nme6 NME/NM23 nucleoside diphosphate kinase 6 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nme6provided by ZNC
Official Full Name: NME/NM23 nucleoside diphosphate kinase 6provided by ZNC
Primary source: ZFIN:ZDB-GENE-000710-3
See related: Ensembl:ENSDARG00000016138 AllianceGenome:ZFIN:ZDB-GENE-000710-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ndpkz6; NDPK-Z6; fj33c02; zgc:86565; wu:fj33c02
Summary: Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in negative regulation of cell growth and negative regulation of mitotic nuclear division. Predicted to act upstream of or within phosphorylation and ribonucleoside triphosphate biosynthetic process. Predicted to be active in mitochondrion. Is expressed in several structures, including eye; female organism; gill; gonad; and male organism. Orthologous to human NME6 (NME/NM23 nucleoside diphosphate kinase 6). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (19556828..19575574)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (19662800..19675991)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside diphosphate kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within CTP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within GTP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within UTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of mitotic nuclear division	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nucleotide metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nucleoside diphosphate kinase 6

Names: NDK 6; NDP kinase 6; NM23-Z6; non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase); nucleoside diphosphate kinase-Z6

NP_571672.2

EC 2.7.4.6

XP_021324189.1

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131597.2 → NP_571672.2 nucleoside diphosphate kinase 6

See identical proteins and their annotated locations for NP_571672.2

Status: VALIDATED

Source sequence(s)

BX276101, EH550824, EH561410

UniProtKB/Swiss-Prot

Q6DI51

Related

ENSDARP00000094574.4, ENSDART00000103798.5

Conserved Domains (2) summary

smart00562
Location:8 → 144

NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates

cd04414
Location:8 → 141

NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

19556828..19575574

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021468514.2 → XP_021324189.1 nucleoside diphosphate kinase 6 isoform X1

UniProtKB/TrEMBL

A0A8M9PHJ1

Conserved Domains (1) summary

cl00335
Location:11 → 128

NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...