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AURKC aurora kinase C [ Homo sapiens (human) ]

Gene ID: 6795, updated on 27-Nov-2024

Summary

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Official Symbol
AURKCprovided by HGNC
Official Full Name
aurora kinase Cprovided by HGNC
Primary source
HGNC:HGNC:11391
See related
Ensembl:ENSG00000105146 MIM:603495; AllianceGenome:HGNC:11391
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIE2; AIK3; ARK3; AurC; SPGF5; STK13; HEL-S-90; aurora-C
Summary
This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 14.8), brain (RPKM 1.0) and 1 other tissue See more
Orthologs
mouse all
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Genomic context

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See AURKC in Genome Data Viewer
Location:
19q13.43
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57231023..57235548)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60327568..60332080)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57742391..57746916)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904780 Neighboring gene pentatricopeptide repeat domain 3 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15125 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15126 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11072 Neighboring gene zinc finger protein 264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11073 Neighboring gene Sharpr-MPRA regulatory region 2652 Neighboring gene zinc finger protein 805 Neighboring gene NANOG hESC enhancer GRCh37_chr19:57774577-57775110 Neighboring gene ZNF460 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11074 Neighboring gene Sharpr-MPRA regulatory region 5355 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:57791112-57792311 Neighboring gene zinc finger protein 460

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Aberrantly expressed AURKC enhances the transformation and tumourigenicity of epithelial cells. Tsou JH, et al. J Pathol, 2011 Oct. PMID 21710690
  2. Whole-exome sequencing identified a novel mutation of AURKC in a Chinese family with macrozoospermia. Hua J, et al. J Assist Reprod Genet, 2019 Mar. PMID 30594972, Free PMC Article
  3. [Idiopathic teratozoospermia is not correlated with c.144delC polymorphism in the AURKC gene in Sichuan]. Mu XM, et al. Zhonghua Nan Ke Xue, 2017 Dec. PMID 29738175
  4. Macrozoospermia: screening for the homozygous c.144delC mutation in AURKC gene in infertile men and estimation of its heterozygosity frequency in the Tunisian population. Ghédir H, et al. J Assist Reprod Genet, 2015 Nov. PMID 26341096, Free PMC Article
  5. Regulation of AURKC expression by CpG island methylation in human cancer cells. Fujii S, et al. Tumour Biol, 2015 Sep. PMID 25990457

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Computational study of the potential impact of AURKC missense SNPs on AURKC-INCENP interaction and their correlation to macrozoospermia.
    Title: Computational study of the potential impact of AURKC missense SNPs on AURKC-INCENP interaction and their correlation to macrozoospermia.
  2. Aurora kinase genetic polymorphisms: an association study in Down syndrome and spontaneous abortion.
    Title: Aurora kinase genetic polymorphisms: an association study in Down syndrome and spontaneous abortion.
  3. Purging human ovarian cortex of contaminating leukaemic cells by targeting the mitotic catastrophe signalling pathway.
    Title: Purging human ovarian cortex of contaminating leukaemic cells by targeting the mitotic catastrophe signalling pathway.
  4. The oncogenic role of meiosis-specific Aurora kinase C in mitotic cells.
    Title: The oncogenic role of meiosis-specific Aurora kinase C in mitotic cells.
  5. Genetic variations in AURORA cell cycle kinases are associated with glioblastoma multiforme.
    Title: Genetic variations in AURORA cell cycle kinases are associated with glioblastoma multiforme.
  6. Co-relation with novel phosphorylation sites of IkappaBalpha and necroptosis in breast cancer cells.
    Title: Co-relation with novel phosphorylation sites of IκBα and necroptosis in breast cancer cells.
  7. Mutational analysis of Aurora kinase C gene in Egyptian patients with macrozoospermia.
    Title: Mutational analysis of Aurora kinase C gene in Egyptian patients with macrozoospermia.
  8. Two frequent loss-of-function mutations in Aurora Kinase C gene in Algerian infertile men with macrozoospermia.
    Title: Two frequent loss-of-function mutations in Aurora Kinase C gene in Algerian infertile men with macrozoospermia.
  9. Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis.
    Title: Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis.
  10. Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction.
    Title: Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction.
Submit: New GeneRIF Correction See all GeneRIFs (53)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Infertility associated with multi-tailed spermatozoa and excessive DNA
MedGen: C0403812 OMIM: 243060 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine/tyrosine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in attachment of spindle microtubules to kinetochore TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle midzone assembly TAS
Traceable Author Statement
more info
 PubMed 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytokinesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromosome passenger complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromosome passenger complex TAS
Traceable Author Statement
more info
 PubMed 
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
located_in midbody TAS
Traceable Author Statement
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle TAS
Traceable Author Statement
more info
 PubMed 
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle midzone IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
aurora kinase C
Names
ARK-3
aurora 3
aurora-related kinase 3
aurora/IPL1-related kinase 3
aurora/IPL1/EG2 protein 2
epididymis secretory protein Li 90
serine/threonine kinase 13 (aurora/IPL1-like)
serine/threonine-protein kinase 13
serine/threonine-protein kinase aurora-C
NP_001015878.1
NP_001015879.1
NP_003151.2
XP_047295209.1
XP_054177818.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012134.1 RefSeqGene

    Range
    5015..9540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001015878.2 → NP_001015878.1  aurora kinase C isoform 1

    See identical proteins and their annotated locations for NP_001015878.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC005261, AF054621, AY661554
    Consensus CDS
    CCDS33128.1
    UniProtKB/Swiss-Prot
    O60681, O75442, Q6AZY8, Q6DLZ0, Q9UPK5, Q9UQB9
    UniProtKB/TrEMBL
    Q5Y191
    Related
    ENSP00000302898.6, ENST00000302804.12
    Conserved Domains (2) summary
    smart00220
    Location:43 → 293
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14117
    Location:36 → 305
    STKc_Aurora-B_like; Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins

  2. NM_001015879.2 → NP_001015879.1  aurora kinase C isoform 2

    See identical proteins and their annotated locations for NP_001015879.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as Aurora C-SV, uses an alternate splice site at the 5' end of the first intron and an alternate upstream translation initiation site, compared to variant 1. The encoded protein (isoform 2) contains a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB017332, AY661554, BX092186
    Consensus CDS
    CCDS46205.1
    UniProtKB/TrEMBL
    V9HW16
    Related
    ENSP00000407162.1, ENST00000415300.6
    Conserved Domains (2) summary
    smart00220
    Location:24 → 274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14117
    Location:17 → 286
    STKc_Aurora-B_like; Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins

  3. NM_003160.3 → NP_003151.2  aurora kinase C isoform 3

    See identical proteins and their annotated locations for NP_003151.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site at the 5' end of the first intron and an alternate downstream translation initiation site, compared to variant 1. The encoded protein (isoform 3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB017332, AF054621, AF059681, AY661554
    Consensus CDS
    CCDS46206.1
    UniProtKB/TrEMBL
    V9HW16
    Related
    ENSP00000471830.1, ENST00000598785.5
    Conserved Domains (1) summary
    cl21453
    Location:2 → 271
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    57231023..57235548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439253.1 → XP_047295209.1  aurora kinase C isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    60327568..60332080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321843.1 → XP_054177818.1  aurora kinase C isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UQB9.1 GenPept UniProtKB/Swiss-Prot:Q9UQB9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Medical
Molecular Biology Databases
Research Materials
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