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    TAOK2 TAO kinase 2 [ Homo sapiens (human) ]

    Gene ID: 9344, updated on 4-Jan-2025

    Summary

    Official Symbol
    TAOK2provided by HGNC
    Official Full Name
    TAO kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:16835
    See related
    Ensembl:ENSG00000149930 MIM:613199; AllianceGenome:HGNC:16835
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PSK; PSK1; TAO1; TAO2; MAP3K17; Tao2beta; PSK1-BETA
    Summary
    Enables mitogen-activated protein kinase kinase binding activity; neuropilin binding activity; and protein serine/threonine kinase activity. Involved in several processes, including focal adhesion assembly; intracellular signal transduction; and positive regulation of MAPK cascade. Located in cytoplasmic vesicle; cytosol; and nuclear lumen. Part of receptor complex. [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in fat (RPKM 12.5), testis (RPKM 11.6) and 25 other tissues See more
    Orthologs
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    Genomic context

    See TAOK2 in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (29973868..29992261)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (30256503..30274899)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (29985189..30003582)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerization domain containing 13 Neighboring gene KCTD13 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10684 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7345 Neighboring gene transmembrane protein 219 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7346 Neighboring gene uncharacterized LOC124903762 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:29985672-29986443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:29987081-29987582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:29987583-29988082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30002153-30002740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30004428-30004928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30004929-30005429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10687 Neighboring gene HIRA interacting protein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30015046-30015830 Neighboring gene INO80 complex subunit E Neighboring gene double C2 domain alpha

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (19 hits/1314 screens)

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • KIAA0881

    Gene Ontology Provided by GOA

    Items 1 - 25 of 32
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables MAP kinase kinase kinase activity PubMed 
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables mitogen-activated protein kinase kinase binding PubMed 
    enables neuropilin binding PubMed 
    enables protein binding PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activator activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity PubMed 
    enables ribosomal protein S6 kinase activity  
    enables tau protein binding PubMed 
    enables tau-protein kinase activity PubMed 
    Items 1 - 25 of 32
    Items 1 - 25 of 28
    Process Evidence Code Pubs
    involved_in DNA damage response PubMed 
    involved_in actin cytoskeleton organization PubMed 
    involved_in activation of protein kinase activity PubMed 
    involved_in apoptotic process PubMed 
    involved_in axonogenesis PubMed 
    involved_in axonogenesis PubMed 
    involved_in basal dendrite arborization PubMed 
    involved_in basal dendrite morphogenesis PubMed 
    involved_in cell migration PubMed 
    involved_in chromatin remodeling  
    involved_in focal adhesion assembly PubMed 
    involved_in mitotic G2 DNA damage checkpoint signaling PubMed 
    involved_in positive regulation of JNK cascade  
    involved_in positive regulation of JNK cascade PubMed 
    involved_in positive regulation of JNK cascade PubMed 
    NOT involved_in positive regulation of JNK cascade PubMed 
    involved_in positive regulation of JNK cascade PubMed 
    involved_in positive regulation of MAPK cascade PubMed 
    involved_in positive regulation of protein autophosphorylation PubMed 
    involved_in positive regulation of stress-activated MAPK cascade  
    involved_in positive regulation of stress-activated MAPK cascade PubMed 
    involved_in protein autophosphorylation PubMed 
    involved_in protein targeting to membrane PubMed 
    involved_in regulation of actin cytoskeleton organization PubMed 
    involved_in regulation of actin cytoskeleton organization PubMed 
    involved_in regulation of cell growth PubMed 
    involved_in regulation of cell shape PubMed 
    involved_in stress-activated MAPK cascade PubMed 
    Items 1 - 25 of 28
    Component Evidence Code Pubs
    colocalizes_with actin cytoskeleton PubMed 
    located_in axon PubMed 
    located_in axonal growth cone PubMed 
    is_active_in cytoplasm  
    located_in cytoplasmic vesicle PubMed 
    located_in cytoplasmic vesicle membrane  
    located_in cytosol  
    located_in dendritic growth cone PubMed 
    located_in neuron projection PubMed 
    located_in nucleolus  
    located_in nucleoplasm  
    part_of receptor complex PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase TAO2
    Names
    PSK-1
    hKFC-C
    kinase from chicken homolog C
    prostate derived STE20-like kinase PSK
    prostate-derived STE20-like kinase 1
    prostate-derived sterile 20-like kinase 1
    thousand and one amino acid protein kinase 2
    NP_001238972.1
    NP_004774.1
    NP_057235.2
    XP_011544284.1
    XP_011544285.1
    XP_011544286.1
    XP_011544287.1
    XP_011544288.1
    XP_047290873.1
    XP_047290874.1
    XP_047290875.1
    XP_047290876.1
    XP_047290877.1
    XP_047290878.1
    XP_054170391.1
    XP_054170392.1
    XP_054170393.1
    XP_054170394.1
    XP_054170395.1
    XP_054170396.1
    XP_054170397.1
    XP_054170398.1
    XP_054170399.1
    XP_054170400.1
    XP_054170401.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030462.1 RefSeqGene

