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    Nufip1 nuclear FMR1 interacting protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364430, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nufip1provided by RGD
    Official Full Name
    nuclear FMR1 interacting protein 1provided by RGD
    Primary source
    RGD:1359440
    See related
    EnsemblRapid:ENSRNOG00000001033 AllianceGenome:RGD:1359440
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including ATPase binding activity; identical protein binding activity; and protein-macromolecule adaptor activity. Predicted to contribute to snoRNA binding activity. Predicted to be involved in box C/D snoRNP assembly and positive regulation of transcription by RNA polymerase II. Located in presynaptic active zone. Orthologous to human NUFIP1 (nuclear FMR1 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 105.5), Spleen (RPKM 85.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nufip1 in Genome Data Viewer
    Location:
    15q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (57838864..57869597)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (51429518..51460308)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (58171163..58201888)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097044 Neighboring gene uncharacterized LOC103690313 Neighboring gene GPALPP motifs containing 1 Neighboring gene RAN, member RAS oncogene family, pseudogene 6 Neighboring gene uncharacterized LOC134482154 Neighboring gene uncharacterized LOC134482155 Neighboring gene high mobility group AT-hook 1, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NUFIP1 (nuclear FMRP interacting protein 1) is a nucleocytoplasmic shuttling protein associated with active synaptoneurosomes. Bardoni B, et al. Exp Cell Res, 2003 Sep 10. PMID 12941608
    2. BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II. Cabart P, et al. Oncogene, 2004 Jul 8. PMID 15107825
    3. A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein. Bardoni B, et al. Hum Mol Genet, 1999 Dec. PMID 10556305
    4. A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly. McKeegan KS, et al. Mol Cell Biol, 2007 Oct. PMID 17636026, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC95323

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to snoRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in box C/D snoRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in box C/D snoRNP assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perichromatin fibrils ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of pre-snoRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    FMR1-interacting protein NUFIP1
    Names
    NUFIP1, FMR1 interacting protein 1
    nuclear FMRP-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007758.1 → NP_001007759.1  FMR1-interacting protein NUFIP1

      See identical proteins and their annotated locations for NP_001007759.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082111
      UniProtKB/Swiss-Prot
      Q641W3
      UniProtKB/TrEMBL
      A6HTU8
      Related
      ENSRNOP00000001366.4, ENSRNOT00000001366.7
      Conserved Domains (1) summary
      pfam10453
      Location:209 → 261
      NUFIP1; Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      57838864..57869597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093556.2 → XP_038949484.1  FMR1-interacting protein NUFIP1 isoform X1

      Conserved Domains (1) summary
      pfam10453
      Location:1 → 49
      NUFIP1; Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q641W3.1 GenPept UniProtKB/Swiss-Prot:Q641W3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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