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Conserved domains on  [gi|238480717|ref|NP_001154239|]
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importin alpha isoform 2 [Arabidopsis thaliana]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
10-535 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 600.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717  10 EVRRNRY--KVAVDAEEGRRRREDNMVEIRKSKREESLQKKRreglqanqlpQFAPSPVPASSTV----EKKLESLPAMV 83
Cdd:COG5064    8 EARRYNFkgKGRFSADELRRRREEQQVELRKQKREELLNKRR----------NLADVSEEAESSFipmeQQFYSELPQLT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717  84 GGVWSDDRSLQLEATTQFRKLLSIERSPPIEEVIDAGVVPRFVEFLTREDYPQLQFEAAWALTNIASGTSENTKVVIEHG 163
Cdd:COG5064   78 QQLFSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717 164 AVPIFVQLLASQSDDVREQAVWALGNVAGDSPRCRDLVLGQGALIPLLSQLNEHA-KLSMLRNATWTLSNFCRGK-PQPP 241
Cdd:COG5064  158 AVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLLSSAiHISMLRNATWTLSNLCRGKnPPPD 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717 242 FDQVRPALPALERLIHSTDEEVLTDACWALSYLSDGTNDKIQSVIEAGVVPRLVELLQHQSPSVLIPALRSIGNIVTGDD 321
Cdd:COG5064  238 WSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSD 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717 322 LQTQCVISHGALLSLLSLLTHNhKKSIKKEACWTISNITAGNRDQIQAVCEAGLICPLVNLLQNAEFDIKKEAAWAISNA 401
Cdd:COG5064  318 DQTQVIINCGALKAFRSLLSSP-KENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNA 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717 402 TSGGS--PDQIKYMVEQGVVKPLCDLLVCPDPRIITVCLEGLENILKVGEAEKvTGNTGDVNFYAQLIDDAEGLEKIENL 479
Cdd:COG5064  397 TSGGLnrPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEQDR-LRYGKNINIYAVYVEKAGGMDAIHGL 475

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 238480717 480 QSHDNSEIYEKAVKILETYWLEEED-ETLPPgDPSAQGFQFGGGNDAAvppggFNFQ 535
Cdd:COG5064  476 QDSVNRTIYDKAYSIIEKFFGEEDAvDELAP-ETAGNTFTFGSNVNQQ-----GNFN 526
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
10-535 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 600.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717  10 EVRRNRY--KVAVDAEEGRRRREDNMVEIRKSKREESLQKKRreglqanqlpQFAPSPVPASSTV----EKKLESLPAMV 83
Cdd:COG5064    8 EARRYNFkgKGRFSADELRRRREEQQVELRKQKREELLNKRR----------NLADVSEEAESSFipmeQQFYSELPQLT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717  84 GGVWSDDRSLQLEATTQFRKLLSIERSPPIEEVIDAGVVPRFVEFLTREDYPQLQFEAAWALTNIASGTSENTKVVIEHG 163
Cdd:COG5064   78 QQLFSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717 164 AVPIFVQLLASQSDDVREQAVWALGNVAGDSPRCRDLVLGQGALIPLLSQLNEHA-KLSMLRNATWTLSNFCRGK-PQPP 241
Cdd:COG5064  158 AVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLLSSAiHISMLRNATWTLSNLCRGKnPPPD 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717 242 FDQVRPALPALERLIHSTDEEVLTDACWALSYLSDGTNDKIQSVIEAGVVPRLVELLQHQSPSVLIPALRSIGNIVTGDD 321
Cdd:COG5064  238 WSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSD 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717 322 LQTQCVISHGALLSLLSLLTHNhKKSIKKEACWTISNITAGNRDQIQAVCEAGLICPLVNLLQNAEFDIKKEAAWAISNA 401
Cdd:COG5064  318 DQTQVIINCGALKAFRSLLSSP-KENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNA 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717 402 TSGGS--PDQIKYMVEQGVVKPLCDLLVCPDPRIITVCLEGLENILKVGEAEKvTGNTGDVNFYAQLIDDAEGLEKIENL 479
Cdd:COG5064  397 TSGGLnrPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEQDR-LRYGKNINIYAVYVEKAGGMDAIHGL 475

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 238480717 480 QSHDNSEIYEKAVKILETYWLEEED-ETLPPgDPSAQGFQFGGGNDAAvppggFNFQ 535
Cdd:COG5064  476 QDSVNRTIYDKAYSIIEKFFGEEDAvDELAP-ETAGNTFTFGSNVNQQ-----GNFN 526
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 12-99 8.76e-34

