ten-1 EGF-like domain-containing protein;Teneurin-1;Tox-GHH domain-containing protein [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: ten-1
Official Full Name: EGF-like domain-containing protein;Teneurin-1;Tox-GHH domain-containing protein
Primary source: WormBase:WBGene00006498
Locus tag: CELE_R13F6.4
See related: AllianceGenome:WB:WBGene00006498
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in several processes, including axon development; basement membrane assembly involved in embryonic body morphogenesis; and gonad development. Located in nucleus and plasma membrane. Is expressed in several structures, including body muscle cell; epithelial cell; gonad; hypodermis; and nervous system. Human ortholog(s) of this gene implicated in cocaine dependence and essential tremor 5. Orthologous to several human genes including TENM2 (teneurin transmembrane protein 2) and TENM3 (teneurin transmembrane protein 3). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See ten-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 20

Sequence:: Chromosome: III; NC_003281.10 (6820935..6847283)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic interaction between Caenorhabditis elegans teneurin ten-1 and prolyl 4-hydroxylase phy-1 and their function in collagen IV-mediated basement membrane integrity during late elongation of the embryo
Title: Genetic interaction between Caenorhabditis elegans teneurin ten-1 and prolyl 4-hydroxylase phy-1 and their function in collagen IV-mediated basement membrane integrity during late elongation of the embryo.
Results are consistent with ten-1 normally providing a function complementary to the cytoskeletal remodeling processes that occur in migrating cells or cells undergoing morphogenesis.
Title: C. elegans ten-1 is synthetic lethal with mutations in cytoskeleton regulators, and enhances many axon guidance defective mutants.
ten-1 is required for gonadal and pharyngeal basement membrane integrity and acts redundantly with integrin ina-1 and dystroglycan dgn-1
Title: Caenorhabditis elegans teneurin, ten-1, is required for gonadal and pharyngeal basement membrane integrity and acts redundantly with integrin ina-1 and dystroglycan dgn-1.
Ten-1 acts as a receptor for morphogenetic cue(s) and directly signals to the nucleus by translocation of its intracellular domain to the nucleus following its proteolytic release from the cell membrane.
Title: ten-1, an essential gene for germ cell development, epidermal morphogenesis, gonad migration, and neuronal pathfinding in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

R13F6.4 (e-PCR)
- UniSTS:311602

STS3-155 (e-PCR)
- UniSTS:241996

F28F5.1 (e-PCR)
- UniSTS:318175

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basement membrane assembly involved in embryonic body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basement membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defecation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic body morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamete generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inductive cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode pharynx development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-embryonic body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sexual reproduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sexual reproduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: EGF-like domain-containing protein;Teneurin-1;Tox-GHH domain-containing protein

NP_001022723.2

Confirmed by transcript evidence

NP_001254940.1

Partially confirmed by transcript evidence

NP_001254941.1

Partially confirmed by transcript evidence

NP_001379903.1

Confirmed by transcript evidence

NP_498487.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6820935..6847283

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001268011.3 → NP_001254940.1 EGF-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254940.1

Status: REVIEWED

UniProtKB/TrEMBL

H1ZUX0

Conserved Domains (5) summary

cd05819
Location:1335 → 1372

NHL; NHL repeat [structural motif]

pfam07974
Location:662 → 686

EGF_2; EGF-like domain

pfam12785
Location:792 → 896

VESA1_N; Variant erythrocyte surface antigen-1

pfam15636
Location:2763 → 2835

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

cl18310
Location:1305 → 1663

NHL; NHL repeat unit of beta-propeller proteins
NM_001268012.3 → NP_001254941.1 EGF-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254941.1

Status: REVIEWED

UniProtKB/TrEMBL

H1ZUX1

Conserved Domains (5) summary

cd05819
Location:1261 → 1298

NHL; NHL repeat [structural motif]

pfam07974
Location:588 → 612

EGF_2; EGF-like domain

pfam12785
Location:718 → 822

VESA1_N; Variant erythrocyte surface antigen-1

pfam15636
Location:2689 → 2761

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

cl18310
Location:1231 → 1589

NHL; NHL repeat unit of beta-propeller proteins
NM_001027552.5 → NP_001022723.2 Teneurin-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022723.2

Status: REVIEWED

UniProtKB/Swiss-Prot

B5BM17, G5EGQ6, Q5CCJ6

Conserved Domains (5) summary

cd05819
Location:1182 → 1219

NHL; NHL repeat [structural motif]

pfam07974
Location:509 → 533

EGF_2; EGF-like domain

pfam12785
Location:639 → 743

VESA1_N; Variant erythrocyte surface antigen-1

pfam15636
Location:2610 → 2682

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

cl18310
Location:1152 → 1510

NHL; NHL repeat unit of beta-propeller proteins
NM_001392130.1 → NP_001379903.1 Teneurin-1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (6) summary

cd05819
Location:1000 → 1037

NHL; NHL repeat [structural motif]

cl18310
Location:970 → 1328

NHL; NHL repeat unit of beta-propeller proteins

pfam00053
Location:262 → 313

Laminin_EGF; Laminin EGF domain

pfam15636
Location:2428 → 2500

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

NF033662
Location:578 → 595

acid_disulf_rpt; acidic double-disulfide repeat

cl19567
Location:306 → 351

DSL; Delta serrate ligand
NM_066086.8 → NP_498487.2 Tox-GHH domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498487.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8I7J1

Conserved Domains (1) summary

pfam15636
Location:815 → 853

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin