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Conserved domains on  [gi|845633928|ref|NP_571672|]
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nucleoside diphosphate kinase 6 [Danio rerio]

Protein Classification

nucleoside diphosphate kinase 6( domain architecture ID 10138302)

nucleoside diphosphate kinase 6 plays a major role in the synthesis of nucleoside triphosphates other than ATP

CATH:  3.30.70.141
EC:  2.7.4.6
Gene Ontology:  GO:0006241|GO:0004550|GO:0046872|GO:0005524|GO:0006228|GO:0006183
SCOP:  4001261

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NDPk6 cd04414
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced ...
 8-141 5.78e-87

Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has all nine residues considered crucial for enzyme structure and activity, and has been found to have NDP kinase activity. It may play a role in cell growth and cell cycle progression. The nm23-H6 gene locus has been implicated in a variety of malignant tumors.


:

Pssm-ID: 239877  Cd Length: 135  Bit Score: 251.16  E-value: 5.78e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928   8 QLTLAVIKPDAMAHPLILEALHQKIL-ENFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDA 86
Cdd:cd04414    1 QLTLALIKPDAVAHPLALEAVRQLILsNGFTIVRKKELRWTTEDAERFYAEHKGKFFYDRLVSFMTSGPSWALILAHENA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 845633928  87 ITHWRTMMGPTKVFRARFSSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFFP 141
Cdd:cd04414   81 IKTWRALMGPTKVFRARASAPDSIRGLYGLTDTRNATHGSDSPASAQREIALFFP 135
 
Name Accession Description Interval E-value
NDPk6 cd04414
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced ...
 8-141 5.78e-87

Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has all nine residues considered crucial for enzyme structure and activity, and has been found to have NDP kinase activity. It may play a role in cell growth and cell cycle progression. The nm23-H6 gene locus has been implicated in a variety of malignant tumors.


Pssm-ID: 239877  Cd Length: 135  Bit Score: 251.16  E-value: 5.78e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928   8 QLTLAVIKPDAMAHPLILEALHQKIL-ENFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDA 86
Cdd:cd04414    1 QLTLALIKPDAVAHPLALEAVRQLILsNGFTIVRKKELRWTTEDAERFYAEHKGKFFYDRLVSFMTSGPSWALILAHENA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 845633928  87 ITHWRTMMGPTKVFRARFSSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFFP 141
Cdd:cd04414   81 IKTWRALMGPTKVFRARASAPDSIRGLYGLTDTRNATHGSDSPASAQREIALFFP 135
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 8-144 4.34e-66

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 198.16  E-value: 4.34e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928     8 QLTLAVIKPDAMAHPLILEALHQKILENFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAI 87
Cdd:smart00562   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDAV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 845633928    88 THWRTMMGPTKvfrARFSSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFFPEFS 144
Cdd:smart00562  81 KTWRTLMGPTD---PREAAPGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPESE 134
NDK pfam00334
Nucleoside diphosphate kinase;
10-143 5.39e-49

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 154.95  E-value: 5.39e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928   10 TLAVIKPDAMAHPLILEALHQKILENFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITH 89
Cdd:pfam00334   3 TLAIIKPDAVQRGLIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTSGPVVAMVLEGENAISK 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 845633928   90 WRTMMGPTKVFRARfssPETLRGKYGLTDTRNTTHGSDSIESAKREISFFFPEF 143
Cdd:pfam00334  83 WRELMGATNPAEAA---PGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFPEE 133
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 6-142 1.93e-40

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 133.27  E-value: 1.93e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928   6 ALQLTLAVIKPDAMAHPLILEALHQkiLEN--FIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAR 83
Cdd:COG0105    1 AMERTLVIIKPDAVQRGLIGEIISR--FERkgLKIVALKMLQLTREQAEEHYAEHKGKPFFGELVEFMTSGPVVAMVLEG 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 845633928  84 EDAITHWRTMMGPTKVFRArfsSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFFPE 142
Cdd:COG0105   79 ENAVAVVRKLMGATNPAEA---APGTIRGDFALSIGENAVHGSDSPESAEREIALFFSE 134
PLN02931 PLN02931
nucleoside diphosphate kinase family protein
 10-147 2.40e-40

nucleoside diphosphate kinase family protein


Pssm-ID: 215503  Cd Length: 177  Bit Score: 134.18  E-value: 2.40e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928  10 TLAVIKPDAMAHPLIlEALHQKILEN-FIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAIT 88
Cdd:PLN02931  32 TLAMIKPDGLSGNYT-ERIKEVILESgFSIVKEMTTQLDEDRASLFYAEHSSRSFFPSLVKYMTSGPVLVMVLEKENAVS 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 845633928  89 HWRTMMGPTKVFRARFSSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFFPEFSAEE 147
Cdd:PLN02931 111 DWRTLIGPTDARKAKISHPNSIRAMCGLDSEKNCVHGSDSPESAEREISFFFGDVSSGD 169
 
