|
Name |
Accession |
Description |
Interval |
E-value |
| NHL super family |
cl18310 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
970-1328 |
1.81e-26 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
The actual alignment was detected with superfamily member cd14953:
Pssm-ID: 302697 [Multi-domain] Cd Length: 323 Bit Score: 112.62 E-value: 1.81e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 970 VSTFAG--LDGVKRDVEclkcegkvDSISLFRPTTVVYAQDGSLIIGD--HNMIRRVSQDGQVSTILTLGLA-------- 1037
Cdd:cd14953 1 VSTVAGsgTAGFSGGGG--------TAARFNSPSGVAVDAAGNLYVADrgNHRIRKITPDGVVTTVAGTGTAgfadggga 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1038 ------------DTSHSYYIA---------VSPvDGTIAislplhkqvwrisslepqdsrnnydVLAGDGTVcasavdSC 1096
Cdd:cd14953 73 aaqfntpsgvavDAAGNLYVAdtgnhrirkITP-DGVVS-------------------------TLAGTGTA------GF 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1097 GDGALAQNAQLIFPKGISFDKMGNLYLADSR--RIRVIDTTGHIRSI---GETTPDQHPIRTCAQITklvdlqmeWPTSL 1171
Cdd:cd14953 121 SDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVTTVagtGGAGYAGDGPATAAQFN--------NPTGV 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1172 TIDPiTGSVLVLDT--NVVYEIDVVHDVVTIAlGSPTTcdLANATSSASAKSLdhrrhliQNARDITVGTDGAIYVVESD 1249
Cdd:cd14953 193 AVDA-AGNLYVADRgnHRIRKITPDGVVTTVA-GTGTA--GFSGDGGATAAQL-------NNPTGVAVDAAGNLYVADSG 261
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1972264537 1250 GRRlnqVRKLSSDrSTFSILTGGKSpcscdvaacgcddAVSLRDVAASQAHLSSPYAVCVSPSGDVIIADSGNSKIKKV 1328
Cdd:cd14953 262 NHR---IRKITPA-GVVTTVAGGGA-------------GFSGDGGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2428-2500 |
1.39e-21 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
:
Pssm-ID: 464783 Cd Length: 78 Bit Score: 90.75 E-value: 1.39e-21
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1972264537 2428 KKIVEELKTRENIAVWRAERKRAEAGEKTWRQWSDRETRELTSKGSVSGYDIEMK-PAHQ-SGLLASVHSWKFRK 2500
Cdd:pfam15636 4 KRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIhPVEQyPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1197-2183 |
1.10e-09 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
:
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 64.39 E-value: 1.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1197 VVTIALGSPTTCDLANATSSASAKSLDHRRHLIQNARDITVGTDGAIYVVESDGRRLNQVRKLSSDRSTFSILTGGKSPC 1276
Cdd:COG3209 7 VGGTTGASSTLLAATNAGGGTAVTNAGSTVLLAKGGLSTAAAAGGAATLTARSASTTDVVGTLTGAGGTSAGGVTALGDA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1277 SCDVAACGCDDAVSLRDVAASQAHLSSPYAVCVSPSGDVIIADSGNSKIKKVSARMAKYDGRSRTYEVTDAERQEKYTFN 1356
Cdd:COG3209 87 SAAGGGYVGGAAAGGGATLTGLAAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1357 RHGQHSSTVSLITGRTFFNFSYQVDSPISMISEIRAASGVVLRVLKRNDSLFDLETTLGQRTTLTMSAYDGTLEQVSKRD 1436
Cdd:COG3209 167 SAYGLTLGGAAAGPATGVGTGAVTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1437 SATSRDATKLFYKKGLLTSRIDVATAVGFEYDEYGRAIGLKRDREYWRLGEETISMGSVNTEVLLNGQRFQQVRLGEGNL 1516
Cdd:COG3209 247 GAGAAVATAATTLGGTTGAGTGASGAGLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAV 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1517 AVHSTNGATTRLISLRNEGYSLASPLGTSTLYDKSSSIPDSN-GEPLISRRRTKVPAIGNPQRRELTTRWDWRHVARRGD 1595
Cdd:COG3209 327 SGAADAGTTTTTGTGTGGTTTTVGGGGSLTLGGYGAAGGLTTsVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAG 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1596 DSDGSLGRRKVAEINGVNMFSMEYDVKSNQDTLRLGSTTDDAQALLFIDYTSSGRIRRISAPEDSQMAEMNITWDGAGRK 1675
Cdd:COG3209 407 TTTTSTTGGDGGPATAAGALTAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTL 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1676 SEVTWGSWKIRLTYDNSNRLTEHAIDGARVpikmSYAGASRRPNEIQHDGAKWNIQYDNYDRIKEVISKSQEATSFSSIA 1755
Cdd:COG3209 487 TSGSAGATTLGTDTTLDDTLGGTTTTTAGA----RGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGT 562
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1756 LGGDEWVLKRRTSLNSKPSLVRLSREGKVLESTTPDENHyWLERKDPITGRTTEILNDEETTVVTCWSPEGAPmcSRSRN 1835
Cdd:COG3209 563 GGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTTTTS-TAGTTTTTTSGYTRAGLTLTLGTGTASGLERAT--ASTGS 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1836 LQENTTMQGHLVARKSVTIMTPTSSEPSITSSFTYEYDDMLRVTTIQPVIEQSVLESIQLSYDERRGHVAAINGFKWARD 1915
Cdd:COG3209 640 TTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRL 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1916 ASTSRCQGHGLMYETSKANDHRQVVERKLIFGDARAS-IKIIRDKAGRASESHLeiSSSGTQRNQKITRTFDAAGRVASV 1994
Cdd:COG3209 720 GTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAGaLTYTYDALGRLTSETT--PGGVTQGTYTTRYTYDALGRLTSV 797
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1995 EQNDQEPVRIIWNSDARVEKindrvVEWNRGGALKTFQDISYQVDSIGWVVKRDN-------TTVFGYDGKGRLVSARSS 2067
Cdd:COG3209 798 TYPDGETVTYTYDALGRLTS-----VITVGSGGGTDLQDRTYTYDAAGNITSITDalragtlTQTYTYDALGRLTSATDP 872
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 2068 QLRINIFYDREDRVVQIQNSKDfIHFYYGYIDTPKLVSHfsKNGKISTLFYDDDSvpfamqsddgtryalLTDETSTIKA 2147
Cdd:COG3209 873 GTTESYTYDANGNLTSRTDGGT-TTYTYDALGRLVSVTK--PDGTTTTYTYDALG---------------HTDHLGSVRA 934
|
970 980 990
....*....|....*....|....*....|....*..
gi 1972264537 2148 IIGDS-NVLRIIDRSVFGALLPSSSSSHPFlPIGYLG 2183
Cdd:COG3209 935 LTDASgQVVWRYDYDPFGNLLAETSGAAAN-PLRFTG 970
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
327-351 |
3.65e-05 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
:
Pssm-ID: 400365 Cd Length: 26 Bit Score: 42.33 E-value: 3.65e-05
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
578-595 |
1.07e-04 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
:
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 41.35 E-value: 1.07e-04
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
263-285 |
3.51e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
:
Pssm-ID: 400365 Cd Length: 26 Bit Score: 39.64 E-value: 3.51e-04
|
| C_rich_MXAN6577 super family |
cl49352 |
MXAN_6577-like cysteine-rich domain; |
259-367 |
1.75e-03 |
|
MXAN_6577-like cysteine-rich domain;
The actual alignment was detected with superfamily member NF041328:
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 40.90 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 259 CESNCNQRGECVHGKCHCAPGFT--GRTC-DEAVCPVVCSGNGVFSGGICVCKSGFkgkecemrhnwCEVADCNGRGRCd 335
Cdd:NF041328 45 CGVACGAGQTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAACAPGQVCEGGA-----------CREACSEGLTRC- 112
|
90 100 110
....*....|....*....|....*....|....*...
gi 1972264537 336 tDGRC------RCNPGWTGEACElracPHASCHDrGVC 367
Cdd:NF041328 113 -GGACvdlatdPLHCGACGVACD----PGESCRG-GAC 144
|
|
| EGF_Tenascin super family |
cl46594 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
356-384 |
2.82e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
The actual alignment was detected with superfamily member pfam18720:
Pssm-ID: 480934 Cd Length: 29 Bit Score: 37.28 E-value: 2.82e-03
10 20
....*....|....*....|....*....
gi 1972264537 356 CPhASCHDRGVCVNGTCYCMDGWRGNDCS 384
Cdd:pfam18720 2 CP-LGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
970-1328 |
1.81e-26 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 112.62 E-value: 1.81e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 970 VSTFAG--LDGVKRDVEclkcegkvDSISLFRPTTVVYAQDGSLIIGD--HNMIRRVSQDGQVSTILTLGLA-------- 1037
Cdd:cd14953 1 VSTVAGsgTAGFSGGGG--------TAARFNSPSGVAVDAAGNLYVADrgNHRIRKITPDGVVTTVAGTGTAgfadggga 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1038 ------------DTSHSYYIA---------VSPvDGTIAislplhkqvwrisslepqdsrnnydVLAGDGTVcasavdSC 1096
Cdd:cd14953 73 aaqfntpsgvavDAAGNLYVAdtgnhrirkITP-DGVVS-------------------------TLAGTGTA------GF 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1097 GDGALAQNAQLIFPKGISFDKMGNLYLADSR--RIRVIDTTGHIRSI---GETTPDQHPIRTCAQITklvdlqmeWPTSL 1171
Cdd:cd14953 121 SDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVTTVagtGGAGYAGDGPATAAQFN--------NPTGV 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1172 TIDPiTGSVLVLDT--NVVYEIDVVHDVVTIAlGSPTTcdLANATSSASAKSLdhrrhliQNARDITVGTDGAIYVVESD 1249
Cdd:cd14953 193 AVDA-AGNLYVADRgnHRIRKITPDGVVTTVA-GTGTA--GFSGDGGATAAQL-------NNPTGVAVDAAGNLYVADSG 261
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1972264537 1250 GRRlnqVRKLSSDrSTFSILTGGKSpcscdvaacgcddAVSLRDVAASQAHLSSPYAVCVSPSGDVIIADSGNSKIKKV 1328
Cdd:cd14953 262 NHR---IRKITPA-GVVTTVAGGGA-------------GFSGDGGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2428-2500 |
1.39e-21 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 90.75 E-value: 1.39e-21
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1972264537 2428 KKIVEELKTRENIAVWRAERKRAEAGEKTWRQWSDRETRELTSKGSVSGYDIEMK-PAHQ-SGLLASVHSWKFRK 2500
Cdd:pfam15636 4 KRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIhPVEQyPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1197-2183 |
1.10e-09 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 64.39 E-value: 1.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1197 VVTIALGSPTTCDLANATSSASAKSLDHRRHLIQNARDITVGTDGAIYVVESDGRRLNQVRKLSSDRSTFSILTGGKSPC 1276
Cdd:COG3209 7 VGGTTGASSTLLAATNAGGGTAVTNAGSTVLLAKGGLSTAAAAGGAATLTARSASTTDVVGTLTGAGGTSAGGVTALGDA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1277 SCDVAACGCDDAVSLRDVAASQAHLSSPYAVCVSPSGDVIIADSGNSKIKKVSARMAKYDGRSRTYEVTDAERQEKYTFN 1356
Cdd:COG3209 87 SAAGGGYVGGAAAGGGATLTGLAAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1357 RHGQHSSTVSLITGRTFFNFSYQVDSPISMISEIRAASGVVLRVLKRNDSLFDLETTLGQRTTLTMSAYDGTLEQVSKRD 1436
Cdd:COG3209 167 SAYGLTLGGAAAGPATGVGTGAVTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1437 SATSRDATKLFYKKGLLTSRIDVATAVGFEYDEYGRAIGLKRDREYWRLGEETISMGSVNTEVLLNGQRFQQVRLGEGNL 1516
Cdd:COG3209 247 GAGAAVATAATTLGGTTGAGTGASGAGLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAV 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1517 AVHSTNGATTRLISLRNEGYSLASPLGTSTLYDKSSSIPDSN-GEPLISRRRTKVPAIGNPQRRELTTRWDWRHVARRGD 1595
Cdd:COG3209 327 SGAADAGTTTTTGTGTGGTTTTVGGGGSLTLGGYGAAGGLTTsVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAG 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1596 DSDGSLGRRKVAEINGVNMFSMEYDVKSNQDTLRLGSTTDDAQALLFIDYTSSGRIRRISAPEDSQMAEMNITWDGAGRK 1675
Cdd:COG3209 407 TTTTSTTGGDGGPATAAGALTAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTL 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1676 SEVTWGSWKIRLTYDNSNRLTEHAIDGARVpikmSYAGASRRPNEIQHDGAKWNIQYDNYDRIKEVISKSQEATSFSSIA 1755
Cdd:COG3209 487 TSGSAGATTLGTDTTLDDTLGGTTTTTAGA----RGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGT 562
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1756 LGGDEWVLKRRTSLNSKPSLVRLSREGKVLESTTPDENHyWLERKDPITGRTTEILNDEETTVVTCWSPEGAPmcSRSRN 1835
Cdd:COG3209 563 GGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTTTTS-TAGTTTTTTSGYTRAGLTLTLGTGTASGLERAT--ASTGS 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1836 LQENTTMQGHLVARKSVTIMTPTSSEPSITSSFTYEYDDMLRVTTIQPVIEQSVLESIQLSYDERRGHVAAINGFKWARD 1915
Cdd:COG3209 640 TTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRL 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1916 ASTSRCQGHGLMYETSKANDHRQVVERKLIFGDARAS-IKIIRDKAGRASESHLeiSSSGTQRNQKITRTFDAAGRVASV 1994
Cdd:COG3209 720 GTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAGaLTYTYDALGRLTSETT--PGGVTQGTYTTRYTYDALGRLTSV 797
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1995 EQNDQEPVRIIWNSDARVEKindrvVEWNRGGALKTFQDISYQVDSIGWVVKRDN-------TTVFGYDGKGRLVSARSS 2067
Cdd:COG3209 798 TYPDGETVTYTYDALGRLTS-----VITVGSGGGTDLQDRTYTYDAAGNITSITDalragtlTQTYTYDALGRLTSATDP 872
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 2068 QLRINIFYDREDRVVQIQNSKDfIHFYYGYIDTPKLVSHfsKNGKISTLFYDDDSvpfamqsddgtryalLTDETSTIKA 2147
Cdd:COG3209 873 GTTESYTYDANGNLTSRTDGGT-TTYTYDALGRLVSVTK--PDGTTTTYTYDALG---------------HTDHLGSVRA 934
|
970 980 990
....*....|....*....|....*....|....*..
gi 1972264537 2148 IIGDS-NVLRIIDRSVFGALLPSSSSSHPFlPIGYLG 2183
Cdd:COG3209 935 LTDASgQVVWRYDYDPFGNLLAETSGAAAN-PLRFTG 970
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
999-1328 |
4.33e-09 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 60.03 E-value: 4.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 999 RPTTVVYAQDGSLIIGD--HNMIRRVS-QDGQVSTILtlgLADTSHSYYIAVSPvDGTIAISLPLHKQVWRISslePQDs 1075
Cdd:COG4257 18 GPRDVAVDPDGAVWFTDqgGGRIGRLDpATGEFTEYP---LGGGSGPHGIAVDP-DGNLWFTDNGNNRIGRID---PKT- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1076 rNNYDVLAGDGTVCAsavdscgdgalaqnaqlifPKGISFDKMGNLYLADSR--RIRVIDT-TGHIRSIGETTPDQHPir 1152
Cdd:COG4257 90 -GEITTFALPGGGSN-------------------PHGIAFDPDGNLWFTDQGgnRIGRLDPaTGEVTEFPLPTGGAGP-- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1153 tcaqitklvdlqmewpTSLTIDPiTGSVLVLD--TNVVYEIDVVHDVVTIALGsPTTcdlanatssasaksldhrrhlIQ 1230
Cdd:COG4257 148 ----------------YGIAVDP-DGNLWVTDfgANAIGRIDPDTGTLTEYAL-PTP---------------------GA 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1231 NARDITVGTDGAIYVVESDGrrlNQVRKLSSDrstfsilTGgkspcscdvaacgcddavSLRDVAASQAhLSSPYAVCVS 1310
Cdd:COG4257 189 GPRGLAVDPDGNLWVADTGS---GRIGRFDPK-------TG------------------TVTEYPLPGG-GARPYGVAVD 239
|
330
....*....|....*...
gi 1972264537 1311 PSGDVIIADSGNSKIKKV 1328
Cdd:COG4257 240 GDGRVWFAESGANRIVRF 257
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
327-351 |
3.65e-05 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 42.33 E-value: 3.65e-05
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
578-595 |
1.07e-04 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 41.35 E-value: 1.07e-04
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
263-285 |
3.51e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 39.64 E-value: 3.51e-04
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
259-367 |
1.75e-03 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 40.90 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 259 CESNCNQRGECVHGKCHCAPGFT--GRTC-DEAVCPVVCSGNGVFSGGICVCKSGFkgkecemrhnwCEVADCNGRGRCd 335
Cdd:NF041328 45 CGVACGAGQTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAACAPGQVCEGGA-----------CREACSEGLTRC- 112
|
90 100 110
....*....|....*....|....*....|....*...
gi 1972264537 336 tDGRC------RCNPGWTGEACElracPHASCHDrGVC 367
Cdd:NF041328 113 -GGACvdlatdPLHCGACGVACD----PGESCRG-GAC 144
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
356-384 |
2.82e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 37.28 E-value: 2.82e-03
10 20
....*....|....*....|....*....
gi 1972264537 356 CPhASCHDRGVCVNGTCYCMDGWRGNDCS 384
Cdd:pfam18720 2 CP-LGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
262-287 |
4.22e-03 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 37.33 E-value: 4.22e-03
10 20 30
....*....|....*....|....*....|..
gi 1972264537 262 NCNQRG----EC--VHGKCHCAPGFTGRTCDE 287
Cdd:cd00055 3 DCNGHGslsgQCdpGTGQCECKPNTTGRRCDR 34
|
|
| I-EGF_1 |
pfam18372 |
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ... |
294-311 |
4.50e-03 |
|
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.
Pssm-ID: 465729 Cd Length: 29 Bit Score: 36.70 E-value: 4.50e-03
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
262-317 |
5.18e-03 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 36.91 E-value: 5.18e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1972264537 262 NCNQRG----EC--VHGKCHCAPGFTGRTCDEavcpvvcsgngvfsggicvCKSGFKGKECE 317
Cdd:smart00180 2 DCDPGGsasgTCdpDTGQCECKPNVTGRRCDR-------------------CAPGYYGDGPP 44
|
|
| DSL |
smart00051 |
delta serrate ligand; |
306-351 |
6.88e-03 |
|
delta serrate ligand;
Pssm-ID: 128366 Cd Length: 63 Bit Score: 37.31 E-value: 6.88e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1972264537 306 VCKSGFKGKECEmrhNWC-EVADCNGRGRCDTDGRCRCNPGWTGEAC 351
Cdd:smart00051 20 TCDENYYGEGCN---KFCrPRDDFFGHYTCDENGNKGCLEGWMGPYC 63
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
970-1328 |
1.81e-26 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 112.62 E-value: 1.81e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 970 VSTFAG--LDGVKRDVEclkcegkvDSISLFRPTTVVYAQDGSLIIGD--HNMIRRVSQDGQVSTILTLGLA-------- 1037
Cdd:cd14953 1 VSTVAGsgTAGFSGGGG--------TAARFNSPSGVAVDAAGNLYVADrgNHRIRKITPDGVVTTVAGTGTAgfadggga 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1038 ------------DTSHSYYIA---------VSPvDGTIAislplhkqvwrisslepqdsrnnydVLAGDGTVcasavdSC 1096
Cdd:cd14953 73 aaqfntpsgvavDAAGNLYVAdtgnhrirkITP-DGVVS-------------------------TLAGTGTA------GF 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1097 GDGALAQNAQLIFPKGISFDKMGNLYLADSR--RIRVIDTTGHIRSI---GETTPDQHPIRTCAQITklvdlqmeWPTSL 1171
Cdd:cd14953 121 SDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVTTVagtGGAGYAGDGPATAAQFN--------NPTGV 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1172 TIDPiTGSVLVLDT--NVVYEIDVVHDVVTIAlGSPTTcdLANATSSASAKSLdhrrhliQNARDITVGTDGAIYVVESD 1249
Cdd:cd14953 193 AVDA-AGNLYVADRgnHRIRKITPDGVVTTVA-GTGTA--GFSGDGGATAAQL-------NNPTGVAVDAAGNLYVADSG 261
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1972264537 1250 GRRlnqVRKLSSDrSTFSILTGGKSpcscdvaacgcddAVSLRDVAASQAHLSSPYAVCVSPSGDVIIADSGNSKIKKV 1328
Cdd:cd14953 262 NHR---IRKITPA-GVVTTVAGGGA-------------GFSGDGGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2428-2500 |
1.39e-21 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 90.75 E-value: 1.39e-21
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1972264537 2428 KKIVEELKTRENIAVWRAERKRAEAGEKTWRQWSDRETRELTSKGSVSGYDIEMK-PAHQ-SGLLASVHSWKFRK 2500
Cdd:pfam15636 4 KRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIhPVEQyPELADDPSNIRFRK 78
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1081-1330 |
2.18e-19 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 91.82 E-value: 2.18e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1081 VLAGDGTVCASavdscGDGALAqnAQLIFPKGISFDKMGNLYLADS--RRIRVIDTTGHIRSIGET-----TPDQHPIrt 1153
Cdd:cd14953 3 TVAGSGTAGFS-----GGGGTA--ARFNSPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTgtagfADGGGAA-- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1154 cAQITKlvdlqmewPTSLTIDPiTGSVLVLDT--NVVYEIDVVHDVVTIAlGSPTTCDLANATssASAKSLDhrrhliqN 1231
Cdd:cd14953 74 -AQFNT--------PSGVAVDA-AGNLYVADTgnHRIRKITPDGVVSTLA-GTGTAGFSDDGG--ATAAQFN-------Y 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1232 ARDITVGTDGAIYVVESDGRRlnqVRKLSSDR--STFSiltggkspcscdvaacGCDDAVSLRDVAASQAHLSSPYAVCV 1309
Cdd:cd14953 134 PTGVAVDAAGNLYVADTGNHR---IRKITPDGvvTTVA----------------GTGGAGYAGDGPATAAQFNNPTGVAV 194
|
250 260
....*....|....*....|.
gi 1972264537 1310 SPSGDVIIADSGNSKIKKVSA 1330
Cdd:cd14953 195 DAAGNLYVADRGNHRIRKITP 215
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1104-1330 |
5.55e-18 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 86.60 E-value: 5.55e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1104 NAQLIFPKGISFDKMGNLYLADSR--RIRVIDTTG-HIRSIGETTPDqhpirtcaqitklvDLQMEWPTSLTIDPiTGSV 1180
Cdd:cd05819 4 PGELNNPQGIAVDSSGNIYVADTGnnRIQVFDPDGnFITSFGSFGSG--------------DGQFNEPAGVAVDS-DGNL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1181 LVLDTN----VVYEIDVVHDVVTIALGSPTTCDlanatssasaksldhrrhliQNARDITVGTDGAIYVVESDGRRlnqV 1256
Cdd:cd05819 69 YVADTGnhriQKFDPDGNFLASFGGSGDGDGEF--------------------NGPRGIAVDSSGNIYVADTGNHR---I 125
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1972264537 1257 RKLSSDRSTFSILTGGKSpcscdvaacgcddavslrdvaaSQAHLSSPYAVCVSPSGDVIIADSGNSKIKKVSA 1330
Cdd:cd05819 126 QKFDPDGEFLTTFGSGGS----------------------GPGQFNGPTGVAVDSDGNIYVADTGNHRIQVFDP 177
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
997-1328 |
5.76e-16 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 80.44 E-value: 5.76e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 997 LFRPTTVVYAQDGSLIIGD--HNMIRRVSQDGQ-VSTILTLGLADTSHSY--YIAVSPvDGTIAISlplhkqvwrissle 1071
Cdd:cd05819 7 LNNPQGIAVDSSGNIYVADtgNNRIQVFDPDGNfITSFGSFGSGDGQFNEpaGVAVDS-DGNLYVA-------------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1072 pqDSRNN-YDVLAGDGTVCASAVDScGDGalaqNAQLIFPKGISFDKMGNLYLADSR--RIRVIDTTGH-IRSIGETTpd 1147
Cdd:cd05819 72 --DTGNHrIQKFDPDGNFLASFGGS-GDG----DGEFNGPRGIAVDSSGNIYVADTGnhRIQKFDPDGEfLTTFGSGG-- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1148 qhpirtcaqitkLVDLQMEWPTSLTIDPiTGSVLVLDT--NVVYEIDvvhdvvtialgspttcdlANATSSASAKSLDHR 1225
Cdd:cd05819 143 ------------SGPGQFNGPTGVAVDS-DGNIYVADTgnHRIQVFD------------------PDGNFLTTFGSTGTG 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1226 RHLIQNARDITVGTDGAIYVVESDGRRlnqVRKLssDRSTFSILTGGKspcscdvaacgcddavslrdVAASQAHLSSPY 1305
Cdd:cd05819 192 PGQFNYPTGIAVDSDGNIYVADSGNNR---VQVF--DPDGAGFGGNGN--------------------FLGSDGQFNRPS 246
|
330 340
....*....|....*....|...