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 122.65  E-value: 8.76e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717   12 RRNRYKVAV-DAEEGRRRREDNMVEIRKSKREESLQKKRReglqanqlpqFAPSPVPASSTVEKKLESLPAMVGGVWSDD 90
Cdd:pfam01749   1 RRKSFKNKGkDADELRRRREEVQVELRKQKREEQLLKRRN----------VGAPSSSSSSAESQLLESLPEMVQGVNSDD 70


                  ....*....
gi 238480717   91 RSLQLEATT 99
Cdd:pfam01749  71 PELQLEATQ 79
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 152-191 2.48e-10

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 55.51  E-value: 2.48e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 238480717   152 TSENTKVVIEHGAVPIFVQLLASQSDDVREQAVWALGNVA 191
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 117-323 1.08e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 42.01  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717  117 IDAGVVPRFVEFLTrEDYPQLQFEAAWALTNIASGTSENTKVVIEHGAVPIFVQLLASQSD-DVREQAVWALGNVAGDSP 195
Cdd:PLN03200  186 LEAGGVDILVKLLS-SGNSDAQANAASLLARLMMAFESSISKVLDAGAVKQLLKLLGQGNEvSVRAEAAGALEALSSQSK 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717  196 RCRDLVLGQGAlIPLL----------SQLNEHAKlSMLRNATWTLSNFCRGKPQppfdqvrpALPALERLIHS-TDEEVL 264
Cdd:PLN03200  265 EAKQAIADAGG-IPALinatvapskeFMQGEFAQ-ALQENAMGALANICGGMSA--------LILYLGELSESpRSPAPI 334

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 238480717  265 TDACWALSY------LSDGTNDKIQ-SVIEAGVV----PRLVELLQHQspsvLIPALRSI-GNIVTGDDLQ 323
Cdd:PLN03200  335 ADTLGALAYalmvfdSSAESTRAFDpTVIEQILVkllkPRDTKLVQER----IIEALASLyGNAYLSRKLN 401
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
10-535 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 600.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717  10 EVRRNRY--KVAVDAEEGRRRREDNMVEIRKSKREESLQKKRreglqanqlpQFAPSPVPASSTV----EKKLESLPAMV 83
Cdd:COG5064    8 EARRYNFkgKGRFSADELRRRREEQQVELRKQKREELLNKRR----------NLADVSEEAESSFipmeQQFYSELPQLT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717  84 GGVWSDDRSLQLEATTQFRKLLSIERSPPIEEVIDAGVVPRFVEFLTREDYPQLQFEAAWALTNIASGTSENTKVVIEHG 163
Cdd:COG5064   78 QQLFSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717 164 AVPIFVQLLASQSDDVREQAVWALGNVAGDSPRCRDLVLGQGALIPLLSQLNEHA-KLSMLRNATWTLSNFCRGK-PQPP 241
Cdd:COG5064  158 AVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLLSSAiHISMLRNATWTLSNLCRGKnPPPD 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717 242 FDQVRPALPALERLIHSTDEEVLTDACWALSYLSDGTNDKIQSVIEAGVVPRLVELLQHQSPSVLIPALRSIGNIVTGDD 321
Cdd:COG5064  238 WSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSD 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717 322 LQTQCVISHGALLSLLSLLTHNhKKSIKKEACWTISNITAGNRDQIQAVCEAGLICPLVNLLQNAEFDIKKEAAWAISNA 401
Cdd:COG5064  318 DQTQVIINCGALKAFRSLLSSP-KENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNA 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717 402 TSGGS--PDQIKYMVEQGVVKPLCDLLVCPDPRIITVCLEGLENILKVGEAEKvTGNTGDVNFYAQLIDDAEGLEKIENL 479
Cdd:COG5064  397 TSGGLnrPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEQDR-LRYGKNINIYAVYVEKAGGMDAIHGL 475

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 238480717 480 QSHDNSEIYEKAVKILETYWLEEED-ETLPPgDPSAQGFQFGGGNDAAvppggFNFQ 535
Cdd:COG5064  476 QDSVNRTIYDKAYSIIEKFFGEEDAvDELAP-ETAGNTFTFGSNVNQQ-----GNFN 526
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 12-99 8.76e-34

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 122.65  E-value: 8.76e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717   12 RRNRYKVAV-DAEEGRRRREDNMVEIRKSKREESLQKKRReglqanqlpqFAPSPVPASSTVEKKLESLPAMVGGVWSDD 90
Cdd:pfam01749   1 RRKSFKNKGkDADELRRRREEVQVELRKQKREEQLLKRRN----------VGAPSSSSSSAESQLLESLPEMVQGVNSDD 70


                  ....*....
gi 238480717   91 RSLQLEATT 99
Cdd:pfam01749  71 PELQLEATQ 79
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 465-505 1.86e-16

