NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1207155215|ref|XP_021324189|]
View 

nucleoside diphosphate kinase 6 isoform X1 [Danio rerio]

Protein Classification

nucleoside-diphosphate kinase( domain architecture ID 1539)

nucleoside-diphosphate kinase catalyzes the exchange of phosphate groups between different nucleoside diphosphates

CATH:  3.30.70.141
EC:  2.7.4.6
Gene Ontology:  GO:0006241|GO:0004550|GO:0046872|GO:0005524|GO:0006228|GO:0006183

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NDPk super family cl00335
Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the ...
 11-128 1.08e-74

Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are vital for DNA/RNA synthesis, cell division, macromolecular metabolism and growth. The enzymes generate NTPs or their deoxy derivatives by terminal (gamma) phosphotransfer from an NTP such as ATP or GTP to any nucleoside diphosphate (NDP) or its deoxy derivative. The sequence of NDPk has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes, which is involved in the catalytic mechanism. The first confirmed metastasis suppressor gene was the NDP kinase protein encoded by the nm23 gene. Unicellular organisms generally possess only one gene encoding NDP kinase, while most multicellular organisms possess not only an ortholog that provides most of the NDP kinase enzymatic activity but also multiple divergent paralogous genes. The human genome codes for at least nine NDP kinases and can be classified into two groups, Groups I and II, according to their genomic architecture and distinct enzymatic activity. Group I isoforms (A-D) are well-conserved, catalytically active, and share 58-88% identity between each other, while Group II are more divergent, with only NDPk6 shown to be active. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. The hexamer can be viewed as trimer of dimers, while tetramers are dimers of dimers, with the dimerization interface conserved.


The actual alignment was detected with superfamily member cd04414:

Pssm-ID: 469726  Cd Length: 135  Bit Score: 219.58  E-value: 1.08e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215  11 KSEALHQKIL-ENFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKVFRA 89
Cdd:cd04414    17 ALEAVRQLILsNGFTIVRKKELRWTTEDAERFYAEHKGKFFYDRLVSFMTSGPSWALILAHENAIKTWRALMGPTKVFRA 96

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1207155215  90 RFSSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFFP 128
Cdd:cd04414    97 RASAPDSIRGLYGLTDTRNATHGSDSPASAQREIALFFP 135
 
Name Accession Description Interval E-value
NDPk6 cd04414
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced ...
 11-128 1.08e-74

Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has all nine residues considered crucial for enzyme structure and activity, and has been found to have NDP kinase activity. It may play a role in cell growth and cell cycle progression. The nm23-H6 gene locus has been implicated in a variety of malignant tumors.


Pssm-ID: 239877  Cd Length: 135  Bit Score: 219.58  E-value: 1.08e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215  11 KSEALHQKIL-ENFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKVFRA 89
Cdd:cd04414    17 ALEAVRQLILsNGFTIVRKKELRWTTEDAERFYAEHKGKFFYDRLVSFMTSGPSWALILAHENAIKTWRALMGPTKVFRA 96

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1207155215  90 RFSSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFFP 128
Cdd:cd04414    97 RASAPDSIRGLYGLTDTRNATHGSDSPASAQREIALFFP 135
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 13-131 2.04e-55

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 170.81  E-value: 2.04e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215   13 EALHQKILENFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKvfrARFS 92
Cdd:smart00562  19 EIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDAVKTWRTLMGPTD---PREA 95

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1207155215   93 SPETLRGKYGLTDTRNTTHGSDSIESAKREISFFFPEFS 131
Cdd:smart00562  96 APGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPESE 134
NDK pfam00334
Nucleoside diphosphate kinase;
22-130 3.07e-42

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 137.23  E-value: 3.07e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215  22 NFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKVFRARfssPETLRGKY 101
Cdd:pfam00334  28 GFKIVALKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTSGPVVAMVLEGENAISKWRELMGATNPAEAA---PGTIRGDF 104

                          90       100
                  ....*....|....*....|....*....
gi 1207155215 102 GLTDTRNTTHGSDSIESAKREISFFFPEF 130
Cdd:pfam00334 105 AVSIGRNAVHGSDSPESAEREIALFFPEE 133
PLN02931 PLN02931
nucleoside diphosphate kinase family protein
 12-134 1.72e-36

nucleoside diphosphate kinase family protein


Pssm-ID: 215503  Cd Length: 177  Bit Score: 124.17  E-value: 1.72e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215  12 SEALHQKILEN-FIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKVFRAR 90
Cdd:PLN02931   46 TERIKEVILESgFSIVKEMTTQLDEDRASLFYAEHSSRSFFPSLVKYMTSGPVLVMVLEKENAVSDWRTLIGPTDARKAK 125

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1207155215  91 FSSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFFPEFSAEE 134
Cdd:PLN02931  126 ISHPNSIRAMCGLDSEKNCVHGSDSPESAEREISFFFGDVSSGD 169
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 35-129 8.36e-36

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 120.94  E-value: 8.36e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215  35 KADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKVFRArfsSPETLRGKYGLTDTRNTTHGSD 114
Cdd:COG0105    43 REQAEEHYAEHKGKPFFGELVEFMTSGPVVAMVLEGENAVAVVRKLMGATNPAEA---APGTIRGDFALSIGENAVHGSD 119

                          90
                  ....*....|....*
gi 1207155215 115 SIESAKREISFFFPE 129
Cdd:COG0105   120 SPESAEREIALFFSE 134
 
Name Accession Description Interval E-value
NDPk6 cd04414
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced ...
 11-128 1.08e-74

Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has all nine residues considered crucial for enzyme structure and activity, and has been found to have NDP kinase activity. It may play a role in cell growth and cell cycle progression. The nm23-H6 gene locus has been implicated in a variety of malignant tumors.


Pssm-ID: 239877  Cd Length: 135  Bit Score: 219.58  E-value: 1.08e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215  11 KSEALHQKIL-ENFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKVFRA 89
Cdd:cd04414    17 ALEAVRQLILsNGFTIVRKKELRWTTEDAERFYAEHKGKFFYDRLVSFMTSGPSWALILAHENAIKTWRALMGPTKVFRA 96

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1207155215  90 RFSSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFFP 128
Cdd:cd04414    97 RASAPDSIRGLYGLTDTRNATHGSDSPASAQREIALFFP 135
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 13-131 2.04e-55

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 170.81  E-value: 2.04e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215   13 EALHQKILENFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKvfrARFS 92
Cdd:smart00562  19 EIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDAVKTWRTLMGPTD---PREA 95

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1207155215   93 SPETLRGKYGLTDTRNTTHGSDSIESAKREISFFFPEFS 131
Cdd:smart00562  96 APGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPESE 134
NDPk cd00595
Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the ...
 11-127 1.39e-49

Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are vital for DNA/RNA synthesis, cell division, macromolecular metabolism and growth. The enzymes generate NTPs or their deoxy derivatives by terminal (gamma) phosphotransfer from an NTP such as ATP or GTP to any nucleoside diphosphate (NDP) or its deoxy derivative. The sequence of NDPk has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes, which is involved in the catalytic mechanism. The first confirmed metastasis suppressor gene was the NDP kinase protein encoded by the nm23 gene. Unicellular organisms generally possess only one gene encoding NDP kinase, while most multicellular organisms possess not only an ortholog that provides most of the NDP kinase enzymatic activity but also multiple divergent paralogous genes. The human genome codes for at least nine NDP kinases and can be classified into two groups, Groups I and II, according to their genomic architecture and distinct enzymatic activity. Group I isoforms (A-D) are well-conserved, catalytically active, and share 58-88% identity between each other, while Group II are more divergent, with only NDPk6 shown to be active. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. The hexamer can be viewed as trimer of dimers, while tetramers are dimers of dimers, with the dimerization interface conserved.


