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Conserved domains on  [gi|23956308|ref|NP_705770|]
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leucine-rich repeat-containing protein 20 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-157 2.58e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 2.58e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956308  26 TLDLADCKLVSFPICIYKvLRNvsdqIHLITLANNELKSLTSKFmTTFNQLRELRLEGNYLFRLPNEVSSLQHLRAIDLS 105
Cdd:COG4886 117 SLDLSGNQLTDLPEELAN-LTN----LKELDLSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLS 190

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 23956308 106 RNQFQDFPEQLTTLPALETINLEENEIVDVPVEkLAAMPALRVINLRLNPLS 157
Cdd:COG4886 191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLT 241
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-157 2.58e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 2.58e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956308  26 TLDLADCKLVSFPICIYKvLRNvsdqIHLITLANNELKSLTSKFmTTFNQLRELRLEGNYLFRLPNEVSSLQHLRAIDLS 105
Cdd:COG4886 117 SLDLSGNQLTDLPEELAN-LTN----LKELDLSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLS 190

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 23956308 106 RNQFQDFPEQLTTLPALETINLEENEIVDVPVEkLAAMPALRVINLRLNPLS 157
Cdd:COG4886 191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLT 241
PLN03150 PLN03150
hypothetical protein; Provisional
 89-160 5.62e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 51.74  E-value: 5.62e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 23956308   89 LPNEVSSLQHLRAIDLSRNQFQ-DFPEQLTTLPALETINLEENEIVDVPVEKLAAMPALRVINLRLNPLSADV 160
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRV 506
LRR_8 pfam13855
Leucine rich repeat;
97-156 5.56e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 5.56e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23956308    97 QHLRAIDLSRNQFQDF-PEQLTTLPALETINLEENEIVDVPVEKLAAMPALRVINLRLNPL 156
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 22-158 5.76e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 5.76e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956308  22 SGSDTLDLADCKLVSFPICIYKVLRNVSDQIHLItLANNEL---------KSLTSKFMttfnQLRELRLEGNYL-----F 87
Cdd:cd00116  81 CGLQELDLSDNALGPDGCGVLESLLRSSSLQELK-LNNNGLgdrglrllaKGLKDLPP----ALEKLVLGRNRLegascE 155

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956308  88 RLPNEVSSLQHLRAIDLSRNQFQDF-----PEQLTTLPALETINLEENEIVDVPVEKLAA----MPALRVINLRLNPLSA 158
Cdd:cd00116 156 ALAKALRANRDLKELNLANNGIGDAgiralAEGLKANCNLEVLDLNNNGLTDEGASALAEtlasLKSLEVLNLGDNNLTD 235
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-157 2.58e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 2.58e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956308  26 TLDLADCKLVSFPICIYKvLRNvsdqIHLITLANNELKSLTSKFmTTFNQLRELRLEGNYLFRLPNEVSSLQHLRAIDLS 105
Cdd:COG4886 117 SLDLSGNQLTDLPEELAN-LTN----LKELDLSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLS 190

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 23956308 106 RNQFQDFPEQLTTLPALETINLEENEIVDVPVEkLAAMPALRVINLRLNPLS 157
Cdd:COG4886 191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLT 241
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-157 6.64e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.58  E-value: 6.64e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956308  26 TLDLADCKLVSFPiciyKVLRNVSdQIHLITLANNELKSLtSKFMTTFNQLRELRLEGNYLFRLPNEVSSLQHLRAIDLS 105
Cdd:COG4886 140 ELDLSNNQLTDLP----EPLGNLT-NLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLS 213

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 23956308 106 RNQFQDFPEQLTTLPALETINLEENEIVDVPveKLAAMPALRVINLRLNPLS 157
Cdd:COG4886 214 GNQLTDLPEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLT 263
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-157 4.76e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.19  E-value: 4.76e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956308  70 MTTFNQLRELRLEGNYLFRLPNEVSSLQHLRAIDLSRNQFQDFPEQLTTLPALETINLEENEIVDVPVEkLAAMPALRVI 149
Cdd:COG4886 109 LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKEL 187


                ....*...
gi 23956308 150 NLRLNPLS 157
Cdd:COG4886 188 DLSNNQIT 195
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-173 1.07e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.56  E-value: 1.07e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956308  26 TLDLADCKLVSFPICIYKvLRNvsdqIHLITLANNELKSLtSKFMTTFNQLRELRLEGNYLFRLPnEVSSLQHLRAIDLS 105
Cdd:COG4886 186 ELDLSNNQITDLPEPLGN-LTN----LEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLS 258

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23956308 106 RNQFQDFPEqLTTLPALETINLEENEIVDVPVEKLAAMPALRVINLRLNPLSADVRVIAPPLIKFDML 173
Cdd:COG4886 259 NNQLTDLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLL 325
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
54-157 1.09e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.48  E-value: 1.09e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956308  54 LITLANNELKSLTSKFMTTFNQLRELRLEGNylfrlpNEVSSLQHLRAIDLSRNQFQDFPEQLTTLPALETINLEENEIV 133
Cdd:COG4886  76 LLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLT 149

                        90       100
                ....*....|....*....|....
gi 23956308 134 DVPvEKLAAMPALRVINLRLNPLS 157
Cdd:COG4886 150 DLP-EPLGNLTNLKSLDLSNNQLT 172
PLN03150 PLN03150
hypothetical protein; Provisional
 89-160 5.62e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 51.74  E-value: 5.62e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 23956308   89 LPNEVSSLQHLRAIDLSRNQFQ-DFPEQLTTLPALETINLEENEIVDVPVEKLAAMPALRVINLRLNPLSADV 160
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRV 506
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
7-136 1.75e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.38  E-value: 1.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956308    7 EAVARVARKVNETVESGSDTLDLADCKLVSFPICIYKVLRNVSDQIHLITLANNELKSLTSKFMTtfnQLRELRLEGNYL 86
Cdd:PRK15370 156 EAPAKEAANREEAVQRMRDCLKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQG---NIKTLYANSNQL 232

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 23956308   87 FRLPNEVSSLqhLRAIDLSRNQFQDFPEQLTTlpALETINLEENEIVDVP 136
Cdd:PRK15370 233 TSIPATLPDT--IQEMELSINRITELPERLPS--ALQSLDLFHNKISCLP 278
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
19-181 5.77e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.92  E-value: 5.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956308   19 TVESGSDTLDLADCKLVSFPIC---IYKV---------LRNVSDQIHLITLANNELKSLTskfmTTFNQLRELRLEGNYL 86
Cdd:PRK15387 339 TLPSGLQELSVSDNQLASLPTLpseLYKLwaynnrltsLPALPSGLKELIVSGNRLTSLP----VLPSELKELMVSGNRL 414

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956308   87 FRLPNEVSSLQHLraiDLSRNQFQDFPEQLTTLPALETINLEENEIVDvpveklAAMPALRVInlrlnplsADVRVIAPP 166
Cdd:PRK15387 415 TSLPMLPSGLLSL---SVYRNQLTRLPESLIHLSSETTVNLEGNPLSE------RTLQALREI--------TSAPGYSGP 477

                        170
                 ....*....|....*..
gi 23956308  167 LIKFDM--LMSPEDTRA 181
Cdd:PRK15387 478 IIRFDMagASAPRETRA 494
LRR_8 pfam13855
Leucine rich repeat;
97-156 5.56e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 5.56e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23956308    97 QHLRAIDLSRNQFQDF-PEQLTTLPALETINLEENEIVDVPVEKLAAMPALRVINLRLNPL 156
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
75-132 5.68e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 5.68e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956308    75 QLRELRLEGNYLFRLPNEV-SSLQHLRAIDLSRNQFQDF-PEQLTTLPALETINLEENEI 132
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 22-158 5.76e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 5.76e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956308  22 SGSDTLDLADCKLVSFPICIYKVLRNVSDQIHLItLANNEL---------KSLTSKFMttfnQLRELRLEGNYL-----F 87
Cdd:cd00116  81 CGLQELDLSDNALGPDGCGVLESLLRSSSLQELK-LNNNGLgdrglrllaKGLKDLPP----ALEKLVLGRNRLegascE 155

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956308  88 RLPNEVSSLQHLRAIDLSRNQFQDF-----PEQLTTLPALETINLEENEIVDVPVEKLAA----MPALRVINLRLNPLSA 158
Cdd:cd00116 156 ALAKALRANRDLKELNLANNGIGDAgiralAEGLKANCNLEVLDLNNNGLTDEGASALAEtlasLKSLEVLNLGDNNLTD 235
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 52-160 7.15e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 7.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956308   52 IHLITLANNELKSLTSKFMTTFNQLRELRLEGNYLF-RLPNEVSSlQHLRAIDLSRNQFQD-FPEQLTTLPALETINLEE 129
Cdd:PLN00113 430 VYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFgGLPDSFGS-KRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSE 508

                         90       100       110
                 ....*....|....*....|....*....|.
gi 23956308  130 NEIVDVPVEKLAAMPALRVINLRLNPLSADV 160
Cdd:PLN00113 509 NKLSGEIPDELSSCKKLVSLDLSHNQLSGQI 539
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
10-146 4.80e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.15  E-value: 4.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956308   10 ARVARKVNETVESGSDTLDLADCKLVSFPICIykvlrnvSDQIHLITLANNELKSLTSkfmtTFNQLRELRLEGNYLFRL 89
Cdd:PRK15387 189 AAVVQKMRACLNNGNAVLNVGESGLTTLPDCL-------PAHITTLVIPDNNLTSLPA----LPPELRTLEVSGNQLTSL 257

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23956308   90 PN------EVS----SLQHLRAIDLSRNQFQDFPEQLTTLPALETiNLEENEIVDvpvEKLAAMPAL 146
Cdd:PRK15387 258 PVlppgllELSifsnPLTHLPALPSGLCKLWIFGNQLTSLPVLPP-GLQELSVSD---NQLASLPAL 320
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 53-160 6.97e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.45  E-value: 6.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956308   53 HLITLANNelksLTSKFMTTFNQLRELRlegnYLF--------RLPNEVSSLQHLRAIDLSRNQFQ-DFPEQLTTLPALE 123
Cdd:PLN00113 240 HLDLVYNN----LTGPIPSSLGNLKNLQ----YLFlyqnklsgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLE 311

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 23956308  124 TINLEENEIVDVPVEKLAAMPALRVINLRLNPLSADV 160
Cdd:PLN00113 312 ILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEI 348
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 27-159 1.25e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.49  E-value: 1.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956308  27 LDLADCKLVSFP-ICIYKVLRNVSDqIHLITLANNELKS----LTSKFMTTFNQLRELRLEGNYLFR-----LPNEVSSL 96
Cdd:cd00116 142 LVLGRNRLEGAScEALAKALRANRD-LKELNLANNGIGDagirALAEGLKANCNLEVLDLNNNGLTDegasaLAETLASL 220

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 23956308  97 QHLRAIDLSRNQFQDFPEQ------LTTLPALETINLEENEIVDVPVEKLA----AMPALRVINLRLNPLSAD 159
Cdd:cd00116 221 KSLEVLNLGDNNLTDAGAAalasalLSPNISLLTLSLSCNDITDDGAKDLAevlaEKESLLELDLRGNKFGEE 293
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 74-132 5.68e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 36.30  E-value: 5.68e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 23956308  74 NQLRELRLEGNYLfRLPNEVSSLQHLRAIDLSRNQFQDFPEQ---LTTLPALETINLEENEI 132
Cdd:cd21340 120 NSLRVLNISGNNI-DSLEPLAPLRNLEQLDASNNQISDLEELldlLSSWPSLRELDLTGNPV 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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