Name Accession Description Interval E-value
NDPk6 cd04414
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced ...
 8-141 5.78e-87

Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has all nine residues considered crucial for enzyme structure and activity, and has been found to have NDP kinase activity. It may play a role in cell growth and cell cycle progression. The nm23-H6 gene locus has been implicated in a variety of malignant tumors.


Pssm-ID: 239877  Cd Length: 135  Bit Score: 251.16  E-value: 5.78e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928   8 QLTLAVIKPDAMAHPLILEALHQKIL-ENFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDA 86
Cdd:cd04414    1 QLTLALIKPDAVAHPLALEAVRQLILsNGFTIVRKKELRWTTEDAERFYAEHKGKFFYDRLVSFMTSGPSWALILAHENA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 845633928  87 ITHWRTMMGPTKVFRARFSSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFFP 141
Cdd:cd04414   81 IKTWRALMGPTKVFRARASAPDSIRGLYGLTDTRNATHGSDSPASAQREIALFFP 135
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 8-144 4.34e-66

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 198.16  E-value: 4.34e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928     8 QLTLAVIKPDAMAHPLILEALHQKILENFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAI 87
Cdd:smart00562   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDAV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 845633928    88 THWRTMMGPTKvfrARFSSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFFPEFS 144
Cdd:smart00562  81 KTWRTLMGPTD---PREAAPGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPESE 134
NDPk cd00595
Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the ...
 8-140 8.51e-57

Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are vital for DNA/RNA synthesis, cell division, macromolecular metabolism and growth. The enzymes generate NTPs or their deoxy derivatives by terminal (gamma) phosphotransfer from an NTP such as ATP or GTP to any nucleoside diphosphate (NDP) or its deoxy derivative. The sequence of NDPk has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes, which is involved in the catalytic mechanism. The first confirmed metastasis suppressor gene was the NDP kinase protein encoded by the nm23 gene. Unicellular organisms generally possess only one gene encoding NDP kinase, while most multicellular organisms possess not only an ortholog that provides most of the NDP kinase enzymatic activity but also multiple divergent paralogous genes. The human genome codes for at least nine NDP kinases and can be classified into two groups, Groups I and II, according to their genomic architecture and distinct enzymatic activity. Group I isoforms (A-D) are well-conserved, catalytically active, and share 58-88% identity between each other, while Group II are more divergent, with only NDPk6 shown to be active. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. The hexamer can be viewed as trimer of dimers, while tetramers are dimers of dimers, with the dimerization interface conserved.


Pssm-ID: 238335  Cd Length: 133  Bit Score: 174.46  E-value: 8.51e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928   8 QLTLAVIKPDAMAHpLILEALHQKILEN-FIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDA 86
Cdd:cd00595    1 ERTLALIKPDAVAE-GLLGEIIMRIEDAgFEIVAMKELHLTEEQAEEFYVEHKGRPFFPDLVQFMSSGPVVAMILEKDNA 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 845633928  87 ITHWRTMMGPTKVFRARFSSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFF 140
Cdd:cd00595   80 VGEWREMLGPTNPEIARHLAPGSLRADFGTDVLRNAVHGSDSVESAAREIAFFF 133
NDK pfam00334
Nucleoside diphosphate kinase;
10-143 5.39e-49

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 154.95  E-value: 5.39e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928   10 TLAVIKPDAMAHPLILEALHQKILENFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITH 89
Cdd:pfam00334   3 TLAIIKPDAVQRGLIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTSGPVVAMVLEGENAISK 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 845633928   90 WRTMMGPTKVFRARfssPETLRGKYGLTDTRNTTHGSDSIESAKREISFFFPEF 143
Cdd:pfam00334  83 WRELMGATNPAEAA---PGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFPEE 133
NDPk5 cd04418
Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of ...
 10-141 1.35e-42

Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, in association with axoneme microtubules, and may play a role in spermatogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species. It belongs to the nm23 Group II genes and appears to differ from the other human NDPks in that it lacks two important catalytic site residues, and thus does not appear to possess NDP kinase activity. NDPk5 confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes, including glutathione peroxidase 5 (Gpx5).


