Slc25a23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc25a23provided by MGI
Official Full Name: solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23provided by MGI
Primary source: MGI:MGI:1914222
See related: Ensembl:ENSMUSG00000046329 AllianceGenome:MGI:1914222
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SCaMC-3; 2310067G05Rik
Summary: Predicted to enable ADP:phosphate antiporter activity and ATP:phosphate antiporter activity. Acts upstream of or within several processes, including adenine nucleotide transport; cellular response to calcium ion; and regulation of oxidative phosphorylation. Located in mitochondrion. Is expressed in embryo. Orthologous to human SLC25A23 (solute carrier family 25 member 23). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver adult (RPKM 76.5), cortex adult (RPKM 70.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 D; 17 29.64 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (57350711..57366863, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (57043711..57059909, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SCaMC-3 KO neurons have higher vulnerability to in vitro excitotoxicity, and SCaMC-3 KO mice are more susceptible to kainate-induced seizures.
Title: Mitochondrial ATP-Mg/Pi carrier SCaMC-3/Slc25a23 counteracts PARP-1-dependent fall in mitochondrial ATP caused by excitotoxic insults in neurons.
Glucagon regulation of oxidative phosphorylation requires an increase in matrix adenine nucleotide content through Ca2+ activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3
Title: Glucagon regulation of oxidative phosphorylation requires an increase in matrix adenine nucleotide content through Ca2+ activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

NoName (e-PCR)
- UniSTS:547044

Slc25a23 (e-PCR), detects polymorphism
- UniSTS:547044

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP:phosphate antiporter activity	ISO Inferred from Sequence Orthology more info
enables ADP:phosphate antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP:phosphate antiporter activity	ISO Inferred from Sequence Orthology more info
enables ATP:phosphate antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables adenine nucleotide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables adenine nucleotide transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ADP transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in ADP transport	IEA Inferred from Electronic Annotation more info
involved_in ATP transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenine nucleotide transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenine nucleotide transport	ISO Inferred from Sequence Orthology more info
involved_in adenine nucleotide transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium import into the mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in calcium import into the mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to calcium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial ATP transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial ATP transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial calcium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitochondrial calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cellular hyperosmotic salinity response	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular hyperosmotic salinity response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of cellular respiration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of oxidative phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of sequestering of calcium ion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within renal system process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial adenyl nucleotide antiporter SLC25A23

Names: calcium-binding mitochondrial carrier protein SCaMC-3; short calcium-binding mitochondrial carrier protein 3; small calcium-binding mitochondrial carrier protein 3; solute carrier family 25 member 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001379067.1 → NP_001365996.1 mitochondrial adenyl nucleotide antiporter SLC25A23 isoform 2

Status: VALIDATED

Source sequence(s)

CT571247

Conserved Domains (2) summary

COG5126
Location:7 → 142

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

PTZ00169
Location:189 → 475

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
NM_001379068.1 → NP_001365997.1 mitochondrial adenyl nucleotide antiporter SLC25A23 isoform 3

Status: VALIDATED

Source sequence(s)

CT571247

Conserved Domains (2) summary

COG5126
Location:7 → 142

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

PTZ00169
Location:189 → 426

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
NM_001379069.1 → NP_001365998.1 mitochondrial adenyl nucleotide antiporter SLC25A23 isoform 4

Status: VALIDATED

Source sequence(s)

CT571247

Conserved Domains (2) summary

COG5126
Location:7 → 142

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

pfam00153
Location:223 → 316

Mito_carr; Mitochondrial carrier protein
NM_001379070.1 → NP_001365999.1 mitochondrial adenyl nucleotide antiporter SLC25A23 isoform 5

Status: VALIDATED

Source sequence(s)

CT571247

Conserved Domains (1) summary

PTZ00169
Location:66 → 339

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
NM_001412719.1 → NP_001399648.1 mitochondrial adenyl nucleotide antiporter SLC25A23 isoform 6

Status: VALIDATED

Source sequence(s)

CT571247
NM_025877.4 → NP_080153.2 mitochondrial adenyl nucleotide antiporter SLC25A23 isoform 1

See identical proteins and their annotated locations for NP_080153.2

Status: VALIDATED

Source sequence(s)

BC017139, BC072660, CX566083

Consensus CDS

CCDS28923.1

UniProtKB/Swiss-Prot

Q6GQS1

Related

ENSMUSP00000040198.8, ENSMUST00000040280.14

Conserved Domains (4) summary

cd00051
Location:84 → 141

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

PTZ00169
Location:189 → 462

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:274 → 367

Mito_carr; Mitochondrial carrier protein

pfam13499
Location:81 → 136

EF-hand_7; EF-hand domain pair