Pssm-ID: 238335  Cd Length: 133  Bit Score: 155.97  E-value: 1.39e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215  11 KSEALHQKILEN-FIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKVFRA 89
Cdd:cd00595    16 LLGEIIMRIEDAgFEIVAMKELHLTEEQAEEFYVEHKGRPFFPDLVQFMSSGPVVAMILEKDNAVGEWREMLGPTNPEIA 95

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1207155215  90 RFSSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFF 127
Cdd:cd00595    96 RHLAPGSLRADFGTDVLRNAVHGSDSVESAAREIAFFF 133
NDK pfam00334
Nucleoside diphosphate kinase;
22-130 3.07e-42

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 137.23  E-value: 3.07e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215  22 NFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKVFRARfssPETLRGKY 101
Cdd:pfam00334  28 GFKIVALKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTSGPVVAMVLEGENAISKWRELMGATNPAEAA---PGTIRGDF 104

                          90       100
                  ....*....|....*....|....*....
gi 1207155215 102 GLTDTRNTTHGSDSIESAKREISFFFPEF 130
Cdd:pfam00334 105 AVSIGRNAVHGSDSPESAEREIALFFPEE 133
NDPk5 cd04418
Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of ...
 8-128 1.20e-38

Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, in association with axoneme microtubules, and may play a role in spermatogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species. It belongs to the nm23 Group II genes and appears to differ from the other human NDPks in that it lacks two important catalytic site residues, and thus does not appear to possess NDP kinase activity. NDPk5 confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes, including glutathione peroxidase 5 (Gpx5).


Pssm-ID: 239880  Cd Length: 132  Bit Score: 127.94  E-value: 1.20e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215   8 GASKSEALHQKILEN-FIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKV 86
Cdd:cd04418    11 AVHKAEEIEDIILESgFTIVQKRKLQLSPEQCSDFYAEHYGKMFFPHLVAYMSSGPIVAMVLARHNAISYWKELLGPTNS 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1207155215  87 FRARFSSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFFP 128
Cdd:cd04418    91 LKAKETHPDSLRAIYGTDDLRNAVHGSDSFSSAEREIRFMFP 132
PLN02931 PLN02931
nucleoside diphosphate kinase family protein
 12-134 1.72e-36

nucleoside diphosphate kinase family protein


Pssm-ID: 215503  Cd Length: 177  Bit Score: 124.17  E-value: 1.72e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215  12 SEALHQKILEN-FIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKVFRAR 90
Cdd:PLN02931   46 TERIKEVILESgFSIVKEMTTQLDEDRASLFYAEHSSRSFFPSLVKYMTSGPVLVMVLEKENAVSDWRTLIGPTDARKAK 125

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1207155215  91 FSSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFFPEFSAEE 134
Cdd:PLN02931  126 ISHPNSIRAMCGLDSEKNCVHGSDSPESAEREISFFFGDVSSGD 169
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 35-129 8.36e-36

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 120.94  E-value: 8.36e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215  35 KADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKVFRArfsSPETLRGKYGLTDTRNTTHGSD 114
Cdd:COG0105    43 REQAEEHYAEHKGKPFFGELVEFMTSGPVVAMVLEGENAVAVVRKLMGATNPAEA---APGTIRGDFALSIGENAVHGSD 119

                          90
                  ....*....|....*
gi 1207155215 115 SIESAKREISFFFPE 129
Cdd:COG0105   120 SPESAEREIALFFSE 134
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 35-127 1.11e-35

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


Pssm-ID: 239876  Cd Length: 130  Bit Score: 120.27  E-value: 1.11e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215  35 KADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKVFRArfsSPETLRGKYGLTDTRNTTHGSD 114
Cdd:cd04413    41 EELAEEHYAEHKGKPFFPELVEFMTSGPVVAMVLEGENAVKTVRKLMGATNPADA---APGTIRGDFALSIGRNIVHGSD 117

                          90
                  ....*....|...
gi 1207155215 115 SIESAKREISFFF 127
Cdd:cd04413   118 SVESAEREIALWF 130
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 35-129 1.80e-35

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 119.83  E-value: 1.80e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215  35 KADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKVFRArfsSPETLRGKYGLTDTRNTTHGSD 114
Cdd:PRK00668   42 RELAEGHYAEHKEKPFFGELVEFMTSGPVVVMVLEGENAIAKVRELMGATNPAEA---APGTIRGDFALSIGENVVHGSD 118

