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    sli slit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36746, updated on 17-Dec-2024

    Summary

    Official Symbol
    sliprovided by FlyBase
    Official Full Name
    slitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264089
    Locus tag
    Dmel_CG43758
    See related
    AllianceGenome:FB:FBgn0264089
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG33464; CG43758; CG8355; CT21700; CT37068; Dmel\CG43758; dSlit; fus3; l(2)05248; Sli; Slit; wdh
    Old locus tag
    Dmel_CG33464; Dmel_CG8355
    Summary
    Enables Roundabout binding activity and heparin binding activity. Involved in several processes, including heart development; neurogenesis; and regulation of cell migration. Located in axon; cell surface; and extracellular region. Part of Slit-Robo signaling complex. Is expressed in several structures, including central nervous system; ganglia; glial cell; larval multidendritic neurons; and tract. Orthologous to human SLIT1 (slit guidance ligand 1); SLIT2 (slit guidance ligand 2); and SLIT3 (slit guidance ligand 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See sli in Genome Data Viewer
    Location:
    52C9-52D2; 2-76 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15869495..15922118, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11757000..11809623, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Glycerophosphate oxidase 1 Neighboring gene Rap1 interacting factor 1 Neighboring gene antisense RNA:CR46471 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44373 Neighboring gene bedraggled Neighboring gene Death-associated inhibitor of apoptosis 2 Neighboring gene bunker gear

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Roundabout binding  
    enables Roundabout binding PubMed 
    enables calcium ion binding  
    enables heparin binding  
    enables heparin binding PubMed 
    Process Evidence Code Pubs
    involved_in Roundabout signaling pathway PubMed 
    involved_in axon guidance  
    involved_in axon guidance PubMed 
    involved_in axon guidance PubMed 
    involved_in axon guidance PubMed 
    involved_in axon midline choice point recognition PubMed 
    involved_in axon midline choice point recognition PubMed 
    involved_in dendrite morphogenesis PubMed 
    involved_in digestive tract mesoderm development PubMed 
    involved_in embryonic heart tube development PubMed 
    involved_in epithelial cell migration, open tracheal system PubMed 
    involved_in glial cell migration PubMed 
    involved_in gonad development PubMed 
    involved_in induction of negative chemotaxis PubMed 
    involved_in mesoderm migration involved in gastrulation PubMed 
    involved_in mesodermal cell migration PubMed 
    involved_in neuron differentiation PubMed 
    involved_in neuron migration PubMed 
    involved_in outflow tract morphogenesis PubMed 
    involved_in positive regulation of cell migration PubMed 
    involved_in positive regulation of cell-cell adhesion PubMed 
    involved_in regulation of epithelial cell migration PubMed 
    involved_in regulation of epithelial cell migration, open tracheal system PubMed 
    involved_in salivary gland boundary specification PubMed 
    involved_in synaptic target inhibition PubMed 
    Component Evidence Code Pubs
    part_of Slit-Robo signaling complex PubMed 
    located_in axon PubMed 
    located_in cell surface PubMed 
    located_in extracellular region PubMed 

    General protein information

    Preferred Names
    slit
    Names
    CG43758-PA
    CG43758-PB
    CG43758-PC
    CG43758-PD
    CG43758-PE
    CG43758-PF
    SGP cluster fusion defects 3
    lethal (2) 05248
    sli-PA
    sli-PB
    sli-PC
    sli-PD
    sli-PE
    sli-PF

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15869495..15922118 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103863.3 → NP_001097333.1  slit, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097333.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1NZD5
      Conserved Domains (12) summary
      smart00370
      Location:813 → 836
      LRR; Leucine-rich repeats, outliers
      smart00013
      Location:518 → 550
      LRRNT; Leucine rich repeat N-terminal domain
      smart00041
      Location:1411 → 1480
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00082
      Location:653 → 702
      LRRCT; Leucine rich repeat C-terminal domain
      cd00054
      Location:1064 → 1100
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00116
      Location:550 → 654
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:444 → 456
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:83 → 104
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00008
      Location:911 → 942
      EGF; EGF-like domain
      pfam00054
      Location:1180 → 1311
      Laminin_G_1; Laminin G domain
      pfam12799
      Location:347 → 387
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:766 → 826
      LRR_8; Leucine rich repeat
    2. NM_057380.4 → NP_476728.1  slit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476728.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1NZD5
      Related
      FBpp0303573
      Conserved Domains (12) summary
      smart00370
      Location:813 → 836
      LRR; Leucine-rich repeats, outliers
      smart00013
      Location:518 → 550
      LRRNT; Leucine rich repeat N-terminal domain
      smart00041
      Location:1411 → 1480
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00082
      Location:653 → 702
      LRRCT; Leucine rich repeat C-terminal domain
      cd00054
      Location:1064 → 1100
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00116
      Location:550 → 654
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:444 → 456
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:83 → 104
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00008
      Location:911 → 942
      EGF; EGF-like domain
      pfam00054
      Location:1180 → 1311
      Laminin_G_1; Laminin G domain
      pfam12799
      Location:347 → 387
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:766 → 826
      LRR_8; Leucine rich repeat
    3. NM_057379.4 → NP_476727.1  slit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476727.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8DYF5, A8DYF6, P24014, Q24526, Q8MLB9, Q9V7F8, Q9V7F9, Q9XYV4
      UniProtKB/TrEMBL
      F0JAL2
      Related
      FBpp0303575
      Conserved Domains (11) summary
      smart00369
      Location:837 → 860
      LRR_TYP; Leucine-rich repeats, typical (most populated) subfamily
      smart00013
      Location:542 → 574
      LRRNT; Leucine rich repeat N-terminal domain
      smart00041
      Location:1435 → 1504
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00082
      Location:677 → 726
      LRRCT; Leucine rich repeat C-terminal domain
      cd00054
      Location:1088 → 1124
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00116
      Location:119 → 259
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:83 → 104
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00008
      Location:935 → 966
      EGF; EGF-like domain
      pfam00054
      Location:1204 → 1335
      Laminin_G_1; Laminin G domain
      pfam12799
      Location:371 → 411
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:790 → 850
      LRR_8; Leucine rich repeat
    4. NM_001274088.1 → NP_001261017.1  slit, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261017.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KES0
      Conserved Domains (11) summary
      smart00013
      Location:542 → 574
      LRRNT; Leucine rich repeat N-terminal domain
      smart00041
      Location:1435 → 1504
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00082
      Location:677 → 726
      LRRCT; Leucine rich repeat C-terminal domain
      cd00054
      Location:1088 → 1124
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00116
      Location:119 → 259
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:468 → 480
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:83 → 104
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00008
      Location:935 → 966
      EGF; EGF-like domain
      pfam00054
      Location:1204 → 1335
      Laminin_G_1; Laminin G domain
      pfam12799
      Location:371 → 411
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:790 → 850
      LRR_8; Leucine rich repeat
    5. NM_057381.4 → NP_476729.1  slit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476729.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1NZD5
      Related
      FBpp0303574
      Conserved Domains (11) summary
      smart00370
      Location:813 → 836
      LRR; Leucine-rich repeats, outliers
      smart00013
      Location:518 → 550
      LRRNT; Leucine rich repeat N-terminal domain
      smart00041
      Location:1400 → 1469
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00082
      Location:653 → 702
      LRRCT; Leucine rich repeat C-terminal domain
      cd00054
      Location:1064 → 1100
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00116
      Location:550 → 654
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:83 → 104
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00008
      Location:911 → 942
      EGF; EGF-like domain
      pfam00054
      Location:1180 → 1311
      Laminin_G_1; Laminin G domain
      pfam12799
      Location:347 → 387
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:766 → 826
      LRR_8; Leucine rich repeat
    6. NM_001103864.3 → NP_001097334.1  slit, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097334.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8DYF5, A8DYF6, P24014, Q24526, Q8MLB9, Q9V7F8, Q9V7F9, Q9XYV4
      UniProtKB/TrEMBL
      F0JAL2
      Conserved Domains (11) summary
      smart00369
      Location:837 → 860
      LRR_TYP; Leucine-rich repeats, typical (most populated) subfamily
      smart00013
      Location:542 → 574
      LRRNT; Leucine rich repeat N-terminal domain
      smart00041
      Location:1435 → 1504
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00082
      Location:677 → 726
      LRRCT; Leucine rich repeat C-terminal domain
      cd00054
      Location:1088 → 1124
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00116
      Location:119 → 259
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:83 → 104
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00008
      Location:935 → 966
      EGF; EGF-like domain
      pfam00054
      Location:1204 → 1335
      Laminin_G_1; Laminin G domain
      pfam12799
      Location:371 → 411
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:790 → 850
      LRR_8; Leucine rich repeat
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