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Conserved domains on  [gi|1958790794|ref|XP_038935599|]
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KN motif and ankyrin repeat domain-containing protein 3 isoform X3 [Rattus norvegicus]

Protein Classification

KN_motif domain-containing protein( domain architecture ID 10572546)

KN_motif domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
32-73 1.11e-16

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


:

Pssm-ID: 432311  Cd Length: 39  Bit Score: 73.54  E-value: 1.11e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1958790794  32 PYSVETPYGFHLDLDFLKYVEEIERGPASRRApgpPHARRPR 73
Cdd:pfam12075   1 PYSVETPYGFHLDLDFLKYVEDIESGQTIRRA---RVQRRPR 39
COG4913 super family cl25907
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
129-322 1.85e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


The actual alignment was detected with superfamily member COG4913:

Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.44  E-value: 1.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790794  129 VEH--TLLETSRRLEQAQAQERALSPARAATRSpRGSGRSSPAPNPALASPSPVLAspGPAQLQLVREQMAVALRRLREL 206
Cdd:COG4913    231 VEHfdDLERAHEALEDAREQIELLEPIRELAER-YAAARERLAELEYLRAALRLWF--AQRRLELLEAELEELRAELARL 307
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790794  207 EDQARALP----ELQEQVRALRAEKARLLAGRVQP-EQDVEievrpDKLSQLRRLTERLATSDRGVRSRASPRAEDPDGL 281
Cdd:COG4913    308 EAELERLEarldALREELDELEAQIRGNGGDRLEQlEREIE-----RLERELEERERRRARLEALLAALGLPLPASAEEF 382
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1958790794  282 AARRSEGALQVLDPASRTPDGEPQTREAGTEVVPETREVDA 322
Cdd:COG4913    383 AALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRE 423
 
Name Accession Description Interval E-value
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
32-73 1.11e-16

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


Pssm-ID: 432311  Cd Length: 39  Bit Score: 73.54  E-value: 1.11e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1958790794  32 PYSVETPYGFHLDLDFLKYVEEIERGPASRRApgpPHARRPR 73
Cdd:pfam12075   1 PYSVETPYGFHLDLDFLKYVEDIESGQTIRRA---RVQRRPR 39
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
129-322 1.85e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.44  E-value: 1.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790794  129 VEH--TLLETSRRLEQAQAQERALSPARAATRSpRGSGRSSPAPNPALASPSPVLAspGPAQLQLVREQMAVALRRLREL 206
Cdd:COG4913    231 VEHfdDLERAHEALEDAREQIELLEPIRELAER-YAAARERLAELEYLRAALRLWF--AQRRLELLEAELEELRAELARL 307
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790794  207 EDQARALP----ELQEQVRALRAEKARLLAGRVQP-EQDVEievrpDKLSQLRRLTERLATSDRGVRSRASPRAEDPDGL 281
Cdd:COG4913    308 EAELERLEarldALREELDELEAQIRGNGGDRLEQlEREIE-----RLERELEERERRRARLEALLAALGLPLPASAEEF 382
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1958790794  282 AARRSEGALQVLDPASRTPDGEPQTREAGTEVVPETREVDA 322
Cdd:COG4913    383 AALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRE 423
 
Name Accession Description Interval E-value
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
32-73 1.11e-16

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


Pssm-ID: 432311  Cd Length: 39  Bit Score: 73.54  E-value: 1.11e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1958790794  32 PYSVETPYGFHLDLDFLKYVEEIERGPASRRApgpPHARRPR 73
Cdd:pfam12075   1 PYSVETPYGFHLDLDFLKYVEDIESGQTIRRA---RVQRRPR 39
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
129-322 1.85e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.44  E-value: 1.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790794  129 VEH--TLLETSRRLEQAQAQERALSPARAATRSpRGSGRSSPAPNPALASPSPVLAspGPAQLQLVREQMAVALRRLREL 206
Cdd:COG4913    231 VEHfdDLERAHEALEDAREQIELLEPIRELAER-YAAARERLAELEYLRAALRLWF--AQRRLELLEAELEELRAELARL 307
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790794  207 EDQARALP----ELQEQVRALRAEKARLLAGRVQP-EQDVEievrpDKLSQLRRLTERLATSDRGVRSRASPRAEDPDGL 281
Cdd:COG4913    308 EAELERLEarldALREELDELEAQIRGNGGDRLEQlEREIE-----RLERELEERERRRARLEALLAALGLPLPASAEEF 382
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1958790794  282 AARRSEGALQVLDPASRTPDGEPQTREAGTEVVPETREVDA 322
Cdd:COG4913    383 AALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRE 423
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
196-329 5.96e-03

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 39.36  E-value: 5.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790794 196 MAVALRRLRELEDQARALPELQEQVRALRAEKARLLAGRVQPEQ---DVEIEVRPDKLSQLRRLTERLATSDrGVRSRAS 272
Cdd:COG2409   374 LALPALGLRLGLPDADSLPADSPSRQGYDALAEHFPPGSNGPLTvvvESDDDLDPADLAALDALAAALAAVP-GVASVQP 452
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958790794 273 P-RAEDPDGLAARrsegaLQVldpasrTPDGEPQTREAgTEVVPETREVDAQAVPETR 329
Cdd:COG2409   453 PtRPEGTDGDAAR-----LQV------VPDGDPDSPEA-IDLVDRLRDAAAPALEGAE 498
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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