      Range
      5002..19527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001252043.2 → NP_001238972.1  serine/threonine-protein kinase TAO2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) is alternatively spliced at the 3' end compared to variant 1. However, it maintains the reading frame, and encodes a shorter isoform (3) missing a protein segment compared to isoform 1.
      Source sequence(s)
      BC144344, BC151221, BP233788
      Consensus CDS
      CCDS58448.1
      UniProtKB/Swiss-Prot
      Q9UL54
      Related
      ENSP00000440336.1, ENST00000543033.5
      Conserved Domains (2) summary
      smart00220
      Location:28 → 281
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06634
      Location:12 → 319
      STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2
    2. NM_004783.4 → NP_004774.1  serine/threonine-protein kinase TAO2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains alternate exons at the 3' end compared to variant 1. This results in a shorter isoform (2, also known as PSK1-beta) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AF263313, AI805725, BC152413, BP233788, CN286840
      Consensus CDS
      CCDS10662.1
      UniProtKB/Swiss-Prot
      Q9UL54
      Related
      ENSP00000279394.3, ENST00000279394.7
      Conserved Domains (2) summary
      COG0419
      Location:478 → 913
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06634
      Location:12 → 319
      STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2
    3. NM_016151.4 → NP_057235.2  serine/threonine-protein kinase TAO2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1, also known as PSK1-alpha).
      Source sequence(s)
      BC136653, BC151221, BP233788
      Consensus CDS
      CCDS10663.1
      UniProtKB/Swiss-Prot
      A5PKY1, A7MCZ2, B2RN35, B7ZM88, O94957, Q6UW73, Q7LC09, Q9NSW2, Q9UL54
      UniProtKB/TrEMBL
      Q86V37
      Related
      ENSP00000310094.4, ENST00000308893.9
      Conserved Domains (2) summary
      smart00220
      Location:28 → 281
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06634
      Location:12 → 319
      STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      29973868..29992261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545984.2 → XP_011544286.1  serine/threonine-protein kinase TAO2 isoform X3

      Conserved Domains (2) summary
      smart00220
      Location:28 → 281
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06634
      Location:12 → 319
      STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2
    2. XM_011545985.2 → XP_011544287.1  serine/threonine-protein kinase TAO2 isoform X4

      Conserved Domains (2) summary
      smart00220
      Location:28 → 281
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06634
      Location:12 → 319
      STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2
    3. XM_047434917.1 → XP_047290873.1  serine/threonine-protein kinase TAO2 isoform X5

      UniProtKB/TrEMBL
      A0PJ48
    4. XM_011545986.4 → XP_011544288.1  serine/threonine-protein kinase TAO2 isoform X5

      UniProtKB/TrEMBL
      A0PJ48
      Conserved Domains (2) summary
      smart00220
      Location:28 → 281
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06634
      Location:12 → 319
      STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2
    5. XM_047434918.1 → XP_047290874.1  serine/threonine-protein kinase TAO2 isoform X6

      UniProtKB/TrEMBL
      A0PJ48
    6. XM_047434919.1 → XP_047290875.1  serine/threonine-protein kinase TAO2 isoform X7

      UniProtKB/TrEMBL
      A0PJ48
    7. XM_047434922.1 → XP_047290878.1  serine/threonine-protein kinase TAO2 isoform X10

      UniProtKB/TrEMBL
      A0PJ48
    8. XM_047434920.1 → XP_047290876.1  serine/threonine-protein kinase TAO2 isoform X8

      UniProtKB/TrEMBL
      A0PJ48
    9. XM_047434921.1 → XP_047290877.1  serine/threonine-protein kinase TAO2 isoform X9

      UniProtKB/TrEMBL
      A0PJ48
    10. XM_011545982.3 → XP_011544284.1  serine/threonine-protein kinase TAO2 isoform X1

      UniProtKB/TrEMBL
      Q86V37
      Conserved Domains (2) summary
      smart00220
      Location:28 → 281
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06634
      Location:12 → 319
      STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2
    11. XM_011545983.4 → XP_011544285.1  serine/threonine-protein kinase TAO2 isoform X2

      UniProtKB/TrEMBL
      Q86V37
      Conserved Domains (2) summary
      smart00220
      Location:28 → 281
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06634
      Location:12 → 319
      STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      30256503..30274899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314418.1 → XP_054170393.1  serine/threonine-protein kinase TAO2 isoform X3

    2. XM_054314419.1 → XP_054170394.1  serine/threonine-protein kinase TAO2 isoform X4

    3. XM_054314421.1 → XP_054170396.1  serine/threonine-protein kinase TAO2 isoform X5

      UniProtKB/TrEMBL
      A0PJ48
    4. XM_054314420.1 → XP_054170395.1  serine/threonine-protein kinase TAO2 isoform X5

      UniProtKB/TrEMBL
      A0PJ48
    5. XM_054314422.1 → XP_054170397.1  serine/threonine-protein kinase TAO2 isoform X6

      UniProtKB/TrEMBL
      A0PJ48
    6. XM_054314426.1 → XP_054170401.1  serine/threonine-protein kinase TAO2 isoform X10

      UniProtKB/TrEMBL
      A0PJ48
    7. XM_054314423.1 → XP_054170398.1  serine/threonine-protein kinase TAO2 isoform X7

      UniProtKB/TrEMBL
      A0PJ48
    8. XM_054314424.1 → XP_054170399.1  serine/threonine-protein kinase TAO2 isoform X8

      UniProtKB/TrEMBL
      A0PJ48
    9. XM_054314425.1 → XP_054170400.1  serine/threonine-protein kinase TAO2 isoform X9

      UniProtKB/TrEMBL
      A0PJ48
    10. XM_054314416.1 → XP_054170391.1  serine/threonine-protein kinase TAO2 isoform X1

      UniProtKB/TrEMBL
      Q86V37
    11. XM_054314417.1 → XP_054170392.1  serine/threonine-protein kinase TAO2 isoform X2

      UniProtKB/TrEMBL
      Q86V37
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