                          90
                  ....*....|....*
gi 1207155215 115 SIESAKREISFFFPE 129
Cdd:PRK00668  119 SPESAAREIALFFSE 133
NDPk7A cd04415
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate ...
 22-127 4.00e-32

Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239878  Cd Length: 131  Bit Score: 111.38  E-value: 4.00e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215  22 NFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKVFRARFSSPETLRGKY 101
Cdd:cd04415    26 GFTITKAKMTKLSRKEAQDFYAEHQSKPFYNELVQFMTSGPIVAMELVGDDAISEWRKLLGPTNSSVARSDAPNSIRALF 105

                          90       100
                  ....*....|....*....|....*.
gi 1207155215 102 GLTDTRNTTHGSDSIESAKREISFFF 127
Cdd:cd04415   106 GTDGTRNAAHGSDSVASAARELEFFF 131
NDPk_TX cd04416
NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 ...
 9-127 4.74e-31

NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which has a tissue specific distribution in human testis, has been considered as a member of the nm23 family (nm23-H8) and exhibits a high homology with sea urchin IC1 (intermediate chain-1) protein, a component of the sperm axonemal outer dynein arm complex. Txl-2 is mainly represented in close association with microtubules within tissues with cilia and flagella such as seminiferous epithelium (spermatids) and lung airway epithelium, suggesting possible role in control of microtubule stability and maintenance.


Pssm-ID: 239879  Cd Length: 132  Bit Score: 108.45  E-value: 4.74e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215   9 ASKSEALHQKILE-NFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKVF 87
Cdd:cd04416    13 AEKKDEILEKIKEaGFEILAQKEMVLTEEQAREFYKEHEEEDYFEDLVEFMTSGPSLILVLSKENAVEEWRELMGPTDPE 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1207155215  88 RARFSSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFF 127
Cdd:cd04416    93 EAKEEKPDSLRAQFARDHLSNAVHGSSSAEEAEKEIDFFF 132
PRK14540 PRK14540
nucleoside diphosphate kinase; Provisional
 22-129 1.73e-24

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184733  Cd Length: 134  Bit Score: 91.81  E-value: 1.73e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215  22 NFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKVFRArfsSPETLRGKY 101
Cdd:PRK14540   30 GFEIVEMKMLKLTREMAEEYYEEHKGKEFYERLINFMTSGRIVAMVIEGENAISTVRKMIGKTNPAEA---EPGTIRGDF 106

                          90       100
                  ....*....|....*....|....*...
gi 1207155215 102 GLTDTRNTTHGSDSIESAKREISFFFPE 129
Cdd:PRK14540  107 GLYTPANIIHASDSKESAEREIKLFFGE 134
PTZ00093 PTZ00093
nucleoside diphosphate kinase, cytosolic; Provisional
 42-129 7.11e-24

nucleoside diphosphate kinase, cytosolic; Provisional


Pssm-ID: 173387  Cd Length: 149  Bit Score: 90.94  E-value: 7.11e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215  42 YAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTkvfRARFSSPETLRGKYGLTDTRNTTHGSDSIESAKR 121
Cdd:PTZ00093   50 YKEHKGKPFFPGLVKYISSGPVVCMVWEGKNVVKQGRKLLGAT---NPLESAPGTIRGDFCVDVGRNVIHGSDSVESAKR 126


                  ....*....
gi 1207155215 122 EISFFF-PE 129
Cdd:PTZ00093  127 EIALWFkPE 135
PRK14542 PRK14542
nucleoside diphosphate kinase; Provisional
 21-127 1.10e-21

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173008 [Multi-domain]  Cd Length: 137  Bit Score: 85.11  E-value: 1.10e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215  21 ENFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKVFRARFSspeTLRGK 100
Cdd:PRK14542   28 EGFKILGLKYLKLSLEDAKQFYKVHSARPFYNDLCNYMSSGPIVAAALERDNAVLHWREVIGATDPKEAAAG---TIRAL 104

                          90       100
                  ....*....|....*....|....*..
gi 1207155215 101 YGLTDTRNTTHGSDSIESAKREISFFF 127
Cdd:PRK14542  105 YAESKEANAVHGSDSDANAALEISFFF 131
PRK14545 PRK14545
nucleoside diphosphate kinase; Provisional
 36-127 3.10e-19