gi 1972264537 1306 AVCVSPSGDVIIADSGNSKIKKV 1328
Cdd:cd05819 247 GLAVDSDGNLYVADTGNNRIQVF 269
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1074-1326 |
2.08e-10 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 64.21 E-value: 2.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1074 DSRNNYDVLAGDGTVCASAVDSCGDGalaqNAQLIFPKGISFDKMGNLYLADS--RRIRVIDTTG-HIRSIGETTpdqhp 1150
Cdd:cd14957 35 DTGNNRIQVFTSSGVYSYSIGSGGTG----SGQFNSPYGIAVDSNGNIYVADTdnNRIQVFNSSGvYQYSIGTGG----- 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1151 irtcaqitkLVDLQMEWPTSLTIDPiTGSVLVLDTN----VVYEIDvvhDVVTIALGSPTTCDLAnatssasaksldhrr 1226
Cdd:cd14957 106 ---------SGDGQFNGPYGIAVDS-NGNIYVADTGnhriQVFTSS---GTFSYSIGSGGTGPGQ--------------- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1227 hlIQNARDITVGTDGAIYVVESDGRRlnqVRKLSSDRST-FSILTGGKSPcscdvaacgcddavslrdvaasqAHLSSPY 1305
Cdd:cd14957 158 --FNGPQGIAVDSDGNIYVADTGNHR---IQVFTSSGTFqYTFGSSGSGP-----------------------GQFSDPY 209
|
250 260
....*....|....*....|.
gi 1972264537 1306 AVCVSPSGDVIIADSGNSKIK 1326
Cdd:cd14957 210 GIAVDSDGNIYVADTGNHRIQ 230
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1197-2183 |
1.10e-09 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 64.39 E-value: 1.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1197 VVTIALGSPTTCDLANATSSASAKSLDHRRHLIQNARDITVGTDGAIYVVESDGRRLNQVRKLSSDRSTFSILTGGKSPC 1276
Cdd:COG3209 7 VGGTTGASSTLLAATNAGGGTAVTNAGSTVLLAKGGLSTAAAAGGAATLTARSASTTDVVGTLTGAGGTSAGGVTALGDA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1277 SCDVAACGCDDAVSLRDVAASQAHLSSPYAVCVSPSGDVIIADSGNSKIKKVSARMAKYDGRSRTYEVTDAERQEKYTFN 1356
Cdd:COG3209 87 SAAGGGYVGGAAAGGGATLTGLAAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1357 RHGQHSSTVSLITGRTFFNFSYQVDSPISMISEIRAASGVVLRVLKRNDSLFDLETTLGQRTTLTMSAYDGTLEQVSKRD 1436
Cdd:COG3209 167 SAYGLTLGGAAAGPATGVGTGAVTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1437 SATSRDATKLFYKKGLLTSRIDVATAVGFEYDEYGRAIGLKRDREYWRLGEETISMGSVNTEVLLNGQRFQQVRLGEGNL 1516
Cdd:COG3209 247 GAGAAVATAATTLGGTTGAGTGASGAGLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAV 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1517 AVHSTNGATTRLISLRNEGYSLASPLGTSTLYDKSSSIPDSN-GEPLISRRRTKVPAIGNPQRRELTTRWDWRHVARRGD 1595
Cdd:COG3209 327 SGAADAGTTTTTGTGTGGTTTTVGGGGSLTLGGYGAAGGLTTsVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAG 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1596 DSDGSLGRRKVAEINGVNMFSMEYDVKSNQDTLRLGSTTDDAQALLFIDYTSSGRIRRISAPEDSQMAEMNITWDGAGRK 1675
Cdd:COG3209 407 TTTTSTTGGDGGPATAAGALTAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTL 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1676 SEVTWGSWKIRLTYDNSNRLTEHAIDGARVpikmSYAGASRRPNEIQHDGAKWNIQYDNYDRIKEVISKSQEATSFSSIA 1755
Cdd:COG3209 487 TSGSAGATTLGTDTTLDDTLGGTTTTTAGA----RGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGT 562
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1756 LGGDEWVLKRRTSLNSKPSLVRLSREGKVLESTTPDENHyWLERKDPITGRTTEILNDEETTVVTCWSPEGAPmcSRSRN 1835
Cdd:COG3209 563 GGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTTTTS-TAGTTTTTTSGYTRAGLTLTLGTGTASGLERAT--ASTGS 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1836 LQENTTMQGHLVARKSVTIMTPTSSEPSITSSFTYEYDDMLRVTTIQPVIEQSVLESIQLSYDERRGHVAAINGFKWARD 1915
Cdd:COG3209 640 TTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRL 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1916 ASTSRCQGHGLMYETSKANDHRQVVERKLIFGDARAS-IKIIRDKAGRASESHLeiSSSGTQRNQKITRTFDAAGRVASV 1994
Cdd:COG3209 720 GTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAGaLTYTYDALGRLTSETT--PGGVTQGTYTTRYTYDALGRLTSV 797
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1995 EQNDQEPVRIIWNSDARVEKindrvVEWNRGGALKTFQDISYQVDSIGWVVKRDN-------TTVFGYDGKGRLVSARSS 2067
Cdd:COG3209 798 TYPDGETVTYTYDALGRLTS-----VITVGSGGGTDLQDRTYTYDAAGNITSITDalragtlTQTYTYDALGRLTSATDP 872
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 2068 QLRINIFYDREDRVVQIQNSKDfIHFYYGYIDTPKLVSHfsKNGKISTLFYDDDSvpfamqsddgtryalLTDETSTIKA 2147
Cdd:COG3209 873 GTTESYTYDANGNLTSRTDGGT-TTYTYDALGRLVSVTK--PDGTTTTYTYDALG---------------HTDHLGSVRA 934
|
970 980 990
....*....|....*....|....*....|....*..
gi 1972264537 2148 IIGDS-NVLRIIDRSVFGALLPSSSSSHPFlPIGYLG 2183
Cdd:COG3209 935 LTDASgQVVWRYDYDPFGNLLAETSGAAAN-PLRFTG 970
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
969-1132 |
1.57e-09 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 62.16 E-value: 1.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 969 RVSTFAGLDGVKRDVEclkceGKVDSISLFRPTTVVYAQDGSLIIGD--HNMIRRVSQDGQVSTILTLGLADTS------ 1040
Cdd:cd14953 163 VVTTVAGTGGAGYAGD-----GPATAAQFNNPTGVAVDAAGNLYVADrgNHRIRKITPDGVVTTVAGTGTAGFSgdggat 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1041 -----HSYYIAVSPvDGTIAISLPLHKQVWRISSLEpqdsrnNYDVLAGDGTvcasavDSCGDGALAQNAQLIFPKGISF 1115
Cdd:cd14953 238 aaqlnNPTGVAVDA-AGNLYVADSGNHRIRKITPAG------VVTTVAGGGA------GFSGDGGPATSAQFNNPTGVAV 304
|
170
....*....|....*....