Pssm-ID: 239880  Cd Length: 132  Bit Score: 138.73  E-value: 1.35e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928  10 TLAVIKPDAMAHPlilEALHQKILEN-FIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAIT 88
Cdd:cd04418    3 TLAIIKPDAVHKA---EEIEDIILESgFTIVQKRKLQLSPEQCSDFYAEHYGKMFFPHLVAYMSSGPIVAMVLARHNAIS 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 845633928  89 HWRTMMGPTKVFRARFSSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFFP 141
Cdd:cd04418   80 YWKELLGPTNSLKAKETHPDSLRAIYGTDDLRNAVHGSDSFSSAEREIRFMFP 132
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 6-142 1.93e-40

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 133.27  E-value: 1.93e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928   6 ALQLTLAVIKPDAMAHPLILEALHQkiLEN--FIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAR 83
Cdd:COG0105    1 AMERTLVIIKPDAVQRGLIGEIISR--FERkgLKIVALKMLQLTREQAEEHYAEHKGKPFFGELVEFMTSGPVVAMVLEG 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 845633928  84 EDAITHWRTMMGPTKVFRArfsSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFFPE 142
Cdd:COG0105   79 ENAVAVVRKLMGATNPAEA---APGTIRGDFALSIGENAVHGSDSPESAEREIALFFSE 134
PLN02931 PLN02931
nucleoside diphosphate kinase family protein
 10-147 2.40e-40

nucleoside diphosphate kinase family protein


Pssm-ID: 215503  Cd Length: 177  Bit Score: 134.18  E-value: 2.40e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928  10 TLAVIKPDAMAHPLIlEALHQKILEN-FIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAIT 88
Cdd:PLN02931  32 TLAMIKPDGLSGNYT-ERIKEVILESgFSIVKEMTTQLDEDRASLFYAEHSSRSFFPSLVKYMTSGPVLVMVLEKENAVS 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 845633928  89 HWRTMMGPTKVFRARFSSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFFPEFSAEE 147
Cdd:PLN02931 111 DWRTLIGPTDARKAKISHPNSIRAMCGLDSEKNCVHGSDSPESAEREISFFFGDVSSGD 169
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 10-140 4.54e-40

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


Pssm-ID: 239876  Cd Length: 130  Bit Score: 131.82  E-value: 4.54e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928  10 TLAVIKPDAMAHPLILEALHQKILENFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITH 89
Cdd:cd04413    3 TLVIIKPDGVQRGLIGEIISRFERKGLKIVALKMLQLTEELAEEHYAEHKGKPFFPELVEFMTSGPVVAMVLEGENAVKT 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 845633928  90 WRTMMGPTKVFRArfsSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFF 140
Cdd:cd04413   83 VRKLMGATNPADA---APGTIRGDFALSIGRNIVHGSDSVESAEREIALWF 130
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 10-142 8.64e-39

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 128.69  E-value: 8.64e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928  10 TLAVIKPDAMAHPLILEALHQkiLEN--FIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAI 87
Cdd:PRK00668   4 TFSIIKPDAVQRGLIGEIISR--FEKkgLKIVALKMMQLSRELAEGHYAEHKEKPFFGELVEFMTSGPVVVMVLEGENAI 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 845633928  88 THWRTMMGPTKVFRArfsSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFFPE 142
Cdd:PRK00668  82 AKVRELMGATNPAEA---APGTIRGDFALSIGENVVHGSDSPESAAREIALFFSE 133
NDPk7A cd04415
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate ...
 10-140 3.33e-37

Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239878  Cd Length: 131  Bit Score: 124.86  E-value: 3.33e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928  10 TLAVIKPDAMAH--PLIlealhQKILE-NFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDA 86
Cdd:cd04415    3 TLALIKPDAYSKigKII-----QIIEDaGFTITKAKMTKLSRKEAQDFYAEHQSKPFYNELVQFMTSGPIVAMELVGDDA 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 845633928  87 ITHWRTMMGPTKVFRARFSSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFF 140
Cdd:cd04415   78 ISEWRKLLGPTNSSVARSDAPNSIRALFGTDGTRNAAHGSDSVASAARELEFFF 131
NDPk_TX cd04416
NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 ...
 8-140 4.18e-36

NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which has a tissue specific distribution in human testis, has been considered as a member of the nm23 family (nm23-H8) and exhibits a high homology with sea urchin IC1 (intermediate chain-1) protein, a component of the sperm axonemal outer dynein arm complex. Txl-2 is mainly represented in close association with microtubules within tissues with cilia and flagella such as seminiferous epithelium (spermatids) and lung airway epithelium, suggesting possible role in control of microtubule stability and maintenance.


Pssm-ID: 239879  Cd Length: 132  Bit Score: 121.93  E-value: 4.18e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928   8 QLTLAVIKPDAMAHPlILEALhQKILE-NFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDA 86
Cdd:cd04416    1 EYTLALIKPDAVAEK-KDEIL-EKIKEaGFEILAQKEMVLTEEQAREFYKEHEEEDYFEDLVEFMTSGPSLILVLSKENA 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 845633928  87 ITHWRTMMGPTKVFRARFSSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFF 140
Cdd:cd04416   79 VEEWRELMGPTDPEEAKEEKPDSLRAQFARDHLSNAVHGSSSAEEAEKEIDFFF 132
PRK14540 PRK14540
nucleoside diphosphate kinase; Provisional
 7-142 1.50e-28

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184733  Cd Length: 134  Bit Score: 102.98  E-value: 1.50e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928   7 LQLTLAVIKPDAMAHPLILEALHQKILENFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDA 86
Cdd:PRK14540   2 KERTFVALKPDAVERKLIGKIIQRFENKGFEIVEMKMLKLTREMAEEYYEEHKGKEFYERLINFMTSGRIVAMVIEGENA 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 845633928  87 ITHWRTMMGPTKVFRArfsSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFFPE 142
Cdd:PRK14540  82 ISTVRKMIGKTNPAEA---EPGTIRGDFGLYTPANIIHASDSKESAEREIKLFFGE 134
PTZ00093 PTZ00093
nucleoside diphosphate kinase, cytosolic; Provisional
 10-142 4.02e-27

nucleoside diphosphate kinase, cytosolic; Provisional


Pssm-ID: 173387  Cd Length: 149  Bit Score: 99.80  E-value: 4.02e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928  10 TLAVIKPDAMAHPLILEALHQKILENFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITH 89
Cdd:PTZ00093   5 TFIMVKPDGVQRGLVGEIIKRFEKKGYKLVALKMLQPTPEIAEEHYKEHKGKPFFPGLVKYISSGPVVCMVWEGKNVVKQ 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 845633928  90 WRTMMGPTkvfRARFSSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFF-PE 142
Cdd:PTZ00093  85 GRKLLGAT---NPLESAPGTIRGDFCVDVGRNVIHGSDSVESAKREIALWFkPE 135
PRK14542 PRK14542
nucleoside diphosphate kinase; Provisional
 7-140 4.28e-25

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173008 [Multi-domain]  Cd Length: 137  Bit Score: 93.97  E-value: 4.28e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928   7 LQLTLAVIKPDAMAHPLILEALHQKILENFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDA 86
Cdd:PRK14542   1 MSRTFIMIKPDGVKNKHVGNILQRIEKEGFKILGLKYLKLSLEDAKQFYKVHSARPFYNDLCNYMSSGPIVAAALERDNA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 845633928  87 ITHWRTMMGPTKVFRARFSspeTLRGKYGLTDTRNTTHGSDSIESAKREISFFF 140
Cdd:PRK14542  81 VLHWREVIGATDPKEAAAG---TIRALYAESKEANAVHGSDSDANAALEISFFF 131
PRK14541 PRK14541
nucleoside diphosphate kinase; Provisional
 7-147 4.17e-23

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173007  Cd Length: 140  Bit Score: 89.24  E-value: 4.17e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928   7 LQLTLAVIKPDAMAHPLILEALHQKILENFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDA 86
Cdd:PRK14541   1 MERTLTILKPDCVRKQLIGAVIDKIERAGFRVVAMKKTRLTKETAGEFYAVHRERPFYGELVEFMSSGPCVPMILEKENA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 845633928  87 ITHWRTMMGPTKVFRArfsSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFfpeFSAEE 147
Cdd:PRK14541  81 VADFRTLIGATDPAEA---AEGTVRKLYADSKGENIVHGSDSAENAAIEAGFF---FSAEE 135
PRK14545 PRK14545
nucleoside diphosphate kinase; Provisional
 10-140 4.28e-23