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184734  Cd Length: 139  Bit Score: 78.79  E-value: 3.10e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215  36 ADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKVFRArfsSPETLRGKYGLTDTRNTTHGSDS 115
Cdd:PRK14545   45 ADAETFYAVHAERPFYGELVEFMSRGPIVAAILEKENAVEDFRTLIGATNPADA---AEGTIRKKYAKSIGENAVHGSDS 121

                          90
                  ....*....|..
gi 1207155215 116 IESAKREISFFF 127
Cdd:PRK14545  122 DENAQIEGAFHF 133
PRK14541 PRK14541
nucleoside diphosphate kinase; Provisional
 23-134 1.96e-18

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173007  Cd Length: 140  Bit Score: 76.53  E-value: 1.96e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215  23 FIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKVFRArfsSPETLRGKYG 102
Cdd:PRK14541   30 FRVVAMKKTRLTKETAGEFYAVHRERPFYGELVEFMSSGPCVPMILEKENAVADFRTLIGATDPAEA---AEGTVRKLYA 106

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1207155215 103 LTDTRNTTHGSDSIESAKREISFFfpeFSAEE 134
Cdd:PRK14541  107 DSKGENIVHGSDSAENAAIEAGFF---FSAEE 135
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 13-127 1.37e-16

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239875  Cd Length: 134  Bit Score: 71.51  E-value: 1.37e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215  13 EALHQKILENFIIIRKKDLIWRKADSEMFYAEHSGRF-FFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKVFRARF 91
Cdd:cd04412    19 EILQQILDEGFEITALQMFNLTRANAEEFLEVYKGVVpELPAMVDELTSGPCIALEIAGENAVKTFREFCGPFDPEIAKQ 98

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1207155215  92 SSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFF 127
Cdd:cd04412    99 LRPNTLRARYGKDKVQNAVHCTDLPEDGPLELKFFF 134
PLN02619 PLN02619
nucleoside-diphosphate kinase
 48-136 1.07e-12

nucleoside-diphosphate kinase


Pssm-ID: 178228  Cd Length: 238  Bit Score: 63.33  E-value: 1.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215  48 RFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKvfrARFSSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFF 127
Cdd:PLN02619  142 RPFFNGLCDFLSSGPVVAMVWEGEGVIKYGRKLIGATD---PQKSEPGTIRGDLAVVVGRNIIHGSDGPETAKDEINLWF 218

                          90
                  ....*....|....*.
gi 1207155215 128 -PE------FSAEEWM 136
Cdd:PLN02619  219 kPEelvsytSNAEKWI 234
PRK14544 PRK14544
nucleoside diphosphate kinase; Provisional
 47-129 4.25e-12

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173010 [Multi-domain]  Cd Length: 183  Bit Score: 60.98  E-value: 4.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215  47 GRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKVFRArfsSPETLRGKYGlTDT-----------RNTTHGSDS 115
Cdd:PRK14544   89 GKKVKESLVKYMTSGPIVAMVLKGNRAVEVVRKLVGPTSPHKA---PPGTIRGDYS-IDSpdlaaeegrvvYNLVHASDS 164

                          90
                  ....*....|....
gi 1207155215 116 IESAKREISFFFPE 129
Cdd:PRK14544  165 PEEAEREIKFWFRE 178
PRK14543 PRK14543
nucleoside diphosphate kinase; Provisional
 25-129 2.67e-04

nucleoside diphosphate kinase; Provisional


Pssm-ID: 237749  Cd Length: 169  Bit Score: 39.49  E-value: 2.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207155215  25 IIRKKDLIWRKADSEMFY-----AEHSGRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKvfrARFSSPETLRG 99
Cdd:PRK14543   36 IVAAKMLLVDRSMAEKHYlyddiAVRHGEAVWKSLIKFISSSPVFVFVVEGVESVEVVRKFCGSTE---PKLAIPGTIRG 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1207155215 100 KYGLTDTR----------NTTHGSDSIESAKREISFFFPE 129
Cdd:PRK14543  113 DFSYHSFNyanekgfsvyNVIHASANEDDALREIPIWFKD 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH