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    Cracd capping protein inhibiting regulator of actin dynamics [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289568, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cracdprovided by RGD
    Official Full Name
    capping protein inhibiting regulator of actin dynamicsprovided by RGD
    Primary source
    RGD:1311575
    See related
    EnsemblRapid:ENSRNOG00000002139 AllianceGenome:RGD:1311575
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311575
    Summary
    Predicted to be involved in maintenance of gastrointestinal epithelium and negative regulation of barbed-end actin filament capping. Orthologous to human CRACD (capping protein inhibiting regulator of actin dynamics). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 66.9), Brain (RPKM 48.8) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cracd in Genome Data Viewer
    Location:
    14p11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (31638328..31874391, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (31284066..31520103, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (33649989..33783794, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase Neighboring gene phosphoribosyl pyrophosphate amidotransferase Neighboring gene aminoadipate-semialdehyde dehydrogenase Neighboring gene uncharacterized LOC120096736 Neighboring gene ribosomal protein L23a, pseudogene 19 Neighboring gene centrosomal protein 135 Neighboring gene exocyst complex component 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin. Jung YS, et al. Nat Cell Biol, 2018 Nov. PMID 30361697, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in epithelial structure maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of gastrointestinal epithelium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of gastrointestinal epithelium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of barbed-end actin filament capping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    capping protein-inhibiting regulator of actin dynamics

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427853.1 → NP_001414782.1  capping protein-inhibiting regulator of actin dynamics

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      D4A5F4
      Related
      ENSRNOP00000002908.8, ENSRNOT00000002908.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      31638328..31874391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272905.1 → XP_063128975.1  capping protein-inhibiting regulator of actin dynamics isoform X3

    2. XM_039092920.2 → XP_038948848.1  capping protein-inhibiting regulator of actin dynamics isoform X2

      Related
      ENSRNOP00000111597.1, ENSRNOT00000169487.1
      Conserved Domains (4) summary
      PTZ00121
      Location:193 → 640
      PTZ00121; MAEBL; Provisional
      PTZ00449
      Location:971 → 1312
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03307
      Location:790 → 1148
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15262
      Location:51 → 178
      DUF4592; Domain of unknown function (DUF4592)

    3. XM_039092919.2 → XP_038948847.1  capping protein-inhibiting regulator of actin dynamics isoform X1

      Conserved Domains (3) summary
      PTZ00121
      Location:193 → 640
      PTZ00121; MAEBL; Provisional
      PTZ00449
      Location:971 → 1315
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam15262
      Location:51 → 178
      DUF4592; Domain of unknown function (DUF4592)

    4. XM_039092927.2 → XP_038948855.1  capping protein-inhibiting regulator of actin dynamics isoform X4

      Related
      ENSRNOP00000099078.1, ENSRNOT00000153116.1
      Conserved Domains (3) summary
      PTZ00121
      Location:187 → 634
      PTZ00121; MAEBL; Provisional
      PTZ00449
      Location:965 → 1309
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam15262
      Location:45 → 172
      DUF4592; Domain of unknown function (DUF4592)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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