kra krasavietz [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: kraprovided by FlyBase
Official Full Name: krasavietzprovided by FlyBase
Primary source: FLYBASE:FBgn0250753
Locus tag: Dmel_CG2922
See related: AllianceGenome:FB:FBgn0250753
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 5MP; anon-WO0172774.49; CG2922; chr3R:1423015..1423173; CT7240; Decp; Dmel\CG2922; ecp; Ecp; ECP; eIF; eiF-5C; eIf-5c; eIF-5c; eIF-5C; eIF5; eIF5c; eIF5C; elf-5C; elF-5C; elF5C; exba; Exba; exba/kra; Kra; l(3)03022; l(3)j9B6
Summary: Enables ribosomal small subunit binding activity and translation initiation factor binding activity. Involved in several processes, including behavioral response to ethanol; long-term memory; and positive regulation of filopodium assembly. Located in several cellular components, including axonal growth cone; filopodium; and neuronal cell body. Is expressed in several structures, including adult head; central nervous system; dopaminergic PPL1 neuron; intrinsic neurons; and synaptic neuropil domain. Orthologous to several human genes including BZW2 (basic leucine zipper and W2 domains 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 83B4-83B4; 3-47.5 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (5595364..5601136, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (1421086..1426858, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

preliminary crystallographic studies of the W2 domain of Drosophila melanogaster eukaryotic translation initiation factor 5C domain-containing protein
Title: Crystallization and preliminary crystallographic studies of the W2 domain of Drosophila melanogaster eukaryotic translation initiation factor 5C domain-containing protein.
Krasavietz mutants exhibit altered ethanol sensitivity, tolerance, and preference.
Title: Preferential ethanol consumption in Drosophila models features of addiction.
These data suggest that Kra(Exba)-mediated translational regulation plays important roles in midline axon repulsion and that Shot functions as a direct physical link between translational regulation and cytoskeleton reorganization.
Title: The F-actin-microtubule crosslinker Shot is a platform for Krasavietz-mediated translational regulation of midline axon repulsion.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0563 (e-PCR)
- UniSTS:78680

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosomal small subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables ribosome binding	IDA Inferred from Direct Assay more info	PubMed
enables translation initiation factor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon midline choice point recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of filopodium assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: krasavietz

Names: CG2922-PA; CG2922-PB; CG2922-PC; CG2922-PD; CG2922-PE; CG2922-PF; CG2922-PG; drosophila eIF5C-containing protein; eIF5-mimic protein; eukaryotic initiation factor 5C; extra bases; extra bses; extra-bases; kra-PA; kra-PB; kra-PC; kra-PD; kra-PE; kra-PF; kra-PG; lethal (3) j9B6

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

5595364..5601136 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169074.2 → NP_730958.1 krasavietz, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730958.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V2F9, Q9VNE2

Related

FBpp0078393

Conserved Domains (1) summary

cd11560
Location:218 → 406

W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins
NM_079514.3 → NP_524238.1 krasavietz, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524238.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V2F9, Q9VNE2

Related

FBpp0078394

Conserved Domains (1) summary

cd11560
Location:218 → 406

W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins
NM_169075.2 → NP_730959.1 krasavietz, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730959.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V2F9, Q9VNE2

Related

FBpp0078398

Conserved Domains (1) summary

cd11560
Location:218 → 406

W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins
NM_169079.2 → NP_730963.1 krasavietz, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730963.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V2F9, Q9VNE2

Related

FBpp0078396

Conserved Domains (1) summary

cd11560
Location:218 → 406

W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins
NM_169076.2 → NP_730960.1 krasavietz, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730960.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V2F9, Q9VNE2

Related

FBpp0078395

Conserved Domains (1) summary

cd11560
Location:218 → 406

W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins
NM_169077.2 → NP_730961.1 krasavietz, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730961.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V2F9, Q9VNE2

Related

FBpp0078397

Conserved Domains (1) summary

cd11560
Location:218 → 406

W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins
NM_169078.2 → NP_730962.1 krasavietz, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730962.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V2F9, Q9VNE2

Related

FBpp0078399

Conserved Domains (1) summary

cd11560
Location:218 → 406

W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins