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    mrtfab myocardin related transcription factor Ab [ Danio rerio (zebrafish) ]

    Gene ID: 559638, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mrtfabprovided by ZNC
    Official Full Name
    myocardin related transcription factor Abprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-681
    See related
    Ensembl:ENSDARG00000076229 AllianceGenome:ZFIN:ZDB-GENE-030131-681
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mkl1b; fb39e12; wu:fb39e12
    Summary
    Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and smooth muscle cell differentiation. Predicted to be active in nucleus. Is expressed in heart. Human ortholog(s) of this gene implicated in acute megakaryocytic leukemia and immunodeficiency 66. Orthologous to human MRTFA (myocardin related transcription factor A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mrtfab in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (18718133..18787317)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (18596321..18665443)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene serine/threonine-protein kinase pim-2-like Neighboring gene regulator of G protein signaling 9b Neighboring gene shisa family member 8b Neighboring gene desumoylating isopeptidase 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency. Zhang Q, et al. Nucleic Acids Res, 2021 May 7. PMID 33836087, Free PMC Article
    2. Protein kinase C family evolution in jawed vertebrates. Garcia-Concejo A, et al. Dev Biol, 2021 Nov. PMID 34329618
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in smooth muscle cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myocardin related transcription factor Ab
    Names
    megakaryoblastic leukemia (translocation) 1b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201558.1 → NP_001188487.1  myocardin related transcription factor Ab

      See identical proteins and their annotated locations for NP_001188487.1

      Status: VALIDATED

      Source sequence(s)
      AL772266, CU571387
      UniProtKB/TrEMBL
      A0A8M1P1Q1, E7F9J6
      Related
      ENSDARP00000127385.1, ENSDART00000152935.3
      Conserved Domains (3) summary
      smart00707
      Location:85 → 110
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:385 → 418
      SAP; SAP domain
      pfam02755
      Location:131 → 151
      RPEL; RPEL repeat

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      18718133..18787317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480117.2 → XP_021335792.1  myocardin related transcription factor Ab isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q8G2
      Conserved Domains (5) summary
      smart00707
      Location:85 → 109
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:400 → 433
      SAP; SAP domain
      pfam02755
      Location:146 → 166
      RPEL; RPEL repeat
      cl17044
      Location:591 → 623
      DD_cGKI; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I
      cl27333
      Location:361 → 437
      PARP_reg; Poly(ADP-ribose) polymerase, regulatory domain

    2. XM_021480118.2 → XP_021335793.1  myocardin related transcription factor Ab isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q8G2
      Conserved Domains (5) summary
      smart00707
      Location:85 → 109
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:400 → 433
      SAP; SAP domain
      pfam02755
      Location:146 → 166
      RPEL; RPEL repeat
      cl17044
      Location:591 → 623
      DD_cGKI; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I
      cl27333
      Location:361 → 437
      PARP_reg; Poly(ADP-ribose) polymerase, regulatory domain

    3. XM_021480121.2 → XP_021335796.1  myocardin related transcription factor Ab isoform X6

      UniProtKB/TrEMBL
      A0A8M9QIS0
      Conserved Domains (5) summary
      smart00707
      Location:5 → 30
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:364 → 397
      SAP; SAP domain
      pfam02755
      Location:110 → 130
      RPEL; RPEL repeat
      cl17044
      Location:555 → 587
      DD_cGKI; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I
      cl27333
      Location:325 → 401
      PARP_reg; Poly(ADP-ribose) polymerase, regulatory domain

    4. XM_021480116.2 → XP_021335791.1  myocardin related transcription factor Ab isoform X1

      UniProtKB/TrEMBL
      A0A8M9QIR6
      Conserved Domains (5) summary
      smart00707
      Location:87 → 111
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:402 → 435
      SAP; SAP domain
      pfam02755
      Location:148 → 168
      RPEL; RPEL repeat
      cl17044
      Location:593 → 625
      DD_cGKI; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I
      cl27333
      Location:363 → 439
      PARP_reg; Poly(ADP-ribose) polymerase, regulatory domain

    5. XM_021480120.2 → XP_021335795.1  myocardin related transcription factor Ab isoform X5

      UniProtKB/TrEMBL
      A0A8M9QMJ6
      Conserved Domains (4) summary
      smart00707
      Location:87 → 111
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:402 → 435
      SAP; SAP domain
      pfam02755
      Location:148 → 168
      RPEL; RPEL repeat
      cl27333
      Location:363 → 439
      PARP_reg; Poly(ADP-ribose) polymerase, regulatory domain

    6. XM_021480119.2 → XP_021335794.1  myocardin related transcription factor Ab isoform X3

      UniProtKB/TrEMBL
      A0A8M9QEC1
      Conserved Domains (5) summary
      smart00707
      Location:87 → 111
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:398 → 431
      SAP; SAP domain
      pfam02755
      Location:148 → 168
      RPEL; RPEL repeat
      cl17044
      Location:589 → 621
      DD_cGKI; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I
      cl27333
      Location:359 → 435
      PARP_reg; Poly(ADP-ribose) polymerase, regulatory domain

    7. XM_005156147.5 → XP_005156204.1  myocardin related transcription factor Ab isoform X4

      UniProtKB/TrEMBL
      A0A8M2B2H4
      Conserved Domains (3) summary
      smart00707
      Location:87 → 112
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:387 → 420
      SAP; SAP domain
      pfam02755
      Location:133 → 153
      RPEL; RPEL repeat

    8. XM_068224603.1 → XP_068080704.1  myocardin related transcription factor Ab isoform X7

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394835.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      710918..781418
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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