|
Name |
Accession |
Description |
Interval |
E-value |
| NHL super family |
cl18310 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1152-1510 |
2.36e-26 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
The actual alignment was detected with superfamily member cd14953:
Pssm-ID: 302697 [Multi-domain] Cd Length: 323 Bit Score: 112.62 E-value: 2.36e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1152 VSTFAG--LDGVKRDVEclkcegkvDSISLFRPTTVVYAQDGSLIIGD--HNMIRRVSQDGQVSTILTLGLA-------- 1219
Cdd:cd14953 1 VSTVAGsgTAGFSGGGG--------TAARFNSPSGVAVDAAGNLYVADrgNHRIRKITPDGVVTTVAGTGTAgfadggga 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1220 ------------DTSHSYYIA---------VSPvDGTIAislplhkqvwrisslepqdsrnnydVLAGDGTVcasavdSC 1278
Cdd:cd14953 73 aaqfntpsgvavDAAGNLYVAdtgnhrirkITP-DGVVS-------------------------TLAGTGTA------GF 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1279 GDGALAQNAQLIFPKGISFDKMGNLYLADSR--RIRVIDTTGHIRSI---GETTPDQHPIRTCAQITklvdlqmeWPTSL 1353
Cdd:cd14953 121 SDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVTTVagtGGAGYAGDGPATAAQFN--------NPTGV 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1354 TIDPiTGSVLVLDT--NVVYEIDVVHDVVTIAlGSPTTcdLANATSSASAKSLdhrrhliQNARDITVGTDGAIYVVESD 1431
Cdd:cd14953 193 AVDA-AGNLYVADRgnHRIRKITPDGVVTTVA-GTGTA--GFSGDGGATAAQL-------NNPTGVAVDAAGNLYVADSG 261
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212645858 1432 GRRlnqVRKLSSDrSTFSILTGGKSpcscdvaacgcddAVSLRDVAASQAHLSSPYAVCVSPSGDVIIADSGNSKIKKV 1510
Cdd:cd14953 262 NHR---IRKITPA-GVVTTVAGGGA-------------GFSGDGGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2610-2682 |
1.49e-21 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
:
Pssm-ID: 464783 Cd Length: 78 Bit Score: 90.75 E-value: 1.49e-21
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212645858 2610 KKIVEELKTRENIAVWRAERKRAEAGEKTWRQWSDRETRELTSKGSVSGYDIEMK-PAHQ-SGLLASVHSWKFRK 2682
Cdd:pfam15636 4 KRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIhPVEQyPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1379-2365 |
3.80e-09 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
:
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 62.47 E-value: 3.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1379 VVTIALGSPTTCDLANATSSASAKSLDHRRHLIQNARDITVGTDGAIYVVESDGRRLNQVRKLSSDRSTFSILTGGKSPC 1458
Cdd:COG3209 7 VGGTTGASSTLLAATNAGGGTAVTNAGSTVLLAKGGLSTAAAAGGAATLTARSASTTDVVGTLTGAGGTSAGGVTALGDA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1459 SCDVAACGCDDAVSLRDVAASQAHLSSPYAVCVSPSGDVIIADSGNSKIKKVSARMAKYDGRSRTYEVTDAERQEKYTFN 1538
Cdd:COG3209 87 SAAGGGYVGGAAAGGGATLTGLAAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1539 RHGQHSSTVSLITGRTFFNFSYQVDSPISMISEIRAASGVVLRVLKRNDSLFDLETTLGQRTTLTMSAYDGTLEQVSKRD 1618
Cdd:COG3209 167 SAYGLTLGGAAAGPATGVGTGAVTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1619 SATSRDATKLFYKKGLLTSRIDVATAVGFEYDEYGRAIGLKRDREYWRLGEETISMGSVNTEVLLNGQRFQQVRLGEGNL 1698
Cdd:COG3209 247 GAGAAVATAATTLGGTTGAGTGASGAGLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAV 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1699 AVHSTNGATTRLISLRNEGYSLASPLGTSTLYDKSSSIPDSN-GEPLISRRRTKVPAIGNPQRRELTTRWDWRHVARRGD 1777
Cdd:COG3209 327 SGAADAGTTTTTGTGTGGTTTTVGGGGSLTLGGYGAAGGLTTsVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAG 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1778 DSDGSLGRRKVAEINGVNMFSMEYDVKSNQDTLRLGSTTDDAQALLFIDYTSSGRIRRISAPEDSQMAEMNITWDGAGRK 1857
Cdd:COG3209 407 TTTTSTTGGDGGPATAAGALTAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTL 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1858 SEVTWGSWKIRLTYDNSNRLTEHAIDGARVpikmSYAGASRRPNEIQHDGAKWNIQYDNYDRIKEVISKSQEATSFSSIA 1937
Cdd:COG3209 487 TSGSAGATTLGTDTTLDDTLGGTTTTTAGA----RGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGT 562
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1938 LGGDEWVLKRRTSLNSKPSLVRLSREGKVLESTTPDENHyWLERKDPITGRTTEILNDEETTVVTCWSPEGAPmcSRSRN 2017
Cdd:COG3209 563 GGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTTTTS-TAGTTTTTTSGYTRAGLTLTLGTGTASGLERAT--ASTGS 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 2018 LQENTTMQGHLVARKSVTIMTPTSSEPSITSSFTYEYDDMLRVTTIQPVIEQSVLESIQLSYDERRGHVAAINGFKWARD 2097
Cdd:COG3209 640 TTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRL 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 2098 ASTSRCQGHGLMYETSKANDHRQVVERKLIFGDARAS-IKIIRDKAGRASESHLeiSSSGTQRNQKITRTFDAAGRVASV 2176
Cdd:COG3209 720 GTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAGaLTYTYDALGRLTSETT--PGGVTQGTYTTRYTYDALGRLTSV 797
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 2177 EQNDQEPVRIIWNSDARVEKindrvVEWNRGGALKTFQDISYQVDSIGWVVKRDN-------TTVFGYDGKGRLVSARSS 2249
Cdd:COG3209 798 TYPDGETVTYTYDALGRLTS-----VITVGSGGGTDLQDRTYTYDAAGNITSITDalragtlTQTYTYDALGRLTSATDP 872
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 2250 QLRINIFYDREDRVVQIQNSKDfIHFYYGYIDTPKLVSHfsKNGKISTLFYDDDSvpfamqsddgtryalLTDETSTIKA 2329
Cdd:COG3209 873 GTTESYTYDANGNLTSRTDGGT-TTYTYDALGRLVSVTK--PDGTTTTYTYDALG---------------HTDHLGSVRA 934
|
970 980 990
....*....|....*....|....*....|....*..
gi 212645858 2330 IIGDS-NVLRIIDRSVFGALLPSSSSSHPFlPIGYLG 2365
Cdd:COG3209 935 LTDASgQVVWRYDYDPFGNLLAETSGAAAN-PLRFTG 970
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
509-533 |
3.15e-05 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
:
Pssm-ID: 400365 Cd Length: 26 Bit Score: 42.72 E-value: 3.15e-05
10 20
....*....|....*....|....*.
gi 212645858 509 DCNGRGRCDT-DGRCRCNPGWTGEAC 533
Cdd:pfam07974 1 ICSGRGTCVNqCGKCVCDSGYQGATC 26
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
760-777 |
9.66e-05 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
:
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 41.35 E-value: 9.66e-05
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
445-467 |
3.10e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
:
Pssm-ID: 400365 Cd Length: 26 Bit Score: 40.02 E-value: 3.10e-04
|
| C_rich_MXAN6577 super family |
cl49352 |
MXAN_6577-like cysteine-rich domain; |
441-549 |
1.31e-03 |
|
MXAN_6577-like cysteine-rich domain;
The actual alignment was detected with superfamily member NF041328:
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 41.67 E-value: 1.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 441 CESNCNQRGECVHGKCHCAPGFT--GRTC-DEAVCPVVCSGNGVFSGGICVCKSGFkgkecemrhnwCEVADCNGRGRCd 517
Cdd:NF041328 45 CGVACGAGQTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAACAPGQVCEGGA-----------CREACSEGLTRC- 112
|
90 100 110
....*....|....*....|....*....|....*...
gi 212645858 518 tDGRC------RCNPGWTGEACElracPHASCHDrGVC 549
Cdd:NF041328 113 -GGACvdlatdPLHCGACGVACD----PGESCRG-GAC 144
|
|
| EGF_Tenascin super family |
cl46594 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
538-566 |
2.53e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
The actual alignment was detected with superfamily member pfam18720:
Pssm-ID: 480934 Cd Length: 29 Bit Score: 37.66 E-value: 2.53e-03
10 20
....*....|....*....|....*....
gi 212645858 538 CPhASCHDRGVCVNGTCYCMDGWRGNDCS 566
Cdd:pfam18720 2 CP-LGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1152-1510 |
2.36e-26 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 112.62 E-value: 2.36e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1152 VSTFAG--LDGVKRDVEclkcegkvDSISLFRPTTVVYAQDGSLIIGD--HNMIRRVSQDGQVSTILTLGLA-------- 1219
Cdd:cd14953 1 VSTVAGsgTAGFSGGGG--------TAARFNSPSGVAVDAAGNLYVADrgNHRIRKITPDGVVTTVAGTGTAgfadggga 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1220 ------------DTSHSYYIA---------VSPvDGTIAislplhkqvwrisslepqdsrnnydVLAGDGTVcasavdSC 1278
Cdd:cd14953 73 aaqfntpsgvavDAAGNLYVAdtgnhrirkITP-DGVVS-------------------------TLAGTGTA------GF 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1279 GDGALAQNAQLIFPKGISFDKMGNLYLADSR--RIRVIDTTGHIRSI---GETTPDQHPIRTCAQITklvdlqmeWPTSL 1353
Cdd:cd14953 121 SDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVTTVagtGGAGYAGDGPATAAQFN--------NPTGV 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1354 TIDPiTGSVLVLDT--NVVYEIDVVHDVVTIAlGSPTTcdLANATSSASAKSLdhrrhliQNARDITVGTDGAIYVVESD 1431
Cdd:cd14953 193 AVDA-AGNLYVADRgnHRIRKITPDGVVTTVA-GTGTA--GFSGDGGATAAQL-------NNPTGVAVDAAGNLYVADSG 261
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212645858 1432 GRRlnqVRKLSSDrSTFSILTGGKSpcscdvaacgcddAVSLRDVAASQAHLSSPYAVCVSPSGDVIIADSGNSKIKKV 1510
Cdd:cd14953 262 NHR---IRKITPA-GVVTTVAGGGA-------------GFSGDGGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2610-2682 |
1.49e-21 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 90.75 E-value: 1.49e-21
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212645858 2610 KKIVEELKTRENIAVWRAERKRAEAGEKTWRQWSDRETRELTSKGSVSGYDIEMK-PAHQ-SGLLASVHSWKFRK 2682
Cdd:pfam15636 4 KRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIhPVEQyPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1379-2365 |
3.80e-09 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 62.47 E-value: 3.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1379 VVTIALGSPTTCDLANATSSASAKSLDHRRHLIQNARDITVGTDGAIYVVESDGRRLNQVRKLSSDRSTFSILTGGKSPC 1458
Cdd:COG3209 7 VGGTTGASSTLLAATNAGGGTAVTNAGSTVLLAKGGLSTAAAAGGAATLTARSASTTDVVGTLTGAGGTSAGGVTALGDA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1459 SCDVAACGCDDAVSLRDVAASQAHLSSPYAVCVSPSGDVIIADSGNSKIKKVSARMAKYDGRSRTYEVTDAERQEKYTFN 1538
Cdd:COG3209 87 SAAGGGYVGGAAAGGGATLTGLAAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1539 RHGQHSSTVSLITGRTFFNFSYQVDSPISMISEIRAASGVVLRVLKRNDSLFDLETTLGQRTTLTMSAYDGTLEQVSKRD 1618
Cdd:COG3209 167 SAYGLTLGGAAAGPATGVGTGAVTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1619 SATSRDATKLFYKKGLLTSRIDVATAVGFEYDEYGRAIGLKRDREYWRLGEETISMGSVNTEVLLNGQRFQQVRLGEGNL 1698
Cdd:COG3209 247 GAGAAVATAATTLGGTTGAGTGASGAGLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAV 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1699 AVHSTNGATTRLISLRNEGYSLASPLGTSTLYDKSSSIPDSN-GEPLISRRRTKVPAIGNPQRRELTTRWDWRHVARRGD 1777
Cdd:COG3209 327 SGAADAGTTTTTGTGTGGTTTTVGGGGSLTLGGYGAAGGLTTsVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAG 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1778 DSDGSLGRRKVAEINGVNMFSMEYDVKSNQDTLRLGSTTDDAQALLFIDYTSSGRIRRISAPEDSQMAEMNITWDGAGRK 1857
Cdd:COG3209 407 TTTTSTTGGDGGPATAAGALTAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTL 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1858 SEVTWGSWKIRLTYDNSNRLTEHAIDGARVpikmSYAGASRRPNEIQHDGAKWNIQYDNYDRIKEVISKSQEATSFSSIA 1937
Cdd:COG3209 487 TSGSAGATTLGTDTTLDDTLGGTTTTTAGA----RGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGT 562
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1938 LGGDEWVLKRRTSLNSKPSLVRLSREGKVLESTTPDENHyWLERKDPITGRTTEILNDEETTVVTCWSPEGAPmcSRSRN 2017
Cdd:COG3209 563 GGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTTTTS-TAGTTTTTTSGYTRAGLTLTLGTGTASGLERAT--ASTGS 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 2018 LQENTTMQGHLVARKSVTIMTPTSSEPSITSSFTYEYDDMLRVTTIQPVIEQSVLESIQLSYDERRGHVAAINGFKWARD 2097
Cdd:COG3209 640 TTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRL 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 2098 ASTSRCQGHGLMYETSKANDHRQVVERKLIFGDARAS-IKIIRDKAGRASESHLeiSSSGTQRNQKITRTFDAAGRVASV 2176
Cdd:COG3209 720 GTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAGaLTYTYDALGRLTSETT--PGGVTQGTYTTRYTYDALGRLTSV 797
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 2177 EQNDQEPVRIIWNSDARVEKindrvVEWNRGGALKTFQDISYQVDSIGWVVKRDN-------TTVFGYDGKGRLVSARSS 2249
Cdd:COG3209 798 TYPDGETVTYTYDALGRLTS-----VITVGSGGGTDLQDRTYTYDAAGNITSITDalragtlTQTYTYDALGRLTSATDP 872
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 2250 QLRINIFYDREDRVVQIQNSKDfIHFYYGYIDTPKLVSHfsKNGKISTLFYDDDSvpfamqsddgtryalLTDETSTIKA 2329
Cdd:COG3209 873 GTTESYTYDANGNLTSRTDGGT-TTYTYDALGRLVSVTK--PDGTTTTYTYDALG---------------HTDHLGSVRA 934
|
970 980 990
....*....|....*....|....*....|....*..
gi 212645858 2330 IIGDS-NVLRIIDRSVFGALLPSSSSSHPFlPIGYLG 2365
Cdd:COG3209 935 LTDASgQVVWRYDYDPFGNLLAETSGAAAN-PLRFTG 970
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1181-1510 |
5.93e-09 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 59.65 E-value: 5.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1181 RPTTVVYAQDGSLIIGD--HNMIRRVS-QDGQVSTILtlgLADTSHSYYIAVSPvDGTIAISLPLHKQVWRISslePQDs 1257
Cdd:COG4257 18 GPRDVAVDPDGAVWFTDqgGGRIGRLDpATGEFTEYP---LGGGSGPHGIAVDP-DGNLWFTDNGNNRIGRID---PKT- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1258 rNNYDVLAGDGTVCAsavdscgdgalaqnaqlifPKGISFDKMGNLYLADSR--RIRVIDT-TGHIRSIGETTPDQHPir 1334
Cdd:COG4257 90 -GEITTFALPGGGSN-------------------PHGIAFDPDGNLWFTDQGgnRIGRLDPaTGEVTEFPLPTGGAGP-- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1335 tcaqitklvdlqmewpTSLTIDPiTGSVLVLD--TNVVYEIDVVHDVVTIALGsPTTcdlanatssasaksldhrrhlIQ 1412
Cdd:COG4257 148 ----------------YGIAVDP-DGNLWVTDfgANAIGRIDPDTGTLTEYAL-PTP---------------------GA 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1413 NARDITVGTDGAIYVVESDGrrlNQVRKLSSDrstfsilTGgkspcscdvaacgcddavSLRDVAASQAhLSSPYAVCVS 1492
Cdd:COG4257 189 GPRGLAVDPDGNLWVADTGS---GRIGRFDPK-------TG------------------TVTEYPLPGG-GARPYGVAVD 239
|
330
....*....|....*...
gi 212645858 1493 PSGDVIIADSGNSKIKKV 1510
Cdd:COG4257 240 GDGRVWFAESGANRIVRF 257
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
509-533 |
3.15e-05 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 42.72 E-value: 3.15e-05
10 20
....*....|....*....|....*.
gi 212645858 509 DCNGRGRCDT-DGRCRCNPGWTGEAC 533
Cdd:pfam07974 1 ICSGRGTCVNqCGKCVCDSGYQGATC 26
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
760-777 |
9.66e-05 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 41.35 E-value: 9.66e-05
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
445-467 |
3.10e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 40.02 E-value: 3.10e-04
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
441-549 |
1.31e-03 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 41.67 E-value: 1.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 441 CESNCNQRGECVHGKCHCAPGFT--GRTC-DEAVCPVVCSGNGVFSGGICVCKSGFkgkecemrhnwCEVADCNGRGRCd 517
Cdd:NF041328 45 CGVACGAGQTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAACAPGQVCEGGA-----------CREACSEGLTRC- 112
|
90 100 110
....*....|....*....|....*....|....*...
gi 212645858 518 tDGRC------RCNPGWTGEACElracPHASCHDrGVC 549
Cdd:NF041328 113 -GGACvdlatdPLHCGACGVACD----PGESCRG-GAC 144
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
538-566 |
2.53e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 37.66 E-value: 2.53e-03
10 20
....*....|....*....|....*....
gi 212645858 538 CPhASCHDRGVCVNGTCYCMDGWRGNDCS 566
Cdd:pfam18720 2 CP-LGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
444-469 |
4.18e-03 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 37.33 E-value: 4.18e-03
10 20 30
....*....|....*....|....*....|..
gi 212645858 444 NCNQRG----EC--VHGKCHCAPGFTGRTCDE 469
Cdd:cd00055 3 DCNGHGslsgQCdpGTGQCECKPNTTGRRCDR 34
|
|
| I-EGF_1 |
pfam18372 |
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ... |
476-493 |
4.42e-03 |
|
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.
Pssm-ID: 465729 Cd Length: 29 Bit Score: 36.70 E-value: 4.42e-03
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
444-499 |
4.98e-03 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 36.91 E-value: 4.98e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 212645858 444 NCNQRG----EC--VHGKCHCAPGFTGRTCDEavcpvvcsgngvfsggicvCKSGFKGKECE 499
Cdd:smart00180 2 DCDPGGsasgTCdpDTGQCECKPNVTGRRCDR-------------------CAPGYYGDGPP 44
|
|
| DSL |
smart00051 |
delta serrate ligand; |
488-533 |
6.62e-03 |
|
delta serrate ligand;
Pssm-ID: 128366 Cd Length: 63 Bit Score: 37.31 E-value: 6.62e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 212645858 488 VCKSGFKGKECEmrhNWC-EVADCNGRGRCDTDGRCRCNPGWTGEAC 533
Cdd:smart00051 20 TCDENYYGEGCN---KFCrPRDDFFGHYTCDENGNKGCLEGWMGPYC 63
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1152-1510 |
2.36e-26 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 112.62 E-value: 2.36e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1152 VSTFAG--LDGVKRDVEclkcegkvDSISLFRPTTVVYAQDGSLIIGD--HNMIRRVSQDGQVSTILTLGLA-------- 1219
Cdd:cd14953 1 VSTVAGsgTAGFSGGGG--------TAARFNSPSGVAVDAAGNLYVADrgNHRIRKITPDGVVTTVAGTGTAgfadggga 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1220 ------------DTSHSYYIA---------VSPvDGTIAislplhkqvwrisslepqdsrnnydVLAGDGTVcasavdSC 1278
Cdd:cd14953 73 aaqfntpsgvavDAAGNLYVAdtgnhrirkITP-DGVVS-------------------------TLAGTGTA------GF 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1279 GDGALAQNAQLIFPKGISFDKMGNLYLADSR--RIRVIDTTGHIRSI---GETTPDQHPIRTCAQITklvdlqmeWPTSL 1353
Cdd:cd14953 121 SDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVTTVagtGGAGYAGDGPATAAQFN--------NPTGV 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1354 TIDPiTGSVLVLDT--NVVYEIDVVHDVVTIAlGSPTTcdLANATSSASAKSLdhrrhliQNARDITVGTDGAIYVVESD 1431
Cdd:cd14953 193 AVDA-AGNLYVADRgnHRIRKITPDGVVTTVA-GTGTA--GFSGDGGATAAQL-------NNPTGVAVDAAGNLYVADSG 261
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212645858 1432 GRRlnqVRKLSSDrSTFSILTGGKSpcscdvaacgcddAVSLRDVAASQAHLSSPYAVCVSPSGDVIIADSGNSKIKKV 1510
Cdd:cd14953 262 NHR---IRKITPA-GVVTTVAGGGA-------------GFSGDGGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2610-2682 |
1.49e-21 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 90.75 E-value: 1.49e-21
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212645858 2610 KKIVEELKTRENIAVWRAERKRAEAGEKTWRQWSDRETRELTSKGSVSGYDIEMK-PAHQ-SGLLASVHSWKFRK 2682
Cdd:pfam15636 4 KRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIhPVEQyPELADDPSNIRFRK 78
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1263-1512 |
2.57e-19 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 91.82 E-value: 2.57e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1263 VLAGDGTVCASavdscGDGALAqnAQLIFPKGISFDKMGNLYLADS--RRIRVIDTTGHIRSIGET-----TPDQHPIrt 1335
Cdd:cd14953 3 TVAGSGTAGFS-----GGGGTA--ARFNSPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTgtagfADGGGAA-- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1336 cAQITKlvdlqmewPTSLTIDPiTGSVLVLDT--NVVYEIDVVHDVVTIAlGSPTTCDLANATssASAKSLDhrrhliqN 1413
Cdd:cd14953 74 -AQFNT--------PSGVAVDA-AGNLYVADTgnHRIRKITPDGVVSTLA-GTGTAGFSDDGG--ATAAQFN-------Y 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1414 ARDITVGTDGAIYVVESDGRRlnqVRKLSSDR--STFSiltggkspcscdvaacGCDDAVSLRDVAASQAHLSSPYAVCV 1491
Cdd:cd14953 134 PTGVAVDAAGNLYVADTGNHR---IRKITPDGvvTTVA----------------GTGGAGYAGDGPATAAQFNNPTGVAV 194
|
250 260
....*....|....*....|.
gi 212645858 1492 SPSGDVIIADSGNSKIKKVSA 1512
Cdd:cd14953 195 DAAGNLYVADRGNHRIRKITP 215
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1286-1512 |
5.29e-18 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 86.60 E-value: 5.29e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1286 NAQLIFPKGISFDKMGNLYLADSR--RIRVIDTTG-HIRSIGETTPDqhpirtcaqitklvDLQMEWPTSLTIDPiTGSV 1362
Cdd:cd05819 4 PGELNNPQGIAVDSSGNIYVADTGnnRIQVFDPDGnFITSFGSFGSG--------------DGQFNEPAGVAVDS-DGNL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1363 LVLDTN----VVYEIDVVHDVVTIALGSPTTCDlanatssasaksldhrrhliQNARDITVGTDGAIYVVESDGRRlnqV 1438
Cdd:cd05819 69 YVADTGnhriQKFDPDGNFLASFGGSGDGDGEF--------------------NGPRGIAVDSSGNIYVADTGNHR---I 125
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212645858 1439 RKLSSDRS-TFSILTGGKSPcscdvaacgcddavslrdvaasqAHLSSPYAVCVSPSGDVIIADSGNSKIKKVSA 1512
Cdd:cd05819 126 QKFDPDGEfLTTFGSGGSGP-----------------------GQFNGPTGVAVDSDGNIYVADTGNHRIQVFDP 177
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1179-1510 |
5.29e-16 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 80.83 E-value: 5.29e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1179 LFRPTTVVYAQDGSLIIGD--HNMIRRVSQDGQ-VSTILTLGLADTSHSY--YIAVSPvDGTIAISlplhkqvwrissle 1253
Cdd:cd05819 7 LNNPQGIAVDSSGNIYVADtgNNRIQVFDPDGNfITSFGSFGSGDGQFNEpaGVAVDS-DGNLYVA-------------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1254 pqDSRNN-YDVLAGDGTVCASAVDScGDGalaqNAQLIFPKGISFDKMGNLYLADSR--RIRVIDTTGH-IRSIGETTpd 1329
Cdd:cd05819 72 --DTGNHrIQKFDPDGNFLASFGGS-GDG----DGEFNGPRGIAVDSSGNIYVADTGnhRIQKFDPDGEfLTTFGSGG-- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1330 qhpirtcaqitkLVDLQMEWPTSLTIDPiTGSVLVLDT--NVVYEIDvvhdvvtialgspttcdlANATSSASAKSLDHR 1407
Cdd:cd05819 143 ------------SGPGQFNGPTGVAVDS-DGNIYVADTgnHRIQVFD------------------PDGNFLTTFGSTGTG 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1408 RHLIQNARDITVGTDGAIYVVESDGRRlnqVRKLssDRSTFSILTGGKspcscdvaacgcddavslrdVAASQAHLSSPY 1487
Cdd:cd05819 192 PGQFNYPTGIAVDSDGNIYVADSGNNR---VQVF--DPDGAGFGGNGN--------------------FLGSDGQFNRPS 246
|
330 340
....*....|....*....|...
gi 212645858 1488 AVCVSPSGDVIIADSGNSKIKKV 1510
Cdd:cd05819 247 GLAVDSDGNLYVADTGNNRIQVF 269
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1256-1508 |
2.53e-10 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 63.82 E-value: 2.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1256 DSRNNYDVLAGDGTVCASAVDSCGDGalaqNAQLIFPKGISFDKMGNLYLADS--RRIRVIDTTG-HIRSIGETTpdqhp 1332
Cdd:cd14957 35 DTGNNRIQVFTSSGVYSYSIGSGGTG----SGQFNSPYGIAVDSNGNIYVADTdnNRIQVFNSSGvYQYSIGTGG----- 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1333 irtcaqitkLVDLQMEWPTSLTIDPiTGSVLVLDTN----VVYEIDvvhDVVTIALGSPTTCDLAnatssasaksldhrr 1408
Cdd:cd14957 106 ---------SGDGQFNGPYGIAVDS-NGNIYVADTGnhriQVFTSS---GTFSYSIGSGGTGPGQ--------------- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1409 hlIQNARDITVGTDGAIYVVESDGRRlnqVRKLSSDRST-FSILTGGKSPcscdvaacgcddavslrdvaasqAHLSSPY 1487
Cdd:cd14957 158 --FNGPQGIAVDSDGNIYVADTGNHR---IQVFTSSGTFqYTFGSSGSGP-----------------------GQFSDPY 209
|
250 260
....*....|....*....|.
gi 212645858 1488 AVCVSPSGDVIIADSGNSKIK 1508
Cdd:cd14957 210 GIAVDSDGNIYVADTGNHRIQ 230
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1151-1314 |
1.72e-09 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 61.78 E-value: 1.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1151 RVSTFAGLDGVKRDVEclkceGKVDSISLFRPTTVVYAQDGSLIIGD--HNMIRRVSQDGQVSTILTLGLADTS------ 1222
Cdd:cd14953 163 VVTTVAGTGGAGYAGD-----GPATAAQFNNPTGVAVDAAGNLYVADrgNHRIRKITPDGVVTTVAGTGTAGFSgdggat 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1223 -----HSYYIAVSPvDGTIAISLPLHKQVWRISSLEpqdsrnNYDVLAGDGTvcasavDSCGDGALAQNAQLIFPKGISF 1297
Cdd:cd14953 238 aaqlnNPTGVAVDA-AGNLYVADSGNHRIRKITPAG------VVTTVAGGGA------GFSGDGGPATSAQFNNPTGVAV 304
|
170
....*....|....*....
gi 212645858 1298 DKMGNLYLADSR--RIRVI 1314
Cdd:cd14953 305 DAAGNLYVADTGnnRIRKI 323
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1379-2365 |
3.80e-09 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 62.47 E-value: 3.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1379 VVTIALGSPTTCDLANATSSASAKSLDHRRHLIQNARDITVGTDGAIYVVESDGRRLNQVRKLSSDRSTFSILTGGKSPC 1458
Cdd:COG3209 7 VGGTTGASSTLLAATNAGGGTAVTNAGSTVLLAKGGLSTAAAAGGAATLTARSASTTDVVGTLTGAGGTSAGGVTALGDA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1459 SCDVAACGCDDAVSLRDVAASQAHLSSPYAVCVSPSGDVIIADSGNSKIKKVSARMAKYDGRSRTYEVTDAERQEKYTFN 1538
Cdd:COG3209 87 SAAGGGYVGGAAAGGGATLTGLAAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1539 RHGQHSSTVSLITGRTFFNFSYQVDSPISMISEIRAASGVVLRVLKRNDSLFDLETTLGQRTTLTMSAYDGTLEQVSKRD 1618
Cdd:COG3209 167 SAYGLTLGGAAAGPATGVGTGAVTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1619 SATSRDATKLFYKKGLLTSRIDVATAVGFEYDEYGRAIGLKRDREYWRLGEETISMGSVNTEVLLNGQRFQQVRLGEGNL 1698
Cdd:COG3209 247 GAGAAVATAATTLGGTTGAGTGASGAGLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAV 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1699 AVHSTNGATTRLISLRNEGYSLASPLGTSTLYDKSSSIPDSN-GEPLISRRRTKVPAIGNPQRRELTTRWDWRHVARRGD 1777
Cdd:COG3209 327 SGAADAGTTTTTGTGTGGTTTTVGGGGSLTLGGYGAAGGLTTsVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAG 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1778 DSDGSLGRRKVAEINGVNMFSMEYDVKSNQDTLRLGSTTDDAQALLFIDYTSSGRIRRISAPEDSQMAEMNITWDGAGRK 1857
Cdd:COG3209 407 TTTTSTTGGDGGPATAAGALTAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTL 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1858 SEVTWGSWKIRLTYDNSNRLTEHAIDGARVpikmSYAGASRRPNEIQHDGAKWNIQYDNYDRIKEVISKSQEATSFSSIA 1937
Cdd:COG3209 487 TSGSAGATTLGTDTTLDDTLGGTTTTTAGA----RGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGT 562
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1938 LGGDEWVLKRRTSLNSKPSLVRLSREGKVLESTTPDENHyWLERKDPITGRTTEILNDEETTVVTCWSPEGAPmcSRSRN 2017
Cdd:COG3209 563 GGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTTTTS-TAGTTTTTTSGYTRAGLTLTLGTGTASGLERAT--ASTGS 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 2018 LQENTTMQGHLVARKSVTIMTPTSSEPSITSSFTYEYDDMLRVTTIQPVIEQSVLESIQLSYDERRGHVAAINGFKWARD 2097
Cdd:COG3209 640 TTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRL 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 2098 ASTSRCQGHGLMYETSKANDHRQVVERKLIFGDARAS-IKIIRDKAGRASESHLeiSSSGTQRNQKITRTFDAAGRVASV 2176
Cdd:COG3209 720 GTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAGaLTYTYDALGRLTSETT--PGGVTQGTYTTRYTYDALGRLTSV 797
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 2177 EQNDQEPVRIIWNSDARVEKindrvVEWNRGGALKTFQDISYQVDSIGWVVKRDN-------TTVFGYDGKGRLVSARSS 2249
Cdd:COG3209 798 TYPDGETVTYTYDALGRLTS-----VITVGSGGGTDLQDRTYTYDAAGNITSITDalragtlTQTYTYDALGRLTSATDP 872
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 2250 QLRINIFYDREDRVVQIQNSKDfIHFYYGYIDTPKLVSHfsKNGKISTLFYDDDSvpfamqsddgtryalLTDETSTIKA 2329
Cdd:COG3209 873 GTTESYTYDANGNLTSRTDGGT-TTYTYDALGRLVSVTK--PDGTTTTYTYDALG---------------HTDHLGSVRA 934
|
970 980 990
....*....|....*....|....*....|....*..
gi 212645858 2330 IIGDS-NVLRIIDRSVFGALLPSSSSSHPFlPIGYLG 2365
Cdd:COG3209 935 LTDASgQVVWRYDYDPFGNLLAETSGAAAN-PLRFTG 970
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1181-1510 |
5.93e-09 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 59.65 E-value: 5.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1181 RPTTVVYAQDGSLIIGD--HNMIRRVS-QDGQVSTILtlgLADTSHSYYIAVSPvDGTIAISLPLHKQVWRISslePQDs 1257
Cdd:COG4257 18 GPRDVAVDPDGAVWFTDqgGGRIGRLDpATGEFTEYP---LGGGSGPHGIAVDP-DGNLWFTDNGNNRIGRID---PKT- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1258 rNNYDVLAGDGTVCAsavdscgdgalaqnaqlifPKGISFDKMGNLYLADSR--RIRVIDT-TGHIRSIGETTPDQHPir 1334
Cdd:COG4257 90 -GEITTFALPGGGSN-------------------PHGIAFDPDGNLWFTDQGgnRIGRLDPaTGEVTEFPLPTGGAGP-- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1335 tcaqitklvdlqmewpTSLTIDPiTGSVLVLD--TNVVYEIDVVHDVVTIALGsPTTcdlanatssasaksldhrrhlIQ 1412
Cdd:COG4257 148 ----------------YGIAVDP-DGNLWVTDfgANAIGRIDPDTGTLTEYAL-PTP---------------------GA 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1413 NARDITVGTDGAIYVVESDGrrlNQVRKLSSDrstfsilTGgkspcscdvaacgcddavSLRDVAASQAhLSSPYAVCVS 1492
Cdd:COG4257 189 GPRGLAVDPDGNLWVADTGS---GRIGRFDPK-------TG------------------TVTEYPLPGG-GARPYGVAVD 239
|
330
....*....|....*...
gi 212645858 1493 PSGDVIIADSGNSKIKKV 1510
Cdd:COG4257 240 GDGRVWFAESGANRIVRF 257
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1289-1512 |
4.99e-08 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 56.45 E-value: 4.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1289 LIFPKGISFDKMGNLYLADSRRIRVIDTTGhirsiGETTPdqhpirtcaqiTKLvdlqmewPTSLTIDPitGSVLVLDTN 1368
Cdd:cd14952 9 LDGPGGVAVDAAGNVYVADSGNNRVLKLAA-----GSTTQ-----------TVL-------PFTGLYQP--QGVAVDAAG 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1369 VVYEIDVVHD-VVTIALGSPTTCDLANAtssasakSLDhrrhliqNARDITVGTDGAIYVVESDGrrlNQVRKLSSDRST 1447
Cdd:cd14952 64 TVYVTDFGNNrVLKLAAGSTTQTVLPFT-------GLN-------DPTGVAVDAAGNVYVADTGN---NRVLKLAAGSNT 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1448 FSIL--TGGKSPCscDVAAcgcDDA-------------VSLRDVAASQ-----AHLSSPYAVCVSPSGDVIIADSGNSKI 1507
Cdd:cd14952 127 QTVLpfTGLSNPD--GVAV---DGAgnvyvtdtgnnrvLKLAAGSTTQtvlpfTGLNSPSGVAVDTAGNVYVTDHGNNRV 201
|
....*
gi 212645858 1508 KKVSA 1512
Cdd:cd14952 202 LKLAA 206
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1285-1512 |
2.58e-06 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 51.88 E-value: 2.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1285 QNAQLIFPKGISFDKMGNLYLADS--RRIRVIDTTG-HIRSIGE--TTPDQhpirtcaqitklvdlqMEWPTSLTIDPiT 1359
Cdd:cd14957 13 GNGQFNTPRGIAVDSAGNIYVADTgnNRIQVFTSSGvYSYSIGSggTGSGQ----------------FNSPYGIAVDS-N 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1360 GSVLVLDTNVvYEIDVvhdvvtiaLGSPTTCDLANATSSASAKSLDhrrhliqNARDITVGTDGAIYVVESDGRRlnqVR 1439
Cdd:cd14957 76 GNIYVADTDN-NRIQV--------FNSSGVYQYSIGTGGSGDGQFN-------GPYGIAVDSNGNIYVADTGNHR---IQ 136
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 212645858 1440 KLSSDRST-FSILTGGKSPcscdvaacgcddavslrdvaasqAHLSSPYAVCVSPSGDVIIADSGNSKIKKVSA 1512
Cdd:cd14957 137 VFTSSGTFsYSIGSGGTGP-----------------------GQFNGPQGIAVDSDGNIYVADTGNHRIQVFTS 187
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1273-1434 |
6.38e-06 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 50.36 E-value: 6.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1273 SAVDSCGD-GALAQnaQLIFPKGISFDKMGNLYLADSR--RIRVIDTTGH-IRSIGE--TTPDqhpirtcaqitklvdlQ 1346
Cdd:cd14956 138 SFLRQWGGtGIEPG--SFNYPRGVAVDPDGTLYVADTYndRIQVFDNDGAfLRKWGGrgTGPG----------------Q 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1347 MEWPTSLTIDPiTGSVLVLDTN----VVYEIDVvhdVVTIALGSPTtcdlanatssasaksldHRRHLIQNARDITVGTD 1422
Cdd:cd14956 200 FNYPYGIAIDP-DGNVFVADFGnnriQKFTADG---TFLTSWGSPG-----------------TGPGQFKNPWGVVVDAD 258
|
170
....*....|..
gi 212645858 1423 GAIYVVESDGRR 1434
Cdd:cd14956 259 GTVYVADSNNNR 270
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
509-533 |
3.15e-05 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 42.72 E-value: 3.15e-05
10 20
....*....|....*....|....*.
gi 212645858 509 DCNGRGRCDT-DGRCRCNPGWTGEAC 533
Cdd:pfam07974 1 ICSGRGTCVNqCGKCVCDSGYQGATC 26
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1291-1526 |
3.53e-05 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 48.09 E-value: 3.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1291 FPKGISFDKMGNLYLADSR--RIRVID-TTGhirsigettpdqhpirtcaQITKLVDLQMEWPTSLTIDPiTGSVLVLDT 1367
Cdd:COG4257 18 GPRDVAVDPDGAVWFTDQGggRIGRLDpATG-------------------EFTEYPLGGGSGPHGIAVDP-DGNLWFTDN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1368 --NVVYEIDVV-HDVVTIALGSPttcdlanatssasaksldhrrhlIQNARDITVGTDGAIYVVESDGrrlNQVRKLSSD 1444
Cdd:COG4257 78 gnNRIGRIDPKtGEITTFALPGG-----------------------GSNPHGIAFDPDGNLWFTDQGG---NRIGRLDPA 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1445 RSTFSILTGGKSPcscdvaacgcddavslrdvaasqahlSSPYAVCVSPSGDVIIADSGNSKIKKVSARmakyDGRSRTY 1524
Cdd:COG4257 132 TGEVTEFPLPTGG--------------------------AGPYGIAVDPDGNLWVTDFGANAIGRIDPD----TGTLTEY 181
|
..
gi 212645858 1525 EV 1526
Cdd:COG4257 182 AL 183
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1289-1511 |
4.15e-05 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 47.59 E-value: 4.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1289 LIFPKGISFDKMGNLYLADSRRIRVIDTTGhirsiGETTPdqhpirtcaqiTKLVDLQMEWPTSLTIDPiTGSVLVLDTn 1368
Cdd:cd14952 51 LYQPQGVAVDAAGTVYVTDFGNNRVLKLAA-----GSTTQ-----------TVLPFTGLNDPTGVAVDA-AGNVYVADT- 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1369 vvyeidVVHDVVTIALGS--PTTCDLAnatssasaksldhrrHLIqNARDITVGTDGAIYVVESDGrrlNQVRKLSSDRS 1446
Cdd:cd14952 113 ------GNNRVLKLAAGSntQTVLPFT---------------GLS-NPDGVAVDGAGNVYVTDTGN---NRVLKLAAGST 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1447 TFSIL--TGGKSPCSCDVAACGC--------DDAVSLRDVAASQA-----HLSSPYAVCVSPSGDVIIADSGNSKIKKVS 1511
Cdd:cd14952 168 TQTVLpfTGLNSPSGVAVDTAGNvyvtdhgnNRVLKLAAGSTTPTvlpftGLNGPLGVAVDAAGNVYVADRGNDRVVKLP 247
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1379-1512 |
5.62e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 47.91 E-value: 5.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1379 VVTIAlGSPTTCDLANATSSASaksldhrrhlIQNARDITVGTDGAIYVVESDGRRlnqVRKLSSDrSTFSILTGGKSPC 1458
Cdd:cd14953 1 VSTVA-GSGTAGFSGGGGTAAR----------FNSPSGVAVDAAGNLYVADRGNHR---IRKITPD-GVVTTVAGTGTAG 65
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 212645858 1459 ScdvaacgcddavslRDVAASQAHLSSPYAVCVSPSGDVIIADSGNSKIKKVSA 1512
Cdd:cd14953 66 F--------------ADGGGAAAQFNTPSGVAVDAAGNLYVADTGNHRIRKITP 105
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
760-777 |
9.66e-05 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 41.35 E-value: 9.66e-05
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
489-534 |
1.03e-04 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 41.84 E-value: 1.03e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 212645858 489 CKSGFKGKECEmrhNWCEV-ADCNGRGRCDTDGRCRCNPGWTGEACE 534
Cdd:pfam01414 1 CDENYYGSTCS---KFCRPrDDKFGHYTCDANGNKVCLPGWTGPYCD 44
|
|
| NHL_like_4 |
cd14955 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1277-1509 |
1.52e-04 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271325 [Multi-domain] Cd Length: 279 Bit Score: 46.42 E-value: 1.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1277 SCGDGalaqNAQLIFPKGISFDKMGNLYLADSR--RIRVIDTTG-HIRSIGETTPDqhpirtcaqitklvDLQMEWPTSL 1353
Cdd:cd14955 101 SSGSG----DGQFNSPSGIAVDSAGNVYVTDSGnnRIQKFDSSGtFITKWGSFGSG--------------DGQFNSPTGI 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1354 TIDPiTGSVLVLDT--NVVYEIDVVHDVVTiALGSPTTCDlanatssasaksldhrrHLIQNARDITVGTDGAIYVVESD 1431
Cdd:cd14955 163 AVDS-AGNVYVADTgnNRIQKFTSTGTFLT-KWGSEGSGD-----------------GQFNAPYGIAVDSAGNVYVADTG 223
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 212645858 1432 GRRlnqVRKLSSDrSTFsILTGGKSpcscdvaacGCDDavslrdvaaSQahLSSPYAVCVSPSGDVIIADSGNSKIKK 1509
Cdd:cd14955 224 NNR---IQKFDSS-GTF-ITKWGSE---------GSGD---------GQ--FNSPSGIAVDSAGNVYVADSGNNRIQK 276
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1417-1510 |
1.92e-04 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 46.42 E-value: 1.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1417 ITVGTDGAIYVVESDGrrlNQVRKLSsdrstfsiLTGGKspcscdVAACGCDDAVSL-------RDVAASQAHLSSPYAV 1489
Cdd:cd14951 139 LSLAGWGELFVADSES---SAIRAVS--------LKDGG------VKTLVGGTRVGTglfdfgdRDGPGAEALLQHPLGV 201
|
90 100
....*....|....*....|.
gi 212645858 1490 CVSPSGDVIIADSGNSKIKKV 1510
Cdd:cd14951 202 AALPDGSVYVADTYNHKIKRV 222
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
445-467 |
3.10e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 40.02 E-value: 3.10e-04
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1411-1515 |
1.14e-03 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 43.35 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1411 IQNARDITVGTDGAIYVVESDGRRlnqVRKLSSDRSTFSIL--TGGKSPCSCDVAACG---CDDAVSLRDV-----AASQ 1480
Cdd:cd14952 9 LDGPGGVAVDAAGNVYVADSGNNR---VLKLAAGSTTQTVLpfTGLYQPQGVAVDAAGtvyVTDFGNNRVLklaagSTTQ 85
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 212645858 1481 -----AHLSSPYAVCVSPSGDVIIADSGNSKIKKVSARMA 1515
Cdd:cd14952 86 tvlpfTGLNDPTGVAVDAAGNVYVADTGNNRVLKLAAGSN 125
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
441-549 |
1.31e-03 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 41.67 E-value: 1.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 441 CESNCNQRGECVHGKCHCAPGFT--GRTC-DEAVCPVVCSGNGVFSGGICVCKSGFkgkecemrhnwCEVADCNGRGRCd 517
Cdd:NF041328 45 CGVACGAGQTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAACAPGQVCEGGA-----------CREACSEGLTRC- 112
|
90 100 110
....*....|....*....|....*....|....*...
