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Conserved domains on  [gi|1039732680|ref|XP_017169373|]
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leucine-rich repeat-containing protein 20 isoform X1 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
17-107 1.94e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 1.94e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732680  17 NETVESGSDTLELRLEGNYLFRLPNEVSSLQHLRAIDLSRNQFQDFPEQLTTLPALETINLEENEIVDVPVEkLAAMPAL 96
Cdd:COG4886   106 NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNL 184

                          90
                  ....*....|.
gi 1039732680  97 RVINLRLNPLS 107
Cdd:COG4886   185 KELDLSNNQIT 195
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
17-107 1.94e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 1.94e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732680  17 NETVESGSDTLELRLEGNYLFRLPNEVSSLQHLRAIDLSRNQFQDFPEQLTTLPALETINLEENEIVDVPVEkLAAMPAL 96
Cdd:COG4886   106 NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNL 184

                          90
                  ....*....|.
gi 1039732680  97 RVINLRLNPLS 107
Cdd:COG4886   185 KELDLSNNQIT 195
PLN03150 PLN03150
hypothetical protein; Provisional
 39-110 1.62e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 51.74  E-value: 1.62e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039732680  39 LPNEVSSLQHLRAIDLSRNQFQ-DFPEQLTTLPALETINLEENEIVDVPVEKLAAMPALRVINLRLNPLSADV 110
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRV 506
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 28-111 1.51e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 1.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732680  28 ELRLEGNylfRLPNEVS-------------SLQHLraiDLSRNQFQDfPEQLTTLPALETINLEENEIVDVP--VEKLAA 92
Cdd:cd21340    94 ELHIENQ---RLPPGEKltfdprslaalsnSLRVL---NISGNNIDS-LEPLAPLRNLEQLDASNNQISDLEelLDLLSS 166

                          90
                  ....*....|....*....
gi 1039732680  93 MPALRVINLRLNPLSADVR 111
Cdd:cd21340   167 WPSLRELDLTGNPVCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
47-106 8.42e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 8.42e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039732680  47 QHLRAIDLSRNQFQDF-PEQLTTLPALETINLEENEIVDVPVEKLAAMPALRVINLRLNPL 106
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
17-107 1.94e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 1.94e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732680  17 NETVESGSDTLELRLEGNYLFRLPNEVSSLQHLRAIDLSRNQFQDFPEQLTTLPALETINLEENEIVDVPVEkLAAMPAL 96
Cdd:COG4886   106 NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNL 184

                          90
                  ....*....|.
gi 1039732680  97 RVINLRLNPLS 107
Cdd:COG4886   185 KELDLSNNQIT 195
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
28-107 2.53e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.04  E-value: 2.53e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732680  28 ELRLEGNYLFRLPNEVSSLQHLRAIDLSRNQFQDFPEQLTTLPALETINLEENEIVDVPVEkLAAMPALRVINLRLNPLS 107
Cdd:COG4886   163 SLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLT 241
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
28-107 4.33e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.57  E-value: 4.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732680  28 ELRLEGNYLFRLPNEVSSLQHLRAIDLSRNQFQDFPEQLTTLPALETINLEENEIVDVPVEkLAAMPALRVINLRLNPLS 107
Cdd:COG4886   140 ELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLT 218
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
28-107 4.82e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.57  E-value: 4.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732680  28 ELRLEGNYLFRLPNEVSSLQHLRAIDLSRNQFQDFPEQLTTLPALETINLEENEIVDVPveKLAAMPALRVINLRLNPLS 107
Cdd:COG4886   186 ELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLT 263
PLN03150 PLN03150
hypothetical protein; Provisional
 39-110 1.62e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 51.74  E-value: 1.62e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039732680  39 LPNEVSSLQHLRAIDLSRNQFQ-DFPEQLTTLPALETINLEENEIVDVPVEKLAAMPALRVINLRLNPLSADV 110
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRV 506
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
28-123 1.01e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.47  E-value: 1.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732680  28 ELRLEGNYLFRLPnEVSSLQHLRAIDLSRNQFQDFPEqLTTLPALETINLEENEIVDVPVEKLAAMPALRVINLRLNPLS 107
Cdd:COG4886   232 TLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309

                          90
                  ....*....|....*.
gi 1039732680 108 ADVRVIAPPLIKFDML 123
Cdd:COG4886   310 LLELLILLLLLTTLLL 325
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 28-111 1.51e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 1.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732680  28 ELRLEGNylfRLPNEVS-------------SLQHLraiDLSRNQFQDfPEQLTTLPALETINLEENEIVDVP--VEKLAA 92
Cdd:cd21340    94 ELHIENQ---RLPPGEKltfdprslaalsnSLRVL---NISGNNIDS-LEPLAPLRNLEQLDASNNQISDLEelLDLLSS 166

                          90
                  ....*....|....*....
gi 1039732680  93 MPALRVINLRLNPLSADVR 111
Cdd:cd21340   167 WPSLRELDLTGNPVCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
47-106 8.42e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 8.42e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039732680  47 QHLRAIDLSRNQFQDF-PEQLTTLPALETINLEENEIVDVPVEKLAAMPALRVINLRLNPL 106
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 30-108 7.48e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.80  E-value: 7.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732680  30 RLEGNYLFRLPNEVSSLQHLRAIDLSRNQFQDF-----PEQLTTLPALETINLEENEIVDVPVEKLAA----MPALRVIN 100
Cdd:cd00116   148 RLEGASCEALAKALRANRDLKELNLANNGIGDAgiralAEGLKANCNLEVLDLNNNGLTDEGASALAEtlasLKSLEVLN 227


                  ....*...
gi 1039732680 101 LRLNPLSA 108
Cdd:cd00116   228 LGDNNLTD 235
LRR_8 pfam13855
Leucine rich repeat;
28-82 2.39e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 2.39e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039732680  28 ELRLEGNYLFRLPNEV-SSLQHLRAIDLSRNQFQDF-PEQLTTLPALETINLEENEI 82
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 38-110 5.06e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.68  E-value: 5.06e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039732680  38 RLPNEVSSLQHLRAIDLSRNQFQ-DFPEQLTTLPALETINLEENEIV-DVPVEkLAAMPALRVINLRLNPLSADV 110
Cdd:PLN00113  155 EIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRE-LGQMKSLKWIYLGYNNLSGEI 228
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 34-110 5.21e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.68  E-value: 5.21e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039732680  34 NYLFRLPNEVSSlQHLRAIDLSRNQFQD-FPEQLTTLPALETINLEENEIVDVPVEKLAAMPALRVINLRLNPLSADV 110
Cdd:PLN00113  463 KFFGGLPDSFGS-KRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQI 539
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-107 5.29e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.38  E-value: 5.29e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039732680  39 LPNEVSSLQHLRAIDLSRNqfqdfpEQLTTLPALETINLEENEIVDVPVEkLAAMPALRVINLRLNPLS 107
Cdd:COG4886    88 GLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLT 149
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 45-109 8.31e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 37.72  E-value: 8.31e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039732680  45 SLQHLRAIDLSRNQF-----QDFPEQLTTLPALETINLEENEIVDVPVEKLA-AMPA----LRVINLRLNPLSAD 109
Cdd:cd00116   191 ANCNLEVLDLNNNGLtdegaSALAETLASLKSLEVLNLGDNNLTDAGAAALAsALLSpnisLLTLSLSCNDITDD 265
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 39-110 8.98e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.91  E-value: 8.98e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039732680  39 LPNEVSSLQHLRAIDLSRNQFQ-DFPEQLTTLPALETINLEENEIVDVPVEKLAAMPALRVINLRLNPLSADV 110
Cdd:PLN00113  276 IPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEI 348
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 22-110 1.20e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.52  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732680  22 SGSDTLE-LRLEGNYLF-RLPNEVSSLQHLRAIDLSRNQFQ-DFPEQLTTLPALETINLEENEIVDVPVEKLAAMPALRV 98
Cdd:PLN00113  472 FGSKRLEnLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQ 551

                          90
                  ....*....|..
gi 1039732680  99 INLRLNPLSADV 110
Cdd:PLN00113  552 LDLSQNQLSGEI 563
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
24-131 1.20e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 37.45  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039732680  24 SDTLELRLEGNYLFRLPNEVSSLQHLraiDLSRNQFQDFPEQLTTLPALETINLEENEIVDvpveklAAMPALRVInlrl 103
Cdd:PRK15387  402 SELKELMVSGNRLTSLPMLPSGLLSL---SVYRNQLTRLPESLIHLSSETTVNLEGNPLSE------RTLQALREI---- 468

                          90       100       110
                  ....*....|....*....|....*....|
gi 1039732680 104 nplsADVRVIAPPLIKFDM--LMSPEDTRA 131
Cdd:PRK15387  469 ----TSAPGYSGPIIRFDMagASAPRETRA 494
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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