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Conserved domains on  [gi|56090303|ref|NP_001007759|]
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FMR1-interacting protein NUFIP1 [Rattus norvegicus]

Protein Classification

nuclear FMR1 interacting protein 1( domain architecture ID 10573452)

nuclear FMR1 interacting protein 1 (NUFIP1) functions in the assembly of the large subunit of the ribosome and in telomere maintenance; contains a C2H2 zinc finger

Gene Symbol:  NUFIP1
Gene Ontology:  GO:0000027|GO:0008270|GO:0003723
PubMed:  15963892|15718139|29700228|35326495

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NUFIP1 pfam10453
Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1); Proteins in this family ...
 209-261 3.61e-21

Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1); Proteins in this family have been implicated in the assembly of the large subunit of the ribosome and in telomere maintenance. Some proteins in this family contain a CCCH zinc finger. This family contains a protein called human fragile X mental retardation-interacting protein 1, which is known to bind RNA and is phosphorylated upon DNA damage.


:

Pssm-ID: 463096 [Multi-domain]  Cd Length: 53  Bit Score: 86.51  E-value: 3.61e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 56090303   209 HWRNMHAPGmKKIKLDTPEDIARWREERRKNYPTLANIERKKLLQLEKEKRGE 261
Cdd:pfam10453   2 HNKNVKIPG-TSITLETPEDIAKWIEERRKNWPTKINIEKKKKMEEEKIKRGE 53
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 4-140 4.77e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 4.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090303     4 PTPAGWPSAPELTPAPGTPSE-------------------------AAPPQDNWVYWAMLPPPPPPLSSPVAGTEPCQKE 58
Cdd:PHA03247 2830 PPTSAQPTAPPPPPGPPPPSLplggsvapggdvrrrppsrspaakpAAPARPPVRRLARPAVSRSTESFALPPDQPERPP 2909

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090303    59 QPHVEPQPTSGAFPPFDAQILPAAQPPFDAQAPPDGQSQFNDQQAWNFQASTPWYWGLSPNGFPTYNTSFHSPATHSYFP 138
Cdd:PHA03247 2910 QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAP 2989


                  ..
gi 56090303   139 QS 140
Cdd:PHA03247 2990 AS 2991
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 166-190 5.39e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


:

Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 34.45  E-value: 5.39e-03
                          10        20
                  ....*....|....*....|....*
gi 56090303   166 HFFCDTCDRGFKNQEKYDIHMSEHK 190
Cdd:pfam12171   1 QFYCVLCDKYFKSENALQNHLKSKK 25
 
Name Accession Description Interval E-value
NUFIP1 pfam10453
Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1); Proteins in this family ...
 209-261 3.61e-21

Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1); Proteins in this family have been implicated in the assembly of the large subunit of the ribosome and in telomere maintenance. Some proteins in this family contain a CCCH zinc finger. This family contains a protein called human fragile X mental retardation-interacting protein 1, which is known to bind RNA and is phosphorylated upon DNA damage.


Pssm-ID: 463096 [Multi-domain]  Cd Length: 53  Bit Score: 86.51  E-value: 3.61e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 56090303   209 HWRNMHAPGmKKIKLDTPEDIARWREERRKNYPTLANIERKKLLQLEKEKRGE 261
Cdd:pfam10453   2 HNKNVKIPG-TSITLETPEDIAKWIEERRKNWPTKINIEKKKKMEEEKIKRGE 53
PHA03247 PHA03247
large tegument protein UL36; Provisional
 4-140 4.77e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 4.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090303     4 PTPAGWPSAPELTPAPGTPSE-------------------------AAPPQDNWVYWAMLPPPPPPLSSPVAGTEPCQKE 58
Cdd:PHA03247 2830 PPTSAQPTAPPPPPGPPPPSLplggsvapggdvrrrppsrspaakpAAPARPPVRRLARPAVSRSTESFALPPDQPERPP 2909

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090303    59 QPHVEPQPTSGAFPPFDAQILPAAQPPFDAQAPPDGQSQFNDQQAWNFQASTPWYWGLSPNGFPTYNTSFHSPATHSYFP 138
Cdd:PHA03247 2910 QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAP 2989


                  ..
gi 56090303   139 QS 140
Cdd:PHA03247 2990 AS 2991
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 166-190 5.39e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 34.45  E-value: 5.39e-03
                          10        20
                  ....*....|....*....|....*
gi 56090303   166 HFFCDTCDRGFKNQEKYDIHMSEHK 190
Cdd:pfam12171   1 QFYCVLCDKYFKSENALQNHLKSKK 25
 
Name Accession Description Interval E-value
NUFIP1 pfam10453
Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1); Proteins in this family ...
 209-261 3.61e-21

Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1); Proteins in this family have been implicated in the assembly of the large subunit of the ribosome and in telomere maintenance. Some proteins in this family contain a CCCH zinc finger. This family contains a protein called human fragile X mental retardation-interacting protein 1, which is known to bind RNA and is phosphorylated upon DNA damage.


Pssm-ID: 463096 [Multi-domain]  Cd Length: 53  Bit Score: 86.51  E-value: 3.61e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 56090303   209 HWRNMHAPGmKKIKLDTPEDIARWREERRKNYPTLANIERKKLLQLEKEKRGE 261
Cdd:pfam10453   2 HNKNVKIPG-TSITLETPEDIAKWIEERRKNWPTKINIEKKKKMEEEKIKRGE 53
PHA03247 PHA03247
large tegument protein UL36; Provisional
 4-140 4.77e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 4.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090303     4 PTPAGWPSAPELTPAPGTPSE-------------------------AAPPQDNWVYWAMLPPPPPPLSSPVAGTEPCQKE 58
Cdd:PHA03247 2830 PPTSAQPTAPPPPPGPPPPSLplggsvapggdvrrrppsrspaakpAAPARPPVRRLARPAVSRSTESFALPPDQPERPP 2909

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56090303    59 QPHVEPQPTSGAFPPFDAQILPAAQPPFDAQAPPDGQSQFNDQQAWNFQASTPWYWGLSPNGFPTYNTSFHSPATHSYFP 138
Cdd:PHA03247 2910 QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAP 2989


                  ..
gi 56090303   139 QS 140
Cdd:PHA03247 2990 AS 2991
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 166-190 5.39e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 34.45  E-value: 5.39e-03
                          10        20
                  ....*....|....*....|....*
gi 56090303   166 HFFCDTCDRGFKNQEKYDIHMSEHK 190
Cdd:pfam12171   1 QFYCVLCDKYFKSENALQNHLKSKK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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