAAAA 406

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790792 297 SRTPDGEPQTREAGTEVVPETREVDAQAVPETREAGVEVVPETVEVDTWVTEALLGLPEAAERELELLRT 366
Cdd:COG0515   407 AAAAAAAAAAAAALAAAAAAAAAAAAAAAAAAAAAARLLAAAAAAAAAAAAAPLLAALLAAAALAAAAAA 476
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH