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Abl Abl tyrosine kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45821, updated on 9-Dec-2024

Summary

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Official Symbol
Ablprovided by FlyBase
Official Full Name
Abl tyrosine kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0000017
Locus tag
Dmel_CG4032
See related
AllianceGenome:FB:FBgn0000017
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
4674; abl; ABL; abl1; Abl1; Ableson; AblK; Am ABL; c-abl; C-abl; cAbl; CG4032; D-abl; D-Abl; D-ash; dAbl; Dabl; DAbl; Dash; Ddash/abl; Dmel\CG4032; DROTKABL3; Dsrc7; l(3)04674; l(3)73Ba; l(3)c-abl
Summary
Enables non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including embryonic morphogenesis; generation of neurons; and regulation of plasma membrane bounded cell projection organization. Located in apical cortex; axon; and cytosol. Is extrinsic component of cytoplasmic side of plasma membrane. Colocalizes with cell-cell junction and muscle tendon junction. Is expressed in several structures, including adult brain; adult brain cell body rind; adult mushroom body; ovary; and presumptive embryonic/larval central nervous system. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple) and leukemia (multiple). Orthologous to human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) and ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Abl in Genome Data Viewer
Location:
73B1-73B4; 3-44 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16615866..16647882, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16608966..16640982, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45865 Neighboring gene uncharacterized protein Neighboring gene Mo25 Neighboring gene baldspot Neighboring gene small nuclear RNA U12 Neighboring gene antisense RNA:CR46033 Neighboring gene G protein alpha subunit f

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Abl signaling directs growth of a pioneer axon in Drosophila by shaping the intrinsic fluctuations of actin. Clarke A, et al. Mol Biol Cell, 2020 Mar 15. PMID 31967946, Free PMC Article
  2. Conservation of function of Drosophila melanogaster abl and murine v-abl proteins in transformation of mammalian cells. Holland GD, et al. J Virol, 1990 May. PMID 2157882, Free PMC Article
  3. Dynamic morphogenesis of a pioneer axon in Drosophila and its regulation by Abl tyrosine kinase. Clarke A, et al. Mol Biol Cell, 2020 Mar 15. PMID 31967935, Free PMC Article
  4. Multiple β-sheet molecular dynamics of amyloid formation from two ABl-SH3 domain peptides. Lapidus D, et al. Biopolymers, 2012. PMID 23203761
  5. DNA sequence, structure, and tyrosine kinase activity of the Drosophila melanogaster Abelson proto-oncogene homolog. Henkemeyer MJ, et al. Mol Cell Biol, 1988 Feb. PMID 2832740, Free PMC Article

See all (308) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Abl-interactor Abi suppresses the function of the BRAG2 GEF family member Schizo.
    Title: The Abl-interactor Abi suppresses the function of the BRAG2 GEF family member Schizo.
  2. Abelson kinase's intrinsically disordered region plays essential roles in protein function and protein stability.
    Title: Abelson kinase's intrinsically disordered region plays essential roles in protein function and protein stability.
  3. Htt is a repressor of Abl activity required for APP-induced axonal growth.
    Title: Htt is a repressor of Abl activity required for APP-induced axonal growth.
  4. Abl and Canoe/Afadin mediate mechanotransduction at tricellular junctions.
    Title: Abl and Canoe/Afadin mediate mechanotransduction at tricellular junctions.
  5. Abl signaling directs growth of a pioneer axon in Drosophila by shaping the intrinsic fluctuations of actin.
    Title: Abl signaling directs growth of a pioneer axon in Drosophila by shaping the intrinsic fluctuations of actin.
  6. Dynamic morphogenesis of a pioneer axon in Drosophila and its regulation by Abl tyrosine kinase.
    Title: Dynamic morphogenesis of a pioneer axon in Drosophila and its regulation by Abl tyrosine kinase.
  7. BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis
    Title: BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis.
  8. Notch-Abl axonal signaling requires proteolytic cleavage events that initiate canonical Notch signaling. Some Notch protein is tyrosine phosphorylated, this form of the protein is selectively associated with Disabled and Trio, and relevant tyrosines are essential for Notch-dependent axon patterning but not for canonical Notch-dependent regulation of cell fate.
    Title: Tyrosine phosphorylation and proteolytic cleavage of Notch are required for non-canonical Notch/Abl signaling in Drosophila axon guidance.
  9. The Abl tyrosine kinase signaling network controls cell migration, epithelial organization, axon patterning and other aspects of development. Abl suppresses the actin-regulatory factor Enabled, and we find that Abl also acts through the GEF Trio to stimulate the signaling activity of Rac GTPase.
    Title: The Abl pathway bifurcates to balance Enabled and Rac signaling in axon patterning in Drosophila.
  10. In conjunction with its receptor Neurotactin (Nrt) and the effector kinase Abelson tyrosine kinase (Abl), Ama is necessary in parallel to the cell-autonomous Dfd pathway for the correct specification of the maxillary identity of NB6-4
    Title: Cell-Autonomous and Non-cell-autonomous Function of Hox Genes Specify Segmental Neuroblast Identity in the Gnathal Region of the Embryonic CNS in Drosophila.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein tyrosine kinase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
involved_in axis elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon midline choice point recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axonogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in branchiomotor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in central nervous system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in learning or memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ommatidial rotation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ovarian nurse cell to oocyte transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in photoreceptor cell axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in photoreceptor cell axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of actin polymerization or depolymerization TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of adherens junction organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ventral cord development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ventral cord development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ventral furrow formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with contractile ring HDA PubMed 
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extrinsic component of cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with muscle tendon junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Abl tyrosine kinase
Names
Abl oncogene
Abl-PA
Abl-PB
Abl-PC
Abl-PD
Abl-PE
Abl-PF
Abl-PG
Abl-PH
Abl-PI
Abl-PJ
CG4032-PA
CG4032-PB
CG4032-PC
CG4032-PD
CG4032-PE
CG4032-PF
CG4032-PG
CG4032-PH
CG4032-PI
CG4032-PJ
D-abelson
abelson
abelson kinase
abelson tyrosine kinase
abl kinase
NP_001097623.1
NP_001261959.1
NP_001261960.1
NP_001261961.1
NP_001261962.1
NP_001261963.1
NP_001261964.1
NP_001261965.1
NP_001287085.1
NP_524843.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16615866..16647882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300156.1 → NP_001287085.1  Abl tyrosine kinase, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287085.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P00522, Q95TV1, Q9VV86
    UniProtKB/TrEMBL
    X2JGR4
    Conserved Domains (5) summary
    smart00808
    Location:1481 → 1620
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:250 → 345
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:191 → 245
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:364 → 626
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:371 → 622
    Pkinase_Tyr; Protein tyrosine kinase

  2. NM_001104153.3 → NP_001097623.1  Abl tyrosine kinase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097623.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JNU2
    Conserved Domains (5) summary
    smart00808
    Location:1499 → 1638
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:268 → 363
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:209 → 263
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:382 → 644
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:389 → 640
    Pkinase_Tyr; Protein tyrosine kinase

  3. NM_001275035.1 → NP_001261964.1  Abl tyrosine kinase, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261964.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCU1
    Conserved Domains (5) summary
    smart00808
    Location:1365 → 1504
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:250 → 345
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:191 → 245
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:364 → 626
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:371 → 622
    Pkinase_Tyr; Protein tyrosine kinase

  4. NM_080104.3 → NP_524843.2  Abl tyrosine kinase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524843.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P00522, Q95TV1, Q9VV86
    UniProtKB/TrEMBL
    X2JGR4
    Related
    FBpp0075116
    Conserved Domains (5) summary
    smart00808
    Location:1481 → 1620
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:250 → 345
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:191 → 245
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:364 → 626
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:371 → 622
    Pkinase_Tyr; Protein tyrosine kinase

  5. NM_001275032.1 → NP_001261961.1  Abl tyrosine kinase, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261961.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFX0
    Conserved Domains (5) summary
    smart00808
    Location:1450 → 1589
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:250 → 345
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:191 → 245
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:364 → 626
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:371 → 622
    Pkinase_Tyr; Protein tyrosine kinase

  6. NM_001275030.1 → NP_001261959.1  Abl tyrosine kinase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261959.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCT8
    Conserved Domains (5) summary
    smart00808
    Location:1566 → 1705
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:250 → 345
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:191 → 245
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:364 → 626
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:371 → 622
    Pkinase_Tyr; Protein tyrosine kinase

  7. NM_001275034.1 → NP_001261963.1  Abl tyrosine kinase, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261963.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PI83
    Conserved Domains (5) summary
    smart00808
    Location:1383 → 1522
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:268 → 363
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:209 → 263
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:382 → 644
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:389 → 640
    Pkinase_Tyr; Protein tyrosine kinase

  8. NM_001275036.1 → NP_001261965.1  Abl tyrosine kinase, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261965.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFI8
    Conserved Domains (5) summary
    smart00808
    Location:1499 → 1638
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:268 → 363
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:209 → 263
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:382 → 644
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:389 → 640
    Pkinase_Tyr; Protein tyrosine kinase

  9. NM_001275031.1 → NP_001261960.1  Abl tyrosine kinase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261960.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFI5
    Conserved Domains (5) summary
    smart00808
    Location:1468 → 1607
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:268 → 363
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:209 → 263
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:382 → 644
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:389 → 640
    Pkinase_Tyr; Protein tyrosine kinase

  10. NM_001275033.1 → NP_001261962.1  Abl tyrosine kinase, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261962.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFS1
    Conserved Domains (5) summary
    smart00808
    Location:1584 → 1723
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:268 → 363
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:209 → 263
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:382 → 644
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:389 → 640
    Pkinase_Tyr; Protein tyrosine kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8JNU2 A8JNU2
M9PCT8 M9PCT8
M9PCU1 M9PCU1
M9PFI5 M9PFI5
M9PFI8 M9PFI8
M9PFS1 M9PFS1
M9PFX0 M9PFX0
M9PI83 M9PI83
P00522.3 P00522
X2JGR4 X2JGR4

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