U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Eukaryotic translation initiation factor 2 subunit 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818621, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Full Name
Eukaryotic translation initiation factor 2 subunit 1
Primary source
TAIR:AT2G40290
Locus tag
AT2G40290
See related
Araport:AT2G40290
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
T7M7.14
Summary
Encodes an eIF2alpha homolog that can be phosphorylated by GCN2 in vitro.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 2
Exon count:
7
Sequence:
Chromosome: 2; NC_003071.7 (16828766..16831226, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Protein kinase family protein Neighboring gene ncRNA Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene ferritin 4 Neighboring gene Pectin lyase-like superfamily protein Neighboring gene autophagy-like protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The in vitro assays demonstrate the binding of the C-terminus of AtGCN2 to uncharged tRNA molecules and the enzymatic activities of AtGCN2 on both eIF2alpha homologues in A. thaliana.
    Title: The GCN2 homologue in Arabidopsis thaliana interacts with uncharged tRNA and uses Arabidopsis eIF2α molecules as direct substrates.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

NM_001036441.1
NM_129587.3
NM_201919.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding HDA PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in nucleus HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Eukaryotic translation initiation factor 2 subunit 1
NP_001031518.1
  • Eukaryotic translation initiation factor 2 subunit 1; FUNCTIONS IN: RNA binding, translation initiation factor activity; INVOLVED IN: translation; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Ribosomal protein S1, RNA-binding domain (InterPro:IPR003029), Eukaryotic translation initiation factor 2, alpha subunit (InterPro:IPR011488); BEST Arabidopsis thaliana protein match is: eukaryotic translation initiation factor 2 alpha subunit (TAIR:AT5G05470.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_565927.1
  • Eukaryotic translation initiation factor 2 subunit 1; FUNCTIONS IN: RNA binding, translation initiation factor activity; INVOLVED IN: translation; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Ribosomal protein S1, RNA-binding domain (InterPro:IPR003029), Eukaryotic translation initiation factor 2, alpha subunit (InterPro:IPR011488); BEST Arabidopsis thaliana protein match is: eukaryotic translation initiation factor 2 alpha subunit (TAIR:AT5G05470.1); Has 4919 Blast hits to 4230 proteins in 1696 species: Archae - 235; Bacteria - 3462; Metazoa - 170; Fungi - 142; Plants - 94; Viruses - 32; Other Eukaryotes - 784 (source: NCBI BLink).
NP_973648.1
  • Eukaryotic translation initiation factor 2 subunit 1; FUNCTIONS IN: RNA binding, translation initiation factor activity; INVOLVED IN: translation; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Ribosomal protein S1, RNA-binding domain (InterPro:IPR003029), Eukaryotic translation initiation factor 2, alpha subunit (InterPro:IPR011488); BEST Arabidopsis thaliana protein match is: eukaryotic translation initiation factor 2 alpha subunit (TAIR:AT5G05470.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    16828766..16831226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_129587.3 → NP_565927.1  Eukaryotic translation initiation factor 2 subunit 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565927.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8LEV8, Q9SIZ2
    UniProtKB/TrEMBL
    A0A178VYF4, A0A5S9X5P1, Q9XEF6
    Conserved Domains (1) summary
    PTZ00248
    Location:4 → 315
    PTZ00248; eukaryotic translation initiation factor 2 subunit 1; Provisional

  2. NM_201919.1 → NP_973648.1  Eukaryotic translation initiation factor 2 subunit 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_973648.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A2RVK1
    Conserved Domains (2) summary
    cd04452
    Location:18 → 93
    S1_IF2_alpha; S1_IF2_alpha: The alpha subunit of translation Initiation Factor 2, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Eukaryotic and archaeal Initiation Factor 2 (e- and aIF2, respectively) ...
    pfam07541
    Location:131 → 225
    EIF_2_alpha; Eukaryotic translation initiation factor 2 alpha subunit

  3. NM_001036441.1 → NP_001031518.1  Eukaryotic translation initiation factor 2 subunit 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031518.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A2RVK1
    Conserved Domains (2) summary
    cd04452
    Location:18 → 93
    S1_IF2_alpha; S1_IF2_alpha: The alpha subunit of translation Initiation Factor 2, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Eukaryotic and archaeal Initiation Factor 2 (e- and aIF2, respectively) ...
    pfam07541
    Location:131 → 225
    EIF_2_alpha; Eukaryotic translation initiation factor 2 alpha subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SIZ2.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools