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    MAN1 MAN1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37838, updated on 9-Dec-2024

    Summary

    Official Symbol
    MAN1provided by FlyBase
    Official Full Name
    MAN1provided by FlyBase
    Primary source
    FLYBASE:FBgn0034962
    Locus tag
    Dmel_CG3167
    See related
    AllianceGenome:FB:FBgn0034962
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD24895; CG3167; dMan1; dMAN1; Dmel\CG3167
    Summary
    Predicted to enable chromatin DNA binding activity. Involved in negative regulation of BMP signaling pathway. Located in endomembrane system. Is expressed in adult head; organism; wing hinge primordium; and wing pouch. Human ortholog(s) of this gene implicated in Buschke-Ollendorff syndrome and cataract 46 juvenile-onset. Orthologous to several human genes including LEMD3 (LEM domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See MAN1 in Genome Data Viewer
    Location:
    60B5-60B5; 2-106 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24033974..24036707)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19921497..19924230)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Chip Neighboring gene CCR4-NOT transcription complex subunit 11 Neighboring gene Integrator 1 Neighboring gene twinstar

    Genomic regions, transcripts, and products

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin DNA binding  
    enables nucleic acid binding  
    Component Evidence Code Pubs
    located_in endomembrane system PubMed 

    General protein information

    Preferred Names
    MAN1
    Names
    CG3167-PA
    CG3167-PB
    CG3167-PC
    MAN1-PA
    MAN1-PB
    MAN1-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24033974..24036707
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299883.1 → NP_001286812.1  MAN1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286812.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JRE4, Q961B2
      Conserved Domains (3) summary
      smart00540
      Location:4 → 47
      LEM; in nuclear membrane-associated proteins
      cd12286
      Location:542 → 631
      RRM_Man1; RNA recognition motif in inner nuclear membrane protein Man1 (Man1) and similar proteins
      pfam09402
      Location:381 → 509
      MSC; Man1-Src1p-C-terminal domain
    2. NM_166651.2 → NP_726404.1  MAN1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726404.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JRE4, Q961B2
      Related
      FBpp0072075
      Conserved Domains (3) summary
      smart00540
      Location:4 → 47
      LEM; in nuclear membrane-associated proteins
      cd12286
      Location:542 → 631
      RRM_Man1; RNA recognition motif in inner nuclear membrane protein Man1 (Man1) and similar proteins
      pfam09402
      Location:381 → 509
      MSC; Man1-Src1p-C-terminal domain
    3. NM_138029.3 → NP_611873.1  MAN1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611873.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JRE4, Q961B2
      Related
      FBpp0072076
      Conserved Domains (3) summary
      smart00540
      Location:4 → 47
      LEM; in nuclear membrane-associated proteins
      cd12286
      Location:542 → 631
      RRM_Man1; RNA recognition motif in inner nuclear membrane protein Man1 (Man1) and similar proteins
      pfam09402
      Location:381 → 509
      MSC; Man1-Src1p-C-terminal domain
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