gi 212645858 518 tDGRC------RCNPGWTGEACElracPHASCHDrGVC 549
Cdd:NF041328 113 -GGACvdlatdPLHCGACGVACD----PGESCRG-GAC 144
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
444-495 |
1.44e-03 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 38.87 E-value: 1.44e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 212645858 444 NCNQRG----EC--VHGKCHCAPGFTGRTCDEavcpvvcsgngvfsggicvCKSGFKG 495
Cdd:pfam00053 2 DCNPHGslsdTCdpETGQCLCKPGVTGRHCDR-------------------CKPGYYG 40
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
538-566 |
2.53e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 37.66 E-value: 2.53e-03
10 20
....*....|....*....|....*....
gi 212645858 538 CPhASCHDRGVCVNGTCYCMDGWRGNDCS 566
Cdd:pfam18720 2 CP-LGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| NHL_TRIM71_like |
cd14954 |
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ... |
1225-1366 |
3.12e-03 |
|
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271324 [Multi-domain] Cd Length: 285 Bit Score: 42.15 E-value: 3.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1225 YYIAVSPvDGTIAISlplhkqvwrisslepqDSRNN-YDVLAGDGTVcASAVDSCGDGalaqNAQLIFPKGISFDKMGNL 1303
Cdd:cd14954 168 RGVAVNP-DGNIVVS----------------DFNNHrLQVFDPDGQF-LRFFGSEGSG----NGQFKRPRGVAVDDEGNI 225
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 212645858 1304 YLADSR--RIRVIDTTG-HIRSIGETTPDqhpirtcaqitklvDLQMEWPTSLTIDPiTGSVLVLD 1366
Cdd:cd14954 226 IVADSGnhRVQVFSPDGeFLCSFGTEGNG--------------EGQFDRPSGVAVTP-DGRIVVVD 276
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|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1280-1367 |
3.40e-03 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 41.89 E-value: 3.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1280 DGALAQNAQLIFPKGISFDKMGNLYLAD--SRRIRVIDTTGH-IRSIGETTPDqhpirtcaqitklvDLQMEWPTSLTID 1356
Cdd:cd14963 185 NGSPDGKSGFVNPRGIAVDPDGNLYVVDnlSHRVYVFDEQGKeLFTFGGRGKD--------------DGQFNLPNGLFID 250
|
90
....*....|.
gi 212645858 1357 PiTGSVLVLDT 1367
Cdd:cd14963 251 D-DGRLYVTDR 260
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
543-565 |
3.43e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.94 E-value: 3.43e-03
|
| NHL_TRIM32_like |
cd14961 |
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ... |
1286-1507 |
3.86e-03 |
|
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271331 [Multi-domain] Cd Length: 273 Bit Score: 41.88 E-value: 3.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1286 NAQLIFPKGISFDKMGNLYLADS--RRIRVIDTTGH-IRSIGETTPDQHPIRTcaqitklvdlqmewPTSLTIDPI---- 1358
Cdd:cd14961 7 PGTLNNPTGVAVTPTGRVVVADDgnKRIQVFDSDGNcLQQFGPKGDAGQDIRY--------------PLDVAVTPDghiv 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1359 -----TGSVLVLDTN-----VVYE-----IDVV-----HDVVTIALGSPTTCdlanATSSASAKSLDHRRHLIQNA---R 1415
Cdd:cd14961 73 vtdagDRSVKVFSFDgrlklFVRKsfslpWGVAvnpsgEILVTDSEAGKLFV----LTVDFKLGILKKGQKLCSQLcrpR 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1416 DITVGTDGAIYVVEsdgrRLNQVRKLSSDRST---FSILTGGkspcscdvaacGCDDAVSLRDVAASQAHLSspyAVCVS 1492
Cdd:cd14961 149 FVAVSRLGAVAVTE----HLFANGTRSSSTRVkvfSSGGQLL-----------GQIDSFGLNLVFPSLICAS---GVAFD 210
|
250
....*....|....*
gi 212645858 1493 PSGDVIIADSGNSKI 1507
Cdd:cd14961 211 SEGNVIVADTGSGAI 225
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
444-469 |
4.18e-03 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 37.33 E-value: 4.18e-03
10 20 30
....*....|....*....|....*....|..
gi 212645858 444 NCNQRG----EC--VHGKCHCAPGFTGRTCDE 469
Cdd:cd00055 3 DCNGHGslsgQCdpGTGQCECKPNTTGRRCDR 34
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|
| I-EGF_1 |
pfam18372 |
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ... |
476-493 |
4.42e-03 |
|
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.
Pssm-ID: 465729 Cd Length: 29 Bit Score: 36.70 E-value: 4.42e-03
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
444-499 |
4.98e-03 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 36.91 E-value: 4.98e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 212645858 444 NCNQRG----EC--VHGKCHCAPGFTGRTCDEavcpvvcsgngvfsggicvCKSGFKGKECE 499
Cdd:smart00180 2 DCDPGGsasgTCdpDTGQCECKPNVTGRRCDR-------------------CAPGYYGDGPP 44
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|
| NHL_PAL_like |
cd14958 |
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ... |
1417-1512 |
5.34e-03 |
|
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271328 [Multi-domain] Cd Length: 300 Bit Score: 41.48 E-value: 5.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645858 1417 ITVGTDGAIYVVESDgrrLNQVRKLSSDRSTFSILTGGKspcscdvaacgcddavslRDVA-ASQAHLSSPYAVCVSPSG 1495
Cdd:cd14958 81 LTIDPDGNIWVTDVG---LHQVFKFDPEGKLLPLLTLGE------------------RGEPgSDQTHFCKPTDVAVAPDG 139
|
90
....*....|....*...
gi 212645858 1496 DVIIADS-GNSKIKKVSA 1512
Cdd:cd14958 140 DIFVADGyCNSRIVKFSP 157
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|
| DSL |
smart00051 |
delta serrate ligand; |
488-533 |
6.62e-03 |
|
delta serrate ligand;
Pssm-ID: 128366 Cd Length: 63 Bit Score: 37.31 E-value: 6.62e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 212645858 488 VCKSGFKGKECEmrhNWC-EVADCNGRGRCDTDGRCRCNPGWTGEAC 533
Cdd:smart00051 20 TCDENYYGEGCN---KFCrPRDDFFGHYTCDENGNKGCLEGWMGPYC 63
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
441-467 |
9.45e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 36.08 E-value: 9.45e-03
10 20 30
....*....|....*....|....*....|...
gi 212645858 441 CESN--CNQRGECVHG----KCHCAPGFTGRTC 467
Cdd:cd00054 5 CASGnpCQNGGTCVNTvgsyRCSCPPGYTGRNC 37
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