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184734  Cd Length: 139  Bit Score: 89.19  E-value: 4.28e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928  10 TLAVIKPDAMAHPLILEALHQKILENFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDAITH 89
Cdd:PRK14545   6 TFTMIKPDAVENGHIGGILDMITAAGFRIVAMKLTQLTVADAETFYAVHAERPFYGELVEFMSRGPIVAAILEKENAVED 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 845633928  90 WRTMMGPTKVFRArfsSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFF 140
Cdd:PRK14545  86 FRTLIGATNPADA---AEGTIRKKYAKSIGENAVHGSDSDENAQIEGAFHF 133
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 8-140 6.11e-22

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239875  Cd Length: 134  Bit Score: 85.76  E-value: 6.11e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928   8 QLTLAVIKPDAMAHPLILEALHQKILENFIIIRKKDLIWRKADSEMFYAEHSGRF-FFQRLVEFMSSGPMRAYILAREDA 86
Cdd:cd04412    1 NCTVCIIKPHAVSHGLLGEILQQILDEGFEITALQMFNLTRANAEEFLEVYKGVVpELPAMVDELTSGPCIALEIAGENA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 845633928  87 ITHWRTMMGPTKVFRARFSSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFF 140
Cdd:cd04412   81 VKTFREFCGPFDPEIAKQLRPNTLRARYGKDKVQNAVHCTDLPEDGPLELKFFF 134
PLN02619 PLN02619
nucleoside-diphosphate kinase
 7-149 9.74e-17

nucleoside-diphosphate kinase


Pssm-ID: 178228  Cd Length: 238  Bit Score: 74.89  E-value: 9.74e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928   7 LQLTLAVIKPDAMAHPLILEALHQKILENFIIIRKKDLIWRKADSEMFYAEHSGRFFFQRLVEFMSSGPMRAYILAREDA 86
Cdd:PLN02619  88 MERTFIAIKPDGVQRGLISEIISRFERKGFKLVAIKVVVPSKEFAQKHYHDLKERPFFNGLCDFLSSGPVVAMVWEGEGV 167

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928  87 ITHWRTMMGPTKvfrARFSSPETLRGKYGLTDTRNTTHGSDSIESAKREISFFF-PE------FSAEEWM 149
Cdd:PLN02619 168 IKYGRKLIGATD---PQKSEPGTIRGDLAVVVGRNIIHGSDGPETAKDEINLWFkPEelvsytSNAEKWI 234
PRK14544 PRK14544
nucleoside diphosphate kinase; Provisional
 60-142 3.71e-12

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173010 [Multi-domain]  Cd Length: 183  Bit Score: 61.37  E-value: 3.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928  60 GRFFFQRLVEFMSSGPMRAYILAREDAITHWRTMMGPTKVFRArfsSPETLRGKYGlTDT-----------RNTTHGSDS 128
Cdd:PRK14544  89 GKKVKESLVKYMTSGPIVAMVLKGNRAVEVVRKLVGPTSPHKA---PPGTIRGDYS-IDSpdlaaeegrvvYNLVHASDS 164

                         90
                 ....*....|....
gi 845633928 129 IESAKREISFFFPE 142
Cdd:PRK14544 165 PEEAEREIKFWFRE 178
PRK14543 PRK14543
nucleoside diphosphate kinase; Provisional
 7-142 3.16e-08

nucleoside diphosphate kinase; Provisional


Pssm-ID: 237749  Cd Length: 169  Bit Score: 50.66  E-value: 3.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 845633928   7 LQLTLAVIKPDAMAHPLILEALHQKILENFIIIRKKDLIWRKADSEMFY-----AEHSGRFFFQRLVEFMSSGPMRAYIL 81
Cdd:PRK14543   5 IQKTLCIIKPDGVRRGLIGNVVSRFERVGLKIVAAKMLLVDRSMAEKHYlyddiAVRHGEAVWKSLIKFISSSPVFVFVV 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 845633928  82 AREDAITHWRTMMGPTKvfrARFSSPETLRGKYGLTDTR----------NTTHGSDSIESAKREISFFFPE 142
Cdd:PRK14543  85 EGVESVEVVRKFCGSTE---PKLAIPGTIRGDFSYHSFNyanekgfsvyNVIHASANEDDALREIPIWFKD 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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