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 73.01  E-value: 1.86e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 238480717  465 QLIDDAEGLEKIENLQSHDNSEIYEKAVKILETYWLEEEDE 505
Cdd:pfam16186   1 LLIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEEE 41
HEAT COG1413
HEAT repeat [General function prediction only];
141-316 1.19e-11

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 62.34  E-value: 1.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717 141 AAWALTNIASgtsentkvvieHGAVPIFVQLLASQSDDVREQAVWALGNVagDSPRCRDlvlgqgALIPLLSQLNEHAKl 220
Cdd:COG1413    5 AARALGRLGD-----------PAAVPALIAALADEDPDVRAAAARALGRL--GDPRAVP------ALLEALKDPDPEVR- 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717 221 smlRNATWTLSNFcrGKPQppfdqvrpALPALERLIHSTDEEVLTDACWALSYLSDgtndkiqsvieAGVVPRLVELLQH 300
Cdd:COG1413   65 ---AAAAEALGRI--GDPE--------AVPALIAALKDEDPEVRRAAAEALGRLGD-----------PAAVPALLEALKD 120

                        170
                 ....*....|....*.
gi 238480717 301 QSPSVLIPALRSIGNI 316
Cdd:COG1413  121 PDWEVRRAAARALGRL 136
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 152-191 7.38e-11

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 57.08  E-value: 7.38e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 238480717  152 TSENTKVVIEHGAVPIFVQLLASQSDDVREQAVWALGNVA 191
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 152-191 2.48e-10

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 55.51  E-value: 2.48e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 238480717   152 TSENTKVVIEHGAVPIFVQLLASQSDDVREQAVWALGNVA 191
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 363-403 5.02e-10

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 54.77  E-value: 5.02e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 238480717  363 NRDQIQAVCEAGLICPLVNLLQNAEFDIKKEAAWAISNATS 403
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 109-150 3.30e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 49.35  E-value: 3.30e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 238480717   109 RSPPIEEVIDAGVVPRFVEFLTREDyPQLQFEAAWALTNIAS 150
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSED-EEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 110-150 3.31e-08

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 49.38  E-value: 3.31e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 238480717  110 SPPIEEVIDAGVVPRFVEFLTREDyPQLQFEAAWALTNIAS 150
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPD-EEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 363-403 4.05e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 49.35  E-value: 4.05e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 238480717   363 NRDQIQAVCEAGLICPLVNLLQNAEFDIKKEAAWAISNATS 403
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 278-318 4.48e-08

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 48.99  E-value: 4.48e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 238480717  278 TNDKIQSVIEAGVVPRLVELLQHQSPSVLIPALRSIGNIVT 318
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 135-190 1.00e-07

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 48.52  E-value: 1.00e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 238480717  135 PQLQFEAAWALTNIASGTSENTKVVIEhGAVPIFVQLLASQSDDVREQAVWALGNV 190
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVP-ELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
179-316 2.20e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 50.01  E-value: 2.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717 179 VREQAVWALGNvagdsprcrdlvLGQGALIPLLSQLNEHAKLSMLRNATWTLSNFcrGKPQppfdqvrpALPALERLIHS 258
Cdd:COG1413    1 VRRAAARALGR------------LGDPAAVPALIAALADEDPDVRAAAARALGRL--GDPR--------AVPALLEALKD 58

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 238480717 259 TDEEVLTDACWALSYLSDgtndkiqsvieAGVVPRLVELLQHQSPSVLIPALRSIGNI 316
Cdd:COG1413   59 PDPEVRAAAAEALGRIGD-----------PEAVPALIAALKDEDPEVRRAAAEALGRL 105
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 406-444 1.06e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.14  E-value: 1.06e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 238480717  406 SPDQIKYMVEQGVVKPLCDLLVCPDPRIITVCLEGLENI 444
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNL 39
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 278-317 1.34e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 45.11  E-value: 1.34e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 238480717   278 TNDKIQSVIEAGVVPRLVELLQHQSPSVLIPALRSIGNIV 317
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 406-444 1.89e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 44.73  E-value: 1.89e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 238480717   406 SPDQIKYMVEQGVVKPLCDLLVCPDPRIITVCLEGLENI 444
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNL 39
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 248-276 3.03e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 43.98  E-value: 3.03e-06
                          10        20
                  ....*....|....*....|....*....
gi 238480717  248 ALPALERLIHSTDEEVLTDACWALSYLSD 276
Cdd:pfam00514  13 AVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT COG1413
HEAT repeat [General function prediction only];
118-232 1.96e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 44.62  E-value: 1.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717 118 DAGVVPRFVEFLTREDyPQLQFEAAWALTNIasGTSEntkvviehgAVPIFVQLLASQSDDVREQAVWALGNvagdsprc 197
Cdd:COG1413   45 DPRAVPALLEALKDPD-PEVRAAAAEALGRI--GDPE---------AVPALIAALKDEDPEVRRAAAEALGR-------- 104

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 238480717 198 rdlvLGQGALIPLLSQLNEHAKLSMLRNATWTLSN 232
Cdd:COG1413  105 ----LGDPAAVPALLEALKDPDWEVRRAAARALGR 135
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 194-235 2.58e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 41.29  E-value: 2.58e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 238480717  194 SPRCRDLVLGQGALIPLLSQLNeHAKLSMLRNATWTLSNFCR 235
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 248-276 8.79e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.72  E-value: 8.79e-05
                           10        20
                   ....*....|....*....|....*....
gi 238480717   248 ALPALERLIHSTDEEVLTDACWALSYLSD 276
Cdd:smart00185  13 GLPALVELLKSEDEEVVKEAAWALSNLSS 41
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 224-274 9.04e-05

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 40.43  E-value: 9.04e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 238480717  224 RNATWTLSNFCRGKPQPPFDQVRPALPALERLIHSTDEEVLTDACWALSYL 274
Cdd:pfam13513   5 EAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 122-190 3.54e-04

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 39.63  E-value: 3.54e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 238480717  122 VPRFVEFLTREDYPQLQFEAAWALTNIASGTsentkvviehgAVPIFVQLLASQSDDVREQAVWALGNV 190
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALGRIGDPE-----------AVPALLELLKDEDPAVRRAAAEALGKI 58
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 179-233 3.58e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.50  E-value: 3.58e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 238480717  179 VREQAVWALGNVAGDSPrcRDLVLGQGALIPLLSQLNEHAKLSMLRNATWTLSNF 233
Cdd:pfam13513   3 VREAAALALGSLAEGGP--DLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
118-191 4.18e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.77  E-value: 4.18e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 238480717 118 DAGVVPRFVEFLTREDyPQLQFEAAWALTNIASGTsentkvviehgAVPIFVQLLASQSDDVREQAVWALGNVA 191
Cdd:COG1413   76 DPEAVPALIAALKDED-PEVRRAAAEALGRLGDPA-----------AVPALLEALKDPDWEVRRAAARALGRLG 137
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 117-323 1.08e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 42.01  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717  117 IDAGVVPRFVEFLTrEDYPQLQFEAAWALTNIASGTSENTKVVIEHGAVPIFVQLLASQSD-DVREQAVWALGNVAGDSP 195
Cdd:PLN03200  186 LEAGGVDILVKLLS-SGNSDAQANAASLLARLMMAFESSISKVLDAGAVKQLLKLLGQGNEvSVRAEAAGALEALSSQSK 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717  196 RCRDLVLGQGAlIPLL----------SQLNEHAKlSMLRNATWTLSNFCRGKPQppfdqvrpALPALERLIHS-TDEEVL 264
Cdd:PLN03200  265 EAKQAIADAGG-IPALinatvapskeFMQGEFAQ-ALQENAMGALANICGGMSA--------LILYLGELSESpRSPAPI 334

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 238480717  265 TDACWALSY------LSDGTNDKIQ-SVIEAGVV----PRLVELLQHQspsvLIPALRSI-GNIVTGDDLQ 323
Cdd:PLN03200  335 ADTLGALAYalmvfdSSAESTRAFDpTVIEQILVkllkPRDTKLVQER----IIEALASLyGNAYLSRKLN 401
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 113-188 2.68e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.93  E-value: 2.68e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 238480717  113 IEEVIDAGVVPRFVEFLTREDyPQLQFEAAWALTNIASgtsentkvvieHGAVPIFVQLLASQSDD-VREQAVWALG 188
Cdd:pfam13646  24 LGRIGDPEAVPALLELLKDED-PAVRRAAAEALGKIGD-----------PEALPALLELLRDDDDDvVRAAAAEALA 88
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 170-272 3.63e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.55  E-value: 3.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238480717  170 QLLASQSDDVREQAVWALGNvagdsprcrdlvLGQGALIPLLSQLNEHAKLSMLRNATWTLSNFcrGKPQppfdqvrpAL 249
Cdd:pfam13646   7 ALLRDPDPEVRAAAIRALGR------------IGDPEAVPALLELLKDEDPAVRRAAAEALGKI--GDPE--------AL 64

                          90       100
                  ....*....|....*....|....
gi 238480717  250 PALERLI-HSTDEEVLTDACWALS 272
Cdd:pfam13646  65 PALLELLrDDDDDVVRAAAAEALA 88
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 165-191 5.28e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 34.43  E-value: 5.28e-03
                          10        20
                  ....*....|....*....|....*..
gi 238480717  165 VPIFVQLLASQSDDVREQAVWALGNVA 191
Cdd:pfam02985   2 LPLLLKLLNDPSPEVREAAAEALGELA 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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