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    Lrrc20 leucine rich repeat containing 20 [ Mus musculus (house mouse) ]

    Gene ID: 216011, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lrrc20provided by MGI
    Official Full Name
    leucine rich repeat containing 20provided by MGI
    Primary source
    MGI:MGI:2387182
    See related
    Ensembl:ENSMUSG00000037151 AllianceGenome:MGI:2387182
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Is expressed in embryo and forelimb bud. Orthologous to human LRRC20 (leucine rich repeat containing 20). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 15.7), mammary gland adult (RPKM 10.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrrc20 in Genome Data Viewer
    Location:
    10 B4; 10 32.22 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (61311579..61418570)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (61475769..61582791)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene nodal growth differentiation factor Neighboring gene eukaryotic translation initiation factor 4E binding protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E3888 Neighboring gene STARR-seq mESC enhancer starr_26847 Neighboring gene RIKEN cDNA D830039M14 gene Neighboring gene STARR-positive B cell enhancer ABC_E6860 Neighboring gene predicted gene, 47593 Neighboring gene oligosaccharyltransferase complex subunit pseudogene Neighboring gene STARR-seq mESC enhancer starr_26850 Neighboring gene predicted gene 28447 Neighboring gene neuropeptide FF receptor 1 Neighboring gene STARR-positive B cell enhancer ABC_E10613 Neighboring gene STARR-positive B cell enhancer ABC_E6861 Neighboring gene pyrophosphatase (inorganic) 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome. Unda BK, et al. Mol Psychiatry, 2023 Apr. PMID 36604605, Free PMC Article
    2. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
    3. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC25719

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153542.1 → NP_705770.1  leucine-rich repeat-containing protein 20

      See identical proteins and their annotated locations for NP_705770.1

      Status: PROVISIONAL

      Source sequence(s)
      BC036304
      Consensus CDS
      CCDS23881.1
      UniProtKB/Swiss-Prot
      Q8CI70
      Related
      ENSMUSP00000048042.8, ENSMUST00000049242.9
      Conserved Domains (4) summary
      cd00116
      Location:22 → 158
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:76 → 98
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:26 → 51
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:98 → 156
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      61311579..61418570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313885.1 → XP_017169374.1  leucine-rich repeat-containing protein 20 isoform X2

    2. XM_017313884.1 → XP_017169373.1  leucine-rich repeat-containing protein 20 isoform X1

      Conserved Domains (2) summary
      PLN03150
      Location:39 → 110
      PLN03150; hypothetical protein; Provisional
      sd00031
      Location:28 → 48
      LRR_1; leucine-rich repeat [structural motif]

    3. XM_006513472.5 → XP_006513535.1  leucine-rich repeat-containing protein 20 isoform X3

      Conserved Domains (2) summary
      PLN03150
      Location:20 → 91
      PLN03150; hypothetical protein; Provisional
      sd00031
      Location:7 → 29
      LRR_1; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CI70.1 GenPept UniProtKB/Swiss-Prot:Q8CI70

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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