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    IMPA-2 importin alpha isoform 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827302, updated on 18-Sep-2024

    Summary

    Official Symbol
    IMPA-2
    Official Full Name
    importin alpha isoform 2
    Primary source
    TAIR:AT4G16143
    Locus tag
    AT4G16143
    See related
    Araport:AT4G16143
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    importin alpha isoform 2
    Summary
    Protein interacts with Agrobacterium proteins VirD2 and VirE2. Is not individually essential for Agrobacterium-mediated root transformation, but when overexpressed can rescue the impa-4 decreased transformation susceptibility phenotype.
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    Genomic context

    See IMPA-2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Sequence:
    Chromosome: 4; NC_003075.7 (9133750..9137415, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene proline-rich family protein Neighboring gene GATA type zinc finger transcription factor family protein Neighboring gene associated molecule with the SH3 domain of STAM 3 Neighboring gene cAMP-regulated phosphoprotein 19-related protein

    Interactions

    General gene information

    NM_001160767.2
    NM_117708.6

    Gene Ontology Provided by TAIR

    General protein information

    Preferred Names
    importin alpha isoform 2
    NP_001154239.1
    • importin alpha isoform 2 (IMPA-2); FUNCTIONS IN: protein transporter activity, binding; INVOLVED IN: intracellular protein transport, protein import into nucleus; LOCATED IN: cytosol; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Importin-alpha-like, importin-beta-binding domain (InterPro:IPR002652), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: importin alpha isoform 1 (TAIR:AT3G06720.2); Has 4654 Blast hits to 3364 proteins in 293 species: Archae - 4; Bacteria - 33; Metazoa - 1869; Fungi - 640; Plants - 1336; Viruses - 0; Other Eukaryotes - 772 (source: NCBI BLink).
    NP_567485.4
    • importin alpha isoform 2 (IMPA-2); FUNCTIONS IN: protein transporter activity, binding; INVOLVED IN: intracellular protein transport, protein import into nucleus; LOCATED IN: cytosol, nucleolus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Importin-alpha-like, importin-beta-binding domain (InterPro:IPR002652), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: importin alpha isoform 1 (TAIR:AT3G06720.2); Has 4654 Blast hits to 3364 proteins in 293 species: Archae - 4; Bacteria - 33; Metazoa - 1869; Fungi - 640; Plants - 1336; Viruses - 0; Other Eukaryotes - 772 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      9133750..9137415 complement
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117708.6 → NP_567485.4  importin alpha isoform 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567485.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JL11, O49600, Q9ASV4
      UniProtKB/TrEMBL
      A0A178V0W7
      Conserved Domains (4) summary
      COG5064
      Location:10 → 535
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00020
      Location:114 → 235
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:8 → 99
      IBB; Importin beta binding domain
      sd00043
      Location:116 → 148
      ARM; armadillo repeat [structural motif]
    2. NM_001160767.2 → NP_001154239.1  importin alpha isoform 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154239.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JL11, O49600, Q9ASV4
      UniProtKB/TrEMBL
      A0A178V0W7
      Conserved Domains (4) summary
      COG5064
      Location:10 → 535
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00020
      Location:114 → 235
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:8 → 99
      IBB; Importin beta binding domain
      sd00043
      Location:116 → 148
      ARM; armadillo repeat [structural motif]
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