gi 1972264537 1116 DKMGNLYLADSR--RIRVI 1132
Cdd:cd14953 305 DAAGNLYVADTGnnRIRKI 323
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
999-1328 |
4.33e-09 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 60.03 E-value: 4.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 999 RPTTVVYAQDGSLIIGD--HNMIRRVS-QDGQVSTILtlgLADTSHSYYIAVSPvDGTIAISLPLHKQVWRISslePQDs 1075
Cdd:COG4257 18 GPRDVAVDPDGAVWFTDqgGGRIGRLDpATGEFTEYP---LGGGSGPHGIAVDP-DGNLWFTDNGNNRIGRID---PKT- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1076 rNNYDVLAGDGTVCAsavdscgdgalaqnaqlifPKGISFDKMGNLYLADSR--RIRVIDT-TGHIRSIGETTPDQHPir 1152
Cdd:COG4257 90 -GEITTFALPGGGSN-------------------PHGIAFDPDGNLWFTDQGgnRIGRLDPaTGEVTEFPLPTGGAGP-- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1153 tcaqitklvdlqmewpTSLTIDPiTGSVLVLD--TNVVYEIDVVHDVVTIALGsPTTcdlanatssasaksldhrrhlIQ 1230
Cdd:COG4257 148 ----------------YGIAVDP-DGNLWVTDfgANAIGRIDPDTGTLTEYAL-PTP---------------------GA 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1231 NARDITVGTDGAIYVVESDGrrlNQVRKLSSDrstfsilTGgkspcscdvaacgcddavSLRDVAASQAhLSSPYAVCVS 1310
Cdd:COG4257 189 GPRGLAVDPDGNLWVADTGS---GRIGRFDPK-------TG------------------TVTEYPLPGG-GARPYGVAVD 239
|
330
....*....|....*...
gi 1972264537 1311 PSGDVIIADSGNSKIKKV 1328
Cdd:COG4257 240 GDGRVWFAESGANRIVRF 257
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1107-1330 |
3.89e-08 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 56.83 E-value: 3.89e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1107 LIFPKGISFDKMGNLYLADSRRIRVIDTTGhirsiGETTPdqhpirtcaqiTKLvdlqmewPTSLTIDPitGSVLVLDTN 1186
Cdd:cd14952 9 LDGPGGVAVDAAGNVYVADSGNNRVLKLAA-----GSTTQ-----------TVL-------PFTGLYQP--QGVAVDAAG 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1187 VVYEIDVVHD-VVTIALGSPTTCDLANAtssasakSLDhrrhliqNARDITVGTDGAIYVVESDGrrlNQVRKLSSDRST 1265
Cdd:cd14952 64 TVYVTDFGNNrVLKLAAGSTTQTVLPFT-------GLN-------DPTGVAVDAAGNVYVADTGN---NRVLKLAAGSNT 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1266 FSIL--TGGKSPCscDVAAcgcDDA-------------VSLRDVAASQ-----AHLSSPYAVCVSPSGDVIIADSGNSKI 1325
Cdd:cd14952 127 QTVLpfTGLSNPD--GVAV---DGAgnvyvtdtgnnrvLKLAAGSTTQtvlpfTGLNSPSGVAVDTAGNVYVTDHGNNRV 201
|
....*
gi 1972264537 1326 KKVSA 1330
Cdd:cd14952 202 LKLAA 206
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1103-1330 |
2.17e-06 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 51.88 E-value: 2.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1103 QNAQLIFPKGISFDKMGNLYLADS--RRIRVIDTTG-HIRSIGE--TTPDQhpirtcaqitklvdlqMEWPTSLTIDPiT 1177
Cdd:cd14957 13 GNGQFNTPRGIAVDSAGNIYVADTgnNRIQVFTSSGvYSYSIGSggTGSGQ----------------FNSPYGIAVDS-N 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1178 GSVLVLDTNVvYEIDVvhdvvtiaLGSPTTCDLANATSSASAKSLDhrrhliqNARDITVGTDGAIYVVESDGRRlnqVR 1257
Cdd:cd14957 76 GNIYVADTDN-NRIQV--------FNSSGVYQYSIGTGGSGDGQFN-------GPYGIAVDSNGNIYVADTGNHR---IQ 136
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1972264537 1258 KLSSDRST-FSILTGGKSPcscdvaacgcddavslrdvaasqAHLSSPYAVCVSPSGDVIIADSGNSKIKKVSA 1330
Cdd:cd14957 137 VFTSSGTFsYSIGSGGTGP-----------------------GQFNGPQGIAVDSDGNIYVADTGNHRIQVFTS 187
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1091-1252 |
5.92e-06 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 50.36 E-value: 5.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1091 SAVDSCGD-GALAQnaQLIFPKGISFDKMGNLYLADSR--RIRVIDTTGH-IRSIGE--TTPDqhpirtcaqitklvdlQ 1164
Cdd:cd14956 138 SFLRQWGGtGIEPG--SFNYPRGVAVDPDGTLYVADTYndRIQVFDNDGAfLRKWGGrgTGPG----------------Q 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1165 MEWPTSLTIDPiTGSVLVLDTN----VVYEIDVvhdVVTIALGSPTtcdlanatssasaksldHRRHLIQNARDITVGTD 1240
Cdd:cd14956 200 FNYPYGIAIDP-DGNVFVADFGnnriQKFTADG---TFLTSWGSPG-----------------TGPGQFKNPWGVVVDAD 258
|
170
....*....|..
gi 1972264537 1241 GAIYVVESDGRR 1252
Cdd:cd14956 259 GTVYVADSNNNR 270
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1109-1344 |
2.74e-05 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 48.48 E-value: 2.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1109 FPKGISFDKMGNLYLADSR--RIRVID-TTGhirsigettpdqhpirtcaQITKLVDLQMEWPTSLTIDPiTGSVLVLDT 1185
Cdd:COG4257 18 GPRDVAVDPDGAVWFTDQGggRIGRLDpATG-------------------EFTEYPLGGGSGPHGIAVDP-DGNLWFTDN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1186 --NVVYEIDVV-HDVVTIALGSPttcdlanatssasaksldhrrhlIQNARDITVGTDGAIYVVESDGrrlNQVRKLSSD 1262
Cdd:COG4257 78 gnNRIGRIDPKtGEITTFALPGG-----------------------GSNPHGIAFDPDGNLWFTDQGG---NRIGRLDPA 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1263 RSTFSILTGGKSPcscdvaacgcddavslrdvaasqahlSSPYAVCVSPSGDVIIADSGNSKIKKVSARmakyDGRSRTY 1342
Cdd:COG4257 132 TGEVTEFPLPTGG--------------------------AGPYGIAVDPDGNLWVTDFGANAIGRIDPD----TGTLTEY 181
|
..
gi 1972264537 1343 EV 1344
Cdd:COG4257 182 AL 183
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1107-1329 |
3.25e-05 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 47.97 E-value: 3.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1107 LIFPKGISFDKMGNLYLADSRRIRVIDTTGhirsiGETTPdqhpirtcaqiTKLVDLQMEWPTSLTIDPiTGSVLVLDTn 1186
Cdd:cd14952 51 LYQPQGVAVDAAGTVYVTDFGNNRVLKLAA-----GSTTQ-----------TVLPFTGLNDPTGVAVDA-AGNVYVADT- 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1187 vvyeidVVHDVVTIALGS--PTTCDLAnatssasaksldhrrHLIqNARDITVGTDGAIYVVESDGrrlNQVRKLSSDRS 1264
Cdd:cd14952 113 ------GNNRVLKLAAGSntQTVLPFT---------------GLS-NPDGVAVDGAGNVYVTDTGN---NRVLKLAAGST 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1265 TFSIL--TGGKSPCSCDVAACGC--------DDAVSLRDVAASQA-----HLSSPYAVCVSPSGDVIIADSGNSKIKKVS 1329
Cdd:cd14952 168 TQTVLpfTGLNSPSGVAVDTAGNvyvtdhgnNRVLKLAAGSTTPTvlpftGLNGPLGVAVDAAGNVYVADRGNDRVVKLP 247
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
327-351 |
3.65e-05 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 42.33 E-value: 3.65e-05
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1197-1330 |
4.91e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 47.91 E-value: 4.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1197 VVTIAlGSPTTCDLANATSSASaksldhrrhlIQNARDITVGTDGAIYVVESDGRRlnqVRKLSSDrSTFSILTGGKSPC 1276
Cdd:cd14953 1 VSTVA-GSGTAGFSGGGGTAAR----------FNSPSGVAVDAAGNLYVADRGNHR---IRKITPD-GVVTTVAGTGTAG 65
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1972264537 1277 ScdvaacgcddavslRDVAASQAHLSSPYAVCVSPSGDVIIADSGNSKIKKVSA 1330
Cdd:cd14953 66 F--------------ADGGGAAAQFNTPSGVAVDAAGNLYVADTGNHRIRKITP 105
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
307-352 |
1.01e-04 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 41.84 E-value: 1.01e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1972264537 307 CKSGFKGKECEmrhNWCEV-ADCNGRGRCDTDGRCRCNPGWTGEACE 352
Cdd:pfam01414 1 CDENYYGSTCS---KFCRPrDDKFGHYTCDANGNKVCLPGWTGPYCD 44
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
578-595 |
1.07e-04 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 41.35 E-value: 1.07e-04
|
| NHL_like_4 |
cd14955 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1095-1327 |
1.31e-04 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271325 [Multi-domain] Cd Length: 279 Bit Score: 46.42 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1095 SCGDGalaqNAQLIFPKGISFDKMGNLYLADSR--RIRVIDTTG-HIRSIGETTPDqhpirtcaqitklvDLQMEWPTSL 1171
Cdd:cd14955 101 SSGSG----DGQFNSPSGIAVDSAGNVYVTDSGnnRIQKFDSSGtFITKWGSFGSG--------------DGQFNSPTGI 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1172 TIDPiTGSVLVLDTNvvyeidvVHDVVTIalgSPTTCDLANATSSASAKSldhrrhliQ--NARDITVGTDGAIYVVESD 1249
Cdd:cd14955 163 AVDS-AGNVYVADTG-------NNRIQKF---TSTGTFLTKWGSEGSGDG--------QfnAPYGIAVDSAGNVYVADTG 223
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1972264537 1250 GRRlnqVRKLSSDrSTFsILTGGKSpcscdvaacGCDDavslrdvaaSQahLSSPYAVCVSPSGDVIIADSGNSKIKK 1327
Cdd:cd14955 224 NNR---IQKFDSS-GTF-ITKWGSE---------GSGD---------GQ--FNSPSGIAVDSAGNVYVADSGNNRIQK 276
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1235-1328 |
1.69e-04 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 46.42 E-value: 1.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1235 ITVGTDGAIYVVESDGrrlNQVRKLSsdrstfsiLTGGKspcscdVAACGCDDAVSL-------RDVAASQAHLSSPYAV 1307
Cdd:cd14951 139 LSLAGWGELFVADSES---SAIRAVS--------LKDGG------VKTLVGGTRVGTglfdfgdRDGPGAEALLQHPLGV 201
|
90 100
....*....|....*....|.
gi 1972264537 1308 CVSPSGDVIIADSGNSKIKKV 1328
Cdd:cd14951 202 AALPDGSVYVADTYNHKIKRV 222
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
263-285 |
3.51e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 39.64 E-value: 3.51e-04
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1229-1333 |
9.46e-04 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 43.35 E-value: 9.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1229 IQNARDITVGTDGAIYVVESDGRRlnqVRKLSSDRSTFSIL--TGGKSPCSCDVAACG---CDDAVSLRDV-----AASQ 1298
Cdd:cd14952 9 LDGPGGVAVDAAGNVYVADSGNNR---VLKLAAGSTTQTVLpfTGLYQPQGVAVDAAGtvyVTDFGNNRVLklaagSTTQ 85
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1972264537 1299 -----AHLSSPYAVCVSPSGDVIIADSGNSKIKKVSARMA 1333
Cdd:cd14952 86 tvlpfTGLNDPTGVAVDAAGNVYVADTGNNRVLKLAAGSN 125
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
262-313 |
1.45e-03 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 38.49 E-value: 1.45e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1972264537 262 NCNQRG----EC--VHGKCHCAPGFTGRTCDEavcpvvcsgngvfsggicvCKSGFKG 313
Cdd:pfam00053 2 DCNPHGslsdTCdpETGQCLCKPGVTGRHCDR-------------------CKPGYYG 40
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
259-367 |
1.75e-03 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 40.90 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 259 CESNCNQRGECVHGKCHCAPGFT--GRTC-DEAVCPVVCSGNGVFSGGICVCKSGFkgkecemrhnwCEVADCNGRGRCd 335
Cdd:NF041328 45 CGVACGAGQTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAACAPGQVCEGGA-----------CREACSEGLTRC- 112
|
90 100 110
....*....|....*....|....*....|....*...
gi 1972264537 336 tDGRC------RCNPGWTGEACElracPHASCHDrGVC 367
Cdd:NF041328 113 -GGACvdlatdPLHCGACGVACD----PGESCRG-GAC 144
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
356-384 |
2.82e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 37.28 E-value: 2.82e-03
10 20
....*....|....*....|....*....
gi 1972264537 356 CPhASCHDRGVCVNGTCYCMDGWRGNDCS 384
Cdd:pfam18720 2 CP-LGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1098-1185 |
3.16e-03 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 41.89 E-value: 3.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1098 DGALAQNAQLIFPKGISFDKMGNLYLAD--SRRIRVIDTTGH-IRSIGETTPDqhpirtcaqitklvDLQMEWPTSLTID 1174
Cdd:cd14963 185 NGSPDGKSGFVNPRGIAVDPDGNLYVVDnlSHRVYVFDEQGKeLFTFGGRGKD--------------DGQFNLPNGLFID 250
|
90
....*....|.
gi 1972264537 1175 PiTGSVLVLDT 1185
Cdd:cd14963 251 D-DGRLYVTDR 260
|
|
| NHL_TRIM71_like |
cd14954 |
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ... |
1043-1184 |
3.34e-03 |
|
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271324 [Multi-domain] Cd Length: 285 Bit Score: 42.15 E-value: 3.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1043 YYIAVSPvDGTIAISlplhkqvwrisslepqDSRNN-YDVLAGDGTVcASAVDSCGDGalaqNAQLIFPKGISFDKMGNL 1121
Cdd:cd14954 168 RGVAVNP-DGNIVVS----------------DFNNHrLQVFDPDGQF-LRFFGSEGSG----NGQFKRPRGVAVDDEGNI 225
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1972264537 1122 YLADSR--RIRVIDTTG-HIRSIGETTPDqhpirtcaqitklvDLQMEWPTSLTIDPiTGSVLVLD 1184
Cdd:cd14954 226 IVADSGnhRVQVFSPDGeFLCSFGTEGNG--------------EGQFDRPSGVAVTP-DGRIVVVD 276
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|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
361-383 |
3.67e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.94 E-value: 3.67e-03
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
262-287 |
4.22e-03 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 37.33 E-value: 4.22e-03
10 20 30
....*....|....*....|....*....|..
gi 1972264537 262 NCNQRG----EC--VHGKCHCAPGFTGRTCDE 287
Cdd:cd00055 3 DCNGHGslsgQCdpGTGQCECKPNTTGRRCDR 34
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|
| I-EGF_1 |
pfam18372 |
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ... |
294-311 |
4.50e-03 |
|
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.
Pssm-ID: 465729 Cd Length: 29 Bit Score: 36.70 E-value: 4.50e-03
|
| NHL_PAL_like |
cd14958 |
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ... |
1235-1330 |
4.96e-03 |
|
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271328 [Multi-domain] Cd Length: 300 Bit Score: 41.48 E-value: 4.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1235 ITVGTDGAIYVVESDgrrLNQVRKLSSDRSTFSILTGGKspcscdvaacgcddavslRDVA-ASQAHLSSPYAVCVSPSG 1313
Cdd:cd14958 81 LTIDPDGNIWVTDVG---LHQVFKFDPEGKLLPLLTLGE------------------RGEPgSDQTHFCKPTDVAVAPDG 139
|
90
....*....|....*...
gi 1972264537 1314 DVIIADS-GNSKIKKVSA 1330
Cdd:cd14958 140 DIFVADGyCNSRIVKFSP 157
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|
| NHL_TRIM32_like |
cd14961 |
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ... |
1104-1325 |
5.10e-03 |
|
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271331 [Multi-domain] Cd Length: 273 Bit Score: 41.49 E-value: 5.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1104 NAQLIFPKGISFDKMGNLYLADS--RRIRVIDTTGH-IRSIGETTPDQHPIRTcaqitklvdlqmewPTSLTIDPI---- 1176
Cdd:cd14961 7 PGTLNNPTGVAVTPTGRVVVADDgnKRIQVFDSDGNcLQQFGPKGDAGQDIRY--------------PLDVAVTPDghiv 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1177 -----TGSVLVLDTN-----VVYE-----IDVV-----HDVVTIALGSPTTCdlanATSSASAKSLDHRRHLIQNA---R 1233
Cdd:cd14961 73 vtdagDRSVKVFSFDgrlklFVRKsfslpWGVAvnpsgEILVTDSEAGKLFV----LTVDFKLGILKKGQKLCSQLcrpR 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972264537 1234 DITVGTDGAIYVVEsdgrRLNQVRKLSSDRST---FSILTGGkspcscdvaacGCDDAVSLRDVAASQAHLSspyAVCVS 1310
Cdd:cd14961 149 FVAVSRLGAVAVTE----HLFANGTRSSSTRVkvfSSGGQLL-----------GQIDSFGLNLVFPSLICAS---GVAFD 210
|
250
....*....|....*
gi 1972264537 1311 PSGDVIIADSGNSKI 1325
Cdd:cd14961 211 SEGNVIVADTGSGAI 225
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|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
262-317 |
5.18e-03 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 36.91 E-value: 5.18e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1972264537 262 NCNQRG----EC--VHGKCHCAPGFTGRTCDEavcpvvcsgngvfsggicvCKSGFKGKECE 317
Cdd:smart00180 2 DCDPGGsasgTCdpDTGQCECKPNVTGRRCDR-------------------CAPGYYGDGPP 44
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|
| DSL |
smart00051 |
delta serrate ligand; |
306-351 |
6.88e-03 |
|
delta serrate ligand;
Pssm-ID: 128366 Cd Length: 63 Bit Score: 37.31 E-value: 6.88e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1972264537 306 VCKSGFKGKECEmrhNWC-EVADCNGRGRCDTDGRCRCNPGWTGEAC 351
Cdd:smart00051 20 TCDENYYGEGCN---KFCrPRDDFFGHYTCDENGNKGCLEGWMGPYC 63
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|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
259-285 |
9.53e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 36.08 E-value: 9.53e-03
10 20 30
....*....|....*....|....*....|...
gi 1972264537 259 CESN--CNQRGECVHG----KCHCAPGFTGRTC 285
Cdd:cd00054 5 CASGnpCQNGGTCVNTvgsyRCSCPPGYTGRNC 37
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